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| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | APACHEⅡ:a severity of disease classification system显示文摘 | Knaus W A Draper E A Wagner D P | 1985 | Crit Care Med1985，13，： | 2 |
| 4 | APACHEⅡ:a severity of disease classification system显示文摘 | Knaus W A Zimmerman J E Wagner D P | 1989 | Crit Care Med1989，，： | 2 |
| 5 | Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests显示文摘 | Richard F A Logan Julietta Patnick Claire Nickerson Lynn Coleman Matt D Rutter Christian von Wagner | 2012 | Gut2012，，10： | 2 |
| 6 | Satisfaction, repurchase intent, and repurchase behavior: Investigating the moderating effect of customer characteristics显示文摘 | Vikas Mittal Wagner A Kamakura | 2001 | Journal of Marketing Research2001，，2： | 1 |
| 7 | Plasma adiponectin,insulin sensitivity,and subclinical inflammation in women with prior gestational DM显示文摘 | Winzer C Wagner O Fwata A | 2004 | Diabetes Care2004，27，7： | 1 |
| 8 | Synthesis of oligonucleotide funetionalized magnetic nanoparticles and study on their in vitro cell uptake显示文摘 | Wagner K Kautz A Roder M | 2004 | Appl Organometal Chem2004，18，： | 1 |
| 9 | Induction of cellular genes is mediated by the Bell transactivator in foamy virus-infected human cells显示文摘 | Wagner A Doerks A Aboud M | 2000 | J Virol2000，74，： | 1 |
| 10 | Cochlear implants in isolated temporal hones: evaluation of electrode position with 64-slice computed tomography显示文摘 | Wagner JH Radcmacher G Ernst A | 2009 | HNO2009，57，6： | 1 |
| 11 | Parietal lobe contributions to episodic memory retrieval显示文摘 | Wagner A D Shannon B J Kahn I | 2005 | Trends Cogn Sci2005，9，： | 1 |
| 12 | Comparative characteristics of mesenehymal stern cells from human bone marrow, adipose tissue, and umbilical cord blood 显示文摘 | Wagner W Wein F Seckinger A | 2005 | Exp Hematol2005，33，11： | 1 |
| 13 | Electrophoretic, solubility, and functional properties of commercial soy protein isolartes 显示文摘 | Arrese E L Sorgentini D A Wagner J R Anon M C | 1991 | Journal of Agricultural and Food Chemistry1991，39，： | 1 |
| 14 | Develop- ment of a multiplex and semi-nested PCR assay for detection of Yersinia enterocolitica and Aeromonas hydrophila in rawmilk显示文摘 | YESIM Z O LEHNER A WAGNER M | 2000 | Food Microbiol2000，17，： | 1 |
| 15 | Induction of collagenase and stromelysin gene expression by mechanic injury in vascular smooth - derived cell Line显示文摘 | James T W Wagner R White L A | 1993 | J cell physiol1993，157，： | 1 |
| 16 | Liver surgery in the era of tissue-preserving resections:early and late outcome in patients with primary and secondary hepatic tumors显示文摘 | Redaelli C A Wagner M Krahenbuhi L | 2002 | World J Surg2002，26，9： | 1 |
| 17 | The small world of metabolism 显示文摘 | Fell D A Wagner A | 2000 | Nature (Biotechnology)2000，，18： | 1 |
| 18 | APACHE Ⅱ: a severity of disease classification system 显示文摘 | Knaus W A Draper E A Wagner D P | 1985 | Crit Care Med1985，13，： | 1 |
| 19 | Thermal and electrophoretic behavior,hydrophobicity,and some functional properties of acid-treated soy isolates显示文摘 | Wagner J R Sorgentini D A Anon M C | 1996 | J Agri Food Chem1996，44，： | 1 |
| 20 | Effect of combined use of nonionic surfactant on formation of oil-in-water mlcroemulsions显示文摘 | Li P Ghosh A Wagner R F | 2005 | Int J Pharm2005，288，1： | 1 |
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