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| 1 | Analyses on the climate change responses over China under SRES B2 scenario using PRECIS显示文摘The PRECIS,a regional climate model system developed at the UK Met Office Hadley Cen- tre for Climate Prediction and Research,which is nested in one-way mode within the HadAM3P,a higher-resolution version of the atmospheric com- ponent of the Hadley Centre climate model HadCM3,is employed to simulate the baseline (1961—1990) climate for evaluation of model’s capacity of simu- lating present climate and analyze the future climate change responses in the time-slice of 2071—2100 (2080s) under SRES B2 scenario over China relative to baseline average. It is indicated from the com- parison of the simulated baseline climate with in situ observation that PRECIS can simulate the local dis- tribution characteristics of surface air temperature over China quite well; generally speaking,the simu- lation for precipitation in the north of China and in winter is better than in the south of China and in summer,respectively; the simulation of precipitation in summer is sensitive to topography,and the simu- lated precipitation values are lower than observations over southeast coastal areas. It is shown from the analyses on the simulated climate change responses in 2080s under SRES B2 scenario relative to base- line that there would be an obvious surface air tem- perature increase in the north of China relative to that in the south of China,and especially in Northwest China and Northeast China,the amplitude ofsummer mean surface air temperature increments could reach 5℃; there would be an overall increase of the simulated precipitation in 2080s under SRES B2 scenario over most areas of China,while there would be significant precipitation decreases in South China in winter; there would be obvious precipitation decreases in Northeast China and North China in summer with high surface air temperature increase. However,it presents an obvious precipitation in- crease over the middle and lower reaches of the Yangtze River in summer. | XU Yinlong ZHANG Yong LIN Erda LIN Wantao DONG Wenjie Richard Jones David Hassell Simon Wilson | 2006 | Chinese Science Bulletin2006，51，18： | 39 |
| 2 | Pancreatic cancer and its stroma: A conspiracy theory显示文摘Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells(pancreatic stellate cells, PSCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PSCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biologyand the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease. | Zhihong Xu Srinivasa P Pothula Jeremy S Wilson Minoti V Apte | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 3 | UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis显示文摘Protein biogenesis at the endoplasmic reticulum(ER)in eukaryotic cells is monitored by a protein quality control system named ER-associated protein degradation(ERAD).While there has been substantial progress in understanding how ERAD eliminates defective polypeptides generated from erroneous folding,how cells remove nascent chains stalled in the translocon during co-translational protein insertion into the ER is unclear.Here we show that ribosome stalling during protein translocation induces the attachment of UFM1,a ubiquitin-like modifier,to two conserved lysine residues near the COOH-terminus of the 60S ribosomal subunit RPL26(uL24)at the ER.Strikingly,RPL26 UFMylation enables the degradation of stalled nascent chains,but unlike ERAD or previously established cytosolic ribosome-associated quality control(RQC),which uses proteasome to degrade their client proteins,ribosome UFMylation promotes the targeting of a translocation-arrested ER protein to lysosomes for degradation.RPL26 UFMylation is upregulated during erythroid differentiation to cope with increased secretory flow,and compromising UFMylation impairs protein secretion,and ultimately hemoglobin production.We propose that in metazoan,co-translational protein translocation into the ER is safeguarded by a UFMylation-dependent protein quality control mechanism,which when impaired causes anemia in mice and abnormal neuronal development in humans. | Lihui Wang Yue Xu Heather Rogers Layla Saidi Constance Tom Noguchi Honglin Li Jonathan Wilson Yewdell Nicholas Raymond Guydosh Yihong Ye | 2020 | Cell Research2020，30，1： | 5 |
| 4 | Evaluation of spatial and temporal patterns of insect damage and aflatoxin level in the pre-harvest corn fields to improve management tactics显示文摘在与有一致基因背景的植物的一个玉米领域里的黄麴毒素污染的关系的昆虫损坏的空间、时间的模式很好没被理解。在昆虫损坏和黄麴毒素在的空间模式的以前的考试以后预先收获玉米地,我们进一步与二采样检验了喂圆块、喂核的昆虫损坏,和黄麴毒素水平的空间、时间的模式在在 2008 和 2009 预先收获。由每 ear/kernel-feeding 昆虫的喂的损坏(即,丝绸 / 圆块上的玉米一种有害幼虫 / 秋天粟蚕损坏,和玉米核由的褪色坏透臭虫) 并且玉米象鼻虫人口用五只耳朵在每个格子点被估计。采样数据在两年里处于昆虫损坏和黄麴毒素污染显示出域边效果。玉米象鼻虫比任何一个玉米一种有害幼虫更经常向聚集的分布趋于或坏透两年里的臭虫损坏。为黄麴毒素水平检测聚集的分发的频率是昆虫损坏评价的不到任何东西。坏透臭虫损坏和玉米象鼻虫数字更仔细比是玉米一种有害幼虫的与黄麴毒素水平被联系损坏。另外,空间时间的协会(χ
) 的索引证明玉米象鼻虫的数字被联系在之间第一(4 个星期预先收获) 并且秒(1 个星期预先收获) 所有地上的两年里的采样。相反,在来自 Belflower 农场上的地的第一和第二采样之间的玉米一种有害幼虫损坏,和黄麴毒素水平和玉米一种有害幼虫在 Lang 农场上从这块地损坏在 2009 被分裂。 | Xinzhi Ni Jeffrey P. Wilson Michael D. Toews G. David Buntin R. Dewey Lee Xin Li Zhongren Lei Kanglai He Wenwei Xu Xianchun Li Alisa Huffaker Eric A. Schmelz | 2014 | Insect Science2014，21，5： | 2 |
| 5 | Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis显示文摘 | Zhihong Xu Alain Vonlaufen Phoebe A. Phillips Eva Fiala-Beer Xuguo Zhang Lu Yang Andrew V. Biankin David Goldstein Romano C. Pirola Jeremy S. Wilson Minoti V. Apte | 2010 | The American Journal of Pathology2010，，5： | 2 |
| 6 | Control Design and Dynamic Performance Anslysis of a Wind Turbine Induction Generator Unit 显示文摘 | Ezzeldin S Abdin and Xu Wilson | 2000 | IEEETrans(S1558-0059)2000，3，15： | 1 |
| 7 | Control design and dynamic perforrnance analysis of a wind turbine-induction generator unit 显示文摘 | Ezzeldin S Abdin Wilson Xu | 2000 | IEEE Trans On EC2000，3，15： | 1 |
| 8 | Induction of humanmyeloblasticML21 cell G1 arrest by suppression of K^+ channel activity 显示文摘 | XU B WILSON BA LU L | 1996 | Am J Physiol1996，271，： | 1 |
| 9 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 10 | Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice -translocation defects 显示文摘 | Zhu X Xu X Wilson IA | 2008 | Acta Crystallogr D Biol Crystallogr2008，64，8： | 1 |
| 11 | Structurecontrol and characterization of SrBi2Ta209 thin films by a modified annealing method显示文摘 | Hu G D Wilson L H Xu J B | 1999 | Applied Physics Letters1999，74，： | 1 |
| 12 | Structure control and characterization of SrBi2Ta2O9 thin films by a modified annealing method显示文摘 | G D Hu I H Wilson J B Xu | 1999 | Appl Phys lett1999，74，9： | 1 |
| 13 | Microwave sintering of ZnO at ultra high heating rates 显示文摘 | Xu G F Lloyd I K Wilson O C | 2001 | Journal of Material Research2001，16，10： | 1 |
| 14 | Structure control and characterization of SrBiETa2O9 thin films by a modified annealing method 显示文摘 | HUG D WILSON I H XU J B | 1999 | Appl Phys Lett1999，74，： | 1 |
| 15 | Structure control and characterization of SrBi2Ta2O9 thin films by a modified annealing method显示文摘 | Wilson I H Xu J B | 1999 | Appl Phys Lett1999，74，9： | 1 |
| 16 | Control Design and Dynamic Performance Analysis of a Wind Turbine Induction Generator Unit 显示文摘 | Ezzeldin S Abdin Wilson Xu | 2000 | IEEE Trans (S1558-0059)2000，3，15： | 1 |
| 17 | 3Gb/s AC coupled chip -to-chip communication using a low swing pulse receiv- er显示文摘 | Luo L Wilson J M Xu J | 2006 | IEEE Journal of Solid- State Circuits2006，41，1： | 1 |
| 18 | On the ambiguity of defining and measurging inter-harmonic显示文摘 | LI Chun XU Wilson | 2001 | IEEE Power Engineering Revier2001，15，1： | 1 |
| 19 | Structure control and characterization of SrBhTa209 thin films by a modified annealing method 显示文摘 | HU G D WILSON I H XU J B CHEUNG W Y WONG S P WONG H K | 1999 | Appl Phys Lett1999，74，： | 1 |
| 20 | Bacterial Endotoxin: A Trigger Factor for Alcoholic Pancreatitis? Evidence From a Novel, Physiologically Relevant Animal Model显示文摘 | Alain Vonlaufen Zhihong Xu Balu Daniel Rakesh K. Kumar Romano Pirola Jeremy Wilson Minoti V. Apte | 2007 | Gastroenterology2007，，4： | 1 |
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