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| 1 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 2 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 3 | Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens显示文摘我们采用了结合的复合聚合酶链反应(PCR ) 指向六的毛状的电气泳动(mPCR-CE ) 在为 toxigenic C 的同时的察觉和描述的 tcdC 的 Clostridium 顽固基因,包括的 tpi, tcdA, tcdB, cdtA, cdtB,和删除。顽固直接从烘便的标本。mPCR-CE 每反应有 10 个形成殖民地的单位的察觉的限制没有与另外的相关细菌的基因跨反应。临床的确认在 354 上被执行连续地与怀疑的 C 从病人收集了凳子标本。顽固感染并且 45 孤立。结果与与 BD 最大 Cdiff,即时房间分析试金(RTCA ) ,和 mPCR-CE 相结合的一个参考标准相比。toxigenic C。顽固种类在 36 被检测孤立并且由 mPCR-CE 的 45 个凳子标本,它提供了 20.3% 的积极的率(81/399 ) 。mPCR-CE 有 97.2% 的特性和 96.0% 的敏感,它比 RTCA 高(x 2= 5.67, P = 0.017 ) 但是比 BD 最大 Cdiff 低(P = 0.245 ) 。在 45 紧张之中,(97.8%) 44 作为 non-ribotype 被决定 027 由 mPCR-CE,它充分被适合于 PCR ribotyping。尽管 ribotypes 017 (n = 8, 17.8%) , 001 (n = 6, 13.3%) ,并且 012 (n = 7, 15.6%) 在这个区域是占优势的, ribotype 027 重要遗传型习惯性地被监视。mPCR-CE 为 toxigenic C 的同时的察觉提供了一个其他的诊断工具。在凳子顽固、在 RT027 和 non-RT027 之间潜在地区分。 | Hanjiang Lai Chen Huang Jian Cai Julian Ye Jun She Yi Zheng Liqian Wang Yelin Wei Weijia Fang Xianjun Wang Yi-Wei Tang Yun Luo Dazhi Jin | 2018 | Frontiers of Medicine2018，12，2： | 2 |
| 4 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 5 | Formation of Field Reversed Configuration (FRC) on the Yingguang-I device显示文摘As a hybrid approach to realizing fusion energy,Magnetized Target Fusion(MTF)based on the Field Reversed Configuration(FRC),which has the plasma density and confinement time in the range between magnetic and inertial confinement fusion,has been recently widely pursued around the world.To investigate the formation and confinement of the FRC plasma injector for MTF,the Yingguang-I,which is an FRC test device and contains a multi-bank program-discharged pulsed power sub-system,was constructed at the Institute of Fluid Physics(IFP),China.This paper presents the pulsed power components and their parameters of the device in detail,then gives a brief description of progress in experiments of FRC formation.Experimental results of the pulsed power sub-system show that the peak current/magnetic field of 110 kA/0.3 T,10 kA/1.2 Tand 1.7 MA/3.4 Twere achieved in the bias,mirror and q-pinch circuits with quarter cycle of 80 ms,700 ms and 3.8 ms respectively.The induced electric field in the neutral gas was greater than 0.25 kV/cm when the ionization bank was charged to 70 kV.With H_(2) gas of 8 Pa,the plasma target of density 10^(16) cm^(-3),separatrix radius 4 cm,half-length 17 cm,equilibrium temperature 200 eV and lifetime 3 ms(approximately the half pulse width of the reversed field)have been obtained through the q-pinch method when the bias,mirror,ionization and θ-pinch banks were charged to 5 kV,5 kV,55 kV and ±45 kV respectively.The images from the high-speed end-on framing camera demonstrate the formation processes of FRC and some features agree well with the results with the two-dimension magneto hydrodynamics code(2D-MHD). | Qizhi Sun Xianjun Yang Yuesong Jia Lulu Li Dongfan Fang Xiaoming Zhao Weidong Qin Zhengfen Liu Wei Liu Jun Li Yuan Chi Xiaoguang Wang | 2017 | Matter and Radiation at Extremes2017，2，5： | 2 |
| 6 | Human serum amyloid A (SAA) protein changes in acute epilepsy patients显示文摘 | Guifen Li Fang Ren Jinhua Yao Mingying Wang Xianjun Feng Dong Liu | 2013 | International Journal of Neuroscience2013，，4： | 1 |
| 7 | Zircon U-Pb geochronology of the Chinese continental crust: a preliminary analysis of the Elsevier science database显示文摘The amount of zircon U-Pb geochronological data for China has grown rapidly in recent years.Nearly 410,000 items of zircon U-Pb geochronological data,representing more than 7,000 relevant articles in the Elsevier Science Database,have been collected to a database in this research.Statistics on the ages and absolute errors of these collated data,yielded smallest standard errors for(206Pb/238U),(207Pb/235U),and(207Pb/206Pb)ages within respective time intervals of<1388.96 Ma,1388.96–3282.52 Ma,and>3282.52 Ma.The ages and their absolute errors were determined using three main geochronology methods,based on laser ablation inductively coupled mass spectrometer(LA-ICP-MS),sensitive high-resolution ion microprobe(SHRIMP),and secondary ion mass spectrometer(SIMS)measurements.We compared the influence of these different methods on errors for each age interval.In addition,using a Gaussian model of multi-peak fitting of zircon U-Pb age frequencies,we identified seven growth peaks in zircons from the Chinese continental crust,which are 48.60 Ma,131.49 Ma,249.91 Ma,444.27 Ma,835.95 Ma,1860.65 Ma,and 2505.54 Ma.It is clear that there are correspondences between these ages and various geological events,namely,the Wutai movement,Lvliang movement,Jinning movement,Caledonian movement,Indo-China movement,Yanshan movement,and Himalayaorogeny movement,respectively.The time and spatial distributions of these zircons correspond to distinct geological events on the Chinese continent,reflecting its crustal evolution. | Yujing Wu Xianjun Fang Sisi Liao Lizhi Xue Zhe Chen Jiangnan Yang Yamin Lu Kun Ling Shengyi Hu Shuyuan Kong Yiwei Xiong Huacheng Li Xiuqi Shang Rui Ji Xueyun Lu Biao Song Lei Zhang Jianqing Ji | 2019 | Big Earth Data2019，3，1： | 1 |
| 8 | Lysophosphatidic acid is a bioactive mediator in ovarian cancer显示文摘 | Xianjun Fang Michel Schummer Muling Mao Shuangxing Yu Fazal Haq Tabassam Ramona Swaby Yutaka Hasegawa Janos L Tanyi Ruthie LaPushin Astrid Eder Robert Jaffe Jim Erickson Gordon B Mills | 2002 | BBA - Molecular and Cell Biology of Lipids2002，，1： | 1 |
| 9 | Sensitivity Analysis and Optimization for Connecting Rod of LJ276M Electronic Gasoline Engine 显示文摘 | Xianjun Hou Cuicui Tian Dan Fang | 2009 | Computational Intelligence and Software Engineering2009，，： | 1 |
| 10 | Catalytic Pyrolysis of Soybean Oil with CaO/Bio-Char Based Catalyst to Produce High Quality Biofuel显示文摘In this paper,CaO/bio-char was synthesized by directly co-pyrolysis of Ca(OH)_(2) and rice straw,and used as catalyst to catalytic pyrolysis of soybean oil to produce high quality biofuel.In this co-pyrolysis process,CaO particles has been successfully embedded on the bio-char surface.During the catalytic pyrolysis process,CaO/biochar showed a good catalytic performance on the deoxygenation of soybean oil.Pyrolysis temperature affected the pyrolysis reactions and pyrolytic products distributions dramatically,higher pyrolysis temperature lead to seriously cracking reactions,lower bio-oil yield and higher gases yield,and lower pyrolysis temperature lead to higher bio-oil yield with higher oxygenated compounds content and lower hydrocarbons contents,the suitable pyrolysis temperature was around 650℃.Under the optimal conditions(650℃ with WHSV at 6.4 h^(−1) and carrier gas flow rate at 100 ml/min),the selectivity(%)of hydrocarbons in the bio-oil was more than 90%.CaO/bio-char catalyst still shows good catalytic deoxygenation activity after 4 cycles.1 g of CaO/bio-char catalyst can catalyze pyrolysis of 32 g of soybean oil to produce high-quality liquid fuel.Bio-char based catalyst has been proved to be a promising catalyst for catalytic conversion of triglyceride-based lipids into high quality liquid biofuel. | Lujiang Xu Geliang Xie Xianjun Zhou Yucheng Liu Zhen Fang | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
| 11 | Crustal evolution events in the Chinese continent: evidence from a zircon U-Pb database显示文摘The zircon U-Pb chronology database provides a good opportunity to obtain important zircon growth peak periods in the Earth’s history so as to study the origin and evolution of the crust.It should be noted that research preference affects the objectivity of zircon sampling,leading to hot data in the database and age statistics.To evaluate the influence of hot data on statistical results,the W and Y indexes are introduced.Using a Gaussian model of multipeak fitting of zircon U-Pb age frequencies,we identify seven major growth peaks in zircons from the Chinese continental crust,which are 2498.95,1855.82,828.88,444.29,249.46,131.96,and 58.21 Ma.Due to differences in the time scales of zircon growth peaks,these peaks can be divided into two categories:first-order zircon growth peaks(Ⅰ)and second-order zircon growth peaks(Ⅱ),which represent longer and shorter time scales,perhaps due to different kinds of geological dynamics,respectively.In addition,there are clear correspondences between these ages and various geological events recognized by most scholars,namely,the Wutai orogeny,Lvliang orogeny,Jinning orogeny,Caledonian orogeny,Indosinian orogeny,Yanshanian orogeny,and Himalayan orogeny,respectively. | Yujing Wu Xianjun Fang Sisi Liao Lizhi Xue Zhe Chen Jiangnan Yang Yamin Lu Kun Ling Shengyi Hu Shuyuan Kong Yiwei Xiong Huacheng Li Xiuqi Shang Rui Ji Xueyun Lu Biao Song Lei Zhang Jianqing Ji | 2020 | International Journal of Digital Earth2020，13，12： | 0 |
| 12 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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