|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Bubbleless fiber aerator for surface waters显示文摘 | WEISS P T OAKLEY B T GULLIVER J S | 1996 | Journal of Environmental Engineering1996，122，： | 1 |
| 3 | An empirical investigation of market structure, efficiency, and performance in property-liability insurance显示文摘 | Choi B P M A Weiss | 2005 | Journal of Risk and Insurance2005，72，4： | 1 |
| 4 | Analysis of Franz-Keldysh oscillations in photoreflectance spectra of a AlGaAs/GaAs single-quantum well structure显示文摘 | Hughes P J Weiss B L Hosea T J G | 1995 | J Appl Phys1995，77，12： | 1 |
| 5 | Matrix cells from Wharton's jelly form neu- rons and glia显示文摘 | Mitchell KE ML Weiss BM Mitchell P Martin D Davis L Mo- rales B Helwig M Beerenstrauch K Abou - Easa T Hildreth D rroyer and S Medicetty | 2003 | Stem Cells2003，21，： | 1 |
| 6 | Hypersensitivity reactions from taxol显示文摘 | WEISS R B DONEHOWER R C WIERNIK P H | 1990 | J Clin Oncol1990，8，7： | 1 |
| 7 | State Regulation and theStructure,Conduct,Efficiency and Performance of USAuto Insurers显示文摘 | Weiss M A Choi B P | 2008 | Journal of Banking & Finance2008，，1： | 1 |
| 8 | Early lunar magnetism显示文摘 | Garrick-Bethell I Weiss B P Shuster D L | 2009 | Science2009，，323： | 1 |
| 9 | MMP12,lung function, and COPD in high risk populations 显示文摘 | Hunninghake G M Cho M H Tesfaigzi Y Soto - Quiros M E Avila L Lasky - Su J Stidley C Melen E Soderhall C Hallberg J Kull I KercJ Svartengren M Pershagen G Wickman M Lange C Demeo D L Hersh C P Klanderman B J Raby B A Sparrow D Shapiro S D Silverman E K Litonjua A A Weiss S T Celedon J C | 2009 | New England Journal of Medicine2009，361，27： | 1 |
| 10 | A low temperature transfer of ALH84001 from Mars to Earth显示文摘 | Weiss B P Kirschvink J L Baudenbacher F J | 2000 | Science2000，，290： | 1 |
| 11 | Identification and characterization of genes differentially expressed in the testis/vas deferens of the fed male tick显示文摘 | Weiss B L Stepczynski J M Wong P | 2002 | Amblyomma hebraeum Insect Biochem Mol Biol2002，32，7： | 1 |
| 12 | Paleomagnetic analysis using SQUID microscopy显示文摘 | Weiss B P Lima E A Fong L E | 2007 | Journal of Geophysical Research-Solid Earth2007，112，09： | 1 |
| 13 | Records of an ancient Martian magnetic field in ALH84001显示文摘 | Weiss B P Vali H Baudenbacher F J | 2002 | Earth and Planetary Science Letters2002，，201： | 1 |
| 14 | Function of cytidine coenzymes in the biosynthesis of phospholipides显示文摘 | Kennedy E P Weiss S B | 1956 | Journal of Biological Chemistry1956，222，1： | 1 |
| 15 | The function of cytidine coenzymes in the biosynthesis of phospholipids 显示文摘 | Kennedy E P Weiss S B | 1956 | J Biol Chem1956，，222： | 1 |
| 16 | Paleointensity of the ancient Martian magnetic field显示文摘 | Weiss B P Fong L E Vali H | 2008 | Geophysical Research Letters2008，，23： | 1 |
| 17 | Superoxide production and expression of nox family proteins in human atherosclerosis 显示文摘 | Sorescu D Weiss D Lassegue B Clempus R E Szocs K Sorescu G P | 2002 | Circulation2002，105，： | 1 |
| 18 | Hypersensitivity reactions from taxol 显示文摘 | WEISS R B DONEHOWER R C WIERNIK P H | 1990 | J Clin Oncol1990，8，： | 1 |
| 19 | Paleointensity of the Earth's magnetic field using SQUID microscopy显示文摘 | Weiss B P Lima E A Fong L E | 2007 | Earth and Planetary Science Letters2007，264，12： | 1 |
| 20 | The enzymatic synthesis of trielycerides 显示文摘 | Weiss S B Kennedy E P | 1956 | Journal of the American Chemical Socie- ty1956，78，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员