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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Diffusion properties of major white matter tracts in young, typically develo- ping children显示文摘 | Johnson R T Yeatman J D Wandell B A | 2014 | Neurolmage2014，88，： | 1 |
| 3 | Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein 显示文摘 | Kim R B Wandel C Leake B | 1999 | Pharm Res1999，16，3： | 1 |
| 4 | Laboratory control of minimal heparinization during hemodialysis in patients with a risk of hemorrhage显示文摘 | Hafner G Klingle R Wandel B | 1994 | Blood Coagul Fibrilysis1994，5，： | 1 |
| 5 | 显示文摘 | Aner S M Wandeler R Gobel U | 1997 | Journal of Catalysis1997，169，： | 1 |
| 6 | Prospec-tive evaluation of methylated SEPT9 in plasma for detection of a-symptomatic colorectal cancer 显示文摘 | CHURCH T R WANDELL M LOFTON DAY C | 2014 | Gut2014，63，2： | 1 |
| 7 | Supercritical fluids:opportunities in heterogeneous catalysis 显示文摘 | Baiker A Wandeler R | 2000 | Chemistry and Material Science2000，4，2： | 1 |
| 8 | Midazolam is m- etabolized by at least three different eytochrome P450 en- zymes显示文摘 | Wandel C Brocker R Bohrer H | 1994 | Br J Anaesth1994，73，5： | 1 |
| 9 | 查看详情显示文摘 | Onken C A Ferrarese L Merritt D Peterson B M Pogge R W Vestergaard M Wandel A | | 0，，： | 1 |
| 10 | Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection:a systematic review and meta-analysis显示文摘 | Müller M Wandel S Colebunders R | 2010 | Lancet Infect Dis2010，10，4： | 1 |
| 11 | Interaction of morphine, fentanyl, sufentanil,alfentanil, and loperamide with the efflux drug transporter P- glycoprotein显示文摘 | Wandel C Kim R Wood hi | 2002 | Anesthesiology2002，96，4： | 1 |
| 12 | Laboratory control of minimal heparinization during hemodialysis in patients wish risk of hemorrhage显示文摘 | Hafner F Kingel R Wandel E | | 0，，： | 1 |
| 13 | Vieilin with carboxy-terminal KDEL is retained in the endoplasmic reticulum and accumulates to high levels in the leaves of transgenic plants显示文摘 | Wandel C I Khan M R I Craig S el al | 1992 | The Plant Journal1992，2，2： | 1 |
| 14 | Laboratory control of minimal haparinizayion during hemodialysis in patients with a risk of henorrhage显示文摘 | Hafnde G Klingel R Wandel E | 1994 | Blood Coagul Fibrilysis1994，5，3： | 1 |
| 15 | Interrelationship between substrates and inhibitors of human CYP3A and P-Glycoprotein显示文摘 | Kim R B Wandel C Leake B | 1999 | Pharma Centical1999，16，3： | 1 |
| 16 | 'Inactive' excipients such as Cremophor can affect in vivo drug disposition 显示文摘 | Wandel C Kim R B Stein C M | 2003 | Clin Pharmacol Ther2003，73，5： | 1 |
| 17 | Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection:a systematic review and meta-analysis显示文摘 | Muller M Wandel S Colebunders R | 2010 | Lancet Infect Dis2010，10，4： | 1 |
| 18 | Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer显示文摘 | Church T R Wandell M Lofton-Day C | 2014 | Gut2014，63，2： | 1 |
| 19 | Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P - glycoprotein 显示文摘 | Wandel C Kim R Wood M | 2002 | Anesthesiology2002，96，： | 1 |
| 20 | Supercritical fluids in catalysis:opportunities of in situ spectroscopic studies and monitoring phase behavior 显示文摘 | Grunwaldt J D Wandeler R Baiker A | 2003 | Catalysis Reviews- Science Engineering2003，45，1： | 1 |
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