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| 1 | An efficient route towards R-2-phenoxypropionic acid synthesis for biotransformative production of R-2-(4-hydroxyphenoxy)propionic acid显示文摘R2(4hydroxyphenoxy)propionic acid(RHPPA)is a key intermediate for the synthesis of classic herbicides with high selectivity against grassy weed.The main route for RHPPA biosynthesis is to hydroxylate the substrate R2phenoxypropionic acid(RPPA)at C4 position with microbes.In order to provide sufficient RPPA for the industrial production of RHPPA,an effective RPPA synthesis method was established and optimized in this work.The synthesis process mainly consisted of two steps:(1)synthesis of S2chloropropionic acid from Lalanine via diazotization and chlorination reactions;and(2)synthesis of RPPA from S2chloropropionic acid and phenol via etherification reaction.The optimal reaction conditions were as follows:HCl:NaNO_(2):KI:LAla=2.0:1.2:0.7:1.0(in molar),125℃reflux for 1.5 h,with KI as catalyst,and KI:S2chloropropionic acid:phenol=0.075:1.2:1.0(in molar).Under these conditions,an improved molar conversion rate(74.9%,calculated in phenol)was achieved.After extraction using anionic exchange resin Amberlite IRA400(CI),RPPA product with a purity of 95.08%was obtained.The purified RPPA was identified and evaluated in the application of the biotransformative production of RHPPA.The results indicated that the synthesized RPPA supported the RHPPA biosynthesis with a comparable yield as that of the standard RPPA.The RPPA synthesis method provided herein exhibited the advantages of low price and easy availability of raw materials,less toxicity of reagents,simple manipulations,and low equipment/instrument requirements. | Haiyan Zhou Yizuo Li Rui Jiang Xianlin Wang Yuanshan Wang Yaping Xue Yuguo Zheng | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 2 |
| 2 | Iso- lation and characterization of Delftia tsuruhatensis ZJB-05174, capable of R-enantioseleetive degradation of 2,2-dimethylcy- clopropanecarboxa -mide 显示文摘 | ZHENG Renehao WANG Yuanshan LIU Zhiqiang | 2007 | Research in Microbiology2007，158，3： | 1 |
| 3 | Path Planning for Crane Lifting Based on Bi-directional RRT显示文摘 | Wang Xin Lin Yuanshan Wu Di | 2012 | Advanced Materials Research2012，446，： | 1 |
| 4 | Expression of N-methyl-D-aspartic acid 2A-B and 2B receptors in anterior thalamic nucleus and subiculum complex of rats显示文摘BACKGROUND:Glutamate acid ionotropic receptor N-methyl-D-aspartic acid (NMDA) takes part in long-term potentiation, thereby influencing the process of learning and memory. OBJECTIVE: To verify expression of NMDA 2A/B and 2B receptors in the anterior thalamic nucleus and subiculum complex of rats. DESIGN, TIME AND SETTING: A single-sample observation was performed at Department of Anatomy in Dalian Medical University (Dalian, Liaoning, China) from April to September in 2007. MATERIALS: Ten adult Wistar rats were used for this study, as well as rabbit anti-NMDA 2A/B and 2B antibodies. METHODS: The rats were anesthetized and perfused, followed by brain resection and coronal sectioning of the brain tissue. A 1:3 series was selected for immunohistochemistry, using antibodies specific to NMDA 2A/B and 2B receptors. Photos were taken using the Nikon image analysis system. MAIN OUTCOME MEASURES: Expression and distribution of immunohistochemistry staining of NMDA 2A/B and 2B receptor subunits. RESULTS: There were a large number of NMDA 2A/B and 2B receptor-positive neurons distributed throughout the anterior dorsal thalamic nucleus. In the anterior ventral thalamic nucleus, distribution of positive neurons was rare, staining intensity was lighter, and cell bodies were smaller compared with the anterior dorsal thalamic nucleus. In the subiculum complex, staining intensity of NMDA 2A/B and 2B-positive neurons was weakest in the molecular layer and stronger in the pyramidal layer, in particular the region with large cell bodies adjacent to the molecular layer. In the multiform layer, more positive neurons of various sizes were detected. CONCLUSION: NMDA 2A/B and 2B receptor subunits were richly distributed in the anterior thalamic nucleus, with a small difference existing between the anterior dorsal nucleus and anterior ventral nucleus. These neurons were also differentially distributed within the three layers of the subiculum complex. | Yuanshan Fu Xiaokai Ma Xiaoling Yue Bin Wang | 2008 | Neural Regeneration Research2008，3，8： | 1 |
| 5 | Bioleaching of chromium from tannery sludge by indigenous Acidithiobacillus thiooxidans 显示文摘 | Wang Yuanshan Pan Zhiyan Lang Jianmin | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 6 | Statics - Based Simulation Approach for Two - Crane Lift 显示文摘 | Yuanshan Lin Di Wu Xin Wang | 2012 | Journal of construction engi- neering and management2012，138，10： | 1 |
| 7 | Detection of Low Density Lipoprotein Receptor Related Protein Gene Polymorphism and Serum Lipid Levels in Renal Transplant Recipients显示文摘 | Yuxin Wang Qingqin Li Hequn Zou Yuanshan Lu Qinjun Xu Xiaodao Tang Dai Li | 2008 | 器官移植内科学杂志2008，3，4： | 0 |
| 8 | Expression of bFGF and Its Receptor mRNA in Kidney Transplant Recipients with Hyperlipidemia and Its Treatment显示文摘 | Yuxin Wang Hequn Zou Qingqin Li Yuanshan Lu Qinjun Xu Xiaoda Tang | 2009 | 器官移植内科学杂志2009，4，4： | 0 |
| 9 | Effect of Apolipoprotein E Gene Polymorphism on Serum Lipid Level before and after Renal Transplantation显示文摘 | Yuxin Wang Yuanshan Lu Hequn Zou Qinjun Xu | 2008 | 器官移植内科学杂志2008，3，3： | 0 |
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