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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | Oil and gas in reservoirs with subnormal pressure显示文摘 | Prake A D Wayne C | 1977 | AAPG Bulletin1977，61，12： | 1 |
| 4 | 显示文摘 | Jason C Wayne D Mader J T | 1988 | J Bone Joint Surg (Am)1988，70，： | 1 |
| 5 | An overview of NSPCG:A nonsymmetric preconditioned conjugate gradient package显示文摘 | THOMAS C OPPE WAYNE D | | 0，，53： | 1 |
| 6 | Dynamic adsorption of radon by activated carbon 显示文摘 | WAYNE C G UNDERHILL D W | 2005 | Health Physics2005，88，4： | 1 |
| 7 | Cotton (Gossypium hirsutum) MatP6 and MatP7 Oleosin Genes 显示文摘 | D Wayne Hughes Helen Y C Wang Clenn A Calau | 1993 | Plant Physiology1993，101，： | 1 |
| 8 | Determination of tylosin and tilmicosin residues in animal tissues by reversed-phase liquid chromatography显示文摘 | Wayne C Geoff C G Craig D C S | 1994 | Journal of AOAC International1994，77，： | 1 |
| 9 | A Gaussian Noise Generator for Hardware-based Simulations 显示文摘 | Dong U L Wayne L J D villasenior Peter Y K C | 2004 | IEEE transactions on computers2004，53，12： | 1 |
| 10 | A longitudinal study on the early development of leader-member exchange 显示文摘 | LIDEN R C WAYNE S J STILWELL D (1993) | 1993 | Journal of Applied Psychology1993，78，： | 1 |
| 11 | A longitudinal study on the early developmentof leader-member exchanges显示文摘 | Liden R C Wayne S J Stilwell D | 1993 | Journal of Applied Psychology1993，78，4： | 1 |
| 12 | IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells显示文摘 | Stefan Pflanz Jackie C Timans Jeanne Cheung Rency Rosales Holger Kanzler Jonathan Gilbert Linda Hibbert Tatyana Churakova Marilyn Travis Elena Vaisberg Wendy M Blumenschein Jeanine D Mattson Janet L Wagner Wayne To Sandra Zurawski Terrill K McClanahan Dan | 2002 | Immunity2002，，6： | 1 |
| 13 | Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘 | Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T | 2004 | Bioorganic & Medicinal Chemistry Letters2004，，8： | 1 |
| 14 | Glucose metabolism in the amygdala in depression: Relationship to diagnostic subtype and plasma cortisol levels显示文摘 | Wayne C Drevets Joseph L Price Mark E Bardgett Theodore Reich Richard D Todd Marcus E Raichle | 2002 | Pharmacology Biochemistry and Behavior2002，，3： | 1 |
| 15 | A longitudinalstudy on the early development of leader - member ex-changes 显示文摘 | Liden R C Wayne S J Stilwell D | 1993 | Journal of Applied Psychology1993，78，4： | 1 |
| 16 | A longitudinal study on the early development of leader - member exchange 显示文摘 | Liden R C Wayne S J & Stilwell D | 1993 | Journal of Applied Psychology1993，78，4： | 1 |
| 17 | A longitudinal study on the early development of leader-member exchanges显示文摘 | Liden R C Wayne S J Stiwell D | 1993 | Journal of Applied Psychology1993，78，： | 1 |
| 18 | Neurotoxicological evaluation of methyl tertiary-butyl ether in Rats显示文摘 | Wayne C D Michael W G Irvin M | 1997 | Journal of Applied toxicology1997，17，1： | 1 |
| 19 | Servant Leadership: Development of a Multidimensional Measure and Multi- level Assessment 显示文摘 | Liden R C Wayne S J Zhao H Henderson D | 2008 | The Leadership Quarterly2008，，19： | 1 |
| 20 | Reproductive cycle of Sydney rock oysters,Saccostrea glomerata(Gould 1850)selectively bred for faster growth显示文摘 | Michael C D Wayne A O | 2011 | Aquaculture2011，，： | 1 |
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