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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Pharmacokinetic in- teraction between ivabradine and carbamazepine in healthy volunteers显示文摘 | Vlase L Neag M Popa A etal | 2011 | J Clin Pharm Ther2011，36，2： | 1 |
| 3 | Pharmacokinetics and compar ative bioavailability of two fenofibrate capsule formulations in healthy volunteers显示文摘 | Vlase L Popa A Muntean D | 2010 | Arzneimittelforschung2010，60，9： | 1 |
| 4 | Determination of lorutu- dine and its active metabolite in human plasma by high-perform- ance liquid chromatography with mass spectrometry detection 显示文摘 | VLASE L IMRE S MUNTEAN D | 2007 | J Pharm Biomed Anal2007，44，3： | 1 |
| 5 | Antioxidant, diuretic activities and polyphenol content of Stereospermum kunthianum Cham. (Bignoniaceae)显示文摘 | M. Compaoré A. Lamien-Meda C. Mogo?an C.E. Lamien M. Kiendrebeogo O. Vo?tinaru L. Vlase C. Ionescu O.G. Nacoulma | 2011 | Natural Product Research2011，，19： | 1 |
| 6 | Specificity of decomposition of solids in non-isothermal conditions显示文摘 | VLASE T VLASE G DOCA M | 2003 | J Therm Anal Cal2003，72，2： | 1 |
| 7 | Grapefruit juice-drug interactions:importance for pharmacotherapy显示文摘 | Cuciureanu M Vlase L Muntean D | | 0，，： | 1 |
| 8 | HPLC analysis of salicylic de-rivatives from natural prouducts显示文摘 | Toiu A Vlase L Oniga I | 2011 | Farmacia2011，59，1： | 1 |
| 9 | Characterization of the murine immune response to the murine TSH receptor ectodomain:induction of hypothyroidism and TSH receptor antibodies 显示文摘 | Vlase H Weiss M Graves P N | 1998 | Clin Exp Immunol1998，113，1： | 1 |
| 10 | Determination of loratadine and its active metabolite in human plasma by high performance liquid chromatography with mass spectrometry detection显示文摘 | VLASE L IMRE S MUNTEAN D | 2006 | Pharm Biomed Anal2006，，： | 1 |
| 11 | Fast determination of colchicine by TLC-densitometry from pharmaceuticals and vegetal extracts显示文摘 | Bodoki E Oprean R Vlase L | 2005 | J Pharm Biomed Anal2005，37，5： | 1 |
| 12 | Compensation effect as a consequence of vibrational energy transfer in homogeneous and isotropic heat field 显示文摘 | Pop N Vlase G Vlase T | 2008 | Journal of Thermal Analysis and Calorimetry2008，92，1： | 1 |
| 13 | Determination of some polyphenolic compounds from Allium species by HPLC-UV-MS显示文摘 | Parvu M Toiu A Vlase L | 2010 | NaturalProduct Research2010，24，14： | 1 |
| 14 | Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes显示文摘Genistein, the main isoflavone from soy, and bisphenol A(BPA), a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BPA on estrone(E1) metabolism in rat liver microsomes. Both substances inhibited the 2-hydroxylation and 16α-hydroxylation of E1, but in different degrees, thereby reducing the 2-OH-E1/16α-OH-E1 ratio, a biomarker for the risk of breast cancer. Although the 2-OH-E1/16α-OH-E1 ratio was lower under BPA treatment than under the control condition, the difference was not statistically significant. The 2-OH-E1/16α-OH-E1 ratio was significantly reduced by genistein treatment(P<0.05), and this effect was more pronounced when using a combination of BPA and genistein(P<0.01). Our findings suggest that a synergistic inhibition effect of genistein and BPA on E1 metabolism is associated with an increased risk of breast cancer. | GHELDIU Ana-Maria POPA Daniela-Saveta LOGHIN Felicia VLASE Laurian | 2015 | Biomedical and Environmental Sciences2015，28，11： | 1 |
| 15 | Determination of fluoxetine and its N-desmethyl metabolite in human plasma by high -performance liquid chromatography 显示文摘 | Vlase L Imre S Leucuta S | 2005 | Talanta2005，66，： | 1 |
| 16 | Compensation effect as a consequence of vibrational energy transfer in homogeneous and isotropic heat field显示文摘 | POP N VLASE G VLASE T | 2008 | Journal of Thermal Analysis and Calorimetry2008，92，1： | 1 |
| 17 | Compensation effect as a consequence of vibrational energy transfer in homogeneous and isotropic heat field显示文摘 | POP N VLASE G VLASE T | 2008 | Journal of Thermal Analysis and Calorimetry2008，92，1： | 1 |
| 18 | Pharmacokinetic interaction study between ranitidine and metoclopramide 显示文摘 | Leucuta A Vlase L Farcau D | 2004 | Rom J Gastroenterol2004，13，3： | 1 |
| 19 | Pharmacokinetics and metabolic drug interactions 显示文摘 | LEUCUTA S E VLASE L V | 2006 | Curr Clin Pharmacol2006，1，1： | 1 |
| 20 | Pharmacokinetic interaction between ivabradine and carbamazepine in healthy volunteers显示文摘 | VLASE L NEAG M POPA A | 2011 | J Clin Pharm and Ther2011，36，2： | 1 |
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