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| 1 | Reliability analysis of climate change of tropical cyclone activity over the western North Pacific显示文摘 | Ren E J.Liang G.Wu W.Dong and X.Yang | | 0，，： | 1 |
| 2 | 震害预测的神经网络法显示文摘一、前言 现行的震害分析方法,无论是确定性分析方法还是概率方法,都是以地面加速度峰值(PGA)作为地面运动的幅值参数来度量地震地面运动的激烈程度的。从设计者的观点来看,PGA是非常实用的,但是它与观察到的结构性能间的关系并不很密切,也不是震害评估中采用的参数。一般情况下,先考虑PGA从震源到场地的衰减,然后将之转换成修正的麦加利地震烈度(MMI)用于破坏估计。这两步过程,即衰减过程和PGA—MMI转换过程都涉及大量的不确定因素。 | F.S.Wong A.T.Y.Tung W.Dong 陈隽 | 1994 | 世界地震工程1994，10，1： | 0 |
| 3 | α-Synuclein arginylation in the human brain显示文摘Background: Alpha-synuclein (α-syn) exhibits pathological misfolding in many human neurodegenerative disorders. We previously showed that α-syn is arginylated in the mouse brain and that lack of arginylation leads to neurodegen-eration in mice. Methods: Here, we tested α-syn arginylation in human brain pathology using newly derived antibodies in combina-tion with Western blotting, biochemical assays, and experiments in live neurons. Results: We found that α-syn was arginylated in the human brain on E46 and E83, two sites previously implicated in α-syn pathology and familial cases of Parkinson’s disease. The levels of arginylation in different brain samples ranged between ~ 3% and ~ 50% of the total α-syn pool, and this arginylation nearly exclusively concentrated in the subcellu-lar α-syn fraction that sedimented at low centrifugation speeds and appeared to be simultaneously targeted by multi-ple posttranslational modifications. Arginylated α-syn was less susceptible to S129 phosphorylation and pathological aggregation in neurons. The arginylation level inversely correlated with the overall α-syn levels and with patient age, suggesting a possible causal relationship between arginylation decline and α-syn-dependent neuropathology. Conclusion: We propose that α-syn arginylation constitutes a potential neuroprotective mechanism that prevents its abnormal accumulation during neurodegeneration and aging in the human brain. | Jun Zhao Buyan Pan Marie Fina Yun Huang Marie Shimogawa Kelvin C.Luk Elizabeth Rhoades EJames Petersson Dawei W.Dong Anna Kashina | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
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