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| 1 | Liver cancer incidence and mortality in China: Temporal trends and projections to 2030显示文摘Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths worldwide.The systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other countries.Methods: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries' data selected from Chinese National Cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to 2014.The burden of liver cancer through 2030 was projected using age-period-cohort model.Results: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in 2014.Western regions of China had the highest incidence and mortality rates.Incidence and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in China.The young generation,particularly for those aged under 40 years,showed a faster down trend.Conclusions: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western areas.Most cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups. | Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li Wenqiang Wei Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 132 |
| 2 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 3 | Calcineurin B-like interacting protein kinase OsCIPK23 functions in pollination and drought stress responses in rice (Oryza sativa L.)显示文摘Drought is very harmful to grain yield due to its adverse effect on reproduction, especially on pollination process in rice. However, the molecular basis of such an effect still remains largely unknown. Here, we report the role of a member of CBL (Calcineurin B-Like) Interacting Protein Kinase (CIPK) family, OsCIPK23, in pollination and stress responses in rice. Molecular analyses revealed that it is mainly expressed in pistil and anther but up-regulated by pollination, as well as by treatments of various abiotic stresses and phytohormones. RNA interference-mediated suppression of OsCIPK23 expression significantly reduced seed set and conferred a hypersensitive response to drought stress, indicating its possible roles in pollination and drought stress. In consistent, overexpression of OsCIPK23 induced the expression of several drought tolerance related genes. Taken together, these results indicate that OsCIPK23 is a multistress induced gene and likely mediates a signaling pathway commonly shared by both pollination and drought stress responses in rice. | Wenqiang Yang Zhaosheng Kong Edith Omo-Ikerodah Wenying Xu Qun Li Yongbiao Xue | 2008 | Journal of Genetics and Genomics2008，35，9： | 21 |
| 4 | Molecular mechanisms governing plant responses to high temperatures显示文摘The increased prevalence of high temperatures(HTs) around the world is a major global concern, as they dramatically affect agronomic productivity. Upon HT exposure, plants sense the temperature change and initiate cellular and metabolic responses that enable them to adapt to their new environmental conditions.Decoding the mechanisms by which plants cope with HT will facilitate the development of molecular markers to enable the production of plants with improved thermotolerance. In recent decades, genetic, physiological, molecular, and biochemical studies have revealed a number of vital cellular components and processes involved in thermoresponsive growth and the acquisition of thermotolerance in plants. This review summarizes the major mechanisms involved in plant HT responses, with a special focus on recent discoveries related to plant thermosensing, heat stress signaling, and HT-regulated gene expression networks that promote plant adaptation to elevated environmental temperatures. | Bingjie Li Kang Gao Huimin Ren Wenqiang Tang | 2018 | Journal of Integrative Plant Biology2018，60，9： | 19 |
| 5 | Cotton GhPOX1 encoding plant class Ⅲ peroxidase may be responsible for the high level of reactive oxygen species production that is related to cotton fiber elongation显示文摘The accumulation of reactive oxygen species(ROS) is involved in plant cell development.In plant,class Ⅲ peroxidases are heme-containing enzymes encoded by a large multi-gene family participated in the release or consumption of ROS.The specific function of each member of the family is still elusive.Here,we showed that ROS was significantly generated during cotton fiber initiation and elongation,whereas,application of NADPH oxidase inhibitor diphenyleneiodonium(DPI) and peroxidase inhibitor salicylhydroxamic acid(SHAM) to the wild-type cotton ovule culture significantly suppressed fiber growth,respectively.Their inhibitory effects were caused by the reduction of superoxide radical(O2-).Ten GhPOX genes(cDNAs) encoding cotton class Ⅲ peroxidases were isolated,among them eight GhPOX genes were reported for the first time.Microarray analyses indicated that GhPOX1 was the mostly predomi-nantly expressed in fast-elongating cotton fiber cells.Real-time quantitative PCR analysis revealed the transcript level of GhPOX1 was over 400-fold higher in growing fiber cells than in ovules,flowers,roots,stems and leaves.To reveal the role of GhPOX1 in plant devel-opment,its Arabidopsis orthologue atpox13 mutant was demonstrated to be defective in branch root development.Taken together,the data suggest that GhPOX1 plays an important role during fiber cell elongation possibly by mediating production of reactive oxygen spe-cies. | Wenqian Mei Yongmei Qin Wenqiang Song Jun Li Yuxian Zhu | 2009 | Journal of Genetics and Genomics2009，36，3： | 19 |
| 6 | Colorectal cancer burden and trends:Comparison between China and major burden countries in the world显示文摘Objective:To summarize the colorectal cancer(CRC)burden and trend in the world,and compare the difference of CRC burden between other countries and China.Methods:Incidence and mortality data were extracted from the GLOBOCAN2018 and Cancer Incidence in Five Continents.Age-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were calculated.Results:About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide,including 0.52 million(28.20%)new cases and 0.25 million(28.11%)deaths in China.Hungary had the highest age-standardized incidence and mortality rates in the world,while for China,the incidence and mortality rates were only half of that.CRC incidence and mortality were highly correlated with human development index(HDI).Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia,the age-standardized incidence rates by world standard population in China and Norway were rising gradually.The age-specific incidence rate in the age group of 50-59 years in China was increasing rapidly,while in Republic of Korea and Canada,the fastest growing age group was 30-39 years.Conclusions:The variations of CRC burden reflect the difference of risk factors,as well as levels of HDI and screening(early detection activities).The burden of CRC in China is high,and the incidence of CRC continues to increase,which may lead to a sustained increase in the burden of CRC in China in the future.Screening should be expanded to control CRC,and focused on young people in China. | Jiachen Zhou Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Ru Chen Kexin Sun Minjuan Li Jianhua Gu Guihua Zhuang Wenqiang Wei | 2021 | Chinese Journal of Cancer Research2021，33，1： | 16 |
| 7 | DNA image cytometry test for primary screening of esophageal cancer: a population-based multi-center study in high-risk areas in China显示文摘Objective: To evaluate the feasibility of DNA image cytometry(DNA-ICM) as a primary screening method for esophageal squamous cell cancer(ESCC).Methods: A total of 5,382 local residents aged 40–69 years from three high-risk areas in China(Linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province) from 2008 to 2011 were recruited in this population-based screening study. And 2,526 subjects declined to receive endoscopic biopsy examination with Lugol's iodine staining, while 9 and 815 subjects were excluded from liquid-based cytology and DNA-ICM test respectively due to slide quality. Finally, 2,856, 5,373 and 4,567 subjects were enrolled in the analysis for endoscopic biopsy examination, liquid-based cytology and DNA-ICM test, respectively. Sensitivity(SE), specificity(SP), negative predictive values(NPV) and positive predictive values(PPV) as well as their 95% confidence intervals(95% CI) for DNA-ICM, liquid-based cytology and the combination of the two methods were calculated. Receiver operating characteristic(ROC) curves were applied to determine the cutoff point of DNA-ICM for esophageal cancer.Results: DNA-ICM results were significantly correlative with esophageal cancer and precancer lesions(χ~2=18.016, P<0.001). The cutoff points were 5,802, 5,803 and 8,002 based on dissimilar pathological types of low grade intraepithelial neoplasia(LGIN), high grade intraepithelial neoplasia(HGIN), and ESCC, respectively, and 5,803 was chosen in this study considering the SE and SP. The SE, SP, PPV, NPV of DNA-ICM test(cutoff point 5,803) combined with liquid-based cytology [threshold atypical squamous cells of undetermined significance(ASCUS)] were separately 72.1%(95% CI: 70.3%-73.9%), 43.3%(95% CI: 41.3%-45.3%), 22.8%(95% CI: 21.1%-24.5%) and 87.0%(95% CI: 85.7%-88.3%) for LGIN, 85.7%(95% CI: 84.3%-87.1%), 41.3%(95% CI: 39.3%-43.3%), 4.6%(95% CI: 3.8%-5.4%) and 98.9%(95% CI: 98.5%-99.3%) for HGIN, and 96.0%(95% CI: 95.2%-96.8%), 40.8%(95% CI: 38.8%-42.8%), 1.7%(95% CI: 1.2%-2.2%) and 99.9%(95% CI: 99.8%-100.0%) for ESCC.Conclusions: It is possible to use DNA-ICM test as a primary screening method before endoscopic screening for esophageal cancer. | Meng Wang Changqing Hao Qing Ma Guohui Song Shanrui Ma Deli Zhao Lin Zhao Xinqing Li Wenqiang Wei | 2016 | Chinese Journal of Cancer Research2016，28，4： | 15 |
| 8 | Cancer statistics in Chinese older people,2022:current burden,time trends,and comparisons with the US,Japan,and the Republic of Korea显示文摘Largely due to population ageing,the cancer burden from older people has been rising,which imposed considerable pressure on current Chinese healthcare system.We provide comprehensive information about cancer burden of Chinese older people based on the most recent data from National Central Cancer Registry of China.The logarithmic linear regression was used to project the current cancer burden in 2022,and Joinpoint regression was used for temporal trend analysis from 2000 to 2017.We also estimated cancer statistics of older people in the US,Japan and the Republic of Korea for comparisons.It is estimated that 2.79 million cases and 1.94 million deaths occur for Chinese older people,representing 55.8%and 68.2%of cases and deaths in all population in 2022.The overall cancer incidence rate gradually increased among older women,while the mortality rates declined for both sexes.Notably,approximately 10.0%of all cases and 17.7%of all deaths are from people aged over 80 years,and cancer incidence and mortality in this age group showed upward trends for women.Lung cancer and digestive cancers are the leading cancer types for Chinese older people.Compared with other countries,China has lower incidence rates but higher mortality rates for older people.The rapidly growing burden of prostate cancer,breast cancer,colorectal cancer,and declines in esophageal cancer,stomach cancer,and liver cancer among older people indicate the cancer pattern in China is being in a transition stage to that in developed countries.Our findings imply that it should be the national health priority to meet the growing demands for cancer diagnosis,treatment and care services from the older people as the rapid population ageing in next few decades. | Wen Ju Rongshou Zheng Siwei Zhang Hongmei Zeng Kexin Sun Shaoming Wang Ru Chen Li Li Wenqiang Wei Jie He | 2023 | Science China(Life Sciences)2023，66，5： | 15 |
| 9 | ZmCOL3, a CCT gene represses flowering in maize by interfering with the circadian clock and activating expression of ZmCCT显示文摘Flowering time is a trait vital to the adaptation of flowering plants to different environments.Here, we report that CCT domain genes play an important role in flowering in maize(Zea mays L.).Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time, based on candidate-gene association mapping analysis.Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering.Overexpressing ZmCOL3 delayed flowering time by approximately 4 d, in either long-day or short-day conditions.The absence of one cytosine in the ZmCOL3 3'UTR and the presence of a 551 bp fragment in the promoter region are likely the causal polymorphisms contributing to the maize adaptation from tropical to temperate regions.We propose a modified model of the maize photoperiod pathway, wherein ZmCOL3 acts as an inhibitor of flowering either by transactivating transcription of ZmCCT, one of the key genes regulating maize flowering, or by interfering with the circadian clock. | Minliang Jin Xiangguo Liu Wei Jia Haijun Liu Wenqiang Li Yong Peng Yanfang Du Yuebin Wang Yuejia Yin Xuehai Zhang Qing Liu Min Deng Nan Li Xiyan Cui Dongyun Hao Jianbing Yan | 2018 | Journal of Integrative Plant Biology2018，60，6： | 14 |
| 10 | Distant eQTLs and Non-coding Sequences Play Critical Roles in Regulating Gene Expression and Quantitative Trait Variation in Maize显示文摘 | Haijun Liu Xin Luo Luyao Niu Yingjie Xiao Lu Chen Jie Liu Xiaqing Wang Minliang Jin Wenqiang Li Qinghua Zhang Jianbing Yan | 2017 | Molecular Plant2017，10，3： | 13 |
| 11 | BZR1 Family Transcription Factors Function Redundantly and Indispensably in BR Signaling but Exhibit BRI1-Independent Function in Regulating Anther Development in Arabidopsis显示文摘BRASSINAZOLE-RESISTANT 1 family proteins(BZRs)are central transcription factors that govern brassinosteroid(BR)-regulated gene expression and plant growth.However,it is unclear whether there exists a BZR-independent pathway that mediates BR signaling.In this study,we found that disruption of all BZRs in Arabidopsis generated a hextuple mutant(bzr-h)displaying vegetative growth phenotypes that were almost identical to those of the null mutant of three BR receptors,bri1brl1brl3(bri-t).By RNA sequencing,we found that global gene expression in bzr-h was unaffected by 2 h of BR treatment.The anthers of bzr-h plants were loculeless,but a similar phenotype was not observed in bri-t,suggesting that BZRs have a BR signaling-independent regulatory role in anther development.By real-time PCR and in situ hybridization,we found that the expression of SPOROCYTELESS(SPL),which encodes a transcription factor essential for anther locule development,was barely detectable in bzr-h,suggesting that BZRs regulate locule development by affecting SPL expression.Our findings reveal that BZRs are indispensable transcription factors required for both BR signaling and anther locule development,providing new insight into the molecular mechanisms underlying the microsporogenesis in Arabidopsis. | Lian-Ge Chen Zhihua Gao Zhiying Zhao Xinye Liu Yongpeng Li Yuxiang Zhang Xigang Liu Yu Sun Wenqiang Tang | 2019 | Molecular Plant2019，12，10： | 11 |
| 12 | Genome-wide analysis of BES1 genes in Gossypium revealed their evolutionary conserved roles in brassinosteroid signaling显示文摘Brassinosteroids(BRs), which are essential phytohormones for plant growth and development, are important for cotton fiber development. Additionally, BES1 transcription factors are critical for BR signal transduction. However, cotton BES1 family genes have not been comprehensively characterized. In this study, we identified 11 BES1 genes in G. arboreum, 11 in G.raimondii, 16 in G. barbadense, and 22 in G. hirsutum. The BES1 sequences were significantly conserved in the Arabidopsis thaliana, rice, and upland cotton genomes. A total of 94 BES1 genes from 10 different plant species were divided into three clades according to the neighbor-joining and minimum-evolution methods. Moreover, the exon/intron patterns and motif distributions were highly conserved among the A. thaliana and cotton BES1 genes. The collinearity among the orthologs from the At and Dt subgenomes was estimated. Segmental duplications in the At and Dt subgenomes were primarily responsible for the expansion of the cotton BES1 gene family. Of the GhBES1 genes, GhBES1.4_At/Dt exhibited BL-induced expression and was predominantly expressed in fibers. Furthermore, Col-0/mGhBES1.4_At plants produced curled leaves with long and bent petioles. These transgenic plants also exhibited decreased hypocotyl sensitivity to brassinazole and constitutive BR induced/repressed gene expression patterns. The constitutive BR responses of the plants overexpressing mGhBES1.4_At were similar to those of the bes1-D mutant. | Zhao Liu Ghulam Qanmber Lili Lu Wenqiang Qin Ji Liu Jie Li Shuya Ma Zhaoen Yang Zuoren Yang | 2018 | Science China(Life Sciences)2018，61，12： | 7 |
| 13 | Autonomous navigation for a wolfberry picking robot using visual cues and fuzzy control显示文摘Lycium barbarum commonly known as wolfberry or Goji is considered an important ingredient in Japanese,Korean,Vietnamese,and Chinese food and medicine.It is cultivated extensively in these countries and is usually harvested manually,which is laborintensive and tedious task.To improve the efficiency of harvesting and reduce manual labor,automatic harvesting technology has been investigated by many researchers in recent years.In this paper,an autonomous navigation algorithm using visual cues and fuzzy control is proposed for Wolfberry orchards.At first,we propose a new weightage(2.4B-0.9G-R)to convert a color image into a grayscale image for better identification of the trunk of Lycium barbarum,the minimum positive circumscribed rectangle is used to describe the contours.Then,using the contour points the least square method is used to fit the navigation line and a region of interest(ROI)is computed that improves the realtime accuracy of the system.Finally,a set of fuzzy controllers,for pneumatic steering system,is designed to achieve real-time autonomous navigation in wolfberry orchard.Static image experiments show that the average accuracy rate of the algorithm is above 90%,and the average time consumption is approximately 162 ms,with good robustness and real-time performance.The experimental results show that when the speed is 1 km/h,the maximum lateral deviation is less than 6.2 cm and the average lateral deviation is 2.9 cm,which meets the requirements of automatic picking of wolfberry picking robot in real-world environments. | Yue Ma Wenqiang Zhang Waqar S.Qureshi Chao Gao Chunlong Zhang Wei Li | 2021 | Information Processing in Agriculture2021，8，1： | 7 |
| 14 | Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts显示文摘Background: The current study was carried out to evaluate the effects of mycotoxin biodegradation agent(MBA, composed of Bacillus subtilis ANSB01 G and Devosia sp. ANSB714) on relieving zearalenone(ZEA) and deoxynivalenol(DON) toxicosis in immature gilts.Methods: A total of forty pre-pubertal female gilts(61.42 ± 1.18 kg) were randomly allocated to four diet treatments: CO(positive control); MO(negative control, ZEA 596.86 μg/kg feed and DON 796 μg/kg feed);COA(CO + 2 g MBA/kg feed); MOA(MO + 2 g MBA/kg feed). Each treatment contained 10 replicates with 1 gilt per replicate. Gilts were housed in an environmentally controlled room with the partially slatted floor.Results: During the entire experimental period of 28 d, average daily gain(ADG) and average daily feed intake(ADFI)of gilts in MO group was significantly reduced compared with those in CO group. The vulva size of gilts was significantly higher in MO group than CO group. In addition, significant increases in the plasma levels of Ig A,Ig G, IL-8, IL-10 and PRL were determined in MO group compared with that in CO group. ZEA and DON in the diet upregulated apoptotic caspase-3 in ovaries and uteri, along with down-regulated the anti-apoptotic protein Bcl-2 in ovaries. The supplementation of MBA into diets co-contaminated with ZEA and DON significantly increased ADG, decreased the vulva sizes, reduced the levels of Ig G, IL-8 and PRL in plasma, and regulated apoptosis in ovaries and uteri of gilts.Conclusions: The present results indicated that feeding diet contaminated with ZEA and DON simultaneously(596.86 μg/kg + 796 μg/kg) had detrimental effects on growth performance, plasma immune function and reproductive status of gilts. And MBA could reduce the negative impacts of these two toxins, believed as a promising feed additive for mitigating toxicosis of ZEA and DON at low levels in gilts. | Donghui Shi Jianchuan Zhou Lihong Zhao Xiaoping Rong Yu Fan Humera Hamid Wenqiang Li Cheng Ji Qiugang Ma | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 7 |
| 15 | The involvement of wheat U-box E3 ubiquitin ligase TaPUB1 in salt stress tolerance显示文摘U-box E3 ubiquitin ligases play important roles in the ubiquitin/26 S proteasome machinery and in abiotic stress responses. Ta PUB1-overexpressing wheat(Triticum aestivum L.) were generated to evaluate its function in salt tolerance. These plants had more salt stress tolerance during seedling and flowering stages, whereas the Ta PUB1-RNA interference(RNAi)-mediated knock-down transgenic wheat showed more salt stress sensitivity than the wild type(WT). Ta PUB1 overexpression upregulated the expression of genes related to ion channels and increased the net root Na+efflux, but decreased the net K+efflux and H+influx, thereby maintaining a low cytosolic Na+/K+ratio, compared with the WT. However,RNAi-mediated knock-down plants showed the opposite response to salt stress. Ta PUB1 could induce the expression of some genes that improved the antioxidant capacity of plants under salt stress. Ta PUB1 also interacted with Ta MP(Triticum aestivum α-mannosidase protein), a regulator playing an important role in salt response in yeast and in plants. Thus, low cytosolic Na+/K+ratios and better antioxidant enzyme activities could be maintained in wheat with overexpression of Ta PUB1 under salt stress. Therefore, we conclude that the U-box E3 ubiquitin ligase Ta PUB1 positively regulates salt stress tolerance in wheat. | Wenlong Wang Wenqiang Wang Yunzhen Wu Qinxue Li Guangqiang Zhang Ruirui Shi Junjiao Yang Yong Wang Wei Wang | 2020 | Journal of Integrative Plant Biology2020，62，5： | 6 |
| 16 | Identification of QTLs and Validation of qCd-2 Associated with Grain Cadmium Concentrations in Rice显示文摘Cadmium(Cd) is one of heavy metals harmful to human health. As rice is the main staple food in Asia and Cd is easily contaminated in rice, the molecular regulation of Cd accumulation should be explored. In this study, a recombinant inbred population derived from Xiang 743/Katy was grown in Cd-polluted fields and used to map the quantitative trait loci(QTLs) for Cd accumulation in rice grains. We identified seven QTLs distributed on chromosomes 2, 3, 6, 7, 8 and 10. These QTLs displayed phenotypic variances of 58.50% and 40.59% in 2014 and 2015, respectively. Two QTLs, qCd-2 and qCd-7, were identified in both the two years. qCd-2 was detected on the interval of RM250–RM207 on chromosome 2, with an LOD of 2.51 and a phenotypic contribution of 13.75% in 2014, and an LOD of 3.35 and a phenotypic contribution of 14.16% in 2015. qCd-7 co-localized with the cloned qCdT7 on chromosome 7 and may represent the correct candidate. The other five QTLs were detected only in one year. To further confirm the effects of qCd-2, a residual heterozygous line designated as RHL945, with a heterozygous interval of RM263–RM207 on chromosome 2, was selected from the recombinant inbred population and used to develop an F2 population consisting of 155 individual plants. By incorporating further simple sequence repeat markers into the segmental linkage map of the target region, qCd-2 was delimited in the interval of RM5404–RM3774, with an LOD value of 4.38 and a phenotypic contribution of 15.52%. These results reflected the genetic regulation of grain Cd in rice and paved the way for the future cloning of qCd-2. | LIU Wenqiang PAN Xiaowu LI Yongchao DUAN Yonghong MIN Jun LIU Sanxiong LIU Licheng SHENG Xinnian LI Xiaoxiang | 2019 | Rice science2019，26，1： | 6 |
| 17 | 寨卡病毒引起小鼠睾丸损伤并导致雄性不育显示文摘虽然寨卡病毒与其他黄病毒属成员,如登革热病毒、乙型脑炎病毒和两尼罗病毒都是通过蚊媒传播,但是前人的研究发现寨卡病毒在精液中存在数月之久,暗示其性接触传播的可能性。本研究表明寨卡病毒影响雄性生殖系统,提示了其对男性健康的潜在危害。 | Wenqiang Ma Shihua Li Shuoqian Ma Lina Jia Fuchun Zhang Yong Zhang Jingyuan Zhang Gary Wong Shanshan Zhang Xuancheng Lu Mei Liu Jinghua Yan Wei Li Chuan Qin Daishu Han Chengfeng Qin Na Wang 李向东 高福 | 2017 | 科学新闻2017，19，4： | 5 |
| 18 | Active/passive Q-switching operation of 2 μm Tm,Ho:YAP laser with an acousto-optical Q-switch/MoS_2 saturable absorber mirror显示文摘The active/passive Q-switching operation of a 2 μm a-cut Tm,Ho:YAP laser was experimentally demonstrated with an acousto-optical Q–switch∕MoS_2 saturable absorber mirror. The active Q-switch laser was operated for the first time, to the best of our knowledge, with an average output power of 12.3 W and a maximum pulse energy of 10.3 mJ. The passive Q-switch laser was also the first acquired with an average output power of 3.3 W and per pulse energy of 23.31 μJ, and the beam quality factors of M_x^2 = 1.06 and M_y^2 = 1.06 were measured at the average output power of 2 W. | LINJUN LI XINING YANG LONG ZHOU WENQIANG XIE YUNLONG WANG YINGJIE SHEN YUQIANG YANG WENLONG YANG WEI WANG ZHIWEI LV XIAOMING DUAN MINGHUA CHEN | 2018 | Photonics Research2018，6，6： | 5 |
| 19 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Cervical Cancer—China,2003–2017显示文摘Introduction:This study reported the trends and analyzed the age-period-cohort effects on the incidence and mortality rates of cervical cancer in China.Methods:The age-standardized incidence rate(ASIR)and mortality rate(ASMR)by Segi’s world standard population were calculated using qualified consecutive data from 22 cancer registries from 2003 to 2017 in China.We performed joinpoint analysis to describe the trends and age-period-cohort analysis to estimate the independent effects of age,period and cohort on trends in incidence and mortality rates of cervical cancer.Results:The ASIR and ASMR for cervical cancer in females over 20 years old increased during 2003−2017.For females<50 years,a decreasing trend in ASIR and a stable trend in ASMR were observed in urban areas after 2009.But the ASIR and ASMR kept increasing in rural areas during the whole period.For females>50 years,the ASIR and ASMR increased both in urban and rural areas.Age-period-cohort analysis showed increasing period effects on cervical cancer incidence and mortality during the whole period.The cohort effects exhibited a downward-upwarddownward pattern for the incidence(1918–1938,1938–1963,1963–1993)and mortality rates(1918–1943,1943–1963,1963–1993)in urban areas,a fluctuating pattern for incidence rate and a continuing downward pattern for mortality rate(1918–1993)in rural areas.Conclusions:The increases in cervical cancer incidence and mortality rates can be mostly explained by period effects.We observed decreases in risk for cervical cancer incidence and mortality in young female generations,which were more obvious in urban areas. | Kexin Sun Rongshou Zheng Lin Lei Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2022 | China CDC weekly2022，4，48： | 4 |
| 20 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
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