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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Student learning with concept mapping of care plans in community-based education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 3 | Frequency and initiation of debris flows in Grand Canyon, Arizona 显示文摘 | Griffiths P G Webb R H Melis T S | 2004 | Journal of Geophysical Research2004，，109： | 1 |
| 4 | Building Corporate Associations:Consumer Attributions for Corporate Socially Responsible Programs 显示文摘 | Ellen P S Webb D J Mohr L A | 2006 | Journal of the Academy of Marketing Science2006，34，2： | 1 |
| 5 | Determination of the deposition order of overlapping latent fingerprints and inks using secondary ion mass spectrometry显示文摘 | Bright N J Webb R P Bleay S | 2012 | Anal Chem2012，84，9： | 1 |
| 6 | Poly(acrylate/siloxane) hybrid adhesives for polymers with low surface energy显示文摘 | Sonnenschein M F Webb S P Wendt B L | 2008 | International Journal of Adhesion & Adhesives2008，28，3： | 1 |
| 7 | Student Learning with Concept Mapping of Care Plans in Community-Based Education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 8 | Targeted disruption of p70 (S6k) defines its role in protein synthesis and rapamycin sensitivity显示文摘 | Kawasome H Papst P Webb S | 1998 | Proc Natl Acad Sci USA1998，95，9： | 1 |
| 9 | The dynamics of livelihood diversification in post - famine Ethiopia显示文摘 | Block S Webb P | 2001 | Food Pilicy2001，26，： | 1 |
| 10 | Shivering during epidural analgesia in women in labor显示文摘 | Webb P J James F M Wheeler A S | | 0，，06： | 1 |
| 11 | Condensation of steam with and without the presence of non-condensable gases in a vertical tube 显示文摘 | AlShammari S B Webb D R Heggs P | 2004 | Desalination2004，169，2： | 1 |
| 12 | Carrier transport in thin films of organic electroluminescent materials显示文摘 | DENG Z LEE S T WEBB D P | 1999 | Synthetic Metals1999，107，2： | 1 |
| 13 | Dose and dura- tion of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve in- jury in the rat显示文摘 | Kemp S W P Webb A A Dhaliwal S etal | 2011 | Experimental Neurology2011，229，2： | 1 |
| 14 | The dynamics of livelihood diversification in post-famine Ethiopia显示文摘 | Block S Webb P | 2001 | Food Policy2001，26，4： | 1 |
| 15 | Compensation of thermal deformation of a hybrid parallel kinematic machine显示文摘 | Eastwood S Webb P | 2009 | Robotics and Computer-Integrated Manufacturing2009，25，： | 1 |
| 16 | Membrane destabilization during freeze-induced dehydration显示文摘 | Steponkus P L Uemura M Webb M S | 1993 | Curr Topics Plant Physiol1993，，10： | 1 |
| 17 | Effects of immunization with somatostatin on growth and arterio-venous differences of metabolites across muscle tissue of growing lambs 显示文摘 | Webb M M S McDowell G H Gooden J M Hoskinson R M Wynn P C | 1986 | Prod Nutr Soc Aust1986，11，： | 1 |
| 18 | Building corporate associa?tions: consumer attributions for corporate socially responsi?ble programs显示文摘 | Ellen P S Webb DJ Mohr L A | 2006 | Journal of the Academy of Marketing Sci?ence2006，34，2： | 1 |
| 19 | Charitable Programs and the Retailer: Do They Mix? 显示文摘 | Ellen P S Mohr L A Webb D J | 2000 | Journal of Retailing2000，76，3： | 1 |
| 20 | Support for agriculture during economic transformation: Impacts on poverty and undernutrition 显示文摘 | Webb P Block S | 2012 | Proc Nat! Acad Sci USA2012，109，12： | 1 |
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