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| 1 | 载瘤动脉壁剪切力作为独立变量在前交通动脉动脉瘤形成中的作用显示文摘目的本研究旨在确定哪些血流动力学参数可以独立影响前交通动脉(AcomA)动脉瘤形成,并探讨母动脉壁剪切力(WSS)的阈值,以更好地证明WSS大小与AcomA动脉瘤形成之间的相关性。 | X.Zhang Z.Q.Yao T.Karuna X.Y.He X.M.Wang X.F.Li 徐晶(译) 陈秀玉(校) | 2019 | 国际医学放射学杂志2019，0，2： | 15 |
| 2 | Effects of Alumina on Cristobalite Crystallization and Properties of Silica-Based Ceramic Cores显示文摘In this work, the influences of alumina addition on cristobalite crystallization and properties of injection molded silica-based ceramic cores were investigated. X-ray diffraction(XRD) was used to characterize phase transformations in the samples, and the XRD result indicated that the addition of alumina promoted crystallization of fused silica during sintering at 1180–1220 °C and thus increases the amount of cristobalite. The increased amount of cristobalite as well as alumina addition led to much more thermal dilation due to their higher coefficients of thermal expansion than that of fused silica. The flexural strengths at room temperature and 1500 °C were tested, and it was shown that alumina addition could not affect room temperature strength, but decreased the flexural strength at 1500 °C. In addition, deflection resistance during heating to high temperatures was investigated, and the result indicated that alumina addition speeded up high temperature softening of the samples. XRD and scanning electron microscopy equipped with energy dispersive spectrometry(SEM/EDS) analysis suggested that this softening behavior was related with viscous flow sintering which could be accelerated by the reaction of alumina and silica with a product of mullite. | J.J.Liang Q.H.Lin X.Zhang T.Jin Y.Z.Zhou X.F.Sun B.G.Choi I.S.Kim J.H.Do C.Y.Jo | 2017 | Journal of Materials Science & Technology2017，33，2： | 14 |
| 3 | Altered Endothelin-1 Signaling in Production of Thromboxane A_(2) in Kupffer Cells from Bile Duct Ligated Rats显示文摘Kupffer cells(KCs),the liver resident macrophages accounting for 80-90%of the total population of fixed tissue macrophages in the body,not only play a key role in host defense via removing particulate materials from the portal circulation,but may also contribute to the pathogenesis of various liver diseases.We have previously demonstrated that KCs play an important role in controlling portal hypertension and hepatocellular injury via releasing thromboxane A_(2)(TXA_(2))in early fibrosis induced by one-week bile duct ligation(BDL).Production of TXA_(2) is controlled by cytosolic phospholipase A_(2)(cPLA_(2))that is activated by the interaction of entothelin-1(ET-1)with its G-protein coupled ET receptor B(ETBR).However,the signaling pathways that contribute to the ET-1-induced activation of cPLA_(2) and production of TXA_(2) in KCs in the normal healthy or injured livers are not yet clear,which are investigated in the present study using isolated KCs from one-week BDL or sham rats.The pharmacological inhibition of cPLA_(2) or chelation of intracellular calcium abrogated the ET-1 induction of TXA_(2) from KCs.Compared to those from sham rats,KCs from BDL animals displayed a significantly enhanced responsiveness of p38 MAPK to ET-1,increased ETBR and Gai subunit but decreased Gaq and Ga11 expression.Inhibition of ERK1/2 or Gq signaling abrogated significantly the ET-1 induction of TXA_(2) in sham KCs but only slightly in BDL KCs.In contrast,inhibition of p38 MAPK and Gi signaling markedly attenuated the ET-1 induction of TXA_(2) in BDL KCs but had no effect in sham KCs.Lastly,inhibition of PLC or PKC abrogated ET-1 induction of TXA_(2) in KCs from both sham and BDL groups.The hepatic stress(such as BDL)induces significant modifications in the receptor and intermediates of ET-1 signaling in KC and subsequently alters ET-1 signaling mechanisms,particularly a shift from Gq induced signaling to Gi induced signaling,in the activation of cPLA_(2) and production of TXA_(2) in response to ET-1. | Andrew M.Miller Jian X.Zhang | 2009 | Cellular & Molecular Immunology2009，6，6： | 4 |
| 4 | Critical flow-storm approach to total maximum daily load (TMDL) development:an analytical conceptual model显示文摘One of the key challenges in the total maximum daily load(TMDL)development process is how to define the critical condition for a receiving waterbody.The main concern in using a continuous simulation approach is the absence of any guarantee that the most critical condition will be captured during the selected representative hydrologic period,given the scarcity of long-term continuous data.The objectives of this paper are to clearly address the critical condition in the TMDL development process and to compare continuous and event-based approaches in defining critical condition during TMDL development for a waterbody impacted by both point and nonpoint source pollution.A practical,event-based critical flow-storm(CFS)approach was developed to explicitly addresses the critical condition as a combination of a low stream flow and a storm event of a selected magnitude,both having certain frequencies of occurrence.This paper illustrated the CFS concept and provided its theoretical basis using a derived analytical conceptual model.The CFS approach clearly defined a critical condition,obtained reasonable results and could be considered as an alternative method in TMDL development. | Harry X.ZHANG Shaw L.YU | 2008 | Frontiers of Environmental Science & Engineering2008，2，3： | 2 |
| 5 | Pim‐3 protects against hepatic failure in D‐galactosamine (D‐GalN)‐sensitized rats显示文摘 | L.‐M.Liu J.‐X.Zhang X.‐P.Wang H.‐X.Guo H.Deng J.Luo | 2010 | European Journal of Clinical Investigation2010，，2： | 2 |
| 6 | 胸片、经胸超声心动图和心电门控增强心脏CT评估心脏电极穿孔的对比研究显示文摘目的心脏电极穿孔虽然罕见但可危及生命。本研究旨在探讨胸片、经胸超声心动图(TTE)和心电门控增强心脏CT在评估心脏电极穿孔中的诊断效能。方法本研究为回顾性研究,经中山大学孙逸仙纪念医院(中国,广州)伦理委员会批准,无需病人知情同意书。 | X.Zhang C.S.Zheng P.W.Wang D.Y.Wang B.S.Huang G.Z.Li 杨凯(译) 陈秀玉(校) | 2019 | 国际医学放射学杂志2019，0，2： | 2 |
| 7 | Study of the Influence of Angiostatin Intravitreal Injection on Vascular Leakage in Retina and Iris of the Experimental Diabetic Rats显示文摘Purpose: To examine the effect of an intravitreal injection of angiostatin on vascular leakage in retina and iris of the diabetes and study its possible mechanism. Methods: Experimental diabetes was induced in 24 rats by an intravenous injection of streptozotocin (STZ) during 48 adult rats. Three groups were randomization distributed of them. There were 8 of both normal and diabetic rats in each group. STZ-diabetic rats and age-matched normal rats received an intravitreal injection of 5 μl of sterile PBS (Phosphate Buffered Saline) into the right eye, and the left eye was non-injected in the group A; Angiostatin was injected into the vitreous of the right eye (7.5 μg / 5 μl / eye), and the left eye received the same volume of sterile PBS as the control in the group B and C. The vascular permeability of retina and iris was measured using the Evans blue method at 2 days following the injection in the group A and B. Expression of VEGF in retina was evaluated using western blot analysis 24 hours following the injection in the group C. Results: Diabetic rats showed significant increases of vascular permeability in the retina ( P < 0.01) and iris ( P < 0.05). Angiostatin-injected eyes showed significant decreases in vascular permeability in the retina ( P < 0.01) and iris ( P < 0.05) comparing with the PBS-injected eyes in STZ-diabetic rats. In contrast, intravitreal injection of the same dose of angiostatin into the age-matched normal rats did not result in any significant reduction in vascular permeability in the retina and iris, when compared with the contralateral eye with PBS injection ( P > 0.05). Angiostatin injection significantly reduced VEGF level in the retinas of STZ-diabetic rats but did not affect retinal VEGF level in normal rats. Conclusions: Angiostatin significantly reduce pathological vascular permeability in the retina and iris of STZ-diabetic rats but not in normal rats. Angiostatin down-regulates VEGF expression and thus, blocks the major cause of vascular leakage in the diabetic retina. Therefore, angiostatin may have a therapeutic potential in the treatment of diabetic macular edema, cystoid macular edema, uvietis and other diseases with vascular leakage. | Jing Sima Jianxing Ma Sarah X.Zhang Jiang Guo | 2006 | 眼科学报2006，22，4： | 2 |
| 8 | 地球磁场起源的3条定律——纪念A.Einstein逝世50年显示文摘从地球磁暴源探讨中,提出了一个地磁起源新观点,并将它总结成地球磁场起源的3条定律. | 张世杰 韩延本 X.Zhang 赵纯善 康国发 | 2005 | 云南大学学报(自然科学版)2005，27，2： | 2 |
| 9 | Emerging roles of circular RNAs in retinal diseases显示文摘Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the retina.Current research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal degeneration.In this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just emerged.While knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and progression.Here,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular degeneration.Further,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases. | Aneliya Hanineva Karen Sophia Park Joshua J.Wang Margaret M.DeAngelis Michael H.Farkas Sarah X.Zhang | 2022 | Neural Regeneration Research2022，17，9： | 2 |
| 10 | The unfolded protein response signaling and retinal Müller cell metabolism显示文摘The retina is one of the most energy demanding tissues in the body. Like most neurons in the central nervous system, retinal neurons consume high amounts of adenosine-5′-triphosphate(ATP) to generate visual signal and transmit the information to the brain. Disruptions in retinal metabolism can cause neuronal dysfunction and degeneration resulting in severe visual impairment and even blindness. The homeostasis of retinal metabolism is tightly controlled by multiple signaling pathways, such as the unfolded protein response(UPR), and the close interactions between retinal neurons and other retinal cell types including vascular cells and Müller glia. The UPR is a highly conserved adaptive cellular response and can be triggered by many physiological stressors and pathophysiological conditions. Activation of the UPR leads to changes in glycolytic rate, ATP production, de novo serine synthesis, and the hexosamine biosynthetic pathway, which are considered critical components of Müller glia metabolism and provide metabolic support to surrounding neurons. When these pathways are disrupted, neurodegeneration occurs rapidly. In this review, we summarize recent advance in studies of the UPR in Müller glia and highlight the potential role of the UPR in retinal degeneration through regulation of Müller glia metabolism. | Kristen Kelly Joshua J.Wang Sarah X.Zhang | 2018 | Neural Regeneration Research2018，13，11： | 2 |
| 11 | Observation of the Crab Nebula with LHAASO-KM2A−a performance study显示文摘A sub-array of the Large High Altitude Air Shower Observatory(LHAASO),KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 TeV.Even though the detector construction is still underway,half of the KM2A array has been operating stably since the end of 2019.In this paper,we present the KM2A data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray astronomy.We detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the KM2A data of 136 live days between December 2019 and May 2020.With the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection power.The energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/20 TeV)-309±0.06stat±0.02syscm^(-2) s^(-1) TeV^(-1).It is consistent with previous measurements by other experiments.This opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered. | F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai D.della Volpe B.D'Ettorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu H.Zhu K.J.Zhu X.Zuo | 2021 | Chinese Physics C2021，45，2： | 2 |
| 12 | Efficient steganographic embedding by exploiting modification direction显示文摘 | X.Zhang S.Wang | | 0，，11： | 1 |
| 13 | 'Context-based hierarchical unequal merging for SAR image segmentation,'显示文摘 | H.Yu X.Zhang S.Wang H.Biao | | 0，，02： | 1 |
| 14 | A Highly Efficient Chemical Sensor Material for H显示文摘 | Z.Sun H.Yuan Z.Liu B.Han X.Zhang | 2005 | Adv Mater2005，，24： | 1 |
| 15 | The existence and nonexistence of entire positive solutions of semilinear elliptic systems with gradient term显示文摘 | X.Zhang L.Liu | | 0，，1： | 1 |
| 16 | 查看详情显示文摘 | X.Zhang L.Kong L.Dai | | 0，，： | 1 |
| 17 | Meta‐analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy显示文摘 | J. L.TONG Z. H.RAN J.SHEN C. X.ZHANG S. D.XIAO | 2006 | Alimentary Pharmacology & Therapeutics2006，，2： | 1 |
| 18 | A Novel 2-D Electromagnetic Bandgap Structure and Its Application in Micro-strip Antenna Arrays显示文摘 | A.Yu X.Zhang | | 0，，08： | 1 |
| 19 | Policy management using access control spaces显示文摘 | T.Jaeger X.Zhang A.Edwards | | 0，，03： | 1 |
| 20 | 查看详情显示文摘 | F.Yu X.Zhang Y.Jiang | | 0，，： | 1 |
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