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| 1 | Genome-wide profiling of RNA editing sites in sheep显示文摘Background: The widely observed RNA-DNA differences(RDDs) have been found to be due to nucleotide alteration by RNA editing. Canonical RNA editing(i.e., A-to-I and C-to-U editing) mediated by the adenosine deaminases acting on RNA(ADAR) family and apolipoprotein B mRNA editing catalytic polypeptide-like(APOBEC)family during the transcriptional process is considered common and essential for the development of an individual.To date, an increasing number of RNA editing sites have been reported in human, rodents, and some farm animals;however, genome-wide detection of RNA editing events in sheep has not been reported. The aim of this study was to identify RNA editing events in sheep by comparing the RNA-seq and DNA-seq data from three biological replicates of the kidney and spleen tissues.Results: A total of 607 and 994 common edited sites within the three biological replicates were identified in the ovine kidney and spleen, respectively. Many of the RDDs were specific to an individual. The RNA editing-related genes identified in the present study might be evolved for specific biological functions in sheep, such as structural constituent of the cytoskeleton and microtubule-based processes. Furthermore, the edited sites found in the ovine BLCAP and NEIL1 genes are in line with those in previous reports on the porcine and human homologs, suggesting the existence of evolutionarily conserved RNA editing sites and they may play an important role in the structure and function of genes.Conclusions: Our study is the first to investigate RNA editing events in sheep. We screened out 607 and 994 RNA editing sites in three biological replicates of the ovine kidney and spleen and annotated 164 and 247 genes in the kidney and spleen, respectively. The gene function and conservation analysis of these RNA editing-related genes suggest that RNA editing is associated with important gene function in sheep. The putative functionally important RNA editing sites reported in the present study will help future studies on the relationship between these edited sites and the genetic traits in sheep. | Yuanyuan Zhang Deping Han Xianggui Dong Jiankui Wang Jianfei Chen Yanzhu Yao Hesham Y.A.Darwish Wansheng Liu Xuemei Deng | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 2 |
| 2 | Adaptive Memory Event-Triggered Observer-Based Control for Nonlinear Multi-Agent Systems Under DoS Attacks显示文摘This paper investigates the event-triggered security consensus problem for nonlinear multi-agent systems(MASs)under denial-of-service(Do S)attacks over an undirected graph.A novel adaptive memory observer-based anti-disturbance control scheme is presented to improve the observer accuracy by adding a buffer for the system output measurements.Meanwhile,this control scheme can also provide more reasonable control signals when Do S attacks occur.To save network resources,an adaptive memory event-triggered mechanism(AMETM)is also proposed and Zeno behavior is excluded.It is worth mentioning that the AMETM's updates do not require global information.Then,the observer and controller gains are obtained by using the linear matrix inequality(LMI)technique.Finally,simulation examples show the effectiveness of the proposed control scheme. | Xianggui Guo Dongyu Zhang Jianliang Wang Choon Ki Ahn | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，10： | 2 |
| 3 | Effects of Er^3+ concentration on UV/blue upconverted luminescence and a three-photon process in the cubic nanocrystalline Y2O5 : Er^3+ 显示文摘 | Wang Xin Shah Guiye Chao Kefu Zhang Youlin Liu Ruilin Feng Liyun Zeng Qinghui Sun Yajuan Liu Yichun Kong Xianggui | 2006 | Materials Chemistry and Physics2006，99，23： | 1 |
| 4 | Genome sequence of Gossypium anomalum facilitates interspecific introgression breeding显示文摘Crop wild relatives are an important reservoir of natural biodiversity. However, incorporating wild geneticdiversity into breeding programs is often hampered by reproductive barriers and a lack of accurate genomicinformation. We assembled a high-quality, accurately centromere-anchored genome of Gossypium anomalum, a stress-tolerant wild cotton species. We provided a strategy to discover and transfer agronomicallyvaluable genes from wild diploid species to tetraploid cotton cultivars. With a (Gossypium hirsutum 3 G.anomalum)2 hexaploid as a bridge parent, we developed a set of 74 diploid chromosome segment substitution lines (CSSLs) of the wild cotton species G. anomalum in the G. hirsutum background. This set of CSSLsincluded 70 homozygous substitutions and four heterozygous substitutions, and it collectively containedabout 72.22% of the G. anomalum genome. Twenty-four quantitative trait loci associated with plant height,yield, and fiber qualities were detected on 15 substitution segments. Integrating the reference genome withagronomic trait evaluation of the CSSLs enabled location and cloning of two G. anomalum genes thatencode peroxiredoxin and putative callose synthase 8, respectively, conferring drought tolerance andimproving fiber strength. We have demonstrated the power of a high-quality wild-species reference genomefor identifying agronomically valuable alleles to facilitate interspecific introgression breeding in crops. | Zhenzhen Xu Jiedan Chen Shan Meng Peng Xu Caijiao Zhai Fang Huang Qi Guo Liang Zhao Yonggang Quan Yixin Shangguan Zhuang Meng Tian Wen Ya Zhang Xianggui Zhang Jun Zhao Jianwen Xu Jianguang Liu Jin Gao Wanchao Ni Xianglong Chen Wei Ji Nanyi Wang Xiaoxi Lu Shihong Wang Kai Wang Tianzhen Zhang Xinlian Shen | 2022 | Plant Communications2022，3，5： | 1 |
| 5 | Optical spectroscopy and visible upconversion studies of YVO4:Er^3+ nanocrystals synthesized by a hydrothermal process显示文摘 | Sun Yajuan Liu Hongjian Wang Xin Kong Xianggui Zhang Hong | 2006 | Chemistry of Materials2006，18，11： | 1 |
| 6 | Hydrothermal synthesis and photoluminescent properties of ZnO nanorods显示文摘 | Libo Fan Hongwei Song Te Li Lixin Yu Zhongxin Liu Guohui Pan Yanqiang Lei Xue Bai Tie Wang Zhuhong Zheng Xianggui Kong | 2006 | Journal of Luminescence2006，，： | 1 |
| 7 | An Electrocatalytic Strategy for Dehydrogenative[4+2]Cycloaddition over a Cobalt-Based Catalyst显示文摘Exploring the anodic reaction to substitute conventional oxygen evolution reaction(OER)for the synthesis of complex pharmaceutical molecules is highly attractive.Here,we report an electrocatalytic strategy for dehydrogenative[4+2]cycloaddition of N,N-dialkylanilines with maleimides via dual functionalization of both C(sp3)-H and C(sp2)-H bonds,by using an electrochemically activated cobalt carbonate hydroxide hydrate supported on carbon cloth(CCHH-A/CC),affording various tetrahydroquinolines with high yields.This electrochemical transformation proceeds with high activity and stability,as well as good substrate compatibility.Mechanism study shows thatα-aminoalkyl radical exists in the electrooxidation reaction.This strategy shows significant potential for the synthesis of valuable chemicals by using an electrocatalytic strategy. | Xiaomeng Xue Ye Wang Lina Zhou Ruixiang Ge Jiangrong Yang Xianggui Kong Ming Xu Zhenhua Li Lina Ma Haohong Duan | 2022 | Chinese Journal of Chemistry2022，40，23： | 1 |
| 8 | Health education improves effectively therapy of inpatients with hypertension显示文摘Objective: Low rate of medication usage and blood pressure(BP) control, bad lifestyle, poor cognition to hypertension, have been obstacles in prevention from hypertensive disease and complication in Chinese cohort. Health education appears to be an impendent measure to improve this situation. To study the effect of health education on the rate of medication usage and BP control, the lifestyle, and the incidence of complication among patients with hypertension. Methods: 284 hypertensive inpatients were divided randomly into two groups: the control group was intervened with routine medication; the education group was intervened with routine medication in combination with intensive health education according to the investigation on the risk factors of cardiocerebrovascular diseases and cognitive levels of hypertensive disease. During 12.16 ± 1.95 months of following up, the status of lifestyle, the rate of medication usage and BP control, and incidence of complications between two groups were analyzed. Results: In education group, the rate of smoking, alcohol intake, lower-salt ingesting, exercise, medication usage and BP control were improved after intervention and significantly different from those before intervention(P < 0.01). After intervention, the incidence of complications in education group and control group was 10.9% and 30.5% respectively(P < 0.01). Conclusion: Intensive health education is an important measure in preventing from hypertension. | Xiang Gu Chunzhi Shi Yibai Feng Xianggui Wang Hongbin Nie Yongming Zhou Yeqiang Liu Xiangdong Xu | 2006 | Journal of Nanjing Medical University2006，20，3： | 1 |
| 9 | Recognition mechanism and sequence optimization of organophosphorus pesticides aptamers for better monitoring contaminations in food显示文摘Aptamers as a kind of biological recognition element have shown great potential in monitoring and the rapid quantification of organophosphorus pesticides(OPPs). However, molecules of OPPs are structurally similar and original aptamers selected by systematic evolution of ligands by exponential enrichment are usually long-chain bases, which hamper the further application under OPPs-aptamer recognition. The aim of the research was to develop a new strategy to design oligonucleotide sequences for binding OPPs by combination of experimental and molecular modeling methods. 3D models of aptamers binding OPPs were constructed, and binding energy and the most probable binding site for the OPPs were then determined by molecular docking, and the binding sites were further confirmed by the results of 2-AP replaced experiments. Based on the docking results, a new aptamer for detection 4 representative OPPs with only 29 bases was designed by reasonable truncation and mutation of the reported aptamer(named S4-29). The interaction between this new aptamer and OPPs were analyzed by molecular docking, microscale thermophoresis, circular dichroism and fluorometric analysis. The results revealed that the new aptamer exhibit more superior recognition performance to OPPs, which can be promote the monitoring ability of OPPs contaminations in food. | Pengfei Chen Chaoqiong Hu Xuan Tao Zheng Zhou Lijun Wang Xiao Yang Zhenming Che Xianggui Chen Yukun Huang | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 10 | Excitation orthogonalized upconversion nanoprobe for instant visual detection of trinitrotoluene显示文摘Excitation-emission orthogonalized luminescent upconversion nanoparticles(OUCNPs),which can respond to changes in external stimuli accordingly,show great promise in many intelligent applications.However,the construction of such materials mostly relies on the selective absorption of Nd3+and Yb3+at different wavelengths and the long-range energy migration between the layers,resulting in complex structures and limited orthogonal luminescence intensity.Herein,we developed a relatively simple structure of OUCNPs(β-NaErF4@NaLuF4@NaYF4:20%Yb,2%Er@NaLuF4),where the fluorescence emission switches from red to green when the excitation wavelength is shifted from 808 to 980 nm.This structure exhibits high-quality,independent,and non-interfering orthogonal luminescence properties without Nd3+sensitization and long-range energy migration.As a proof of concept,we demonstrate the application of the designed OUCNPs in anti-counterfeiting.We also prepared OUCNPs@PEI(PEI=polyethylenimine)self-referencing fluorescent probes to enable quantitative analysis of trinitrotoluene(TNT)in solution with a detection limit of 3.04μM.The probes can be made into test strips for portable on-site visual detection of TNT,and can also be used to image latent fingerprints and detect explosive residues in fingerprints simultaneously.The concept proposed in this work can be extended to the visual detection of a larger range of organic and biological molecules,and is highly promising for practical applications. | Xu Li Xu Zhao Xiaoyu Xu Yang Lu Jiahang Wu Fangmeng Liu Xu Yan Peng Sun Chenguang Wang Xianggui Kong Xiaomin Liu Geyu Lu | 2023 | Nano Research2023，16，1： | 0 |
| 11 | Highly improved cyclic stability of Ni-rich/Li batteries with succinic anhydride as electrolyte additive and underlying mechanism显示文摘Lithium-metal battery based on Ni-rich cathode provides high energy density but presents poor cyclic stability due to the unstable electrode/electrolyte interfaces on both cathode and anode.In this work,we report a new strategy to address this issue.It is found that the cyclic stability of Ni-rich/Li battery can be significantly improved by using succinic anhydride(SA) as an electrolyte additive.Specifically,the capacity retention of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)/Li cell is improved from 14% to 83% after 200cycles at 1 C between 3.0 and 4.35 V by applying 5% SA.The underlying mechanism of SA contribution is understood by comparing the effects of malic anhydride(MA) and citraconic anhydride(CA), both of which share a similar molecular structure to SA but show different effects.On anode side,SA can but MA and CA cannot form a protective solid electrolyte interphase(SEI) on Li anode.On cathode side,three anhydrides can suppress the formation of hydrogen fluoride from electrolyte oxidation decomposition,but SA behaves best.Typically,MA shows adverse effects on the interface stability of Li anode and NCM811 cathode,which originates from its high acidity.Though the acidity of MA can be mitigated by substituting a methyl for one H atom at its C=C bond,the substituent CA cannot compete with SA in cyclic stability improvement of the cell,because the SEI resulting from CA is not as robust as that from SA,which is related to the binding energy of the SEI components.This understanding reveals the importance of the electrolyte acidity on the Ni-rich cathode and the robustness of the SEI on Li anode,which is helpful for rationally designing new electrolyte additives to further improve the cyclic stability of high-energydensity Ni-rich/Li batteries. | Shu Yang Guanjie Li Xiaoyan Lin Changyong Mo Xianggui Zhou Lijiao Quan Kuan Zhou Suli Li Hai Wang Weishan Li | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 12 | Construction of self-sensitized LiErF4:0.5%Tm^3+@LiYF4 upconversion nanoprobe for trace water sensing显示文摘LiErF4 was commonly used as a dipolar-coupled antiferromagnet,and was rarely considered as a luminescent material.Herein,we achieved the strong red upconversion emission of LiErF4 simply by an inert shell coating,i.e.,LiErF4@LiYF4.Owing to the unique and intrinsic ladder-like energy levels of Er3+ions,this LiErF4 core–shell nanostructures present red emission(~650 nm)under multi-band excitation in the near-infrared(NIR)region(~808,~980,and^1,530 nm).A brighter and monochromic red emission can be further obtained via doping 0.5%Tm3+into the LiErF4 core,i.e.,LiErF4:0.5%Tm3+@LiYF4.The enriched Er3+ions and strong monochromic red emission natures make LiErF4:0.5%Tm3+@LiYF4 nanocrystals very sensitive for trace water probing in organic solvents with detection limit of 30 ppm in acetonitrile,50 ppm in dimethyl sulfoxide(DMSO),and 58 ppm in N,N-dimethylformamide(DMF)under excitation of 808 nm.Due to their superior chemical and physical stability,these nanoprobes exhibit excellent antijamming ability and recyclability,offering them suitable for real-time and long-term water monitoring. | Ling Zhang Xiaodan Li Wang Wang Xu Zhao Xu Yan Chenguang Wang Haoqiang Bao Yang Lu Xianggui Kong Fengmin Liu Xiaomin Liu Geyu Lu | 2020 | Nano Research2020，13，10： | 0 |
| 13 | Multiple Cavernous Hemangiomas of the Orbit显示文摘Purpose:Cavernous hemangioma of the orbit is often unilateral and solitary.Multiple cavernous hemangiomas of the orbit are extremely rare.The authors reported four patients who had more than two cavernous hemangiomas in one orbit.Methods:Case reports.The clinical features,imaging findings,differential diagnosis and surgical management were presented.Results:We found 4 cases of multiple cavernous hemangiomas of the orbit out of 214 records of all patients with orbital cavernous hemangiomas who were referred to us from Jan 1,1986 to Dec 31,2000.Two patients were female and two were male.The mean age was 46.5 years,ranging from 37.0 to 57.0 years.The left orbits were affected in all patients,with two,three,eight and ten tumors,respectively.The most common complaint was a painless,gradually progressive proptosis.The characteristic CT imaging features were multiple well circumscribed,round or ovoid masses that were sharply delineated from the surrounding tissue.B-scan ultrasonography showed round-shaped orbital masses with high internal reflectivity.The therapeutic outcomes of lateral or anterior orbitotomy were excellent.Conclusion:Although rare,cavernous hemangioma should be considered in the differential diagnosis of patients with multiple orbital mass lesions. | Xianggui Wang Jianhua Yan | 2011 | Eye Science2011，26，1： | 0 |
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