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| 1 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 2 | Slightly ruthenium doping enables better alloy nanoparticle exsolution of perovskite anode for high-performance direct-ammonia solid oxide fuel cells显示文摘Fuel flexibility is one of the most distinguished advantages of solid oxide fuel cells(SOFCs)over other low-temperature fuel cells.Furthermore,the combination of ammonia fuel and SOFCs technology should be a promising clean energy system after considering the high energy density,easy transportation/storage,matured synthesis technology and carbon-free nature of NH_(3) as well as high efficiency of SOFCs.However,the large-scale applications of direct-ammonia SOFCs(DASOFCs)are strongly limited by the inferior anti-sintering capability and catalytic activity for ammonia decomposition reaction of conventional nickel-based cermet anode.Herein,a slightly ruthenium(Ru)doping in perovskite oxides is proposed to promote the alloy nanoparticle exsolution,enabling better DA-SOFCs with enhanced power outputs and operational stability.After treating Ru-doped Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.75)Ru_(0.05)O_(3-δ) single-phase perovskite in a reducing atmosphere,in addition to the formation of two layered Ruddlesden-Popper perovskites and Pr_(2)O_(3) nanoparticles(the same as the Ru-free counterpart,Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)),the exsolution of CoFeRu-based alloy nanoparticles is remarkably promoted.Such reduced Pr_(0.6)Sr0.4Co_(0.2)Fe_(0.75)Ru_(0.05)O_(3-δ) composite anode shows superior catalytic activity and stability for NH_(3) decomposition reaction as well as anti-sintering capability in DA-SOFCs to those of reduced Pr0.6Sr0.4Co0.2Fe0.8O_(3-δ)due to the facilitated nanoparticle exsolution and stronger nanoparticle/substrate interaction.This work provides a facile and effective strategy to design highly active and durable anodes for DA-SOFCs,promoting large-scale applications of this technology. | Xiandong Xiong Jian Yu Xiaojian Huang Dan Zou Yufei Song Meigui Xu Ran Ran Wei Wang Wei Zhou Zongping Shao | 2022 | Journal of Materials Science & Technology2022，，30： | 3 |
| 3 | Effects of temperature on conversion of Li2CO3 to LiOH in Ca(OH)2 suspension显示文摘 | Bo Yuan Jing Wang Wei Cai Yurong Yang Meigui Yi Lan Xiang | 2017 | Particuology2017，15，5： | 3 |
| 4 | The application of optimization technology on food project 显示文摘 | Wang Meigui | 1995 | Food Science1995，，4： | 1 |
| 5 | Role of plant stanol derivatives in the modulation of cholesterol metabolism and liver gene expression in mice 显示文摘 | HE Wensen WANG Meigui PAN Xiaoxia | 2013 | Food Chem2013，140，： | 1 |
| 6 | Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy显示文摘1.Introduction Chemotherapy is the traditional treatment for clinical cancer patient[1,2].However,the therapeutic effect is often severely limited by the multidrug resistance(MDR)[3,4],which was commonly mediated by inactivating drugs,increasing efflux,stimulating DNA repair mechanisms,and/or activating detoxification pathways[5-7].Recent studies are committing to develop reasonable strategies for intervention of the molecular pathways mediating MDR,of which P-glycoprotein(P-gp)has been widely investigated[8].So far,several kinds of P-gp inhibitors,including verapamil[9],vitamin E[10],cyclosporin A[11],and small interfering RNA(siRNA)[12]. | Jimin Zhang Meigui Deng Xiaoguang Shi Chuangnian Zhang Xiongwei Qu Xiuli Hu Weiwei Wang Deling Kong Pingsheng Huang | 2021 | Bioactive Materials2021，6，10： | 0 |
| 7 | A Survey on Face Anti-Spoofing Algorithms显示文摘The development of artificial intelligence makes the application of face recognition more and more extensive,which also leads to the security of face recognition technology increasingly prominent.How to design a face anti-spoofing method with high accuracy,strong generalization ability and meeting practical needs is the focus of current research.This paper introduces the research progress of face anti-spoofing algorithm,and divides the existing face anti-spoofing methods into two categories:methods based on manual feature expression and methods based on deep learning.Then,the typical algorithms included in them are classified twice,and the basic ideas,advantages and disadvantages of these algorithms are analyzed.Finally,the methods of face anti-spoofing are summarized,and the existing problems and future prospects are expounded. | Meigui Zhang Kehui Zeng Jinwei Wang | 2020 | Journal of Information Hiding and Privacy Protection2020，2，1： | 0 |
| 8 | Impact-sliding wear response of 2.25Cr1Mo steel tubes:Experimental and semi-analytical method显示文摘The impact-sliding wear behavior of steam generator tubes in nuclear power plants is complex owing to the dynamic nature of the mechanical response and self-induced tribological changes.In this study,the effects of impact and sliding velocity on the impact-sliding wear behavior of a 2.25Cr1Mo steel tube are investigated experimentally and numerically.In the experimental study,a wear test rig that can measure changes in the impact and friction forces as well as the compressive displacement over different wear cycles,both in real time,is designed.A semi-analytical model based on the Archard wear law and Hertz contact theory is used to predict wear.The results indicate that the impact dynamic effect by the impact velocity is more significant than that of the sliding velocity,and that both velocities affect the friction force and wear degree.The experimental results for the wear depth evolution agree well with the corresponding simulation predictions. | Meigui YIN Thibaut CHAISE Liwen WANG Daniel NÉLIAS Minhao ZHU Zhenbing CAI | 2022 | Friction2022，10，3： | 0 |
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