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| 1 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 2 | Long-term continuous entecavir therapy in nucleos(t)ide-na?ve chronic hepatitis B patients显示文摘 | Atsushi Ono Fumitaka Suzuki Yusuke Kawamura Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitou Yasuji Arase Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Rie Mineta Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，3： | 3 |
| 3 | Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H显示文摘 | Fumitaka Suzuki Norio Akuta Yoshiyuki Suzuki Hiromi Yatsuji Hitomi Sezaki Yasuji Arase Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Hiromitsu Kumada | 2007 | Journal of Clinical Virology2007，，2： | 2 |
| 4 | Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b显示文摘 | Fumitaka Suzuki Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Yuya Seko Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saito Yasuji Arase Kenji Ikeda Mariko Kobayashi Rie Mineta Sachiyo Watahiki Yuzo Miyakawa Hiromitsu Kumada | 2012 | Journal of Clinical Virology2012，，4： | 2 |
| 5 | Cloning full-length cDNA,Cap trapper selected cDNAs by using the single-strand linker ligation method显示文摘 | ShibataY Carninci P Watahiki A | 2001 | Biology Techniques2001，30，： | 1 |
| 6 | A newmethod for alveolar bone repair using extracted teethfor the graft material显示文摘 | Nampo T Watahiki J Enomoto A | 2010 | J Periodontol2010，81，9： | 1 |
| 7 | Gene expression profiling of mouse condylar cartilage during mastication by means of laser microdissection and cDNA array显示文摘 | Watahiki J Yamaguchi T Irie T | | 0，，03： | 1 |
| 8 | Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer显示文摘 | CREA F WATAHIKI A QUAGLIATA L | 2014 | Oncotarget2014，5，3： | 1 |
| 9 | Hyaluronidase inhibitors from Takuran,Lycopus lucidus显示文摘 | Toshihiro Murata Mai Watahiki Yu Tanaka | | 0，，03： | 1 |
| 10 | Primary involvement of the motor area in association with the nigrostriatal pathway in multiple system atrophy:neuropathological and morphometric evaluations显示文摘 | Su M Yoshida Y Watahiki Y | 2001 | Acta Neuropathol2001，101，： | 1 |
| 11 | The impact of Ge co- doping on the enhancement of photovoltaic characteristics of B-doped Czochralski grown Si crystal显示文摘 | Arivanandhan M Gotoh R Watahiki T | 2012 | J Appl Phys2012，111，04： | 1 |
| 12 | Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: Two-year follow-up显示文摘 | Hiromi Yatsuji Fumitaka Suzuki Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saitoh Yasuji Arase Kenji Ikeda Sachiyo Watahiki Satomi Iwasaki Mariko Kobayashi Hiromitsu Kumada | 2008 | Journal of Hepatology2008，，6： | 1 |
| 13 | Synergistic hybrid catalyst for cyclic carbonate synthesis:remarkable acceleration caused by immobilization of homogeneous catalyst on silica显示文摘 | Takahashi T Watahiki T Kitazume S | | 0，，05： | 1 |
| 14 | Structure of the chicken growth hormone-encoding gene and its promoter region显示文摘 | Tanaka M Hosokawa Y Watahiki M | 1992 | Gene1992，112，： | 1 |
| 15 | Morphology of thyroid follicular cells of Methimazole-treated rats 显示文摘 | Tsujio M Watahiki Y Yoshioka K | 2007 | Anat Histol Embryol2007，36，4： | 1 |
| 16 | Libraries enriched for alternatively spliced exons reveal splicing patterns in melano- cytes and melanomas 显示文摘 | Watahiki A Waki K Hayatsu N | 2004 | Nat Methods2004，1，3： | 1 |
| 17 | Hepatocellular carcinoma associated with autoimmune hepatitis显示文摘 | Raisuke Nishiyama Toshikazu Kanai Jinro Abe Ryuhei Hara Yohichi Watahiki Takanori Sakaguchi Satoshi Nakamura | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，3： | 1 |
| 18 | Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas显示文摘 | WATAHIKI A WAKI K HAYATSU N et oi | 2004 | Nat Methods2004，1，3： | 1 |
| 19 | Structure of the chiken frowth hormone encoding gene and its promoter region 显示文摘 | TANAKA M HOSOKAWA Y WATAHIKI M | 1992 | Gene1992，12，2： | 1 |
| 20 | Structure of the chicken growth hormone-encoding gene and its promoter region显示文摘 | Tanaka M Hosokawa Y Watahiki M | 1992 | Gene1992，112，2： | 1 |
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