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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice显示文摘为在急性冠的症候群(交流) 和经皮的冠的干预(一种总线标准) 以后的口头的 anticoagulation (OAC ) 上的病人的 ObjectiveThe 最佳的 antithrombotic 政体仍然保持辩论。寻求回顾地在真实世界的 setting.MethodsWe 评估 OAC 正 clopidogrel 的功效和安全与或没有阿司匹林的这研究分析了数据从一国际,在 2003 和 2014 之间的多中心登记(n = 15,401 ) 。有在一种总线标准以后的交流和收到的 OAC 的病人被屏蔽。合成主要端点是 1 年的所有原因死亡,重新梗塞,或分析注册了 642 个病人包括的严重 bleeding.ResultsThe 期末考试有 OAC 和 clopidogrel (双治疗) 的 62 个病人(9.7%) ,和有阿司匹林, OAC 和 clopidogrel (三倍的治疗) 的联合的 580 个病人(90.3%) 。三倍的治疗上的病人更经常是女性的并且是更可能的有 comorbidities。关于在与三倍的治疗病人一起的双治疗之间的主要结束点没有重要差别[17.74% 对 17.24% ;unadjusted 危险比率(HR ) :1.035;95% 信心间隔(CI ) :0.556-1.929;调整 HR:1.026;95% CI:0.544-1.937 ] 。然而,重新梗塞率比三倍的治疗病人在双治疗是显著地更高的(14.52% 对 5.34% ;unadjusted HR:2.807;95% CI:1.329-5.928;调整 HR:2.333;95% CI:1.078-5.047 ) 。另外,在所有原因死亡和严重 bleeding.ConclusionsIn 的二政体之间没有差别有交流后面的一种总线标准并且与 OAC 的一个指示的真实病人,三倍的治疗没与双治疗相比与不利结果的增加的率被联系。而且,它减少了重新梗塞冒险并且没增加严重流血的风险。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE SerGio Raooseiras-Roubin Emad Abu-Assi Jose P Simao Henriques: Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzalez-Juanate Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Morettil Zenon Huczek Toshiharu Fujii Luis cL Correia Masa-aki Kawashiri Sasko Kedev | 2017 | Journal of Geriatric Cardiology2017，14，11： | 6 |
| 3 | A New Anthraquinone from Clinopodium polycephalum Glyceroyl-1,6,8-trihydroxy-3-methyl-9,10-dioxo-2-anthracene Carboxylate显示文摘A new anthraquinone, Glyceroyl-l, 6, 8 -trihydroxy-3 -methyl-9, 10-dioxo-2 -anthracenecarboxylate 1, was isolated from Clinopodium polycephalum. The chemical structure was determined by spectroscopic methods. | Chen, JY Chen, JM Wan, CL Yang, JS Xiao, PG | 1998 | Chinese Chemical Letters1998，9，2： | 5 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | DEVELOPMENT OF Sr0.69La0.31F2.31+SrSSOLID ELECTROLYTE SENSOR AND ITS APPLICATION显示文摘DEVELOPMENTOFSr0.69La0.31F2.31+SrSSOLIDELECTROLYTESENSORANDITSAPPLICATIONZhai;YuchunMa;PingTian;YanwenXiao;FeiJi;Chun?.. | ZHAI, YC MA, P TIAN, YW XIAO, F JI, CL | 1995 | 中国有色金属学会会刊:英文版1995，5，1： | 1 |
| 6 | Lactoferrin down regulates GI cyclin-dependent kinases during growth arrest of head and neck cancer cells 显示文摘 | Xiao Y Monitto CL Minhas KM | 2004 | Clin Cancer Res2004，10，23： | 1 |
| 7 | Long-term fertilizer effects on organic carbon and total nitrogen and coupling relationships of C and N in paddy soils in subtropical China显示文摘 | Tong CL Xiao HA Tang GY Wang HQ Huang TP Xia HA Keith S J Li Y Liu SL Wu JS | 2009 | Soil and Tillage Research2009，106，1： | 1 |
| 8 | Detection of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) jn gingival crevicular fluid from health, gingivitis and periodontitis patients显示文摘 | Xiao Y Bunn CL Bartold PM | 2000 | J Clin Periodontol2000，27，3： | 1 |
| 9 | Drying kinetics and quality of monukka seedless grapes dried in an air-im- pingement jet dryer显示文摘 | Xiao HW Pang CL Wang LH | 2010 | Biosystems Engineering2010，105，2： | 1 |
| 10 | Novel biodegradable and double crystalline multiblock eopolymers comprising of poly (butylene succinate) and poly( e- caprolaetone) : Synthesis, characterization, and properties 显示文摘 | Liuchun Zheng CL Zhaodong Wang Jin Wang Yaonan Xiao Dong Zhang Guohu Guan | 2012 | Industrial & Engineering Chemistry Research2012，51，： | 1 |
| 11 | Immunohistochemical demonstration of the plasminogen activator system in human gingival tissues and gingival fibroblasts显示文摘 | Xiao Y Bunn CL Bartold PM | 1998 | J Periodont Res1998，33，1： | 1 |
| 12 | Human rabies in China显示文摘 | Xiong CL Xiao DL | 2005 | Emerg Infect Dis2005，11，12： | 1 |
| 13 | Study on Extrac- tion of Natural Black Soya Bean Peptide and Antioxidant Activity显示文摘 | Zhang YF Xiao CL Jia X | 2013 | Advanced Materials Research2013，，： | 1 |
| 14 | Comparative proteomic analy- sis to discover potential therapeutic targets in human multiple myeloma显示文摘 | Xiao CL Zhang ZP Xiong S | 2009 | Proteomies Clin2009，3，11： | 1 |
| 15 | Association of CDX1 bindingsite of periostin gene with bone mineral density and vertebral fracturerisk显示文摘 | Xiao SM Gao Y Cheung CL | 2012 | Osteoporos Int2012，23，7： | 1 |
| 16 | Human rabies in China显示文摘 | Zhang YZ Xiong CL Xiao DL | 2005 | Emerg Itrfeet Dis2005，11，12： | 1 |
| 17 | Human rabies in China 显示文摘 | Zhang YZ Xiong CL Xiao DL et ol | 2005 | Emerg Infect Dis2005，11，12： | 1 |
| 18 | Progesterone regulates HLA-G gene expression through a novel progesterone response element 显示文摘 | Yie SM Xiao R Librach CL | 2006 | Hum Reprod2006，21，10： | 1 |
| 19 | Lactoferrin down- regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells 显示文摘 | Xiao Y Monitto CL Minhas KM | 2004 | Clin Cancer Res2004，10，： | 1 |
| 20 | Human rabies in China 显示文摘 | Zhang YZ Xiong CL Xiao DL | 2005 | Emerg Infect Dis2005，11，12： | 1 |
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