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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Estimation of the beginning and end of recurrent events within a climate regime显示文摘 | GERSTENGARBE F W WERNER P C | 1999 | Climate Research1999，11，： | 1 |
| 3 | A plant homolog of the neutrophil NADPH oxidase gp^91phox subunit gene encodes a plasma membrane protein with Ca^2- binding motifs显示文摘 | KELLER T DAMUDE H G WERNER D DOERNER P DIXON R A LAMB C | 1998 | Plant Cell1998，10，2： | 1 |
| 4 | Internal fixation of com- plex fractures of the proximal humerus 显示文摘 | Gerber C Werner CM Vienne P | 2004 | J Bone Joint Surg(Br)2004，86，6： | 1 |
| 5 | Estimation of the beginning and end of recurrent events within a climate regime 显示文摘 | GERSTENGARBE F W WERNER P C | 1999 | Climate Research1999，11，： | 1 |
| 6 | Accuracy of Top ographie Maps Derived from ERS-1 Interferometric Radar显示文摘 | Zebker H A Werner C L Rosen P A | 1994 | IEEE Transactions on Geoseience and Remote Sensing1994，32，4： | 1 |
| 7 | Accuracy of Topographic Maps Derived from ERS-1 Interferometric Radar显示文摘 | ZEBKER H A WERNER C L ROSEN P A | 1994 | IEEE Transactions on Geoscience and Remote Sensing1994，32，4： | 1 |
| 8 | Isoflurane is asso- ciated with a similar incidence of emergence agitaion/ delirium as sevflurane in young ehildren--a randomized controlled study显示文摘 | Meyer RR Munster P Werner C et a/ | 2007 | Paediatr Anaesth2007，17，1： | 1 |
| 9 | Accuracy of Topographic Maps Derived from ERS-1 Interferometric Radar 显示文摘 | Zebker H A Werner C L Rosen P A | 1994 | IEEE Transactions on Geosience and Remote Sensing1994，32，4： | 1 |
| 10 | Worldwide occurrence and fate of chlorofluocarbons in groundwater显示文摘 | Hohener P Werner D Balsiger C | 2003 | Critical Reviews in Environmental Science and Technology2003，33，1： | 1 |
| 11 | Internal fixation of complex fractures of the proximal humerus显示文摘 | Gerber C Werner CM Vienne P | 2004 | J Bone Joint Surg Br2004，86，： | 1 |
| 12 | Accura- cy of Topographic Maps Derived from ERS-1 In- terometric Radar 显示文摘 | Zebker H A Werner C L Rosen P A | 1994 | IEEE Trans Geosci Remote Sens1994，32，4： | 1 |
| 13 | Xanthelasma Palpebrarum:Treatment with the Ultrapulsed CO2 Laser显示文摘 | RAULIN C SCHOENERMARK M P WERNER S | 1999 | Lasers Surg Med1999，24，2： | 1 |
| 14 | Impaired oxidation action of pyruvate in human embyonic fibroblasts after exposure to L-dopa显示文摘 | Mytilineou C Cohen G | 1994 | Eur J Pharmacol1994，236，： | 1 |
| 15 | Accuracy of topographic maps derived from ERS-1 interferometrie radar显示文摘 | Zebker H A Werner C L Rosen P A | 1994 | IEEE Transactions on Geoscience and Remote Sensing1994，32，4： | 1 |
| 16 | Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of(-)-linalool in mice显示文摘 | BATISTA P A WERNER M F OLIVEIRA E C | | 0，，03： | 1 |
| 17 | Expression and function of beta - glucuronidase in pancreatic cancer: potential role in drug targeting 显示文摘 | Sperker B Werner U Miirdter TE Tekkaya C Fritz P Wacke R Adam U Gerken M Drewelow B Kroemer HK | 2000 | Naunyn Schmiedebergs Arch Pharma- col2000，362，2： | 1 |
| 18 | Internal fixation of complex fractures of the proximal humerus 显示文摘 | Gerber C Werner CM Vienne P | 2004 | J Bone Joint Surg Br2004，86，6： | 1 |
| 19 | Internal fixation of complex fractures of the proximal humerus显示文摘 | Gerber C Werner CM Vienne P | | 0，，： | 1 |
| 20 | Worldwide occurrence and fate of chlorofluorocarbons in groundwater 显示文摘 | HOHENER P WERNER D BALSIGER C | 2003 | Critical Reviews in Environmental Science and Technology2003，33，1： | 1 |
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