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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 2 | A new model for control of systems with friction 显示文摘 | CANUDAS DE WIT C OLSSON H ASTROM K J | 1995 | IEEE Transaction on Automatic Control1995，40，3： | 2 |
| 3 | Influence of thickness and substrate on the hardness and deformation of TiN film显示文摘 | Witting M Bendavid A Martin P J | 1995 | Thin Solid Films1995，270，： | 1 |
| 4 | A New Mod- el for Control of Systems with Friction显示文摘 | Canudas de Wit C Olsson H Astrom K J | 1995 | Automatic Control IEEE Transactions on1995，40，3： | 1 |
| 5 | Supply chain management in food chains:Im proving performance by reducing uncertainty显示文摘 | VAN D V BEULENS A J M WIT W D | 1998 | International Transactions in Operational Research1998，5，6： | 1 |
| 6 | Probucol protects against smooth muscle cell proliferation by upregulating hemeoxygenase显示文摘 | Deng YM Wu B J Witting PK | | 0，，： | 1 |
| 7 | Tackling Ebola: new in sights into prophylactic and therapeutic intervention strategies 显示文摘 | De Wit E Feldmann H Munster V J | 2011 | Genome &fed2011，3，1： | 1 |
| 8 | Inhibition of novel & coronavirus replica- tion by a combination of interferon-a2b and ribavirin 显示文摘 | Falzarano D de Wit E Martellaro C Callison J Munster VJ Feldmann H | 2013 | Sci Rep2013，3，： | 1 |
| 9 | Influence of high rotational speeds on heat transfer and oil film thickness in aero-engine bearing chamber显示文摘 | Witting S Glahn A Himmelsbach J | 1994 | Journal of Engineering for Gas and Turbines and Power1994，116，2： | 1 |
| 10 | An experimental matrix design to optimize the weldline strength in injection molded parts 显示文摘 | LIU S WIT J CHANG J | 2000 | Polymer Engineering and Science2000，40，5： | 1 |
| 11 | 显示文摘 | Wit H J Brouha M | 1985 | J Appl Phys1985，57，： | 1 |
| 12 | Thermal stability and functionality of whey protein显示文摘 | DE J N WIT | 1990 | J Dairy Sci1990，73，： | 1 |
| 13 | Modified Range-Doppler Processing for FM-CW Synthetic Aperture Radar显示文摘 | De Wit J J M Meta A Hoogeboom P | 2006 | IEEE Geosci Remote Sensing Letters2006，3，1： | 1 |
| 14 | Identification of distinct specificity deternainants in resistance protein Cf-4 allows construction ofa Cf-9 mutant that confers recognition of avirulence protein Avr4 显示文摘 | van der Hoom R A Roth R and De Wit P J | 2001 | The Plant Cell2001，13，2： | 1 |
| 15 | Photolytic debromination of decabromodiphenyl ether (BDE-209)显示文摘 | Sö derströ m J Sellströ m U de Wit C A | 2004 | Environ Sci Technol2004，38，： | 1 |
| 16 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 17 | Growth of preterm born children显示文摘 | Euser AM de Wit CC Finken M J | | 0，，： | 1 |
| 18 | Antiemetic efficacy of the neurokinin-1antagonist, aprepitant, plus a 5HT3 antagonist and a corticosteroid inpatients receiving anthracyclines or cyclophosphamide in addition to highdosecisplatin: analysis of combineddata from two Phase III randomizedclinical trials显示文摘 | Gralla RJ1 de Wit R Herrstedt J | 2005 | Cancer2005，104，4： | 1 |
| 19 | Role of unconditioned and conditioned drug effects in the self-administration of opiates andstimulants显示文摘 | Stewart J de Wit H Eikelboom R | 1984 | Psychol Rev1984，91，2： | 1 |
| 20 | Feeding selectivity of the harpacticoid copepod Canuellaperplexa in benthic muddy environments demonstrated by HPLC analyses of chlorine and carotenoid pigments显示文摘 | Buffan Dubau E Wit R Castel J | 1996 | Mar Ecol Prog Ser1996，137，： | 1 |
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