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| 1 | 青藏高原中东部过去2485年以来温度变化的树轮记录显示文摘通过青藏高原东北部现生活树与墓葬古木相衔接,利用树轮宽度重建了这一地区过去2485a以来的年均温度变化序列.这个温度序列所揭示的气候历史表明序列中有4个时期的温度高于或接近1970~2000AD的平均温度.348~413AD出现过一次快速的由寒冷到温暖的气候突变事件,文中称之为'东晋事件'.计算表明,高原中东部长时间尺度温度变化不仅反映了中国中北地区,同时也响应了北半球的温度变化.在过去2485a里,中国绝大部分朝代的灭亡都与该温度序列的低温时期相对应.此外,与中国其他地区的温度记录相比较,高原中东部在1950年代之后升温幅度更高一些. | 刘禹 安芷生 Hans W. Linderholm Deliang Chen 宋慧明 蔡秋芳 孙军艳 田华 | 2009 | 中国科学(D辑)2009，，2： | 64 |
| 2 | Formation history and protolith characteristics of granulite facies metamorphic rock in Central Cathaysia deduced from U-Pb and Lu-Hf isotopic studies of single zircon grains显示文摘The petrochemical as well as zircon U-Pb and Lu-Hf isotopic studies of granulite facies metamorphic rock from the Taoxi Group in eastern Nanling Range, Central Cathaysia indicate that its protolith is the sedimentary rock with low maturation index. The clastic materials are mostly from middle Neoproterozoic (~736 Ma) granitoid rocks with minor Neoarchaean and Paleoproterozoic rocks. The timing of this Neoproterozoic magmatism is in agreement with the second period of magmatism widespread surrounding the Yangtze Block. Hf isotopic data indicate that the Neoproterozoic granitoids resulted from the recycled Paleoproterozoic mantle-derived crustal materials. The sedimentary rock was deposited in Late Neoproterozoic Era, and carried into low crust in Early Paleozoic. The partial melting of the meta-sedimentary rock took place at about 480 Ma and subsequently granulite facies metamorphism occurred at ca. 443 Ma. The zircons forming during this time interval (Early Paleozoic) show large Hf isotope variations, and their -Hf(t) values increase from -13.2 to +2.36 with decreasing age, suggesting the injection of mantle-derived materials during partial melting and metamorphism processes in the Early Paleozoic. Calculation results show that this metamorphic rock, if evolved to Mesozoic, has similar isotopic composition to the nearby Mesozoic high Si peraluminous granites, implying that this kind of granulite facies metamorphic rock is probably the source material of some Mesozoic peraluminous granitoids in eastern Nanling Range. | YU Jinhai ZHOU Xinmin Y. S. O'Reilly ZHAO Lei W. L. Griffin WANG Rucheng WANG Lijuan CHEN Xiaomin | 2005 | Chinese Science Bulletin2005，50，18： | 35 |
| 3 | Seasonal water storage change of the Yangtze River basin detected by GRACE显示文摘US-Germany co-sponsered satellite gravimetry mission GRACE (Gravity Recovery And Climate Experiment), launched in March 2002, has been producing monthly time series of Earth gravity models up to degree and order of 120. The GRACE mission consists of two identical satellites flying on an almost polar orbit with an altitude of about 300-500 km and satelite-to-satellite ranging of about 220 km. Thanks to the payloads of space-borne GPS receivers, accelerometers and high-precision K-band satelite-to-satellite ranging mesurements, GRACE gravity models are expected to achieve more than one order of magnitude of improvement over previous models at spatial scales of a few hundred kilometers or larger. Recovery of surface mass re-distribution based on GRACE’s time-varying gravity models is applied to studies in solid Earth geophysics, oceanography, climatology and geodesy. At secular time scales, GRACE is expected to provide valuable information on global ice changes, whose variations have profound influences on global climate, and in particular, on sea level changes. At seasonal time scales, GRACE is expected to reveal surface water changes with an ac- curacy of less than 1 cm, or ocean bottom pressure changes with an accuracy of less than 1 mbar (1 mbar =102 Pa). These surface mass redistribution measurements would impove our understanding of the global and regional mass and energy cycles that are critical to human life. Using 15 GRACE monthly gravity models covering the period from April 2002 to December 2003, this study compares seasonal water storage changes recovered from GRACE data and hydrology models at global and regional scales, with particular focus on the Yangtze River basin of China. Annual amplitude of 3.4 cm of equivalent water height change is found for the Yangtze River basin with maximum in Spring and Autumn, agreeing with two state-of-the-art hydrology models. The differences between GRACE re- sults and model predictions are less than 1-2 cm. We conclude that satellite gravimetry has huge potentials in monitering water storage changes in large river basins such as Yangtze. | HU Xiaogong1, CHEN Jianli1,2, ZHOU Yonghong1, HUANG Cheng1 & LIAO Xinhao1 1. Center for Astro-geodynamics Research, Shanghai Astronomical Observatory, National Astronomical Observatories, Shanghai 200030, China 2. Center for Space Research, University of Texas at Austin, 3925 W. Braker Lane, Suite 200, Austin, TX78750, USA | 2006 | Science China Earth Sciences2006，49，5： | 29 |
| 4 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 5 | Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women显示文摘 | Hu, Z. B. Liang, J. Wang, Z. W. Tian, T. Zhou, X. Y. Chen, J. P. Miao, R. F. Wang, Y. Wang, X. R. Shen, H. B. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 29 |
| 6 | Functional Variant in microRNA-196a2 Contributes to the Susceptibility of Congenital Heart Disease in a Chinese Population显示文摘 | XU , J. Hu, Z.B. Xu, Z.F. Gu, H.Y Yi, L. Cao, H. L. Chen, J. P. Tian, T. Liang, J. Lin, Y. Qiu, W. S. Ma, H.X. Shen, H. B Chen, Y. J. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 20 |
| 7 | THE IMPROVEMENT OF ELECTRON FIELD EMISSION FROM AMORPHOUS CARBON FILMS DUE TO HYDROGEN PLASMA CHEMICAL ANNEALING EFFECT显示文摘Hydrogenated amorphous carbon films were fabricated by using layer-by-layer deposition method and hydrogen dilution method in a small d.c.-assisted plasma enhanced chemical vapor deposition system. It was found that the hydrogen plasma treatment could change the sp2/sp3 ratio to some extent by chemical etching. The improvements of field emission characteristics were observed compared with that from conventionally deposited a-C films, which can be attributed to the large field enhancement effect due to the inhomogeneous distribution of nanometer scale sp2 clusters and the reduction of the surface emission barrier due to the hydrogen termination. | J. Xu, X.H. Huang, L. Wang, W. Li and K.J. Chen (National Laboratory of Solid State Microstructures and Departmeat of Physics, Nanjing University, Nanjing 210093, China) J.B. Xu (Department of Electronic Engineering, The Chinese University of Hong Kong, S | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 15 |
| 8 | Contamination by Organochlorine Pesticides in the Estuaries of Southeast China显示文摘Persistent organic pollutants(POPs) such as organochlorine pesticides are of global concern due to their widespread occurrence and persistence. This paper reports recent research studying the distribution and fate of organochlorine pesticides in the Jiulong River, the Minjiang River and the Pearl River estuaries in Southeast China. Eighteen organochlorine pesticides were extracted from water, pore water and sediment samples, followed by analysis by GC ECD. The results showed that the contamination levels were similar in these three estuaries. The levels of the total organochlorine pesticides in porewater were significantly higher than those in surface water, due to the high affinity of these hydrophobic compounds for sediment phase. Among the hexachlorocyclohexane(HCH) compounds, β HCH was found to be the most important isomer. The analysis of 1,1,1 trichloro 2,2 bis chlorophenyl ethane(DDT) and its metabolites showed that 1,1 dichloro 2[ o chlorophenyl] 2[ p chlorophenyl] ethylene(DDE) was dominant in the group. | Z. L. Zhang 1,2 , H. S. Hong 2, J. L. Zhou 3,** , M. H. Dai 2, K. Maskaouib 2 and W. Q. Chen 2 1. Department of Environmental Science and Engineering, Tsinghua POPs Research Centre, Tsinghua University, Beijing 100084, China 2. Key Laborator | 2002 | Chemical Research in Chinese Universities2002，18，2： | 13 |
| 9 | Lessons in bridge damage learned from the Wenchuan earthquake显示文摘A strong earthquake occurred in Wenchuan County,Sichuan Province,China,on May 12,2008.Shortly after the earthquake,the Turner-Fairbank Highway Research Center of the Federal Highway Administration,in partnership with the Research Institute of Highways,the Ministry of Communication of China,led a reconnaissance team to conduct a post-earthquake bridge performance investigation of the transportation system in the earthquake affected areas.The U.S.transportation system reconnaissance team visited the area during July 20-24,2008.This paper presents the fi ndings and lessons learned by the team. | W. Phillip Yen Genda Chen Mark Yashinski Youssef Hashash Curtis Holu Wang Kehai GuoXiaodong | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 11 |
| 10 | Quantitative study of tectonic geomorphology along Haiyuan fault based on airborne LiDAR显示文摘High-precision and high-resolution topography are the fundamental data for active fault research.Light detection and ranging(LiDAR)presents a new approach to build detailed digital elevation models effectively.We take the Haiyuan fault in Gansu Province as an example of how LiDAR data may be used to improve the study of active faults and the risk assessment of related hazards.In the eastern segment of the Haiyuan fault,the Shaomayin site has been comprehensively investigated in previous research because of its exemplary tectonic topographic features.Based on unprecedented LiDAR data,the horizontal and vertical coseismic offsets at the Shaomayin site are described.The measured horizontal value is about 8.6 m,and the vertical value is about 0.8 m.Using prior dating ages sampled from the same location,we estimate the horizontal slip rate as4.0±1.0 mm/a with high confidence and define that the lower bound of the vertical slip rate is 0.4±0.1 mm/a since the Holocene.LiDAR data can repeat the measurements of field work on quantifying offsets of tectonic landform features quite well.The offset landforms are visualized on an office computer workstation easily,and specialized software may be used to obtain displacement quantitatively.By combining precious chronological results,the fundamentallink between fault activity and large earthquakes is better recognized,as well as the potential risk for future earthquake hazards. | Tao Chen Pei Zhen Zhang Jing Liu Chuan You Li Zhi Kun Ren Kenneth W. Hudnut | 2014 | Chinese Science Bulletin2014，59，20： | 10 |
| 11 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 12 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 13 | Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo a pyrene and hydrogen peroxide显示文摘 | Chen, R. Qiu, W. Liu, Z. L. Cao, X. J. Zhu, T. Li, A. P. Wei, Q. Y. Zhou, J. W. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 9 |
| 14 | COMPARISON OF THE ANALYTIC NETWORK PROCESS AND THE GRAPH MODEL FOR CONFLICT RESOLUTION显示文摘A comparison of two decision analysis tools for the analysis of strategic conflicts, the Analytic Network Process (ANP) and the graph model for conflict resolution, is carried out by applying them to the China-US TV dumping conflict. Firstly, the graph model is introduced along with practical procedures for modeling and analyzing conflicts using the decision support software, GMCR II. Next, ANP is explained, emphasizing structural features and procedures for synthesizing priorities. Then a framework for employing ANP to analyze strategic conflicts is designed and used to compare ANP to the graph model. The case study of the China-US TV dumping conflict provides a basis for the graph model and ANP to be compared; different features of the approaches are highlighted. The study shows that because of different theoretical backgrounds, ANP and the graph model for conflict analysis both provide useful information which can be combined to furnish a better understanding of a strategic conflict. | Xin SU Ye CHEN Keith W. HIPEL D. Marc KILGOUR | 2005 | Journal of Systems Science and Systems Engineering2005，14，3： | 9 |
| 15 | BEHAVIOR OF FLOW STRESS OF ALUMINUM SHEETS USED FOR PRESSURE CAN DURING COMPRESSION AT ELEVATED TEMPERATURE显示文摘The behavior of flow stress of Al sheets used for pressure can prepared by different melt-treat- ment during plastic deformation at elevated temperature was studied by isothermal compression test using Gleeble1500 dynamic hot-simulation testing machine. The results show that the Al sheets possess the remarkable characteristic of steady state flow stress when they are deformed in the temperature range of 350-500°C at strain rates within the range of 0.01-10.0s-1. A hyperbolic sine relationship is found to correlate well the flow stress with the strain rate, and an Arrhenius relationship with the temperature, which implies that the process of plastic deformation at ele- vated temperature for this material is thermally activated. Compared with the Al pieces prepared by no or conventional melt-treatment, hot deformation activation energy of Al sheets prepared by high-efficient melt-treatment is the smallest (Q = 168.0kJ/mol), which reveals that the hot work- ing formability of this material is very better, and has directly to do with the effective improve- ment of its metallurgical quality. | G.S. Fu W.Z. Chen K. W. Qian | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，6： | 9 |
| 16 | Late Cretaceous biota and the Cretaceous-Paleogene(K--Pg)Boundary in Jiayin of Heilongjiang,China显示文摘An international cooperative study of the Late Cretaceous biota and non-marine strata including the Cretaceous-Paleogene(K--Pg) boundary in Jiayin near the Heilongjiang River,China during 2002-2010,is summarized in this paper. The strata includes the Upper Cretaceous Yong'ancun-,Taipinglinchang-,Yuliang-zi-,and Furao formations,and the Paleocence Wuyun Formation consisting of Baoshantou Member and a Coalbearing Member. Seven palynological assemblages from Santonian to Paleocene are recognized,which is used for definition of the K--Pg boundary. Through the palynological analysis of three drilled boreholes (XHY-2005,2006,2008) in Xiaoheyan of western Jiayin,the K--Pg boundary is defined within 20. 00-20. 05 m in the borehole XHY-2006 (as a standard boundary) which is just between the top of Furao Formation (late Maasterichtian) and the base of Baishantou Member (early Danian) . These new research results are supported by paleo- magnetic,geochemical and other analyses,also. On the other hand,the presence of eight taxa of Maasterichtian dinosaurs (mostly hadrosaurids) have been recognized by the authors; and two mega-plant assemblages from the Yong'ancun Fm (Santonian) to Taipinglinchang Fm (Campanian) are confirmed. These research a-chievements indicate that the Upper Cretaceous-Paleocene in Jiayin can be well correlated to the strata in the neighboring Zeya-Bureja basin,Russia. The K--Pg boundary definited in Jiayin is the first well documented non-marine K--Pg boundary in China. Also the related paleoclimate,paleoenvironment and the mass extinctions in this area during the Cretaceous-Paleocene transition are also discussed. | Sun G. Akhmetiev M. Markevich V. Ashraf A. R. Bugdaeva E. Godefroit P. Bolotsky Yu. Dong Z. M. Golovneva L. Yang H. X. Sun C. L. Sun Y. W. Quan C. Kodrul T. Kezina T. Johnson K. Nishida H Dilcher D. L. Harding I. Chen Y. J. | 2011 | Global Geology2011，14，3： | 9 |
| 17 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 18 | NUMERICAL SIMULATION OF THE THERMO-MECHANICAL PROCESS FOR BEAM BLANK CONTINUOUS CASTING显示文摘The aim of this study was to simulate the solidification process of beam blank continuous casting, and then find the reasons for the typical defects of the beam blank. A two-dimensional transient coupled finite element model has been developed to compute the temperature and stress profile in beam blank continuous casting. The enthalpy method was used in the heat conduction equation. The thermo-mechanical property in the mushy zone was taken into consideration in this calculation. It is shown that at the mold exit the thickness of the shell had its maximum value at the flange tip and its minimum value at the fillet. The temperature had a great fluctuation on the surface of the beam blank in the secondary cooling zone. At the unbending point, the surface temperature of the web was in the brittleness temperature range under the present condition. To ensure the quality, it is necessary to weaken the intensity of secondary cooling. At the mold exit the equivalent stress and strain have higher values at the flange tip and at the web. From the spray 1 to the unbending point, the maximum values of stress and strain gradually moved to the internal section of the flange tip and the web. However, whenever, there were bigger stress and strain values near the flange tip and the web than in the other parts, it must be very easy to generate cracks at those positions. Now, online verification of this simulation has been developed, which has proved to be very useful and efficient to instruct the practical production of beam blank continuous casting. | W. Chen Y.Z. Zhang C.J. Zhang L.G. Zhu B.X. Wang W.G. Lu J.H. Ma | 2007 | Acta Metallurgica Sinica(English Letters)2007，20，4： | 8 |
| 19 | Optimized quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions in the left anterior descending artery显示文摘 | Tak W. Kwan YANG Song XU Bo Jack Chen XU Tian YE Fei ZHANG Jun-jie TIAN Nai-liang LIU Zhi-zhong CHEN Shao-liang | 2012 | Chinese Medical Journal2012，，23： | 8 |
| 20 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
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