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| 1 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 2 | A comparative investigation into floatability of bastnaesite with three di/trialkyl phosphate surfactants显示文摘Flotation separation and recovery of rare earth minerals(REM) have returned to an important position due to the growing strategy demand for rare earth elements(REE).In this paper,a comparative investigation into the floatability of bastnaesite((Ce,La)FCO3) was conducted by using three di/trialkyl phosphate collectors,di(2-ethylhexyl) phosphate(DEHPA),dibutyl phosphate(DBP) and tributyl phosphate(TBP).The density functional theory(DFT) computation recommends that the chemical activity of the three phosphate collectors is in order of DEHPA≥ DBP >> TBP,and their hydrophobization assuggested by the IgP(oil-water partition coefficient) value is in the order of DEHPA> TBP> DBP.The micro-flotation indicates that the preferable pH values for flotation of bastnaesite with the three phosphate collectors are 7.0-8.0,and DEHPA achieves much higher flotation recovery of bastnaesite,followed by DBP,and then TBP,which coincides with their reactivity and hydrophobicity,the two prerequisites for froth flotation.The contact angle,zeta potential,Fourier transform infrared spectroscopy(FTIR) and X-ray photoelectron spectroscopy(XPS) deduce that DEHPA likely reacts with the Ce(Ⅲ)atoms of bastnaesite interface through its O atom(s) of the P(=O)-O-group to generate the Ce-O-P bonds,and its two 2-ethylhexyl groups orient outside for attaching bubbles,resulting in flotation enrichment of bastnaesite.Furthermore,this investigation offers a novel strategy for developing collectors in selective beneficiation of REM. | Hongli Fan Xianglin Yang Jing Qi Guangyi Liu Jingqin Qin | 2021 | Journal of Rare Earths2021，39，11： | 3 |
| 3 | Construction of 2D/2D Z-scheme MnO_(2-x)/g-C_(3)N_(4) photocatalyst for efficient nitrogen fixation to ammonia显示文摘Reducing nitrogen to ammonia with solar energy has become a wide concern when it comes to photocatalysis research.It is considered to be one of the more promising alternate options for the conventional Haber-Bosch cycle.Herein,2D g-C_(3)N_(4)composites with modifying ultrathin sheet MnO_(2-x)were prepared and used as nitrogen fixation photocatalyst.With the assistance of the nature of MnO_(2-x),the generation rate of NH_(3)reached 225 mmol g^(-1)h^(-1),which is more than twice over the rate of pristine 2D g-C_(3)N_(4)(107 mmol g^(-1)h^(-1)).The presence of ultrathin sheet MnO_(2-x)shortens the gap of the carriers to the surface of photocatalyst.Thus the speed of electron transfer gets increased.Besides,the construction of Z-scheme heterojunction boosts the separation and migration of photogenerated carriers.As a result,the nitrogen reduction reaction(NRR)performance gets enhanced.The work may provide an example of promoting the NRR performance of non-metallic compound. | Limin Yu Zhao Mo Xianglin Zhu Jiujun Deng Fan Xu Yanhua Song Yuanbin She Huaming Li Hui Xu | 2021 | Green Energy & Environment2021，6，4： | 3 |
| 4 | Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization显示文摘Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell viability.Although direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical practice.Previous reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial ischemia.In this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics technology.The results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the exosomes.In addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1αpathway.In brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization. | Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen | 2022 | Bioactive Materials2022，7，8： | 2 |
| 5 | Structures,properties,and challenges of emerging 2D materials in bioelectronics and biosensors显示文摘Bioelectronics are powerful tools for monitoring and stimulating biological and biochemical processes,with applications ranging from neural interface simulation to biosensing.The increasing demand for bioelectronics has greatly promoted the development of new nanomaterials as detection platforms.Recently,owing to their ultrathin structures and excellent physicochemical properties,emerging two-dimensional(2D)materials have become one of the most researched areas in the fields of bioelectronics and biosensors.In this timely review,the physicochemical structures of the most representative emerging 2D materials and the design of their nanostructures for engineering highperformance bioelectronic and biosensing devices are presented.We focus on the structural optimization of emerging 2D material-based composites to achieve better regulation for enhancing the performance of bioelectronics.Subsequently,the recent developments of emerging 2D materials in bioelectronics,such as neural interface simulation,biomolecular/biomarker detection,and skin sensors are discussed thoroughly.Finally,we provide conclusive views on the current challenges and future perspectives on utilizing emerging 2D materials and their composites for bioelectronics and biosensors.This review will offer important guidance in designing and applying emerging 2D materials in bioelectronics,thus further promoting their prospects in a wide biomedical field. | Fan Chen Qing Tang Tian Ma Bihui Zhu Liyun Wang Chao He Xianglin Luo Sujiao Cao Lang Ma Chong Cheng | 2022 | InfoMat2022，4，5： | 1 |
| 6 | Nanoporous Walls on Macroporous Foam: Rational Design of Electrodes to Push Areal Pseudocapacitance显示文摘 | Cao Guan Xianglin Li Zilong Wang Xiehong Cao Cesare Soci Hua Zhang Hong Jin Fan | 2012 | Adv. Mater2012，，30： | 1 |
| 7 | Churn-Resilient Task Scheduling in a Tiered IoT Infrastructure显示文摘Cloud-as-the-center computing paradigms face multiple challenges in the 5G and Internet of Things scenarios, where the service requests are usually initiated by the end-user devices located at network edge and have rigid time constraints. Therefore, Fog computing, or mobile edge computing, is introduced as a promising solution to the service provision in the tiered IoT infrastructure to compensate the shortage of traditional cloud-only architecture. In this cloud-to-things continuum, several cloudlet or mobile edge server entities are placed at the access network to handle the task offloading and processing problems at the network edge. This raises the resource scheduling problem in this tiered system, which is vital for the promotion of the system efficiency. Therefore, in this paper, a scheduling mechanism for the cloudlets or fog nodes are presented, which takes the mobile tasks’ deadline and resources requirements at the same time while promoting the overall profit of the system. First, the problem at the cloudlet, to which IoT devices offload their tasks, is formulated as a multi-dimensional 0-1 knapsack problem. Second, based on ant colony optimization, a scheduling algorithm is presented which treat this problem as a subset selection problem. Third, to promote the performance of the system in the dynamic environments,a churn-refined algorithm is further put forward. A series of simulation experiments have shown that out proposal outperforms many state-of-the-art algorithms in both profit and guarantee ratio. | Jianhua Fan Xianglin Wei Tongxiang Wang Tian Lan Suresh Subramaniam | 2019 | China Communications2019，16，8： | 1 |
| 8 | Baseline radiologic features as predictors of efficacy in patients with pancreatic neuroendocrine tumors with liver metastases receiving surufatinib显示文摘Objective:Currently,pre-treatment prediction of patients with pancreatic neuroendocrine tumors with liver metastases(PNELM)receiving surufatinib treatment was unsatisfying.Our objective was to examine the association between radiological characteristics and efficacy/prognosis.Methods:We enrolled patients with liver metastases in the phase III,SANET-p trial(NCT02589821)and obtained contrast-enhanced computed tomography(CECT)images.Qualitative and quantitative parameters including hepatic tumor margins,lesion volumes,enhancement pattern,localization types,and enhancement ratios were evaluated.The progression-free survival(PFS)and hazard ratio(HR)were calculated using Cox’s proportional hazard model.Efficacy was analyzed by logistic-regression models.Results:Among 152 patients who had baseline CECT assessments and were included in this analysis,the surufatinib group showed statistically superior efficacy in terms of median PFS compared to placebo across various qualitative and quantitative parameters.In the multivariable analysis of patients receiving surufatinib(N=100),those with higher arterial phase standardized enhancement ratio-peri-lesion(ASER-peri)exhibited longer PFS[HR=0.039;95%confidence interval(95%CI):0.003−0.483;P=0.012].Furthermore,patients with a high enhancement pattern experienced an improvement in the objective response ratio[31.3%vs.14.7%,odds ratio(OR)=3.488;95%CI:1.024−11.875;P=0.046],and well-defined tumor margins were associated with a higher disease control rate(DCR)(89.3%vs.68.2%,OR=4.535;95%CI:1.285−16.011;P=0.019)compared to poorlydefined margins.Conclusions:These pre-treatment radiological features,namely high ASER-peri,high enhancement pattern,and well-defined tumor margins,have the potential to serve as predictive markers of efficacy in patients with PNELM receiving surufatinib. | Jianwei Zhang Haibin Zhu Lin Shen Jie Li Xiaoyan Zhang Chunmei Bai Zhiwei Zhou Xianrui Yu Zhiping Li Enxiao Li Xianglin Yuan Wenhui Lou Yihebali Chi Nong Xu Yongmei Yin Yuxian Bai Tao Zhang Dianrong Xiu Jia Chen Shukui Qin Xiuwen Wang Yujie Yang Haoyun Shi Xian Luo Songhua Fan Weiguo Su Ming Lu Jianming Xu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 9 | Request pattern change-based cache pollution attack detection and defense in edge computing显示文摘Through caching popular contents at the network edge,wireless edge caching can greatly reduce both the content request latency at mobile devices and the traffic burden at the core network.However,popularity-based caching strategies are vulnerable to Cache Pollution Attacks(CPAs)due to the weak security protection at both edge nodes and mobile devices.In CPAs,through initiating a large number of requests for unpopular contents,malicious users can pollute the edge caching space and degrade the caching efficiency.This paper firstly integrates the dynamic nature of content request and mobile devices into the edge caching framework,and introduces an eavesdroppingbased CPA strategy.Then,an edge caching mechanism,which contains a Request Pattern Change-based Cache Pollution Detection(RPC2PD)algorithm and an Attack-aware Cache Defense(ACD)algorithm,is proposed to defend against CPAs.Simulation results show that the proposed mechanism could effectively suppress the effects of CPAs on the caching performance and improve the cache hit ratio. | Junwei Wang Xianglin Wei Jianhua Fan Qiang Duan Jianwei Liu Yangang Wang | 2023 | Digital Communications and Networks2023，9，5： | 0 |
| 10 | CuS-PNIPAm nanoparticles with the ability to initiatively capture bacteria for photothermal treatment of infected skin显示文摘Copper sulfide nanoparticles(CuS NPs)have shown great potential in various application fields,especially in biomedical engineering fields.CuS NPs,with the ability to actively capture and kill bacteria and without the worry of biocompatibility,will greatly expand their applications.Herein,a four-arm star thermosensitive polyisopropylacrylamide(4sPNIPAm)was used to modify CuS NPs(CuS-PNIPAm NPs).The obtained NPs displayed the controlled release of copper ions and higher photothermal conversion ability in comparison with contrast materials CuS-PEG NPs and CuS NPs.Aggregation of CuS-PNIPAm NPs at above 34℃resulted in capturing bacteria by forming the aggregates of NPs-bacteria.Both Staphylococcus aureus and Escherichia coli co-cultured with CuS-PNIPAm NPs were completely killed upon near-infrared irradiation in minutes.Furthermore,CuS-PNIPAm NPs were verified to be a photothermal agent without toxic effect.In in vivo experiment,the NPs effectively killed the bacteria in the wound and accelerated the process of wound repairment.Overall,photothermal treatment by CuS-PNIPAm NPs demonstrates the ability to actively capture and kill bacteria,and has a potential in the treatment of infected skin and the regeneration of skin tissues.The therapy will exert a far-reaching impact on the regeneration of stubborn chronic wounds. | Zizhen Wang Zishuo Hou Peiwen Wang Fan Chen Xianglin Luo | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 11 | Role of miRNA-21 in radiation-induced heart disease显示文摘Radiation-induced heart disease(RIHD)is a potentially fatal clinical complication of chest radiotherapy(RT).RIHD is detrimental to the long-term health of post-RT survivors and limits the dose and intensity of RT required to effectively kill tumor cells.However,the cellular and molecular mechanisms underlying these effects remain largely unknown.MicroRNAs(miRNAs)are highly conserved,non-coding,single-stranded,small molecular RNAs that regulate gene expression and participate in cellular proliferation,apoptosis,differentiation,and disease development.Micro RNA-21(miRNA-21)has become one of the most intensively studied miRNAs in the fields of cancer and cardiovascular disease in recent years.miRNA-21 plays an important role in RIHD progression.This article reviews the origin and function of miRNA-21 in the cardiovascular system and its role in RIHD pathogenesis.In addition,the potential role of miRNA-21 as a new target for predicting and treating RIHD is also discussed. | Zhijie Fan Motuma Yigezu Daba Lingyan Xiao Xianglin Yuan | 2023 | Oncology and Translational Medicine2023，9，2： | 0 |
| 12 | Paclitaxel and cisplatin with or without cetuximab in metastatic esophageal squamous cell carcinoma:a randomized,multicenter phase II trial显示文摘Lack of effective targeted therapy in metastatic esophageal squamous cell carcinoma(ESCC)underscores the urgent need for identifying new treatment approaches for this challenging disease.We sought to assess the addition of cetuximab to paclitaxel-cisplatin chemotherapy for first-line treatment in patients with metastatic ESCC.In this randomized,multicenter,open-label,phase II clinical trial,patients were randomized to receive paclitaxel-cisplatin(TP)(paclitaxel[175 mg/m^(2) intravenously(i.v.)on day 1 of every 3-week cycle]and cisplatin[75 mg/m^(2) i.v.on day 1 of every 3-week cycle])and TP plus cetuximab(CTP)(cetuximab,400 mg/m^(2) i.v.on day 1 of week 1,followed by 250 mg/m^(2) weekly). | Zhihao Lu Yanqiao Zhang Qingxia Fan Yueyin Pan Da Jiang Ping Lu Jingdong Zhang Xianglin Yuan Jifeng Feng Shujun Yang Wenbin Yue Lin Zhao Yunhua Xu Jinhua Luo Lin Shen | 2022 | The Innovation2022，3，3： | 0 |
| 13 | Toxic effects of three perfluorinated or polyfluorinated compounds(PFCs)on two strains of freshwater algae:Implications for ecological risk assessments显示文摘Perfluorinated or polyfluorinated compounds(PFCs)continue entering to the environmental as individuals or mixtures,but their toxicological information remains largely unknown.Here,we investigated the toxic effects and ecological risks of Perfluorooctane sulfonic acid(PFOS)and its substitutes on prokaryotes(Chlorella vulgaris)and eukaryotes(Microcystis aeruginosa).Based on the calculated EC50 values,the results showed that PFOS was significantly more toxic to both algae than its alternatives including Perfluorobutane sulfonic acid(PFBS)and 6:2 Fluoromodulated sulfonates(6:2 FTS),and the PFOS-PFBS mixture was more toxic to both algae than the other two PFC mixtures.The action mode of binary PFC mixtures on Chlorella vulgaris was mainly shown as antagonistic and on Microcystis aeruginosa as synergistic,by using Combination index(CI)model coupled with Monte Carlo simulation.The mean risk quotient(RQ)value of three individual PFCs and their mixtures were all below the threshold of 10^(−1),but the risk of those binary mixtures were higher than that of PFCs individually because of their synergistic effect.Our findings contribute to enhance the understanding of the toxicological information and ecological risks of emerging PFCs and provide a scientific basis for their pollution control. | Liangliang Zhang Xiaowei Zheng Xianglin Liu Jue Li Yanyao Li Zeming Wang Nan Zheng Xiangrong Wang Zhengqiu Fan | 2023 | Journal of Environmental Sciences2023，，9： | 0 |
| 14 | Timing of the formation of the Baiyinnuo'er skarn Zn–Pb deposit,NE China:evidence from sulfide Rb–Sr dating显示文摘The Baiyinnuo’er deposit in northern China is located in the south section of the Great Xing’an Range,and it is the largest skarn Zn–Pb deposit in the region.Skarn and Zn–Pb orebodies mainly occur between the different units of the Permian Huanggangliang Formation,or within the contact zone between the intrusive rocks and the marble.Although Baiyinnuo’er has been well investigated previously,the timing of the Zn–Pb mineralization is still controversial,largely due to the lack of appropriate ore or alteration minerals that could be directly used for isotopic dating.In this study,we report the results of Rb–Sr isotopic analysis for sphalerite and pyrite samples from the Baiyinnuo’er orebodies,which yielded two isochron ages of 137.4±3.4 and 140.0±7.8 Ma,respectively,constraining the Zn–Pb mineralization time of the deposit as the Early Cretaceous.The data are also consistent with the age of the granitoids in the mining area,indicating a potential genetic relationship between the Early Cretaceous magmatism and mineralization.Many other intrusion-related hydrothermal deposits(including the two typical skarns,Huanggang and Haobugao)in the southern Great Xing’an Range also share similar mineralization ages(i.e.,140–130 Ma).Together,these data suggest an Early Cretaceous mineralization event in this region,and this largescale mineralization could be related to the regional tectonic regime transition from compression to extension as a result of the rollback of the subducted Paleo-Pacific plate.The initial87 Sr/86 Sr ratios of the sphalerite and pyrite samples are 0.70569 and 0.70616,respectively,implying that the ore-forming material could have a significant contribution from the mantle components.The current study shows that sulfide Rb–Sr dating could be used in deciphering the timing of skarn deposit formation. | Yixin Li Qihai Shu Xudong Niu Fan Yu Qingwen Zeng Liangmin Wei Yang Xiao Xianglin Dai | 2022 | Acta Geochimica2022，41，2： | 0 |
| 15 | Distributed Matching Theory-Based Task Re-Allocating for Heterogeneous Multi-UAV Edge Computing显示文摘Many efforts have been devoted to efficient task scheduling in Multi-Unmanned Aerial Vehicle(UAV)edge computing.However,the heterogeneity of UAV computation resource,and the task re-allocating between UAVs have not been fully considered yet.Moreover,most existing works neglect the fact that a task can only be executed on the UAV equipped with its desired service function(SF).In this backdrop,this paper formulates the task scheduling problem as a multi-objective task scheduling problem,which aims at maximizing the task execution success ratio while minimizing the average weighted sum of all tasks’completion time and energy consumption.Optimizing three coupled goals in a realtime manner with the dynamic arrival of tasks hinders us from adopting existing methods,like machine learning-based solutions that require a long training time and tremendous pre-knowledge about the task arrival process,or heuristic-based ones that usually incur a long decision-making time.To tackle this problem in a distributed manner,we establish a matching theory framework,in which three conflicting goals are treated as the preferences of tasks,SFs and UAVs.Then,a Distributed Matching Theory-based Re-allocating(DiMaToRe)algorithm is put forward.We formally proved that a stable matching can be achieved by our proposal.Extensive simulation results show that Di Ma To Re algorithm outperforms benchmark algorithms under diverse parameter settings and has good robustness. | Yangang Wang Xianglin Wei Hai Wang Yongyang Hu Kuang Zhao Jianhua Fan | 2024 | China Communications2024，21，1： | 0 |
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