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| 1 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 2 | culture: Carbon emissions, Net carbon flux from agri- carbon sequestration, crop yield, and land-use change 显示文摘 | WEST TO MARLAND G | 2003 | Biogeochemistry2003，63，4： | 1 |
| 3 | Assessing terrestrial ecosystem sustainability: usefulness of regional carbon and ni- trogen models显示文摘 | Wali MK Evrendilek F West TO | 1999 | Nature & Resources1999，35，4： | 1 |
| 4 | Molecular characterisation of soft tissue tumours: a gene expression study显示文摘 | Nielsen TO West RB Linn SC | 2002 | Lancet2002，359，9314： | 1 |
| 5 | Measurement of refractive errors in young myopes using the COAS Shack-Hartmann aberrometer显示文摘 | Salmon TO West RW Gasser W | 2003 | Optom Vis Sci2003，80，1： | 1 |
| 6 | Molecular characterisation of soft tissue tumors a gene expression study显示文摘 | West RB Linn SC | 2002 | Lancet2002，359，9314： | 1 |
| 7 | Expression of insulin-lke growth gactor 2 in mesenchymal neoplasms显示文摘 | Steigen SE Schaeffer DF West RB Nielsen TO | 2009 | Mod Pathol2009，22，： | 1 |
| 8 | Molecular characterisation of soft tissue tumours:a gene expression stud y显示文摘 | West RB Linn SC | 2002 | Lancet2002，359，9314： | 1 |
| 9 | Measurement of refractive errors in young myopes using the COAS Shack-Hartmann aberrometer显示文摘 | Salmon TO West RW Gasser W | 2003 | Optometry and vision science2003，80，1： | 1 |
| 10 | Soil Organic Carbon Sequestration Rates by Tillage and Crop Rotation显示文摘 | West TO Post WM | 2002 | Soil Science Society of American Journal2002，66，6： | 1 |
| 11 | Measurement of refractive errors in young myopes using the COAS ShackHartmann aberrometer 显示文摘 | Salmon TO West RW Gasser W | 2003 | Optom Vis Sci2003，80，1： | 1 |
| 12 | Molecular charaeterization of soft tissue tumours: a gene expression study 显示文摘 | Nielsen TO West RB Linn SC | 2002 | Lancet2002，359，： | 1 |
| 13 | Soil organic carbon sequestration rates by tillage and crop rotation: a global data analysis 显示文摘 | WEST TO POST WM | 2002 | Soil Science Society of America Journal2002，66，： | 1 |
| 14 | Reorganization of cytoskeletal proteins of mouse oocytes mediated by integrins显示文摘To study whether integrins on cell membrane ligate with intracellular cytoskeletal proteins and mediate their reorganization in egg activation, female mice were used for su- perovulation. The zona-free oocytes were incubated separately with specific ligand of integrins, an active RGD peptide, in vitro for certain period of time. RGE peptide and mouse capacitated sperm were used as controls. Freshly ovulated oocytes and those treated with different factors were immunostained with FITC-labeled anti-actin antibody, then detected with confocal micro- scope. The results demonstrated that freshly ovulated mouse oocytes, oocytes incubated for 2 h in vitro and those treated with control RGE peptide for 15 min showed hardly visible fluorescene or only thin fluorescence in plasma membrane region. Oocytes coincubated with sperms for 15 min and those treated with active RGD peptide for 10 min, 30 min and 2 hours respectively had strong and thick fluorescence in the plasma membrane and cortical region of oocytes, and some of them showed asymmetrically fluorescent distribution. It is proved that integrins on membrane are ligated directly with cytoskeletal protein. Integrins binding with their ligands regulate reor- ganization of cytoskelal protein, which may be involved in transmembrane signaling in egg acti- vation. | YUE Limin1, ZHANG Lei1, HE Yaping1, ZHANG Jinhu1, ZHENG Jie1, HE Yanfang1, ZHENG Yu1, ZHANG Jie2 & ZHANG Li2 1. Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China 2. West China Hospital of Sichuan University, Chengdu 610041, China Correspondence should be addressed to Yue Limin | 2004 | Science China(Life Sciences)2004，47，6： | 0 |
| 15 | Intratracheally Administered Liposomal α-Tocopherol Protects the Lung against Long-Term Toxic Effects of Paraquat显示文摘Paraquat is a broad-spectrum herbicide known to produce lung injury via oxidative stress-mediated mechanisms. Different pharmacological strategies have been explored to reduce the formation of these reactive oxygen species and/or prevent their toxic effects in the treatment of paraquat poisoning. The present study was carried out to investigate whether the antioxidant (L-tocopherol, incorporated into liposomes and delivered directly to the lungs of rats, could protect the organ against the long-term toxic effects of paraquat.Plain liposomes (composed of dipalmitoylphosphatidylcholine, DPPC) or α-tocopherol liposomes (8 mg α-tocopherol/kg body weight) were administered intratracheally to animals 24 h prior to an intraperitoneal injection of paraquat dichloride (20 mg/kg) and rats wefe killed 0, 1, 4, 6, 8, 10, 12, 16, 19 or 24 days after paraquat treatment. Results of this study showed that lungs of animals treated with paraquat were extensively damaged,as evidenced by significant increases in lung weight and decreases in lung angiotensin converting enzyme (ACE) and alkaline phosphatase enzyme (AKP) activities. Moreover,paraquat treatme; resulted in a significant reduction in the number of neutrophils in the blood of rats with a concurrent increase in the pulmonary myeloperoxidase activity,suggestive of neutrophil infiltration in the lungs of treated animals. Pretreatment of rats with liposomes alone did not significantly alter the paraquat-induced changes of all parameters examined. On the other hand, pretreatment of rats with (t-tocopherol liposomes,24 h prior to paraquat challenge, attenuated paraquat-induced changes in ACE, AKP and myeloperoxidase activities but failed to prevent increases in lung weight. Thus, pretreatment of rats with liposome-associated α-tocopherol appears to protect the lung against some of the toxic effects of | Z. E. SUNTRES AND P. N. SHEK(To whom correspondencc should be addressed at Defence and Civil Institute of Environmental Medicine, 1133 Sheppard Avenue West, North York, Ontario M3M 3B9, Canada.Operational Medicine Division, Defence and Civil Institute of | 1995 | Biomedical and Environmental Sciences1995，8，4： | 0 |
| 16 | Ameliorating Effects of Thyroxine and Atropine in Phosphamidon Intoxicated Chick Embryos显示文摘The effects of thyroxine and atropine in ameliorating phosphamidon intoxication in chick embryos was studied. Treatment of phosphamidon significantly enhanced the moriality and abnormalityrates, decreased the average body weights, and cholinesterase activity in chick embryos. When thyroxine was administered to the phosphamidon intoxicated embryos, the above parameters changedsignificantly, indicating an ameliorating effect of thyroxine against phosphamidon intoxication in chick embryos. The combined thyroxine and atropine therapy did not further improve the ameliorating effect. Since in many respects chick embryo development parallels that of mammalian embryos,a short-term use of thyroxine as a protective agent against organophosphate toxicity might be | CHATTALI GHOSH AND J.N.MEDDA (Department of Zoology, Burdwan University, Burdwan 713104,West Bengal, INDIA)J.N.MEDDA (To whom all corespondences should be addressed.E-mail:zoojnm@burdwan.ernet.in.) | 1999 | Biomedical and Environmental Sciences1999，12，1： | 0 |
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