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| 1 | Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis显示文摘尖锐心肌的梗塞(AMI ) 是一个威胁生活的事件。甚至与及时处理,尖锐 ischemic 心肌的损害和随后的局部缺血灌注损害(IRI ) 能仍然是困难的问题处理。除了放射学并且另外的辅助考试,适用的心脏的 biomarkers 的实验室测试为这混乱监视的早诊断和结束也是必要的。心类型丰满的酸绑定蛋白质(H-FABP ) 主要在 cardiomyocytes 内存在,最近为心肌的损害作为潜在地有希望的 biomarker 出现了。在这评论,我们在对心肌的损害和 IRI 的评价讨论 H-FABP 的敏感和特性,特别在早阶段,和它与另外的通常使用的心脏的 biomarkers 比较的长期的预示的价值,包括肌球素( Mb ),心脏的 troponin 我( cTnI ),肌酸 kinase MB ( CK-MB ),C反应的蛋白质( CRP ),肝糖 phosphorylase isoenzyme BB ( GPBB ),和高敏感的心脏的 troponin T ( hs-cTnT )。有另外的 biomarkers 的 H-FABP 的联合申请的潜力和值也被讨论。最后, H-FABP 的前景被总结;几个技术问题被讨论在临床的实践便于 H-FABP 的更宽的申请。 | Xiao-dong YE Yi HE Sheng WANG Gordon T WONG Michael G IRWIN Zhengyuan XIA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 72 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | Harmonic power flow studies显示文摘 | Xia D Heydt G T | 1982 | IEEE Trans1982，10，6： | 2 |
| 4 | LDL-C levels,lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA显示文摘Background and purpose Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack(TIA).This study aimed to investigate the association between baseline low-density lipoprotein cholesterol(LDL-C)level,lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or TIA.Methods We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Patients with a minor stroke or TIA were categorised by LDL-C level at baseline(<2.6 or≥2.6 mmol/L(100 mg/dL))and with or without lipid-lowering treatment after symptom onset.The primary outcome was a new ischaemic stroke at 3 months.The association of baseline LDL-C level,lowering treatment and outcomes were assessed.Results Among 3027 patients,2154(71.2%)patients had an initial LDL-C≥2.6 mmol/L,of which 1267(41.9%)received lipid-lowering treatment.Elevated LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment(adj.HR=1.35,95%CI:1.19 to 1.53),but not in those with lipid-lowering treatment(adj.HR=0.99,95%CI:0.82 to 1.19)(p for interaction=0.007).Patients with LDL-C≥2.6 mmol/L had a numerically higher risk of ischaemic stroke(11.8%vs 8.0%,adj.HR=1.37,95%CI:0.96 to 1.96)in those without lipid-lowering treatment.For patients with LDL-C≥2.6 mmol/L,lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months(7.9%vs 11.8%;adj.HR=0.54,95%CI:0.39 to 0.75).Conclusions Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or TIA.There was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C≥2.6 mmol/L.Trial registration number NCT00979589. | Yuesong Pan Runqi Wangqin Hao Li Aoming Jin Jiejie Li Jinxi Lin Xia Meng Ying Xian Daniel T Laskowitz Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 5 | Moving target detection in over- the-horizon radar using adaptive chirplet transform显示文摘 | Wang G Xia X G Root B T | 2002 | IEEE Proceedings of Radar Conference2002，，： | 1 |
| 6 | Toxic potential of materials at the nanolevel 显示文摘 | Nel A Xia T Madler L | 2006 | Science2006，311，3： | 1 |
| 7 | Visible gold in arsenian pyrite at the Shuiyindong Carlin -type gold deposit,Guizhou,China implications for the environment and processes of ore fonnation显示文摘 | Su W C Xia B Zhang H T Zhang X C | 2008 | Ore Geology Reviews2008，33，： | 1 |
| 8 | Appling grain boundary engineering to Alloy 690 tube for enhancing intergranular corrosion resistance 显示文摘 | XIA S LI H LIU T G | 2011 | Journal of Nuclear Materials2011，416，3： | 1 |
| 9 | Inhibitory effects of nitric oxide on invasion of human cancer cells显示文摘 | Wang F Zhang R Xia T | 2007 | Cancer Lett2007，257，2： | 1 |
| 10 | Solvent-assisted microcontact molding: A convenient method for fabricating three-dimensional structures of polymeric materials 显示文摘 | Kim E Xia T Zhao X H Whitesides G M | 1997 | Adv Mater1997，9，： | 1 |
| 11 | Flake Cu-Sn Alloys as negative electrode materials for rechargeable lithium batteries显示文摘 | XIA Y SAKAI T FUJIEDA T | 2001 | J Electrochem Soc2001，148，： | 1 |
| 12 | Harmonic power flow studies, part Ⅰ - for-mulation and solution, part Ⅱ- implementation and practical application显示文摘 | Xia D Heydt G T | 1982 | IEEE Trans on Power Apparatus and Systems1982，101，： | 1 |
| 13 | Toxic potential of materials at the nanolevel 显示文摘 | Nel A Xia T Madler L | 2006 | Science2006，311，： | 1 |
| 14 | Atom Transfer Radical Polymerization in Supercritical Carbon Dioxide 显示文摘 | Xia J Johnson T Gaynor S G DeSimone | 1999 | Macromolecules1999，32，15： | 1 |
| 15 | Impro,)ement of thiosul- fate stability in gold leaching 显示文摘 | Xia C Yen W T Deschenes G | 2003 | Minerals & Metallurgi- cal Processing2003，20，： | 1 |
| 16 | On-line transient stability evaluation by system decomposition-aggregation and high order derivative 显示文摘 | XIA D HEYDT G T | 1983 | IEEE Trans on Power Apparatus and Systems1983，102，7： | 1 |
| 17 | Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-Ftisoprostane formation显示文摘 | XIA Z GODIN D V CHANG T K | 2003 | Can J Physiol Pharmacol2003，8，1： | 1 |
| 18 | EBV microRNAs in pri- mary lymphomas and targeting of CXCL-11 by ebv-mir- BHRF1-3 显示文摘 | Xia T O'Hara A Araujo I | 2008 | Cancer Res2008，68，5： | 1 |
| 19 | Non -carcinogenic risks induced by metals in drinking source water of Jiangsu Province, China显示文摘 | Liu N Ni T Xia J | 2011 | Environmental Monitoring and Assessment2011，177，14： | 1 |
| 20 | Time-to-voltage converter for on- chip jitter measurement 显示文摘 | XIA T LO J C | 2003 | IEEE Trans Instru Measur2003，52，6： | 1 |
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