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| 1 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | An update on parenteral lipids and immune function:only smoke,or is there any fire显示文摘 | Wanten G | 2006 | Curt Opin Clin Nutr Metab Care2006，9，2： | 1 |
| 3 | Tocopherol isoforms in parenteral lipid emulsions and neutrophil activation显示文摘 | Wanten G Beunk J Naber A | 2002 | Clin Nutr2002，21，5： | 1 |
| 4 | Immune modulation by parenterallipid emulsions显示文摘 | Wanten GJ Calder PC | 2007 | Am J Clin Nutr2007，85，5： | 1 |
| 5 | Immune modulation by parenteral lipid emulsions显示文摘 | Wanten GJ Calder PC | | 0，，： | 1 |
| 6 | Immune modulation by parenterallipid emulsions显示文摘 | Wanten GJ Calder PC | 2007 | Am J Clin Nutr2007，85，5： | 1 |
| 7 | Immune modulation by parenteral lipid emulsions显示文摘 | Wanten G J Calder PC | 2007 | Am J Clin Nutr2007，85，5： | 1 |
| 8 | Nutritional lipid emulsions modulate cellular signaling and activation of human neutrophils显示文摘 | Wanten G van Enst-De Vries S Naber T | 2001 | J Lipid Res2001，42，： | 1 |
| 9 | Immune modulation by parenteral lipid emulsions显示文摘 | WANTEN G J CALDER P C | 2007 | Am J Clin Nutr2007，85，5： | 1 |
| 10 | Nutritional lipid emulsions modulate cellular signaling and activation of human neutrohils显示文摘 | Wanten C Van Emst-de Vriess Naber T | 2001 | J Lipid Res2001，42，3： | 1 |
| 11 | Cellular and physiological effects of medium-chain triglycerides显示文摘 | Wanten GJ Naber AH | 2004 | Mini Rev Med Chem2004，4，8： | 1 |
| 12 | Tocopherol isoforms in parenteral lipid emulsions and neutrophil activation 显示文摘 | Wanten G Beunk J Naber A | 2002 | Clin Nutr2002，21，5： | 1 |
| 13 | Outcome and complications in patients treated with continuous ambulatory peritoneal dialysis (CAPD) at a single centre during 11 years显示文摘 | Wanten GJ Koolen MI Van Liebergen FJ | 1996 | Neth J Med1996，49，： | 1 |
| 14 | Immune modulation by parenteral lipid emulsions 显示文摘 | Wanten GJ Calder PC | 2007 | Am J Clin Nutr2007，85，5： | 1 |
| 15 | An update on parenteral lipids and immune function: only smoke,or is there any fire 显示文摘 | Wanten G | 2006 | Curr Opin Clin Nutr Metab Care2006，9，2： | 1 |
| 16 | High tech'home care: overview of professional care in patients on home parenteral nutrition and imglications for nursing care显示文摘 | Van AT Jansen J Wanten 6 | 2011 | Journal of clinical nursing2011，20，1516： | 1 |
| 17 | Effects of structurally different lipid emulsions on human neutrophil migration显示文摘 | Wanten GJ Roos D Naber AHJ | 2000 | Clin Nutr2000，19，5： | 1 |
| 18 | Lipid effects on neutrophil calcium signaling induced by opsonized particles:platelet activating factor is only part of the story显示文摘 | Wanten G Kusters A Van Emst De Vries SE | 2004 | Clin Nutr2004，23，4： | 1 |
| 19 | Immune modulation by parenteral lipid emulsions显示文摘 | Wanten G J Calder P C | 2007 | Am J Clin Nutr2007，85，5： | 1 |
| 20 | Phagocytosis and killing of Candida albicans by human neutrophils after exposure to structurally different lipid emulsions显示文摘 | Wanten GJ Curfs JH Meis JF | 2001 | JPEN J Parenter Enteral Nutr2001，25，1： | 1 |
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