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| 1 | Association of serum uric acid levels with the progression of Parkinson's disease in Chinese patients显示文摘背景尿酸( UA )被怀疑在 Parkinson .This 学习试图评估浆液 UA 水平是否在中国 patients.Methods 浆液 UA 层次的一张相对大的人口与 PD 的疾病前进被联系的疾病( PD )起一个neuro保护的作用从 411 个中国 PD 病人被测量并且 396 匹配年龄的控制;跟随尿酸比色的方法,浆液 creatinine (Scr ) 层次也被测量减少可能的差别在肾的排泄 function.The 引起的偏爱疾病前进被 Hoehn 和 Yahr (H&Y ) 规模和疾病持续时间获得; PD 组根据 H&Y scales.Independent样品 ttest 被划分成 3 亚群被执行分析 PD 组之间的差别,协变性的控制 group.Multiple 分析被执行分析 PD subgroups.Spearman 等级关联之间的差别被执行评估在水平和疾病 progression.Results PD 病人被发现的浆液 UA 或 Scr 之间的协会显著地比控制有浆液 UA 的底层(( 243. | Sun Cong-cong Luo Fei-fei Wei Lei Lei Mi Li Guo-fei Liu Zhuo-lin Le Wei-dong Xu Ping-yi | 2012 | Chinese Medical Journal2012，，4： | 43 |
| 2 | Oral health status in Sichuan Province: findings from the oral health survey of Sichuan, 2015–2016显示文摘To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3–5 years,adolescents aged 12 years, and people aged 65–74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0.86 and 5.13, respectively, resulting in a prevalence of 63.47%, 37.20% and 83.20%, respectively.Relative to the high rate of decayed teeth, the prevalence of fillings was very low in all age groups(0.97%, 7.24% and 5.43%,respectively). In the 12-year-old adolescent group, only 3.61% had good pit and fissure sealing. In addition, the rate of dental fluorosis was 24.80%, and the Community Fluorosis Index value was 0.39. In the elder group, the community periodontal index was2.92. The prevalence in the elderly of having lost at least one tooth was 75.54%. Additionally, 4.44% of these participants were edentulous. The incidence of dental prosthesis was 51.75%, the proportion with a removable partial denture, a fixed denture, full dentures, dental implants and an informal fixed bridge was 21.59%, 11.45%, 4.64%, 0 and 16.67%, respectively. In this study,8.2% of the elderly participants were affected by different types of oral mucosal lesions. Among such lesions, recurrent aphthous ulcers were most prevalent(2.69%) and oral lichen planuses were second(1.6%). The conclusion presented in this survey is that oral diseases, especially dental caries and periodontal disease, are frequent and common in Sichuan province, China. Moreover, the treatment rate is very low, and primary prevention and treatment options are therefore urgently needed in this population. | Wei Yin Ying-Ming Yang Hong Chen Xue Li Zhuo Wang Li Cheng Qiu-Dan Yin Hong-Zhi Fang Wei Fei Fang-Lin Mi Min-Hai Nie Tao Hu Xue-Dong Zhou | 2017 | International Journal of Oral Science2017，9，1： | 30 |
| 3 | Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season显示文摘The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains. | HUA Sha LI XiYan LIU Mi CHENG YanHui PENG YouSong HUANG WeiJuan TAN MinJu WEI HeJiang GUO JunFeng WANG DaYan WU AiPing SHU YueLong JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，9： | 17 |
| 4 | An analysis of patients receiving emergency CAG without PCI and the value of GRACE score in predicting PCI possibilities in NSTE-ACS patients显示文摘BackgroundThere 是经历了紧急情况的病人冠的 angiography (CAG ) 但是没收到经皮的冠的干预(一种总线标准) 。学习是分析这些 reasons.MethodsThis 的这的目的是单个中心的回顾的研究。我们招募了 201 consecutive 收到了紧急情况 CAG 的病人但是没收到一种总线标准。为了在在非圣预言一种总线标准可能性调查尖锐冠的事件(优雅)分数的全球注册表的值,分割举起急性冠的症候群(NSTE交流)病人,我们招募了 80 ;与NSTE交流介绍了并且收到了紧急情况 CAG 以及紧急情况 PCI.ResultsAmong 的连续病人收到了紧急情况 CAG 的 201 个病人但是没收到一种总线标准,26%病人有除冠的心疾病以外的最后的诊断。在有重要冠的动脉狭窄的病人, 23 个病人(11.5%) 被推荐到冠的动脉绕过 grafting (CABG ) ,一个病人(0.5%) 拒绝了一种总线标准;有重要血栓负担的 13 个病人(6.5%) 与 glycoprotein IIb/IIIa 受体对手被对待;74 个病人(36.8%) 与药治疗被对待因为没有严重狭窄(>70%) 在罪容器是在场的。而且, 201 个病人中的 80 个与 NSTE 交流被介绍(与除冠的心疾病以外的最后的诊断排除那些病人,排除那些病人为 CABG 治疗计划了) ,是参考了非一种总线标准 NSTE 交流。当比较时,他们的优雅得分,象紧急情况一种总线标准一样收到了紧急情况 CAG 的 80 个连续病人与 NSTE 交流介绍了(作为一种总线标准 NSTE 交流参考了) ,我们发现一种总线标准 NSTE 交流病人有显著地更高的优雅分数与相比非一种总线标准 NSTE 交流病人。我们然后使用了接收装置操作员典型曲线(巨鸟) 测试 GRACE 分数是否擅长在 NSTE 交流病人评估一种总线标准的可能性。在 curve 下面的区域;是 0.854 ±0.030 (P <0.001 ) ,显示好预兆的价值。而且,我们分析了从巨鸟统计导出的结果,并且发现那 125.5 的一个优雅分数,作为一截止,在在 NSTE 交流 patients.ConclusionsOur 调查结果评估一种总线标准可能性让高敏感和特性显示 GRACE 分数在决定 NSTE 交流病人是否将收到一种总线标准有预兆的价值。 | Bo-Da ZHOU | 2015 | Journal of Geriatric Cardiology2015，12，3： | 15 |
| 5 | Altered serum level of cartilage oligomeric matrix protein and its association with coronary calcification in patients with coronary heart disease显示文摘BackgroundCartilage oligomeric 矩阵蛋白质(COMP ) 主要在骨胳的系统和脉管的光滑的肌肉房间被发现。最近的研究证明它在血容器上有保护的功能并且能也禁止脉管的石灰化。我们在冠的心疾病( CHD )调查了浆液 COMP 病人,并且在浆液 COMP 和首先经历了多片跟随的冠的 angiography 的 233 个连续的胸疼痛病人全部的冠的 artery.MethodsA 的石灰化之间的关系在六个月以内计算了断层摄影术( MSCT )被招募并且根据缩小百分比的冠的 angiography 钠直径划分了成二个组:CHD 组(缩小 50% 的直径, n = 194 ) 并且控制组(直径变窄 <50% , n = 39 ) 。Gensini 分数,句法分数和冠的动脉钙分数(CAC ) 是计算的。浆液 COMP 水平用 COMP 的 ELISA.ResultsThe 层次被决定比在控制组在 CHD 组是显著地更高的 155.7 (124.5-194.5 ) ng/mL 对 128.4 (113.0-159.9 ) ng/mL, P = 0.019。在 COMP, Gensini 分数,句法分数,冠的狭窄的严厉和有狭窄的冠的动脉的数字之间没有关联 >50% 。浆液 COMP 与年龄被相关(r = 0.294, P < 0.001 ) , fasting 葡萄糖(r = 0.163, P = 0.015 ) , HbA1c (r = 0.194, P = 0.015 ) 并且 CAC (r = 0.137, P = 0.037 ) 。逐步的线性回归分析显示出那 COMP 水平,年龄是在 CHD 病人的 CAC 的独立预言者(= 0.402, t = 2.612, P = 0.015;= 0.472, t = 3.077, P = 0.005 ) 。为预言 CHD 的 COMP 的性能在曲线(AUC ) 下面作为区域被显示出:0.632, 95% CI:0.549-0.715 和上面的 tertile CAC 是 AUC:0.602, 95% CI:在操作冠的动脉的特征(巨鸟) 曲线 analysis.ConclusionCalcification 的接收装置的 0.526-0.678 是浆液 COMP 的一个独立预言者。 | Fang-Fang WANG Lahati HA Hai-Yi YU Lin MI Jiang-Li HAN Wei GAO | 2017 | Journal of Geriatric Cardiology2017，14，2： | 15 |
| 6 | Correlation between growth differentiation factor-15 and collagen metabolism indicators in patients with myocardial infarction and heart failure显示文摘BackgroundGrowth 区别因素(GDF )-15, 转变生长因素贝它总科的一个分叉的成员确实看起来响应试验性的压力超载和心失败(HF ) 的前进起来调整。HF 经常在心肌的梗塞(MI ) 以后发展,贡献更坏的结果。学习是在 HF.MethodsThe 学习的不同阶段估计在与骨胶原周转有关的 GDF-15 层次和标记之间的关联的这的目的由 179 个病人的一个队组成,包括稳定的心绞痛病人( AP 组, n = 50 ),没有 HF 的旧 MI 病人( OMI 组, n = 56 ),有 HF 的旧 MI 病人( OMI-HF 组, n = 38 )并且正常控制组( n = 35 )。包括 precollagen 反映骨胶原的合成和降级率的两指示物我N终端肽( PINP ),类型我骨胶原carboxy终端肽( ICTP ), precollagen III N终端肽( PIIINP )和 GDF-15 用连接酶的 inmunosorbent assay.ResultsThe 血浆 GDF-15 水平被测量在 OMI-HF 组是更高的( 1373.4 ± ;275.4 ng/L ) 比 OMI 组(1036.1 ±248.6 ng/L ) , AP 组(784.6 ±222.4 ng/L ) 并且控制组(483.8 ±186.4 ng/L )(P <0.001 ) 。骨胶原周转的指示物(ICTP, PINP, PIIINP ) 与控制相比在 OMI-HF 组增加的所有组织(3.03 ±1.02 µ g/L 对 2.08 ±0.95 µ g/L, 22.2 ±6.6 µ g/L 对 16.7 ±5.1 µ g/L 和 13.2 ±7.9 µ g/L 对 6.4 ±2.1 µ g/L 分别地;P <0.01 ) 。GDF-15 断然与 ICTP 和 PIIINP 相关(r = 0.302, P <0.001 并且 r = 0.206, P = 0.006,分别地) 。GDF-15 断然相关到心脏舒张的指示物 E/Em 和左 atrial 迫使的 echocardiographic (r = 0.349 并且 r = 0.358 分别地;P <0.01 ) ,并且相反地相关到收缩指示物左室的喷射部分和山峰的一般水准收缩心肌的速度(Sm )(r =− 0.623 并且 r =− 0.365 分别地;P <0.01 ).ConclusionPlasma GDF-15 与类型的指示物被联系我和 III 骨胶原周转。 | Fang-Fang WANG Bao-Xia CHEN Hai-Yi YU Lin MI Zi-Jian LI Wei GAO | 2016 | Journal of Geriatric Cardiology2016，13，1： | 14 |
| 7 | CIM-Based Grid Model and Graphics Exchange Format显示文摘BackgroundWith the rapid development of electric power system and the unceasing expansion of power grid,the operation and control of large power grid needs the support of on-line safe and stable analysis.In recent years,renewable energy is developing very rapidly,and lots of random,intermittent wind and solar power resources access network Therefore,the operation of power grid urgently needs the support of real-time on-line analysis tools.Severe weather has more and more impact on the operation of power grid.During the process of accident occurrence and recovery,multiple control centers requirecooperation. | Xin Yaozhong Mi Weimin Li Wei | 2011 | China Standardization2011，56，4： | 14 |
| 8 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 9 | Tectonic evolution of the Dabashan orocline, central China: Insights from the superposed folds in the eastern Dabashan foreland显示文摘The Dabashan orocline is situated in the northwestern margin of the central Yangtze block,central China.Previous studies have defned the orthogonal superposed folds growing in its central-western segment thereby confrming its two-stage tectonic evolution history.Geological mapping has revealed that more types of superposed folds have developed in the eastern segment of the orocline,which probably provides more clues for probing the structure and tectonic history of the Dabashan orocline.In this paper,based on geological mapping,structural measurements and analyses of deformation,we have identifed three groups of folds with different trends(e.g.NW-,NE-and nearly E-trending folds)and three types of structural patterns of superposed folds in the eastern Dabashan foreland(e.g.syn-axial,oblique,and conjunctional superposed folds).In combination with geochronological data,we propose that the synaxial superposed folds are due to two stages of wNeS shortening in the west and north of the Shennongjia massif,and that oblique superposed folds have been resulted from the superposition of the NW-and NE-trending folds onto the early ~E-W folds in the east of the Shennongjia massif in the late Jurassic to early Cretaceous.The conjunctional folds are composed of the NW-and NE-trending folds,corresponding to the regional-scale dual-orocline in the eastern Sichuan as a result of the southwestward expansion of the Dabashan foreland during late Jurassic to early Cretaceous,coeval with the northwestward propagation of the Xuefengshan foreland.Integration of the structure and geochronology of the belt shows that the Dabashan orocline is a combined deformation belt primarily experiencing a twostage tectonic evolution history in Mesozoic,initiation of the Dabashan orocline as a foreland basin along the front of the Qinling orogen in late Triassic to early Jurassic due to collisional orogeny,and the fnal formation of the Dabashan orocline owing to the southwestward propagation of the Qinling orogen during late Jurassic to early Cretaceous intra-continental orogeny.Our studies provide some evidences for understanding the structure and deformation of the Dabashan orocline. | Wei Shi Jianhua Li Mi Tian Guoli Wu | 2013 | Geoscience Frontiers2013，4，6： | 12 |
| 10 | Bioactive biodegradable polycitrate nanoclusters enhances the myoblast differentiation and in vivo skeletal muscle regeneration via p38 MAPK signaling pathway显示文摘Complete skeletal muscle repair and regeneration due to severe large injury or disease is still a challenge.Biochemical cues are critical to control myoblast cell function and can be utilized to develop smart biomaterials for skeletal muscle engineering.Citric acid-based biodegradable polymers have received much attention on tissue engineering,however,their regulation on myoblast cell differentiation and mechanism was few investigated.Here,we find that citrate-based polycitrate-polyethylene glycol-polyethylenimine(POCG-PEI600)nanoclusters can significantly enhance the in vitro myoblast proliferation by probably reinforcing the mitochondrial number,promote the myotube formation and full-thickness skeletal muscle regeneration in vivo by activating the myogenic biomarker genes expression of Myod and Mhc.POCG-PEI600 nanoclusters could also promote the phosphorylation of p38 in MAP kinases(MAPK)signaling pathway,which led to the promotion of the myoblast differentiation.The in vivo skeletal muscle loss rat model also confirmed that POCG-PEI600 nanoclusters could significantly improve the angiogenesis,myofibers formation and complete skeletal muscle regeneration.POCG-PEI600 nanocluster could be also biodegraded into small molecules and eliminated in vivo,suggesting their high biocompatibility and biosafety.This study could provide a bioactive biomaterial-based strategy to repair and regenerate skeletal muscle tissue. | Yi Guo Min Wang Juan Ge Wen Niu Mi Chen Wei Cheng Bo Lei | 2020 | Bioactive Materials2020，5，3： | 12 |
| 11 | Solution-processed copper nanowire flexible transparent electrodes with PEDOT:PSS as binder, protector and oxide-layer scavenger for polymer solar cells显示文摘nanowire (NW ) 拍摄的 Cu 的容易的氧化和表面粗糙是为他们在透明传导性的电极(TCE ) 的用法的主要瓶颈。此处,我们开发了一条灵巧、可伸缩起来的答案线路准备 Cu 由把 Cu NW 嵌进的基于 NW 的 TCE pre 涂 poly 变光滑(3,4-ethylenedioxythiophene ): poly (styrenesulfonate )(PEDOT : PSS ) 电影在上 poly (乙烯 terephthalate )( 宠物) 底层。那么获得的 Cu NW-PEDOT : PSS/PET 电影有低表面粗糙(在高度的 70 nm ) ,向氧化的高稳定性和好灵活性。最佳的 TCE 显示出 15 猯'T? 的一个典型的表电阻 ?? | Jianyu Chen Weixin Zhou Jun Chen Yong Fan Ziqiang Zhang Zhendong Huang Xiaomiao Feng Baoxiu Mi Yaowen Ma Wei Huang | 2015 | Nano Research2015，8，3： | 10 |
| 12 | Small-volume chylous ascites after laparoscopic radical gastrectomy for gastric cancer:Results from a large population-based sample显示文摘AIM:To report the incidence and potential risk factors of small-volume chylous ascites(SVCA)following laparoscopic radical gastrectomy(LAG).METHODS:A total of 1366 consecutive gastric cancer patients who underwent LAG from January 2008 to June 2011 were enrolled in this study.We analyzed the patients based on the presence or absence of SVCA.RESULTS:SVCA was detected in 57(4.17%)patients,as determined by the small-volume drainage(range,30-100 m L/24 h)of triglyceride-rich fluid.Both univariate and multivariate analyses revealed that the total number of resected lymph nodes(LNs),No.8 or No.9 LN metastasis and N stage were independent risk factors for SVCA following LAG(P<0.05).Regarding hospital stay,there was a significant difference between the groups with and without SVCA(P<0.001).The 3-year disease-free and overall survival rates of the patients with SVCA were 47.4%and 56.1%,respectively,which were similar to those of the patients without SVCA(P>0.05).CONCLUSION:SVCA following LAG developed significantly more frequently in the patients with≥32harvested LNs,≥3 metastatic LNs,or No.8 or No.9LN metastasis.SVCA,which was successfully treated with conservative management,was associated with a prolonged hospital stay but was not associated with the prognosis. | Jun Lu Zhen-Quan Wei Chang-Ming Huang Chao-Hui Zheng Ping Li Jian-Wei Xie Jia-Bin Wang Jian-Xian Lin Qi-Yue Chen Long-Long Cao Mi Lin | 2015 | World Journal of Gastroenterology2015，21，8： | 10 |
| 13 | Formation of the Moping Dome in the Xuefengshan Orocline, Central China and its Tectonic Significance显示文摘Many equiaxial dome-like structures developed in the north segment of the Xuefengshan orocline, Central China are obviously inconcordant with the NE-trending linear structures in this area, which contain important records for understanding the structural framework and evolution of this belt. In this paper, taking one of the typical dome-like structures in the Xuefengshan orcline (e.g. Moping dome-like structure) as an example, based on its structural framework interpratatoin, superposed deformation analysis and paleo-stress fields reconstruction, we propose the Moping dome-like structure is composed of two populations of different-striking thrust-fold structures, ~E-trending and NE-striking structures, indicative of two-stages shortening, ~N- and NW-striking, respectively. Together with the geochronological analysis, we suggest the first stage of shortening occurred in Late Triassic to Early Jurassic, due to the Indosinian intercollisional orogeny of the Yangtze Block and the North China Block. The second occurred during Late Jurassic Early Cretaceous owing to Yanshanian intracontinental orogeny, leading to the intensive superposition of the NE-trending structures onto the ~E-trending structures, and the final ocurrence of the Moping dome. Thus, our study indicates the Xuefengshan arc-shape belt also experienced two-phase deformation, and resulted from the superposition of NE SW structures onto ~E-W structures in Late Jurassic Early Cretaceous, which could provide new structural evidence for probing the Mesozoic tectonic framework and evolution of the Xuefengshan orocline. | SHI Wei DONG Shuwen LI Jianhua TIAN Mi WU Guoli | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 9 |
| 14 | Endophytes and their role in phytoremediation显示文摘Many endophytes have been found to be resistant to heavy metals and/or capable of degrading organic contaminants,and endophyte-assisted phytoremediation has been documented as a promising technology for in situ remediation of contaminated soils.During the phytoremediation of heavy metals,the heavy-metal-resistant endophytes can enhance plant growth,decrease metal phytotoxicity,and affect metal translocation and accumulation in plants.For the phytoremediation of organic contaminants,endophytes can produce various enzymes to degrade organic contaminants and reduce both the phytotoxicity and evapotranspiration of volatile contaminants.This paper reviews the diversity of contaminant-resistant/degrading endophytes and their role in phytoremediation and discusses some issues that have been raised surrounding this area of research. | Hai-Yan Li Da-Qiao Wei Mi Shen Zuo-Ping Zhou | 2012 | Fungal Diversity2012，，3： | 8 |
| 15 | Efficacy of a Chinese herbal formula on hepatitis B e antigenpositive chronic hepatitis B patients显示文摘BACKGROUND No guideline recommends antiviral therapy for hepatitis B e antigen(HBeAg)-positive chronic hepatitis B patients with persistently normal alanine aminotransferase levels and a high hepatitis B virus(HBV)DNA viral load.AIM To evaluate the feasibility and safety of a Chinese herbal formula as a therapeutic option for chronic HBV infection.METHODS In total,395 patients(30–65 years old)with confirmed HBeAg-positive chronic hepatitis B infection and persistently normal alanine aminotransferase were randomized to receive either Chinese herbal formula or placebo for 96 wk.Endpoints to evaluate therapeutic efficacy included:(1)HBV DNA levels decreased to less than 4 log10 IU/mL at weeks 48 and 96;and(2)HBeAg clearance and seroconversion rates at weeks 48 and 96.RESULTS HBV DNA levels≤4 log10 IU/mL were 10.05%at week 48 and 18.59%at week 96 in the treatment group.The HBeAg clearance and conversion rates were 8.54%and 8.04%at week 48 and 16.08%and 14.57%at week 96,respectively.However,HBV DNA levels≤4 log10 IU/mL were 2.55%and 2.55%at weeks 48 and 96,respectively,and the HBeAg clearance rates were 3.06%and 5.61%at weeks 48 and 96,respectively,in the control group.The quantitative hepatitis B surface antigen and HBeAg levels at baseline and changes during the treatment period as well as the alanine aminotransferase elevation at weeks 12 and 24 were strong predictors of HBeAg clearance.CONCLUSION High rates of HBV DNA reduction,HBeAg clearance and seroconversion could be achieved with Chinese herbal formula treatments,and the treatments were relatively safe for HBeAg-positive chronic hepatitis B-infected patients with persistently normal alanine aminotransferase.The ability of the compound to modulate host immune function probably contributed to this effect. | Yu-Feng Xing Chun-Shan Wei Tian-Ran Zhou Dan-Ping Huang Wei-Chao Zhong Bin Chen Hua Jin Xiao-Yu Hu Zhi-Yun Yang Qing He Kai-Ping Jiang Jun-Min Jiang Zhen-Bin Hu Xin Deng Fan Yang Feng-Yi Li Gang Zhao Li-Chun Wang Yu-Qiang Mi Zuo-Jiong Gong Peng Guo Jian-Hua Wu Wei-Qun Shi Hong-Zhi Yang Da-Qiao Zhou Guang-Dong Tong | 2020 | World Journal of Gastroenterology2020，26，30： | 7 |
| 16 | Establishing an experimental rat model of photo-dynamically-induced retinal vein occlusion using erythrosin B显示文摘AIM:To develop a reliable,reproducible rat model of retinal vein occlusion(RVO)with a novel photosensitizer(erythrosin B)and study the cellular responses in the retina.METHODS:Central and branch RVOs were created in adult male rats via photochemically-induced ischemia.Retinal changes were monitored via color fundus photography and fluorescein angiography at 1 and 3h,and 1,4,7,14,and 21d after irradiation.Tissue slices were evaluated histopathologically.Retinal ganglion cell survival at different times after RVO induction was quantified by nuclear density count.Retinal thickness was also observed.RESULTS:For all rats in both the central and branch RVO groups,blood flow ceased immediately after laser irradiation and retinal edema was evident at one hour.The retinal detachment rate was 100%at 3h and developed into bullous retinal detachment within 24h.Retinal hemorrhages were not observed until 24h.Clearance of the occluded veins at 7d was observed by fluorescein angiography.Disease manifestation in the central RVO eyes was more severe than in the branch RVO group.A remarkable reduction in the ganglion cell count and retinal thickness was observed in the central RVO group by 21d,whereas moderate changes occurred in the branch RVO group.CONCLUSION:Rat RVO created by photochemicallyinduced ischemia using erythrosin B is a reproducible and reliable animal model for mimicking the key features of human RVO.However,considering the 100%rate ofretinal detachment,this animal model is more suitable for studying RVO with chronic retinal detachment. | Wei Chen Ying Wu Mi Zheng Qing Gu Zhi Zheng Xin Xia | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 7 |
| 17 | Recent progress in the numerical modeling for organic thin film solar cells显示文摘Device modeling is constructive in finding the dependency of devices efficiency on structure parameters and material properties. For the sake of looking into the physics mechanism of organic solar cells (OSCs), as well as predicting their maximum attainable efficiency, numerical modeling is widely utilized to simulate the behavior of OSCs. Although some indispensable parameters are neglected or hypothesized because of inexplicitness in simulation models for OSCs, numerical modeling can describe the kinetic process in OSCs intuitively. This paper summarizes the optical/electrical models in the BHJ solar cell, as well as addresses their corresponding development in recent years on the basis of device physics and its working principle. Applications of numerical modeling and comments on modeling results are summarized. Meanwhile, precision and open questions about every model are discussed. | ZHAO XinYan MI BaoXiu GAO ZhiQiang HUANG Wei | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 6 |
| 18 | Computational Path Planner for Product Assembly in Complex Environments显示文摘Assembly path planning is a crucial problem in assembly related design and manufacturing processes. Sampling based motion planning algorithms are used for computational assembly path planning. However, the performance of such algorithms may degrade much in environments with complex product structure, narrow passages or other challenging scenarios. A computational path planner for automatic assembly path planning in complex 3D environments is presented. The global planning process is divided into three phases based on the environment and specific algorithms are proposed and utilized in each phase to solve the challenging issues. A novel ray test based stochastic collision detection method is proposed to evaluate the intersection between two polyhedral objects. This method avoids fake collisions in conventional methods and degrades the geometric constraint when a part has to be removed with surface contact with other parts. A refined history based rapidly-exploring random tree (RRT) algorithm which bias the growth of the tree based on its planning history is proposed and employed in the planning phase where the path is simple but the space is highly constrained. A novel adaptive RRT algorithm is developed for the path planning problem with challenging scenarios and uncertain environment. With extending values assigned on each tree node and extending schemes applied, the tree can adapts its growth to explore complex environments more efficiently. Experiments on the key algorithms are carried out and comparisons are made between the conventional path planning algorithms and the presented ones. The comparing results show that based on the proposed algorithms, the path planner can compute assembly path in challenging complex environments more efficiently and with higher success. This research provides the references to the study of computational assembly path planning under complex environments. | SHANG Wei LIU Jianhua NING Ruxin LIU Mi | 2013 | Chinese Journal of Mechanical Engineering2013，26，2： | 6 |
| 19 | Effect of warm acupuncture on nitric oxide synthase and calcitonin gene-related peptide in a rat model of lumbar nerve root compression显示文摘BACKGROUND:Varying degrees of inflammatory responses occur during lumbar nerve root compression.Studies have shown that nitric oxide synthase(NOS) and calcitonin gene-related peptide(CGRP) are involved in secondary disc inflammation. OBJECTIVE:To observe the effects of warm acupuncture on the ultrastructure of inflammatory mediators in a rat model of lumbar nerve root compression,including NOS and CGRP contents. DESIGN,TIME AND SETTING:Randomized,controlled study,with molecular biological analysis, was performed at the Experimental Center,Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,between September 2006 and April 2007. MATERIALS:Acupuncture needles and refined Moxa grains were purchased from Shanghai Taicheng Technology Development Co.,Ltd.,China;Mobic tablets were purchased from Shanghai Boehringer Ingelheim Pharmaceuticals Co.,Ltd.,China;enzyme linked immunosorbent assay (ELISA) kits for NOS and CGRP were purchased from ADL Biotechnology,Inc.,USA. METHODS:A total of 50,healthy,adult Sprague-Dawley rats,were randomly divided into five groups normal,model,warm acupuncture,acupuncture,and drug,with 10 rats in each group.Rats in the four groups,excluding the normal group,were used to establish models of lumbar nerve root compression.After 3 days,Jiaji points were set using reinforcing-reducing manipulation in the warm acupuncture group.Moxa grains were burned on each needle,with 2 grains each daily.The acupuncture group was the same as the warm acupuncture group,with the exception of non-moxibustion.Mobic suspension(3.75 mg/kg) was used in the oral drug group,once a day. Treatment of each group lasted for 14 consecutive days.Modeling and medication were not performed in the normal group. MAIN OUTCOME MEASURES:The ultrastructure of damaged nerve roots was observed with transmission electron microscopy;NOS and CGRP contents were measured using ELISA. RESULTS:The changes of the radicular ultramicrostructure were characterized by Wallerian degeneration;nerve fibers were clearly demyelinated;axons collapsed or degenerated;outer Schwann cell cytoplasm was swollen and its nucleus was compacted.Compared with the normal group,NOS and CGRP contents in the nerve root compression zone in the model group were significantly increased(P<0.01).Nerve root edema was improved in the drug,acupuncture and the warm acupuncture groups over the model group.NOS and CGRP expressions were also decreased with the warm acupuncture group having the lowest concentration(P<0.01). CONCLUSION:In comparison to the known effects of Mobic drug and acupuncture treatments,the warm acupuncture significantly decreased NOS and CGRP expression which helped improve the ultrastructure of the comoressed nerve root. | Yaochi Wu Yiqun Mi Peng Zhang Junfeng Zhang Wei Chen | 2009 | Neural Regeneration Research2009，4，6： | 5 |
| 20 | Effects of Outdoor Temperature on Blood Pressure in a Prospective Cohort of Northwest China显示文摘Objective The relationship between outdoor temperature and blood pressure(BP) has been inconclusive. We analyzed data from a prospective cohort study in northwestern China to investigate the effect of outdoor temperature on BP and effect modification by season.Methods A total of 32,710 individuals who participated in both the baseline survey and the first follow-up in 2011–2015 were included in the study. A linear mixed-effect model and generalized additive mixed model(GAMM) were applied to estimate the association between outdoor temperature and BP after adjusting for confounding variables.Results The mean differences in systolic blood pressure(SBP) and diastolic blood pressure(DBP)between summer and winter were 3.5 mm Hg and 2.75 mm Hg, respectively. After adjusting for individual characteristics, meteorological factors and air pollutants, a significant increase in SBP and DBP was observed for lag 06 day and lag 04 day, a 0.28 mm Hg(95% CI: 0.27–0.30) per 1 °C decrease in average temperature for SBP and a 0.16 mm Hg(95% CI: 0.15–0.17) per 1 °C decrease in average temperature for DBP, respectively. The effects of the average temperature on both SBP and DBP were stronger in summer than in other seasons. The effects of the average temperature on BP were also greater if individuals were older, male, overweight or obese, a smoker or drinker, or had cardiovascular diseases(CVDs), hypertension, and diabetes.Conclusions This study demonstrated a significant negative association between outdoor temperature and BP in a high-altitude environment of northwest China. Moreover, BP showed a significant seasonal variation. The association between BP and temperature differed by season and individuals' demographic characteristics(age, gender, BMI), unhealthy behaviors(smoking and alcohol consumption), and chronic disease status(CVDs, hypertension, and diabetes). | ZHENG Shan WANG Min Zhen CHENG Zhi Yuan KANG Feng NIE Yong Hong MI Xiu Ying LI Hai Yan JIN Lan ZHANG Ya Wei BAI Ya Na | 2021 | Biomedical and Environmental Sciences2021，34，2： | 5 |
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