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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome based on NMR techniques显示文摘Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome has been performed by comparison with those of normal rats based on NMR techniques. The relative contents of formate,creatinine,2-oxoglutarate(2-OG) ,citrate,taurine,trimethylamine-N-oxide(TMAO) ,succinate and hippurate in the urine of the rats with Qi deficiency and blood stasis syndrome have been changed. These results have provided evidence for understanding the mechanism and the therapy of Qi defi-ciency and blood stasis syndrome. | LI Lin WANG JianNong REN JianXun XIANG JunFeng TANG YaLin LIU JianXun HANDing | 2007 | Chinese Science Bulletin2007，52，22： | 21 |
| 3 | Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury显示文摘Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography(a EEG) for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with a EEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. a EEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, a EEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury. | Wendong You Qilin Tang Xiang Wu Junfeng Feng Qing Mao Guoyi Gao Jiyao Jiang | 2018 | Neuroscience Bulletin2018，34，4： | 15 |
| 4 | PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARy-dependent pathway显示文摘Peroxisome 激活 proliferator 的受体鲸鱼群妈(PPAR γ) coactivator-1 高山哈(PGC-1 α) coactivates 多重抄写因素并且调整几个代谢过程。Thecurrent 学习在人的上皮的卵巢的癌症房间在 apoptosis 的正式就职调查了 PGC-1 α的角色。在人的卵巢和人的卵巢的上皮的肿瘤之间的 PGC-1 α信使 rna 水平被量的 RT-PCR 检验。更少的 PGC-1 α表示与正常卵巢相比在恶意的肿瘤的表面上皮被发现。在人的上皮的卵巢的癌症房间线 Ho-8910 的 PGC-1 α的 Overexpression 通过 Bcl-2 和 Bax 表示的协调规定导致了房间 apoptosis。Microarray 分析证实 PGC-1 α戏剧性地在 Ho-8910 房间影响了 apoptosis 相关的基因。 Mitochondrial 功能的试金证明 apoptosis 的正式就职通过由细胞色素 c.Furthermore 的版本的终端阶段,导致的 apoptosis 部分是,然而并非完全,由 PPAR γa ntagonist ( GW9662 )堵住了的 PGC-1 α-,并且由 siRNA 的 PPAR γ 表示的抑制也在 Ho-8910 房间禁止了 PGC-1 α- inducedapoptosis 。这些数据建议 PGC-1 α通过 aPPAR γ - 依赖者小径施加了它的效果。我们的调查结果显示 PGC-1 α涉及 apoptotic signaltransduction 小径, PGC-1 α的 down 规定可以是在支持上皮的卵巢的癌症生长和前进的一个关键点。 | Yan Zhang Yi Ba Chang Liu Guoxun Sun Li Ding Songyuan Gao Jihui Hao Zhentao Yu Junfeng Zhang Ke Zen Zhongsheng Tong Yang Xiang Chen-Yu Zhang | 2007 | Cell Research2007，17，4： | 14 |
| 5 | Hypoxia induces PGC-la expression and mitochondrial biogenesis in the myocardium of TOF patients显示文摘 | Qiang Wang Lin Zhang Zhixiang Fang Fang Zhao Zhiyuan Lv Zuguang Gu Junfeng Zhang Jin Wang Ke Zen Yang Xiang Dongjin Wang Chen-Yu Zhang | 2010 | Cell Research2010，20，6： | 13 |
| 6 | Anaerobic BTEX degradation in soil bioaugmented with mixed consortia under nitrate reducing conditions显示文摘包括苯,甲苯,乙醇苯,和三二甲苯异构体, BTEX 的不同集中被增加进土壤样品在减少条件的硝酸盐下面由扩充改编 BTEX 的协会调查厌氧的降级潜力。所有 BTEX 底层能是厌氧的当起始的集中在在土壤的 100 mg/kg 下面时,联盟者简历在 70 d 以内降级了到非可检测的层次。甲苯比降级率的顺序是的任何另外的 BTEX 混合物,和 high-to-low 快被降级 toluene>ethylbenzene>m-xylene>o-xylene>benzene>p-xylene.Nitrite 与硝酸盐减小被积累,但是亚硝酸根的累积没在整个整个孵化在 BTEX 的降级上有禁止的效果。在土壤的土生土长的细菌能提高充实的混合细菌的 BTEX 简历降级能力。当六 BTEX 混合物同时是在土壤的现在时,他们有更低的起始的集中的降级上没有明显的禁止的效果。或者,苯,o二甲苯,和p二甲苯降级与 300 mg/kg.Higher BTEX 简历降级的更高起始的集中被禁止率与一个单身者的存在相比与钠醋酸盐的增加在土壤样品被观察 BTEX 底层,并且主要底层的刺激或 BTEX 简历降级的 cometabolic 改进的假设似乎可能。 | DOU Junfeng LIU Xiang HU Zhifeng | 2008 | Journal of Environmental Sciences2008，20，5： | 6 |
| 7 | Anaerobic benzene biodegradation by a pure bacterial culture of Bacillus cereus under nitrate reducing conditions显示文摘A pure culture using benzene as sole carbon and energy sources was isolated by screening procedure from gasoline contaminated soil.The analysis of the 16S rDNA gene sequence,morphological and physiological characteristics showed that the isolated strain was a member of genus Bacillus cereus.The biodegradation performance of benzene by B.cereus was evaluated,and the results showed that benzene could be efficiently biodegraded when the initial benzene concentration was below 150 mg/L.The metabolites of anaerobic nitrate-dependent benzene oxidation by strain B.cereus were identified as phenol and benzoate.The results of substrate interaction between binary combinations for benzene,phenol and benzoate showed that the simultaneous presence of benzene stimulated the degradation of benzoate,whereas the addition of benzene inhibited the degradation of phenol.Benzene degradation by B.cereus was enhanced by the addition of phenol and benzoate,the enhanced effects were more pronounced at higher concentration.To our knowledge,this is the first report that the isolated bacterial culture of B.cereus can efficiently degraded benzene under nitrate reducing conditions. | Junfeng Dou Aizhong Ding Xiang Liu Yongchao Du Dong Deng Jinsheng Wang | 2010 | Journal of Environmental Sciences2010，22，5： | 6 |
| 8 | Comprehensive Proteomic Profiling of Patients'Tears Identifies Potential Biomarkers for the Traumatic Vegetative State显示文摘The vegetative state is a complex condition with unclear mechanisms and limited diagnostic, prognostic,and therapeutic methods. In this study, we aimed to explore the proteomic profile of tears from patients in a traumatic vegetative state and identify potential diagnostic markers using tears—a body fluid that can be collected noninvasively. Using i TRAQ quantitative proteomic technology, in the discovery phase, tear samples collected from 16 patients in a traumatic vegetative state and 16 normal individuals were analyzed. Among 1080 identified tear proteins, 57 were upregulated and 15 were downregulated in the patients compared to the controls. Bioinformatics analysis revealed that the differentially-expressed proteins were mainly involved in the wound response and immune response signaling pathways. Furthermore, we verified the levels of 7 differentially-expressed proteins in tears from50 traumatic vegetative state patients and 50 normal controls(including the samples used in the discovery phase) using ELISA. The results showed that this 7-protein panel had a high discrimination ability for traumatic vegetative state(area under the curve = 0.999). In summary, the altered tear proteomic profile identified in this study provides a basis for potential tear protein markers for diagnosis and prognosis of the traumatic vegetative state and also provides novel insights into the mechanisms of traumatic vegetative state. | Qilin Tang Chao Zhang Xiang Wu Wenbin Duan Weiji Weng Junfeng Feng Qing Mao Shubin Chen Jiyao Jiang Guoyi Gao | 2018 | Neuroscience Bulletin2018，34，4： | 3 |
| 9 | Pathogenesis and Immunogenicity of an Avian H9N2 Influenza Virus Isolated from Human显示文摘Objective To investigate the pathogenesis and immunogenicity of H9N2 influenza virus A/Guangzhou/333/99 (a reassortant of G1 and G9 viruses isolated from a female patient in 1999) in a mouse model of infection.Methods Mice were infected with increasing virus titers.Viral load in the lungs and trachea was determined by EID50 assay.Pulmonary histopathology was assessed by hematoxylin‐eosin staining.Anti‐HI antibody titers and T‐cell responses to viral HA were determined by ELISPOT and confirmed by flow cytometry.Results Mice presented a mild syndrome after intranasal infection with A/Guangzhou/333/99 (H9N2) influenza virus.Virus was detected in the trachea and lungs of mice harvested on days 3,6,and 9 post‐infection.A T‐cell response to viral HA was detected on day 6 and H9 HA‐specific CD 4+ T‐cells predominated.Seroconversion was detected after 14 days and antibody persisted for at least 28 weeks.Conclusion Our results suggest that H9N2 (A/Guangzhou/333/99) can replicate in the murine respiratory tract without prior adaptation,and both humoral and cell‐mediated immunity play an important role in the immune response. | LIU LiQi Li Zi ZHOU JianFang ZHU Yun DONG Jie ZHAO Xiang GUO JunFeng SHU YueLong | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 10 | A resource recycling technique of hydrogen production from the catalytic degradation of organics in wastewater显示文摘A resource recycling technique of hydrogen production from the catalytic degradation of organics in wastewater by aqueous phase reforming (APR) has been proposed. It is worthy of noting that this technique may be a potential way for the purification of refractory and highly toxic organics in water for hydrogen production. Hazardous organics (such as phenol, aniline, nitrobenzene, tetrahydrofuran (THF), toluene, N,N-dimethylformamide (DMF) and cyclohexanol) in water could be completely de-graded into H2 and CO2 with high selectivity over Raney Ni, and Sn-modified Raney Ni (Sn-Raney-Ni) or Pd/C catalyst under mild conditions. The experimental results operated in tubular and autoclave reactors, indicated that the degradation degree of organics and H2 selectivity could reach 100% under the optimal reaction conditions. The Sn-Raney-Ni (Sn/Ni=0.06) and Pd/C catalysts show better catalytic performances than the Raney Ni catalyst for the degradation of organics in water into H2 and CO2 by the aqueous phase reforming process. | LI XiaoNian KONG LingNiao XIANG YiZhi JU YaoMing WU XiaoQiong FENG Feng YUAN JunFeng MA Lei LU ChunShan ZHANG QunFeng | 2008 | Science China Chemistry2008，51，11： | 2 |
| 11 | Influence of proximity to the Qinghai-Tibet highway and railway on variations of soil heavy metal concentrations and bacterial community diversity on the Tibetan Plateau显示文摘An understanding of soil microbial communities is crucial in roadside soil environmental assessments.The 16S rRNA se quencing of a stressed microbial community in soil adjacent to the Qinghai-Tibet Highway(QTH)revealed that the accu mulation of heavy metals(over about 10 years)has affected the diversity of bacterial abundance and microbial community structure.The proximity of a sampling site to the QTH/Qinghai-Tibet Railway(QTR),which is effectively a measure of the density of human engineering,was the dominant factor influencing bacterial community diversity.The diversity of bacterial communities shows that 16S rRNA gene abundance decreased in relation to proximity to the QTH and QTR in both alpine wetland and meadow areas.The dominant phyla across all samples were Actinobacteria and Proteobacteria.The concentration of Cr and Cd in the soil were positively correlated with proximity to the QTH and QTR(MC/WC sam pling sites),and Ni,Co,and V were positively correlated with proximity to the QTH and QTR(MA/WA sampling sites).The results presented in this study provide an insight into the relationships among heavy metals and soil microbial commu nities,and have important implications for assessing and predicting the impacts of human-induced activities from the QTH and QTR in such an extreme and fragile environment. | Xia Zhao JunFeng Wang Yun Wang Xiang Lu ShaoFang Liu YuBao Zhang ZhiHong Guo ZhongKui Xie RuoYu Wang | 2019 | Research in Cold and Arid Regions2019，11，6： | 2 |
| 12 | Pressureless crystallization of glass toward scintillating composite with high crystallinity for radiation detection显示文摘The construction of scintillating ceramics is of great technological importance for various fundamental applications, including medical diagnostic, security inspection, resource exploration and particle physics. The chief challenge is the facile and scalable synthesis of scintillating ceramics with the desirable combination of pore-free, reliable mechanical properties and excellent scintillating performance. Here we present a pressureless glass crystallization strategy for the construction of scintillating composite with high crystallinity. The fabricated scintillating composites are featured by small optical turbidity, excellent mechanical properties, and efficient scintillating luminescence with the scintillating light yield of 15,000 pH/MeV and about 2.46 times higher than that of the commercial BGO single crystal. Moreover, the scintillating composite derived radiation detector device is successfully elaborated. The practical application for monitoring gamma ray is demonstrated and the precision of the device is less than that of the tolerable deviation of 30%. Our results suggest an innovative approach for expanding the category of scintillating material candidates, pointing to practical application in the field of radiation detection. | Junzhou Tang Shichao Lv Ziyu Lin Guanxin Du Manyun Tang Xu Feng Junpeng Guo Xiang Li Junfeng Chen Lei Wei Jianrong Qiu Shifeng Zhou | 2022 | Journal of Materials Science & Technology2022，，34： | 2 |
| 13 | Spectroscopic studies of the interaction between methyleneblue and G-quadruplex显示文摘G-rich single-stranded DNA (5′-TTAG-GG-3′) adopted a G-quadruplex structure in buffercontaining potassium ions. The spectroscopic featureand the interaction between methylene blue andG-quadruplex have been investigated by circular di-chroism, and nuclear magnetic resonance spectros-copy. The UV-Vis absorption and fluorescence spec-tral results show that the fluorescence behavior ofMB by single-stranded DNA fits Stern-Volmer staticquenching equation very well and they formed 1︰1complexes; dimeric G-quadruplexes were bound toMB with 1︰1 or 2︰1, and their equilibrium constantswere 1.047×105 and 8.79×104 L/mol, respectively.Based on the above results and 1H-NMR spectraldata, one may conclude that MB stacked either theterminal tetrads to form 1︰1 complexes or betweentwo terminal tetrads of G-quadruplexes to form 1︰2sandwich complexes with G-qudruplexes. | SUN Hongxia XIANG Junfeng ZHANG Yazhou XU Guangzhi XU Lianghua TANG Yalin | 2006 | Chinese Science Bulletin2006，51，14： | 2 |
| 14 | Modeling high-speed cutting of SiC_(p)/Al composites using a semi-phenomenologically based damage model显示文摘In this paper,we attempts to investigate cutting mechanisms in high-speed cutting of Al6061/Si C_(p)/15p composites using a semi-phenomenologically based damage model in the equivalent homogeneous material(EHM)framework.By combining macroscale EHM modeling and underlying microscale physical mechanisms,a feasible semi-phenomenological plastic model is proposed for prediction of cutting forces and chip morphology during high-speed turning Al6061/Si C_(p)/15p composites.This model incorporates the modified Weibull weakest-link effect to represent the strain-based damage evolution in large deformations.This proposed semi-phenomenological constitutive model is implemented by compiling material subroutines into cutting finite element(FE)codes.The effects of the critical shear stresses on chip formation that depend on the toolchip frictional coefficient are accounted for in the cutting FE model.The chip formation mechanism affecting material removal behaviors during high-speed turning is further investigated.The capabilities of the proposed constitutive model are evaluated by comparing cutting forces and chip morphologies between experiments and simulations at different cutting speeds associated with strain rates.The EHM-based and microstructure-based models are further compared in both computational efficiency and accuracy.The simulation results show that the developed semiphenomenological constitutive formalism and cutting model are promising and efficient tools for further investigation of dynamic mechanical and cutting behaviors of particle-reinforced composites with different volume fraction and particle size. | Junfeng XIANG Lijing XIE Feinong GAO | 2021 | Chinese Journal of Aeronautics2021，34，8： | 2 |
| 15 | Hydrothermal synthesis of LiCoPO4 cathode materials for rechargeable lithium ion batteries显示文摘 | Huang Xiang Ma Junfeng Wu Pingwei | 2005 | Mater Lett2005，59，5： | 1 |
| 16 | Radial friction weld- ing interface between brass and high carbon steel显示文摘 | Luo Jian Liu Dejia Xiang Junfeng | 2012 | Journal of Materials Processing Technology2012，212，2： | 1 |
| 17 | Anaerobic degradation of naphthalene by the mixed bacteria under nitrate reducing conditions 显示文摘 | DOU Junfeng LIU Xiang DING Aizhoug | 2009 | Journal of Hazardous Materials2009，165，： | 1 |
| 18 | Substrate interactions during anaerobic biodegradation of BTEX by the mixed cultures under nitrate reducing conditions显示文摘 | Dou Junfeng Liu Xiang Deng Dong | 2008 | Journal of Hazardous Materials2008，158，23： | 1 |
| 19 | Anaerobic biodegradation of BTEX linked to nitrate and sulfate reduction显示文摘 | Dou Junfeng Liu Xiang Hu Zhifeng | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 20 | Effects of NaCl on the J-aggregation of two thiacarbocyanine dyes in aqueous solutions显示文摘 | Junfeng Xiang Xiaorong Yang Ciping Chen Yalin Tang Wenpeng Yan Guangzhi Xu | 2003 | Journal of Colloid And Interface Science2003，，1： | 1 |
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