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| 1 | CD24 expression predicts distant metastasis in extrahepatic bile duct cancer显示文摘AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer. | Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young Jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang Ja-June Jang Sung W Ha | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 2 | An efficient anonymous channel protocol in wireless communications 显示文摘 | JAN J K WHE D L | 2001 | IEICE Transactions on Communication2001，84，3： | 1 |
| 3 | An efficient anonymous channel protocol in wireless communications显示文摘 | JAN J K WHE D L | 2001 | IEICE Trans- actions on Communication2001，，84： | 1 |
| 4 | The nature of haemorrhoids显示文摘 | Thompson WHE | 1975 | Br J Surg1975，62，1： | 1 |
| 5 | Mechanics of wound healing and importance of vacuum assisted closure in urology显示文摘 | Whe|an C Stewart J Schwartz BF | 2005 | J Urol2005，173，5： | 1 |
| 6 | SOX9 directly n:~ndates thetypel/eollagengene显示文摘 | Bell EM Leung KK Whe~ley SC | | Namre Genet0，16，2： | 1 |
| 7 | Role of Adjuvant Chemoradiotherapy for Ampulla of Vater Cancer显示文摘 | Kyubo Kim Eui Kyu Chie Jin-Young Jang Sun Whe Kim Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang Sung W. Ha | 2009 | International Journal of Radiation Oncology Biology Physics2009，，2： | 1 |
| 8 | An Efficient Anonymous Channel Protocol in Wireless Communications显示文摘 | Jan J K Whe D L | 2001 | IEICE Transactions on Communication2001，84，： | 1 |
| 9 | Fractal scaling of soil particlesize distributions:analysis and limitations显示文摘 | Tyler S W Whe atcraft S W | 1992 | Soil Science Society of America Journal1992，56，2： | 1 |
| 10 | Role of postoperative radiotherapy in the management of extrahepatic bile duct cancer显示文摘 | Suzy Kim Sun Whe Kim Yong Joo Bang Dae-Seog Heo Sung Whan Ha | 2002 | International Journal of Radiation Oncology Biology Physics2002，，2： | 1 |
| 11 | Laparoscopic splenectomy plus cholecystectomy for treating hereditary spherocytosis combined with cholelithiasis in siblings显示文摘 | Yoo‐Shin Choi Ho‐Seong Han Yoo‐Seok Yoon Jin‐Young Jang Sun‐Whe Kim Yong‐Hyun Park | 2007 | Minimally Invasive Therapy & Allied Technologies2007，，5： | 1 |
| 12 | A rapid, straight-forward method for controlling the morphology of stable silver nanopartieles 显示文摘 | Ledwlth D M Whe/an A M Kelly JM | 2007 | Journal of Materials Chemistry2007，17，： | 1 |
| 13 | Clinical Assisted Reproduction: Cumulus Cells Apoptosis as an Indicator to Predict the Quality of Oocytes and the Outcome of IVF–ET显示文摘 | Kyu Sup Lee Bo Sun Joo Yong Jin Na Man Soo Yoon Ook Hwan Choi Won Whe Kim | 2001 | Journal of Assisted Reproduction and Genetics2001，，9： | 1 |
| 14 | Future direc tions of precision agriculture 显示文摘 | McBratney A Whe Ancev T | 2005 | Precision Agriculture2005，6，1： | 1 |
| 15 | The nature of haemorrhoids 显示文摘 | Thompson WHE | 1975 | Br J Surg1975，62，1： | 1 |
| 16 | Post -translational mod- ification of an R2R3-MYB transcription factor by a MAP Kinase during xylem development显示文摘 | MORSE A M WHE'lq'EN R W DUBOS C | 2009 | New Phytol2009，183，4： | 1 |
| 17 | Factors influencing delayed gastric emptying after pylorous pre- serving pancreat oduodenectomy 显示文摘 | YOON CHAN PARK SUN WHE KIM JIN YOUNG JANG | 2003 | The American College of Surgeons2003，196，6： | 1 |
| 18 | Differentiating benign from malignant solid breast masses: value of shear wave elastog- raphy according to lesion stiffness combined with greyscale ul- trasound according to BI-RADS classification 显示文摘 | Evans A Whe/ehan P Thomson K | 2012 | Br J Cancer2012，107，2： | 1 |
| 19 | Innovative dietary sources of to - 3 fatty acids 显示文摘 | Whe|an J Rust C | 2006 | Annu Rev Nutr2006，26，： | 1 |
| 20 | Towards an analysis of the rice mitochondrial proteome显示文摘 | Heazlewood JL Howell KA Whe|an JA | 2003 | Plant Physiology2003，132，： | 1 |
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