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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 3 | ARFI, FibroScan?, ELF, and their combinations in the assessment of liver fibrosis: A prospective study显示文摘 | Gonzalo Crespo Guillermo Fernández-Varo Zoe Mari?o Gregori Casals Rosa Miquel Stella M. Martínez Rosa Gilabert Xavier Forns Wladimiro Jiménez Miquel Navasa | 2012 | Journal of Hepatology2012，，2： | 3 |
| 4 | Non-invasive evaluation of liver fibrosis using transient elastography显示文摘 | Laurent Castera Xavier Forns Alfredo Alberti | 2008 | Journal of Hepatology2008，，5： | 2 |
| 5 | Interferon-Free Regimens in the Liver-Transplant Setting显示文摘 | Sabela Lens Martina Gambato María-Carlota Londo?o Xavier Forns | 2014 | Semin Liver Dis2014，，01： | 2 |
| 6 | Retransplantation in patients with hepatitis C recurrence after liver transplantation显示文摘 | José A. Carrión Miquel Navasa Xavier Forns | 2010 | Journal of Hepatology2010，，5： | 2 |
| 7 | An Interferon-free Antiviral Regimen for HCV after Liver Transplantation显示文摘 | Paul Y. Kwo Parvez S. Mantry Eoin Coakley Helen S. Te Hugo E. Vargas Robert Brown Fredric Gordon Josh Levitsky Norah A. Terrault James R. Burton Wangang Xie Carolyn Setze Prajakta Badri Tami Pilot-Matias Regis A. Vilchez Xavier Forns | 2014 | The New England Journal of Medicine2014，，25： | 2 |
| 8 | Non-invasive evaluation of liver fibrosis using transient elastography显示文摘 | Laurent Castera Xavier Forns Alfredo Alberti | 2008 | Journal of Hepatology2008，，5： | 1 |
| 9 | DNA-based vaccination against hepatitis C virus (HCV):effect of expressing different forms of HCV E2 protein and use of CPG-optimized vectorsin mice 显示文摘 | Xiao Ying Ma Xavier Forns Robin Gutierrez | 2002 | Vaccine2002，20，2002： | 1 |
| 10 | Antiviral therapy increases the risk of bacterial infections in HCV-infected cirrhotic patients awaiting liver transplantation: A retrospective study显示文摘 | Jose A. Carrión Eva Martínez-Bauer Gonzalo Crespo Santseharay Ramírez Sofia Pérez-del-Pulgar Juan Carlos García-Valdecasas Miquel Navasa Xavier Forns | 2009 | Journal of Hepatology2009，，4： | 1 |
| 11 | Graft and viral outcomes in retransplantation for hepatitis C virus recurrence and HCV primary liver transplantation: a case–control study显示文摘 | Josep Martí Sofia De la Serna Gonzalo Crespo Xavier Forns Joana Ferrer Constantino Fondevila Miquel Navasa Josep Fuster Juan Carlos García‐Valdecasas | 2014 | Clin Transplant2014，，7： | 1 |
| 12 | Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-na?ve patients infected with HCV genotype 1显示文摘 | Lawrence Serfaty Xavier Forns Tobias Goeser Peter Ferenci Frederik Nevens Giampiero Carosi Joost P Drenth Isabelle Lonjon-Domanec Ralph DeMasi Gaston Picchio Maria Beumont Patrick Marcellin | 2012 | Gut2012，，10： | 1 |
| 13 | Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation显示文摘 | Gonzalo Crespo José A. Carrión Mairene Coto-Llerena Zoe Mari?o Sabela Lens Sofía Pérez-del-Pulgar Montserrat García-Retortillo Rosa Miquel Jaime Bosch Miquel Navasa Xavier Forns | 2013 | Journal of Gastroenterology2013，，6： | 1 |
| 14 | Life-Threatening Cryoglobulinemia: Clinical and Immunological Characterization of 29 Cases显示文摘 | Manuel Ramos-Casals Angel Robles Pilar Brito-Zerón Norma Nardi José M. Nicolás Xavier Forns Joan Plaza Jordi Yagüe Jose M. Sánchez-Tapias Josep Font | 2006 | Seminars in Arthritis and Rheumatism2006，，3： | 1 |
| 15 | Imaging of hepatitis C virus infection in liver grafts after liver transplantation<!-- Doctopic: TAS -->显示文摘 | Laura Mensa Sofía Pérez-del-Pulgar Gonzalo Crespo George Koutsoudakis Carlos Fernández-Carrillo Mairene Coto-Llerena Rosa Miquel Helena Allende Lluís Castells Miquel Navasa Xavier Forns | 2013 | Journal of Hepatology2013，，2： | 1 |
| 16 | Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-na?ve patients infected with HCV genotype 1显示文摘 | Lawrence Serfaty Xavier Forns Tobias Goeser Peter Ferenci Frederik Nevens Giampiero Carosi Joost P Drenth Isabelle Lonjon-Domanec Ralph DeMasi Gaston Picchio Maria Beumont Patrick Marcellin | 2012 | Gut2012，，10： | 1 |
| 17 | Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-na?ve patients infected with HCV genotype 1显示文摘 | Lawrence Serfaty Xavier Forns Tobias Goeser Peter Ferenci Frederik Nevens Giampiero Carosi Joost P Drenth Isabelle Lonjon-Domanec Ralph DeMasi Gaston Picchio Maria Beumont Patrick Marcellin | 2012 | Gut2012，，10： | 1 |
| 18 | Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model显示文摘 | Xavier Forns Sergi Ampurdanès Josep M. Llovet John Aponte Lloren? Quintó Eva Mart??nez-Bauer Miquel Bruguera Jose Maria Sánchez-Tapias Juan Rodés | 2002 | Hepatology2002，，4： | 1 |
| 19 | ARFI, FibroScan?, ELF, and their combinations in the assessment of liver fibrosis: A prospective study显示文摘 | Gonzalo Crespo Guillermo Fernández-Varo Zoe Mari?o Gregori Casals Rosa Miquel Stella M. Martínez Rosa Gilabert Xavier Forns Wladimiro Jiménez Miquel Navasa | 2012 | Journal of Hepatology2012，，2： | 1 |
| 20 | DNA-based vaccination against hepatitis C virus (HCV): effect of expressing different forms of HCV E2 protein and use of CPG-optimized vectors in mice 显示文摘 | Xiao Ying Ma Xavier Forns Robin Gutierrez | 2002 | Vaccine2002，20，： | 1 |
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