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| 1 | Augmenting peripheral nerve regeneration using stem cells: A review of current opinion显示文摘Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell(SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration. | Neil G Fairbairn Amanda M Meppelink Joanna Ng-Glazier Mark A Randolph Jonathan M Winograd | 2015 | World Journal of Stem Cells2015，7，1： | 12 |
| 2 | The Complex Trial Protocol (CTP) : A new, countermeasure-resistant, accurate P300-based method for detection of concealed informa- tion 显示文摘 | Rosenfeld J P Labkovsky E Lui M A Winograd M Van- denboom C & Chedid K | 2008 | Psychophysiology2008，45，： | 1 |
| 3 | Mass spectral imaging of glycophospholipids, cholesterol, and glycophorin a in model cell mem- branes 显示文摘 | BAKER M J ZHENG L WINOGRAD N | 2008 | Langmuir2008，24，11： | 1 |
| 4 | P900: A Putative Novel ERP Component that Indexes Countermeasure Use in the P300-Based Concealed Information 显示文摘 | Meixner J B Labkovsky E Rosenfeld J P Winograd M Sokolovsky A Weishaar J Ullmann T | 2013 | Appl Psychophysiol Biofeedback2013，38，： | 1 |
| 5 | Continuous 500000-year climatic record from vein calcite in Devils Hole,Nevada显示文摘 | Winograd I J Copen T B Landwehr J M | 1992 | Science1992，258，： | 1 |
| 6 | Early Activation of Extracellular Signal-Regulated Kinase Signaling Pathway in the Hippocampus is Required for Short-Term Memory Formation of a Fear-Motivated Learning显示文摘 | Igaz LM Winograd M Cammarota M | 2006 | Cell Mol Neurobiol2006，26，46： | 1 |
| 7 | Continuous 500,000- year climate record from vein calcite in Devils Hole 显示文摘 | Winograd I J Coplen T B Landwehr J M | 1992 | Nevada Science1992，258，： | 1 |
| 8 | Duration and structure of the past four interglaciations 显示文摘 | Winograd I J Landwehr J M Ludwig K R | 1997 | Quat Res1997，48，： | 1 |
| 9 | Imaging with mass spectrometry显示文摘 | PACHOLSKI M L WINOGRAD N | 1999 | Chem Rev1999，99，10： | 1 |
| 10 | 500 000-year stable carbon isotopic record from Devils Hole, Nevada显示文摘 | Coplen T B Winograd I J Landwehr J M | 1994 | Sci- ence1994，263，： | 1 |
| 11 | Mass transfer in narrow channels in the presence of turbulence promoters 显示文摘 | Winograd Y Solan A Toren M | 1973 | Desalination1973，13，2： | 1 |
| 12 | Direct SIMS observation of methylidyne, methylene and methyl Intermediates on a Ni(1 1 1) methanation Catalyst显示文摘 | Mark P Kaminsky Nicholas Winograd Gregory L Geoffroy M Albert Vannice | 1986 | J Am Chem Soc1986，108，： | 1 |
| 13 | Modelling land-use change for Central America,with special reference to the impact of hurricane Mitch显示文摘 | Kok K M Winograd | 2002 | Ecological ModeUing2002，149，： | 1 |
| 14 | Early activation of extracellular signal - regulated kinase signaling pathway in the hippocampus is required for short - term memory formation of a fear - motivated learning 显示文摘 | Igaz LM Winograd M Cammarota M | 2006 | Cell Mol Neurobiol2006，26，46： | 1 |
| 15 | Continuous 500,000 years climate record from vein calite in Devils Hole,Nevada显示文摘 | Winograd I J Coplen T B Landwehr J M | | 0，，： | 1 |
| 16 | The Complex Trial Protocol (CTP): a new, coun- termeasure-resistant, accurate, P300-based method for detection of concealed information显示文摘 | Rosenfeld JP Labkovsky E Winograd M | 2008 | Psychophysiol- ogy2008，45，6： | 1 |
| 17 | Continuous 500,000-year climate record from vein calcite in Devils Hole,Nevada显示文摘 | Winograd I J Coplen T B Landwehr J M | | 0，，： | 1 |
| 18 | Continuous 500 000 year climate record from vein calcite inDevils Hole, Nevada显示文摘 | WINOGRAD I J COPLEN T B LANDWEHR J M | 1992 | Science1992，258，： | 1 |
| 19 | Continuous 500 000 yeax climate record from vein calcite in Devils Hole,Nevada 显示文摘 | Winograd I J Coplen T B Landwehr J M | 1992 | Science1992，258，： | 1 |
| 20 | Successful distraction osteogenesis across a growing cranial suture without an osteotomy 显示文摘 | Tung T H Robertson B R Winograd J M | 1999 | Plast Reconstr Surg1999，103，2： | 1 |
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