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| 1 | The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows显示文摘Probiotics administration can improve host health.This study aims to determine the effects of probiotics(Lactobacillus casei Zhang and Lactobacillus plantarum P-8) administration on milk production,milk functional components,milk composition,and fecal microbiota of dairy cows.Variations in the fecal bacteria microbiota between treatments were assessed based on 16 S rRNA profiles determined by Pac Bio single molecule real-time sequencing technology.The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin G(IgG),lactoferrin(LTF),lysozyme(LYS)and lactoperoxidase(LP),while the somatic cell counts(SCC) significantly decreased(P < 0.01).However,no significant difference was found in the milk fat,protein and lactose contents(P > 0.05).Although the probiotics supplementation did not change the fecal bacteria richness and diversity,significantly more rumen fermentative bacteria(Bacteroides,Roseburia,Ruminococcus,Clostridium,Coprococcus and Dorea) and beneficial bacteria(Faecalibacterium prausnitzii) were found in the probiotics treatment group.Meanwhile,some opportunistic pathogens e.g.Bacillus cereus,Cronobacter sakazakii and Alkaliphilus oremlandii,were suppressed.Additionally,we found some correlations between the milk production,milk components and fecal bacteria.To sum up,our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production. | Haiyan Xu Weiqiang Huang Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun Lee Heping Zhang | 2017 | Science Bulletin2017，62，11： | 21 |
| 2 | Effect of dietary interventions on the intestinal microbiota of Mongolian hosts显示文摘The gut microbiota of Mongolian hosts has distinctive characteristics due to their meat- and dairyoriented daily diets and unique genotype.The aim of the present study was to investigate the effect of switching from the typical high protein and fat Mongolian diets to carbohydrate-rich meals composed principally of wheat,rice and naked oats on the host gut microbiota within 3 weeks.Our study took the advantage of the long sequence reads produced by the Pac Bio single molecule real-time sequencing technology to enable the profiling of subjects' gut microbiota communities along the diet intervention to the species precision.We found that the bacterial richness and diversity decreased apparently along the diet intervention.During the diet intervention,the gut microbiota composition displayed no significant difference at phylum level(with major phyla of Firmicutes,Bacteroidetes,Tenericutes and Proteobacteria).The relative abundances of some genera such as Bacteroidetes,Faecalibacterium,Roseburia,Alistipes,Streptococcus,and Oscillospira were significantly altered after the diet switching started.Notably,significant changes were also observed in the proportions of the species Bacteroides dorei,Bacteroides fragilis,Bacteroides thetaiotaomicron,Ruminococcus albus,Ruminococcus faecis,Roseburia faecis and Eubacterium ventriosum.These results have demonstrated that diet and host gut microbiota is closely linked. | Jing Li Haiyan Xu Zhihong Sun Qiangchuan Hou Lai-Yu Kwok Wuri Laga Yanjie Wang Huimin Ma Zhongjie Yu Bilige Menghe Heping Zhang | 2016 | Science Bulletin2016，61，20： | 14 |
| 3 | Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals显示文摘线粒体为精力新陈代谢和反应的氧种类(ROS ) 的生产是必要的。在未经触动的房间,呼吸线粒体展览自发的 “ superoxide flashes”,对短暂 mitochondrial 渗透转变(tMPT ) 结果的 quantal 生产 ROS 事件。这里,我们在表示 superoxide 生物传感器 mt-cpYFP 的生活老鼠在 mitochondrial superoxide 闪光和 tMPT 活动的 vivo 成像执行第一,并且表明他们联合到整个身体的葡萄糖新陈代谢。柔韧的 tMPT/superoxide 闪光活动发生在骨胳的肌肉和 anesthetized 的臀部的神经转基因的老鼠。在骨胳的肌肉,成像 tMPT/superoxide 闪光揭示了线粒体的迷宫的三维的网络同时地操作。tMPT/superoxide 闪光活动响应全身的葡萄糖挑战或胰岛素刺激澎湃,以一种显然调制频率的方式并且也在 tMPT 的 gating 模式包含移动。因此,在 tMPT 依赖的 mitochondrial ROS 的 vivo 成像,信号和 metabolism-tMPT-superoxide 的发现闪光联合标记为 mitochondrial 功能并且 ROS 处于健康和疾病发信号的学习的重要工艺、概念的进展。 | Huaqiang Fang Min Chen Yi Ding Wei Shang Jiejia Xu Xing Zhang Wanrui Zhang Kaitao Li Yao Xiao Feng Gao Shujiang Shang Jing-Chao Li Xiao-Li Tian Shi-Qiang Wang Jingsong Zhou Noah Weisleder Jianjie Ma Kunfu Ouyang Ju Chen Xianhua Wang Ming Zheng Wang Wang Xiuqin Zhang Heping Cheng | 2011 | Cell Research2011，21，9： | 11 |
| 4 | Experimental detection of the inner core translational triplet显示文摘The translational oscillation of the solid inner core is one of the Earth’s fundamental normal modes, which is also called Slichter mode. The normal mode should be split to form a triplet due to the Earth’s rotation and ellipticity. In this study, according to the splitting pattern of Slichter mode, an attempt has been made to detect the possibility of Slichter triplet’s existence by using the product spectra of the long-term continuous gravity measurements from the superconducting gravimeters (SG) at 6 glob- ally-distributed permanent stations in the Global Geodynamics Projects network. The results indicate that the background noise level of the global SG observations is 0.0158 nm s–2 and the magnitude threshold of any global harmonic signals, which may be detected by the global SG, is 0.0152 nm s–2 in the subtidal frequency band from 0.162 to 0.285 cph in which Slichter triplet may occur. it implies that the signatures, related to the triplet, may be identified in the global SG observations, if they exist. It is found that there is a group of global harmonic signatures with the periods of 5.310, 4.995 and 4.344 h emerging significantly from the background noise in the global SG observations. They are in good agreement with the splitting pattern of Slichter mode. It implies that this group of signatures may be related to the inner core translational oscillations. The associated density contrast across the inner core boundary may be deduced as between the values provided in the Earth models of the PREM and 1066 A. | XU JianQiao SUN HePing ZHOU JiangCun | 2010 | Chinese Science Bulletin2010，55，3： | 9 |
| 5 | Study on characteristics of long-term gravity changes at Wuhan station显示文摘We consider the characteristics of long-term changes in non-tidal gravity and their implication to the local perturbations in barometric pressure and water storage and to the local vertical crustal movement using the long-term continuous gravity observations from a superconducting gravimeter (SG) at Wu-han station,together with the co-site measurements from a Global Positioning System (GPS) receiver and an absolute gravimeter FG5. The observation results indicate that there are obvious seasonal variations in the long-term gravity changes measured with the SG. About 70 percent of the whole sea-sonal changes come from the contribution of the local disturbances in air pressure and water storage,while over 95 percent of the annual changes are attributed to the loading effects of these environmental perturbations. Due to the absence of direct measurements of the local water storage,especially those of the underground water,the global assimilating models of land water LaD (Land Dynamics) and GLDAS (Global Land Data Assimilation System) cannot virtually describe the real hydrologic distur-bances around the station. The resulting gravity changes,which are simulated theoretically by means of convolution integration of the loading Green’s functions and water models LaD and GLDAS,show significantly time delay of about 55 days from those measured with the SG. Compared with the meas-urements of the absolute gravity with the FG5,the long-term drift rate of the SG is determined as about 17.13 nms-2/a. From the co-site GPS measurements,it is found that the local crust is slowly subsiding at a rate of 3.71±0.16 mm/a,and the related gravity variation is estimated as 13.88±0.22 nms-2/a. In other words,the ratio of the changes in gravity and altitude related to the local vertical crustal movement is about -37.41 nms-2/cm. It implies that a considerable mass adjustment may be associated with the local vertical crustal movement,and its dynamic mechanism should be investigated further. | XU JianQiao ZHOU JiangCun LUO ShaoCong SUN HePing | 2008 | Chinese Science Bulletin2008，53，13： | 8 |
| 6 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 7 | Preparation of YSZ solid electrolyte by slip casting and its properties显示文摘Fully stabilized YSZ solid electrolyte was prepared by slip casting. The density was measured according to the Archimedes principle and the linear shrinkage was calculated from measuring the sizes of samples before and after sintering. XRD analysis was conducted to verify the phase structure of both the starting YSZ powder and the prepared YSZ electrolyte. The microstructure of fracture surface and the electrical properties of the samples sintered at different temperatures were investigated via SEM and a complex impedance method, respectively. By comparison of the properties and features among the samples, a slip casting method was established to be a simple way to manufacture high-quality YSZ electrolyte at the sintering temperature of 1550°C for 3 h, which provides a new approach for YSZ electrolyte with complex shapes and mass production. | DOU Jinga LI Heping XU Liping ZHANG Lei WANG Guangwei | 2009 | Rare Metals2009，28，4： | 5 |
| 8 | Characteristics of tidal gravity changes in Lhasa,Tibet,China显示文摘Tidal gravity changes arise from the response of the solid Earth to the tidal forces of the Sun,Moon and planets close to the Earth,and are a comprehensive reflection of the structure and distribution of physical properties of the Earth's interior.As a result,observations of tidal gravity changes are the basis of studies on other global and/or regional dynamic processes.The characteristics of tidal gravity changes in the region of the Tibetan Plateau were investigated through continuous gravity measurements recorded with a superconducting gravimeter (SG) installed in Lhasa over a year.Through contrast measurements with a spring gravimeter LaCoste-Romberg ET20 at the same site,the gravity observations in Lhasa were scaled to the international tidal gravity reference in Wuhan.Meanwhile,the scale factor of the SG was determined accurately as-777.358 ± 0.136 nm s-2V-1,which is about 2.2% less than the value provided by the manufacturer.The results indicate that the precision of the tidal gravity observations made with the SG in Lhasa was very high.The standard deviation was 0.459 nm s-2,and the uncertainties of for the four main tidal waves (i.e.O 1,K 1,M 2 and S 2) were better than 0.006%.In addition,the observations of the diurnal gravity tides had an obvious pattern of nearly diurnal resonance.As a result,it is affirmed that the Lhasa station can provide a local tidal gravity reference for gravity measurements on the Tibetan Plateau and its surrounding regions.The loading effects of oceanic tides on tidal gravity observations in Lhasa are so weak that the resulting perturbations in the gravimetric factors are less than 0.6%.However,the loading effects of the local atmosphere on either the tidal or nontidal gravity observations are significant,although no seasonal variations were found.After removal of the atmospheric effects,the standard deviation of the SG observations in Lhasa decreased obviously from 2.009 to 0.459 nm s-2.Having removed the loading effects of oceanic tides and local atmosphere,it was found that the tidal gravity observations made with the SG in Lhasa significantly differed by about 1% from those expected theoretically,which may be related to active tectonic movement and the extremely thick crust in the region of the Tibetan Plateau.A more-certain conclusion requires longer accumulation of SG data and further associated theoretical studies. | XU JianQiao CHEN XiaoDong ZHOU JiangCun SUN HePing | 2012 | Chinese Science Bulletin2012，57，20： | 5 |
| 9 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 10 | Remarkable carbon dioxide catalytic capture (CDCC) leading to solid-form carbon material via a new CVD integrated process (CVD-IP): An alternative route for CO_2 sequestration显示文摘Through our newly-developed 'chemical vapor deposition integrated process (CVD-IP)' using carbon dioxide (CO2) as the raw material and only carbon source introduced, CO2 could be catalytically activated and converted to a new solid-form product, i.e., carbon nanotubes (CO2-derived) at a quite high yield (the single-pass carbon yield in the solid-form carbon-product produced from CO2 catalytic capture and conversion was more than 30% at a single-pass carbon-base). For comparison, when only pure carbon dioxide was introduced using the conventional CVD method without integrated process, no solid-form carbon-material product could be formed. In the addition of saturated steam at room temperature in the feed for CVD, there were much more end-opening carbon nano-tubes produced, at a slightly higher carbon yield. These inspiring works opened a remarkable and alternative new approach for carbon dioxide catalytic capture to solid-form product, comparing with that of CO2 sequestration (CCS) or CO2 mineralization (solidification), etc. As a result, there was much less body volume and almost no greenhouse effect for this solid-form carbon-material than those of primitive carbon dioxide. | Wei Chu Maofei Ran Xu Zhang Ning Wang Yufei Wang Heping Xie Xiusong Zhao | 2013 | Journal of Energy Chemistry2013，22，1： | 5 |
| 11 | Check of free oscillation signal with SG data显示文摘The observation of the Earth’s free oscillation is an important way to study the Earth’s inner structure and geophysical parameters. Many geophysicists have investigated the Earth’s normal modes with strainmeters and spring gravimeters. Since the superconducting gravimeters appeared, people have gained a new kind of more stable instruments to detect the normal modes. The measurement for the Earth’s free oscillation with the superconducting gravimeters is one of the main goals of the Global Geodynamics Project. In this note, we have investigated the Earth’s normal modes excited by Peru Ms 7.9 Earthquake on June 23, 2001 with the superconducting gravimeter C032 at the Wuhan station. After having completed the subtraction of gravity tides with the 20th order polynomial fitting, and the correction for pressure and the analysis of the noise spectrum of the superconducting gravimeter, we accurately observed all base normal modes from 0S0 to 0S32 and the splittings of 0S2 and 0S3. Those results show a good | Xiang’e Lei Houze Xu Heping Sun | 2002 | Chinese Science Bulletin2002，47，18： | 4 |
| 12 | Highly efficient difference-frequency generation for mid-infrared pulses by passively synchronous seeding显示文摘We have proposed and experimentally demonstrated a novel scheme for efficient mid-infrared difference-frequency generation based on passively synchronized fiber lasers. The adoption of coincident seeding pulses in the nonlinear conversion process could substantially lower the pumping threshold for mid-infrared parametric emission. Consequently,a picosecond mid-infrared source at 3.1 μm was prepared with watt-level average power, and a maximum power conversion efficiency of 77% was realized from pump to down-converted light. Additionally, the long-term stability of generated power was manifested with a relative fluctuation as low as 0.17% over one hour. Thanks to the all-optical passive synchronization and all-polarization-maintaining fiber architecture, the implemented laser system was also featured with simplicity, compactness and robustness, which would favor subsequent applications beyond laboratory operation. | Kun Huang Yinqi Wang Jianan Fang Huaixi Chen Minghang Xu Qiang Hao Ming Yan Heping Zeng | 2021 | High Power Laser Science and Engineering2021，9，1： | 4 |
| 13 | Detection of spheriodal free oscillation excited by Peru 8.2 M_(s) earthquake with five international superconducting gravimeter data显示文摘In this paper, authors obtain the spectral peaks of the earth free oscillation and check all normal modes from 0S0 to 0S48 accurately, with the Fourier analysis and the maximum entropy spectrum method dealing jointly with six groups of the observational residual data from five international superconducting gravimeter stations. By comparing the observational results in this paper with three former groups of observations or models, authors notice an extra discrepancy between two observational 0S2 modes excited separately by Peru earthquake and Alaska earthquake, which probably mirrors the anisotropy of the Earth's inner core. The analysis on the splitting 1S2 mode shows that the asymmetric factor of rotationwise spectral splitting is possible to be different from that of anti-rotationwise spectral splitting. | LEI Xiang'e XU Houze SUN Heping | 2005 | Science China Earth Sciences2005，48，1： | 4 |
| 14 | A survey on chemical and microbiological composition of kurut, naturally fermented yak milk from Qinghai in China显示文摘 | Heping Zhang Jie Xu Junguo Wang Menghebilige Tiansong Sun Haiping Li Mingruo Guo | 2007 | Food Control2007，，6： | 3 |
| 15 | Up-regulation of heme oxygenase-1 by isoflurane preconditioning during tolerance against neuronal injury induced by oxygen glucose deprivation显示文摘Heme oxygenase (惊讶) 是在降级的限制率的酶他我生产胆汁颜料和碳一氧化物。HO-1 isozyme 被象热那样的许多因素导致,他我,局部缺血,和氢过氧化物。在最近的年里,装调查结果建议了那 HO-1 举办一项 neuroprotective 活动对是化学家损害。isoflurane 的 neuroprotective 角色,一通常使用麻药,很好被记录了,但是很少对包含的内在的机制被知道。最近, isoflurane 在肝被显示出到起来调整 HO-1。在这研究,我们证明 isoflurane preconditioning 支持幸存有教养是化学家由增加熬过神经原和他们的生存能力的数字的海马趾的神经原。由反向的抄写聚合酶链反应和西方的污点分析的进一步的学习证明 isoflurane preconditioning 显著地在导致的氧葡萄糖剥夺(OGD ) 增加 HO-1 表示 neuronal 损害。而且,抑制惊讶由听 protoporphyrin 的活动部分废除 isoflurane preconditioning 测量了由的保护的效果喂奶在 OGD 神经原的脱氢酶版本。这些调查结果显示对导致 OGD 的损害的 isoflurane preconditioning 的 neuroprotective 角色可能在起来调整的 HO-1 与它的角色被联系在是化学家神经原。 | Qifang Li Yesen Zhu Hong Jiang Hui Xu Heping Liu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 3 |
| 16 | Temporal variations in free core nutation period显示文摘Based on the nearly diurnal resonance in the tidal gravity observations,the temporal variations in period of the Earth's free core nutation (FCN) are investigated by using the tidal gravity observations of 18-year duration recorded continu-ously with a superconducting gravimeter (SG) at Brussels. The effects of the global oceanic tide loading and local barometric pressure on the SG observations have been removed by using eleven high-precision global digital models of oceanic tides and barometric pressure measurements recorded simultaneously at the same site. The results indicate that there exist decade-scale variations in the FCN period. The results should be further confirmed by the measurements using other space-based geodetic techniques (such as the very long baseline interferometry) and the SG observations from globally distributed stations. | Jianqiao Xu Heping Sun | 2009 | Earthquake Science2009，22，4： | 3 |
| 17 | Scheduling Fairness of Real-Time Scheduling Algorithms in Wireless Multimedia Application显示文摘 | XU Binyang LI Shaoqian PU Heping TANG Wanbin | 2007 | Chinese Journal of Electronics2007，16，2： | 3 |
| 18 | Application of superconductive gravity technique on the constraints of core-mantle coupling parameters显示文摘The parameters, i.e. the Period and the Quality factor, of the Earth's free core nutation (FCN) are closely related to the dissipative coupling between the core and the mantle. Based on the FCN parameters obtained from the actual observations and theoretical simulation, significantly constrained in this study were several key parameters near the core-mantle boundary (CMB), related to the core and mantle coupling, including viscosity at the top of liquid core, conductivity at the bottom of the mantle, and dynamic ellipticity of the CMB. In order to choose high quality observations from global stations of the superconducting gravimeters (SG) on the Global Geodynamics Project (GGP) network, we adopted two criteria, the standard deviations of harmonic analysis on tidal observations and the quality of the FCN parameters calculated with the observations from single station. After the mean ocean tidal effects of the recent ocean tidal models were removed, the FCN parameters were retrieved by stacking the tidal gravity observations from the GGP network. The results were in a good agreement with those in the recent research by using the SG and/or the VLBI observations. Combined with an FCN theoretical model deduced by angular momentum method, the viscous and electromagnetic coupling parameters near the CMB were evaluated. Numerical results indicated that the viscosity at the top of the liquid core was in the range from 6.6×102 to 2.6×103 Pa·s, which was in good agreement with those obtained from the Earth's nutation, the FCN and variations in the length of day (LOD). The conductivity at the bottom of the mantle should be as large as 2.6×106-1.0×107 S m-1 to match the FCN quality factors from the actual observations. The dissipative coupling had a little influence of 1-2 sidereal days for the FCN period. | CUI XiaoMing SUN HePing XU JianQiao ZHOU JiangCun | 2012 | Science China Earth Sciences2012，55，3： | 2 |
| 19 | Identification of a new isoform of the murine Sh2d1a gene and its functional implications显示文摘Signaling lymphocytic activation molecule(SLAM)-associated protein(SAP)is a Src homology(SH)domain 2-containing intracellular adaptor protein that is predominantly expressed in the hematopoietic system by T lymphocytes and NK cells.SAP protein is encoded by the SH2D1A gene located on the X chromosome.Loss-of-function mutations in SAP cause the X-linked lymphoproliferative disease(XLP),a severe immunodeficiency characterized by heightened susceptibility to Epstein-Barr virus and impaired humoral immunity.Normal individuals express several functional and non-functional isoforms of SAP as a result of alternative splicing.In this study,we identify a cryptic exon in the murine Sh2d1a gene.At the mRNA level,the new isoform of SAP(SAP-2)that includes this new exon is widely expressed in lymphoid tissues by C57BL/6 and 129 strains of inbred mice.SAP-2 accounts for approximately 1%3%of total SAP transcripts,and it is dynamically regulated during lymphocyte activation.At the protein level,the SAP-2 isoform is a 144 amino-acid protein.Compared to the dominant 126 amino-acid SAP-1 isoform,the additional 18 amino acids are inserted into a structural region that is critical for phosphotyrosine binding.Our functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability.Thus,both human and mouse have multiple SAP splice isoforms that may or may not function.Modulation of relative proportions of these isoforms is potentially a mechanism whereby cells can regulate SAP-mediated biological activities. | WU LongYan LU PeiWen MA WeiWei CHU CoCo XU HePing QI Hai | 2014 | Science China(Life Sciences)2014，57，1： | 2 |
| 20 | Effects of lead,cadmium,mercury chlorides and aquatic environmental samples on the growth of Escherichia coli显示文摘In this paper it was reported that PbCl_2 , CdCl_2 , HgCl_2, and aquatic environmental samples con-taining Al, Cd, Cu, Pb, Sr, Zn and other heavy metal ions as well as organic chemicals suppressed thegrowth of E. coli only at higher exposed concentrations | Xu Chao(Department of Environmental Science and Engineering , Nanjing University , Nanjing 210093 , China)Yuan Jing(Department of Plants , Soils , and Biometeorology , Utah State University , Logan , Utah 84322-4820, U. S. A)Xu Heping(Environmental Monito | 1995 | Journal of Environmental Sciences1995，7，4： | 2 |
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