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| 1 | Genome-wide Association Analysis of Ten Chilling Tolerance Indices at the Germination and Seedling Stages in Maize显示文摘玉米幼苗对很敏感寒心,特别在转变阶段从期间对自造营养物质的生长不是自养。寒心的忍耐的基因基础的基因解剖将为玉米 inbreds 的基因改进提供有用信息。在这研究,染色体宽的协会分析被进行探索在种子萌芽和幼苗的寒心的忍耐与 125 inbreds 的一块协会面板上演的玉米的基因体系结构。十个忍耐索引( 10 萌芽率和幼苗的表演的比率在寒心的应力和控制条件下面的生长相关的特点)被调查估计与寒心的忍耐联系的 43 单个核苷酸多型性的 inbreds ,和一个总数的寒心的忍耐的能力被检测,与没有,他们,与在萌芽和幼苗的寒心的忍耐有关同时上演。关联分析也表明在种子萌芽阶段的寒心的忍耐的基因基础在幼苗阶段与那通常不同。另外,包含 43 单个核苷酸多型性中的 31 个的 40 候选人基因的一个总数根据他们的功能被预言,并且被组织进五个范畴。在寒心的忍耐的这些候选人基因的可能的角色也被讨论。 | Juan Huang Jianhua Zhang Wenzhen Li Wei Hu Lichao Duan Yang Feng Fazhan Qiu Bing Yue | 2013 | Journal of Integrative Plant Biology2013，55，8： | 12 |
| 2 | Daily Visibility and Hospital Admission in Shanghai, China显示文摘Objective The study is to investigate the associations between visibility, major air pollutants and daily counts of hospital admission in Shanghai, China. Methods Daily data on hospital admission, visibility, and air pollution during 2005‐2008 were obtained from the Shanghai Insurance Bureau (SHIB), Shanghai Meteorological Bureau, and Shanghai Environmental Monitoring Center, respectively. The generalized additive model (GAM) with penalized splines was used to examine the associations between daily visibility and hospital admission. Results Among various pollutants, PM 2.5 showed strongest correlation with visibility. Decreased visibility was significantly associated with increased risk of hospital admission in Shanghai. An inter‐quartile range decrease in the 2‐day (L01) moving average of visibility corresponded to 3.66% (95%CI: 1.02%, 6.31%), 4.06% (95%CI: 0.84%, 7.27%), and 4.32% (95%CI: 1.67%, 6.97%) increase of total, cardiovascular, and respiratory hospitalizations, respectively. Conclusion Our analyses provide the first piece of evidence in China, demonstrating that decreased visibility has an effect on hospital admission, and this finding strengthens the rationale for further limiting air pollution levels in Shanghai. | GE WenZhen CHEN RenJie SONG WeiMin KAN HaiDong | 2011 | Biomedical and Environmental Sciences2011，24，2： | 9 |
| 3 | Characterization and Fine Mapping of a Novel Rice Narrow Leaf Mutant nal9显示文摘A narrow leaf mutant was isolated from transgenic rice(Oryza sativa L.)lines carrying a T-DNA insertion.The mutant is characterized by narrow leaves during its whole growth period,and was named nal9(narrow leaf 9).The mutant also has other phenotypes,such as light green leaves at the seedling stage,reduced plant height,a small panicle and increased tillering.Genetic analysis revealed that the mutation is controlled by a single recessive gene.A hygromycin resistance assay showed that the mutation was not caused by T-DNA insertion,so a map-based cloning strategy was employed to isolate the nal9 gene.The mutant individuals from the F2generations of a cross between the nal9 mutant and Longtepu were used for mapping.With 24 F2mutants,the nal9 gene was preliminarily mapped near the marker RM156 on the chromosome 3.New INDEL markers were then designed based on the sequence differences between japonica and indica at the region near RM156.The nal9 gene was fnally located in a 69.3 kb region between the markers V239B and V239G within BAC OJ1212_C05 by chromosome walking.Sequence and expression analysis showed that an ATP-dependent Clp protease proteolytic subunit gene(ClpP)was most likely to be the nal9 gene.Furthermore,the nal9 mutation was rescued by transformation of the ClpP cDNA driven by the 35S promoter.Accordingly,the ClpP gene was identifed as the NAL9 gene.Our results provide a basis for functional studies of NAL9 in future work. | Wei Li Chao Wu Guocheng Hu Li Xing Wenjing Qian Huamin Si Zongxiu Sun Xingchun Wang Yaping Fu Wenzhen Liu | 2013 | Journal of Integrative Plant Biology2013，55，11： | 8 |
| 4 | nvolvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis显示文摘 | Haiyan Chu Ting Wu Wenyu Wu Wenzhen Tu Shuai Jiang Sidi Chen Yanyun Ma Qingmei Liu Xiaodong Zhoua Li Jin Jiucun Wang | 2015 | Protein & Cell2015，6，8： | 5 |
| 5 | Numerical Simulation of Shrinkage Cavity Formation in Spheroidal Graphite Iron Castings Based on Micro Modeling显示文摘A micro-modeling method (MM) for the quantitative prediction of the shrinkage cavity formation in SGiron castings is proposed. The mathematical models describing the volume changes during the solidification ofspheroidal graphite cast iron are established based on the models of solidification kinetics. The shrinkage cavityformation of T-shaped SG iron castings is calculated with MM method. The calculated results are compared with theexperimental results. It is shown that the predicted size, shape and distribution of shrinkage cavity by MM methodare in good agreement with the measured results. | Wenzhen Li Baicheng Liu Shantong Jin (Metallurgy Engineering School, University of Science and Technology Beijing, Beijing 100083, China)(Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China) | 1998 | International Journal of Minerals,Metallurgy and Materials1998，12，1： | 5 |
| 6 | Effects of high voltage discharge on the human bodies of workers显示文摘In this paper,as it is reported,through mechanism analysis,calculation,testing,measuring in the site and the observation ofbiologic effect on workers as well as the peripheral blood test in vitro,there are low energy X-ray and so forth produced due to high volt-age discharge which are harmful physical and chemical factors.Theexistence of these harmful factors affect workers’ health to a certaindegree.The observed biologic indexes are those of peripheral bloodcell effect,lymphocyte,micronuclear,chromosomal aberration,sisterchromatid exchange,blood serum immune globulin,electroen-cephalogram and brain blood current gram. The vitro peripheralblood test indexes are including those of chromosmal aberration,sister chromatid exchange and blood serum immune globulin.Theresults obtained from the said observation and testing express thatthe above mentioned indexes have obvious significance after thecomparison of those between test group and control group treated bystatistics (i.e.P<0.05).Further,the test results also point out that theenvironment of high voltage discharge will creat injury to the workers,therefore a detail research should be taken. | Yang Baochu Chongqing UniversityZao Wenzhen Radiative medical Science Research Institute,Medical Science Academy of ChinaZhang Maohua Hygienic and Antiepidemic Station of Qijiang | 1991 | Electricity1991，，2： | 4 |
| 7 | High-Performance Solid-State Supercapacitors Fabricated by Pencil Drawing and Polypyrrole Depositing on Paper Substrate显示文摘A solid-state powerful supercapacitor(SC) is fabricated with a substrate of Xerox paper. Its current collector based on a foldable electronic circuit is developed by simply pencil drawing. Thin graphite sheets on paper provide effective channels for electron transmission with a low resistance of 95 X sq-1. The conductive organic material of polypyrrole coated on thin graphite sheets acts as the electrode material of the device. The as-fabricated SC exhibits a high specific capacitance of 52.9 F cm-3at a scan rate of 1 m V s-1. An energy storage unit fabricated by three full-charged series SCs can drive a commercial light-emitting diode robustly. This work demonstrated a simple, versatile and costeffective method for paper-based devices. | Jiayou Tao Wenzhen Ma Nishuang Liu Xiaoliang Ren Yuling Shi Jun Su Yihua Gao | 2015 | Nano-Micro Letters2015，7，3： | 4 |
| 8 | In-flight observations of electromagnetic interferences emitted by satellite显示文摘Using the data from STAFF/TC-1, this paper for the first time analyzes the electromagnetic interferences of Chinese scientific satellite. The electromagnetic interference of satellite exists mainly below 30 Hz, but can extend to 190 Hz with an obviously decreasing power spectral density. The electromagnetic interferences at frequencies below 190 Hz have good correlation with the solar aspect angle. The electromagnetic interferences at frequencies between 190 and 830 Hz have also correlation with solar as-pect angle. However, the electromagnetic interferences at frequencies above 830 Hz have no correlation with the solar aspect angle. The correlation coefficient between solar aspect angel and electromagnetic interferences is around 0.90. The larger the solar aspect angle, the stronger the satellite electromagnetic interference. When the solar aspect angle increases from 90.6° to 93.6°, the electromagnetic interferences at frequencies <10 Hz increase by 8 times and those at frequencies 190―830 Hz increase by 60%. This close association of electromagnetic interferences with the solar aspect angle indicates that the solar aspect angle is the main factor to determine the electromagnetic interferences. The electromagnetic interferences of satellite in sunlight are larger than those in eclipse. The electro-magnetic interference produced by solar panel occupies about 87% in the low frequency band (<100 Hz) and 94% in the high frequency band (>100 Hz) of the total electromagnetic interference produced by satellite. These in flight observations of electromagnetic radiation of satellites will be very helpful to the designs of future satellites of space sciences or earthquake sciences. | CAO JinBin YANG JunYing YUAN ShiGan SHEN XuHui LIU YuanMo YAN ChunXiao LI WenZhen CHEN Tao | 2009 | Science China(Technological Sciences)2009，52，7： | 4 |
| 9 | Highly regio-and stereo-selective copolymerization of CO_2 with racemic propylene oxide catalyzed by unsymmetrical (S,S,S)-salenCo(Ⅲ) complexes显示文摘A novel unsymmetrical (S,S,S)-salen ligand bearing a derived chiral-BINOL was synthesized by the reaction of the condensation product of (1S,2S)-1,2-diaminocyclohexane mono(hydrogen chloride) with 3-adamanyl-5-tert-butyl-2-hydroxybenzalde-hyde and 3-formoyl-2-hydroxy-2'-alkyloxy-1,1'-binaphthyl,which originated from (S)-1,1'-bi-2-naphthol via a four-step reaction.The cobalt complexes of this ligand,in conjunction with a nucleophilic cocatalyst,exhibited excellent activity in catalyzing asymmetric,regio-and stereo-selective copolymerization of CO2 and racemic propylene oxide.The highest record of kinetic resolution coefficient (Krel) was obtained with the use of binary catalyst system consisting of (S,S,S)-salenCo(III) complex 1c and bulky bis(triphenylphosphine)-iminium chloride (PPNCl).The resulting poly(propylene carbonate)s have more than 99% carbonate linkages and more than 98% head-to-tail content. | REN WeiMin,ZHANG WenZhen & LU XiaoBing State Key Laboratory of Fine Chemicals Dalian University of Technology,Dalian 116012,China | 2010 | Science China Chemistry2010，53，8： | 4 |
| 10 | Increasing the Genetic Recombination Frequency by Partial Loss of Function of the Synaptonemal Complex in Rice显示文摘 | Wang, Kejian Wang, Chun Liu, Qing Liu, Wenzhen Fu, Yaping | 2015 | Molecular Plant2015，8，8： | 4 |
| 11 | Development of an autonomous flapping-wing aerial vehicle显示文摘The flapping-wing aerial vehicle(FWAV) has appealed to more and more researchers recently owing to its outstanding performance in various domains and the development of some related technologies. The research on autonomous flight control of the FWAV involves many challenges and is still in nascent stages. In this work, we develop an FWAV with a mass of 14.1 g and build a vision-based experimental platform. A modelbased controller is proposed on the basis of theory and simulation results prove its effectiveness. A PID control algorithm based on visual measurement is utilized to achieve the height-keeping control of the FWAV, and a software platform is designed to record the flight status determined using Euler angles and position information. | Wei HE Haifeng HUANG Yunan CHEN Wenzhen XIE Fusen FENG Yemeng KANG Changyin SUN | 2017 | Science China(Information Sciences)2017，60，6： | 3 |
| 12 | CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases显示文摘Blood vessel dysfunction causes several retinal diseases,including diabetic retinopathy,familial exudative vitreoretinopathy,macular degeneration and choroidal neovascularization in pathological myopia.Vascular endothelial growth factor(VEGF)-neutralizing proteins provide benefits in most of those diseases,yet unsolved haemorrhage and frequent intraocular injections still bothered patients.Here,we identified endothelial CD146 as a new target for retinal diseases.CD146 expression was activated in two ocular pathological angiogenesis models,a laser-induced choroid neovascularization model and an oxygeninduced retinopathy model.The absence of CD146 impaired hypoxia-induced cell migration and angiogenesis both in cell lines and animal model.Preventive or therapeutic treatment with anti-CD146 antibody AA98 significantly inhibited hypoxia-induced aberrant retinal angiogenesis in two retinal disease models.Mechanistically,under hypoxia condition,CD146 was involved in the activation of NFκB,Erk and Akt signalling pathways,which are partially independent of VEGF.Consistently,anti-CD146therapy combined with anti-VEGF therapy showed enhanced impairment effect of hypoxia-induced angiogenesis in vitro and in vivo.Given the critical role of abnormal angiogenesis in retinal and choroidal diseases,our results provide novel insights into combinatorial therapy for neovascular fundus diseases. | Bai Xue Ping Wang Wenzhen Yu Jing Feng Jie Li Rulian Zhao Zhenglin Yang Xiyun Yan Hongxia Duan | 2022 | Science China(Life Sciences)2022，65，6： | 3 |
| 13 | An accurate solution of point kinetics equations of one-group delayed neutrons and an extraneous neutron source for step reactivity insertion显示文摘The continuous indication of the neutron density and its rate of change are important for the safe startup and operation of reactors. The best way to achieve this is to obtain analytical solutions of the neutron kinetics equations because none of the developed numerical methods can well satisfy the need for real-time or even super-time computation for the safe startup and operation of reactors in practice. In this paper, an accurate analytical solution of point kinetics equations with one-group delayed neutrons and an extraneous neutron source is proposed to calculate the change in neutron density, where the whole process from the subcritical stage to critical and supercritical stages is considered for step reactivity insertions. The accurate analytical solution can also be used as a benchmark of all numerical methods employed to solve stiff neutron kinetics equations. | LI HaoFeng SHANG XueLi CHEN WenZhen | 2010 | Chinese Science Bulletin2010，55，36： | 3 |
| 14 | Weakened anisotropy of mechanical properties in rolled ZK60 magnesium alloy sheets with elevated deformation temperature显示文摘The rolling direction(RD) and the transverse direction(TD) samples were obtained from an as-rolled ZK60 magnesium alloy sheet with strong anisotropy of initial texture and their mechanical properties were tested at various deformation temperatures. Meanwhile, the microstructure and texture of these samples after fracture were investigated. Results revealed that a higher flow stress along the RD than that along the TD at room temperature were ascribed to the strong anisotropy of transitional texture, and this texture effect was remarkably weakened with the increase of deformation temperature. Deformation structure was dominant at 100?C, and was replaced by dynamic recrystallization structure when the deformation temperature increased to 200?C and 300?C. The texture presented a strong texture(transitional texture in the RD sample and basal texture in the TD sample) at 100?C, but its intensity visibly decreased and texture components became more disperse at 200?C and 300?C. These microstructure and texture results were employed in conjunction with calculated results to argue that raising deformation temperature could increase the activity of non-basal slip by tailoring the relative critical resolved shear stress of each deformation mode and finally result in low texture effect on mechanical anisotropy. | Wenke Wang Wenzhen Chen Wencong Zhang Guorong Cui Erde Wang | 2018 | Journal of Materials Science & Technology2018，34，11： | 3 |
| 15 | Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants显示文摘尽管引起 Kallmann 症候群(KS ) 的一些基因被传统的连接分析和候选人基因技术识别了,症候群是在遗体糟糕理解的病人的多数的分子的病原学。在这份报纸,我们在场对与三个 KS 后代一起的一个同宗的汉中国家庭的临床的评价。从一个染色体宽的观点理解 KS 的分子的病原学,我们用 Affymetrix 染色体宽的人的 SNP 数组在这个家庭调查了结构的变化的染色体宽的侧面 6.0 站台。结果表明三个影响个人在染色体 1p21.1, 2q32.2, 8q21.13, 14q21.2 和 Xp22.31 上有普通拷贝数字变体(microdeletions ) 。而且, Xp22.31 上的拷贝数字变体位于 KAL1 的 intron,它引起 X 连接 KS。二 PCR 试金在这些区域上被执行验证用薄片获得的结果。另外,在这个区域的 genomic microdeletions 在 29 个汉中国分散的 KS 案例之一和四个另外的家庭案例之一中,然而并非用 26 汉汉语被验证分散的 normosmic 自发的 hypogonadotropic 性腺机能减退案例和 100 无关的汉汉语正常控制。我们的结果提供新奇卓见进对 KS 的分子的病原学的某些拷贝数字变体的相对贡献并且为进一步的研究产生有趣的候选人区域的一张表。 | Shilin Zhang Yanping Tang Tao Wang Jun Yang Ke Rao Lingyun Zhao Wenzhen Zhu Xianghu Meng Shaogang Wang Jihong Liu Weimin Yang Zhangqun Ye | 2011 | Asian Journal of Andrology2011，13，1： | 3 |
| 16 | Changes in brain functional network connectivity after stroke显示文摘Studies have shown that functional network connection models can be used to study brain network changes in patients with schizophrenia.In this study,we inferred that these models could also be used to explore functional network connectivity changes in stroke patients.We used independent component analysis to find the motor areas of stroke patients,which is a novel way to determine these areas.In this study,we collected functional magnetic resonance imaging datasets from healthy controls and right-handed stroke patients following their first ever stroke.Using independent component analysis,six spatially independent components highly correlated to the experimental paradigm were extracted.Then,the functional network connectivity of both patients and controls was established to observe the differences between them.The results showed that there were 11 connections in the model in the stroke patients,while there were only four connections in the healthy controls.Further analysis found that some damaged connections may be compensated for by new indirect connections or circuits produced after stroke.These connections may have a direct correlation with the degree of stroke rehabilitation.Our findings suggest that functional network connectivity in stroke patients is more complex than that in healthy controls,and that there is a compensation loop in the functional network following stroke.This implies that functional network reorganization plays a very important role in the process of rehabilitation after stroke. | Wei Li Yapeng Li Wenzhen Zhu Xi Chen | 2014 | Neural Regeneration Research2014，9，1： | 3 |
| 17 | Adapitive waveform design for distributed OFDM MIMO radar system in multi-target scenario显示文摘In order to improve detection and estimation performance of distributed OrthogonalFrequency-Division Multiplexing(OFDM) Multiple-Input Multiple-Output(MIMO) radar system in multi-target scene, we propose a novel approach of Adaptive Waveform Design(AWD) based on a constrained Multi-Objective Optimization(MOO). The sparse measurement model of this radar system is derived, and the method based on decomposed Dantzig selectors is applied for the sparse recovery according to the block structures of the sparse vector and the system matrix. An AWD approach is proposed, which optimizes two objective functions, namely minimizing the upper bound of the recovery error and maximizing the weakest-target return, by adjusting the complex weights of the emitting waveform amplitudes. Several numerical simulations are provided and their results show that the detection and estimation performance of the radar system is improved significantly when this MOO-based AWD approach is applied to the distributed OFDM MIMO radar system. Especially, we verify the effectiveness of our AWD approach when the available samples are reduced severally and the technique of compressed sensing is introduced. | Haitao WANG Junpeng YU Wenzhen YU De BEN | 2018 | Chinese Journal of Aeronautics2018，31，3： | 2 |
| 18 | Deducing Complete Selection Rule Set for Driver Nodes to Guarantee Network’s Structural Controllability显示文摘Structural controllability is critical for operating and controlling large-scale complex networks. In real applications, for a given network, it is always desirable to have more selections for driver nodes which make the network structurally controllable. Different from the works in complex network field where structural controllability is often used to explore the emergence properties of complex networks at a macro level,in this paper, we investigate it for control design purpose at the application level and focus on describing and obtaining the solution space for all selections of driver nodes to guarantee structural controllability. In accord with practical applications,we define the complete selection rule set as the solution space which is composed of a series of selection rules expressed by intuitive algebraic forms. It explicitly indicates which nodes must be controlled and how many nodes need to be controlled in a node set and thus is particularly helpful for freely selecting driver nodes. Based on two algebraic criteria of structural controllability, we separately develop an input-connectivity algorithm and a relevancy algorithm to deduce selection rules for driver nodes. In order to reduce the computational complexity,we propose a pretreatment algorithm to reduce the scale of network's structural matrix efficiently, and a rearrangement algorithm to partition the matrix into several smaller ones. A general procedure is proposed to get the complete selection rule set for driver nodes which guarantee network's structural controllability. Simulation tests with efficiency analysis of the proposed algorithms are given and the result of applying the proposed procedure to some real networks is also shown, and these all indicate the validity of the proposed procedure. | Xichen Wang Yugeng Xi Wenzhen Huang Shuai Jia | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，5： | 2 |
| 19 | Analysis of contact melting around a horizontal elliptical cylinder heat source显示文摘The process of DT-driven contact melting of the solid phase change material (PCM) around a horizontal elliptical cylinder heat source is analyzed. Aiming at the problem existed in the published literature, namely the thickness of boundary layer tends to be infinite at φ= 90°, and considering the difference of normal angle between the horizontal elliptical cylinder surface and the solid-liquid interface of PCM, a new mathematic model is proposed, and the fundamental equations for the melting process are derived with the film theory. The new pressure distribution inside the boundary layer, the variation law of normal angle of the solid-liquid interface, the thickness of the boundary layer and the relationship between the melting velocity and resultant force are obtained. The solutions of the fundamental equations under different elliptical compression coeffcients are analyzed and discussed. It is found that the thickness of the boundary layer obtained by the new model is a finite value and accords with the experimental result at φ = 90°. | Miao Gong Wenzhen Chen Yuansong Zhao Bo Zhu Fengrui Sun | 2008 | Progress in Natural Science:Materials International2008，18，4： | 2 |
| 20 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
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