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| 1 | QTL mapping for grain number per spikelet in wheat using a high-density genetic map显示文摘Grain number per spikelet (GNS) is a key determinant of grain yield in wheat.A recombinant inbred line population comprising 300 lines was developed from a cross between a high GNS variety H461 and Chinese Spring from which the reference genome assembly of bread wheat was obtained.Both parents and the recombinant inbred lines were genotyped using the wheat 55K single nucleotide polymorphism(SNP) array.A high-density genetic map containing 21,197 SNPs was obtained.These markers covered each of the 21 chromosomes with a total linkage distance of 3792.71 c M.Locations of these markers in this linkage map were highly consistent with their physical locations in the genome assembly of Chinese Spring.The two parents and the whole RIL population were assessed for GNS in two consecutive years at two different locations.Based on multi-environment phenotype data and best liner unbiased prediction values,three quantitative trait loci (QTL) for GNS were identified.One of them located on chromosomes 2B and the other two on 2D.Phenotypic variation explained by these loci varied from 3.07%to26.57%.One of these QTL,QGns.sicau-2D-2,was identified in each of all trials conducted.Based on the best linear unbiased prediction values,this locus explained 19.59%–26.57%of phenotypic variation.A KASP(Kompetitive Allele-Specific PCR) marker closely linked with this locus was generated and used to validate the effects of this locus in three different genetic backgrounds.The identified QTL and the KASP marker developed for it will be highly valuable in fine-mapping the locus and in exploiting it for markerassisted selection in wheat breeding programs. | Yu Lin Xiaojun Jiang Haiyan Hu Kunyu Zhou Qing Wang Shifan Yu Xilan Yang Zhiqiang Wang Fangkun Wu Shihang Liu Caixia Li Mei Deng Jian Ma Guangdeng Chen Yuming Wei Youliang Zheng Yaxi Liu | 2021 | The Crop Journal2021，9，5： | 4 |
| 2 | Controllable magnetic properties of cobalt ferrite particles derived from layered double hydroxide precursors显示文摘Cobalt ferrite Co x Ni 1-x Fe 2 O 4 (x = 0, 0.5, 1) particles with controllable magnetic properties have been pre- pared by calcination of co-substituted NiFe 2+ Fe 3+ -layered double hydroxide (NiFe 2+ Fe 3+ -LDH) precursors prepared via a scalable method involving separate nucleation and aging steps (SNAS). Their structural and magnetic characteristics were investigated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and vibrating sample magnetometry (VSM). Measurements of magnetic properties show that the saturation magnetization (M s ) and coercivity (H c ) of the calcined products increased with increasing cobalt content. The LDH precursor-based product obtained by calcination of a mixture of CoFe 2+ Fe 3+ -LDH and NiFe 2+ Fe 3+ -LDH powders with a Co/Ni molar ratio of 1:1, exhibits a moderate value of M s and an increased value of H c compared to the corresponding values for an Ni 0.5 Co 0.5 Fe 2 O 4 material prepared by calcination of a Co 0.5 Ni 0.5 Fe 2+ Fe 3+ -LDH precursor, and a physical mixture of CoFe 2 O 4 and NiFe 2 O 4 with a Co/Ni molar ratio of 1:1. These results may provide a way to regulate magnetic anisotropy of ferrite spinels by varying the composition of the LDH precursors. | Yonglian Qi Yingsheng Yang Xiaofei Zhao Xilan Liu Peng Wu Fazhi Zhang Sailong Xu | 2010 | Particuology2010，8，3： | 1 |
| 3 | A new upper bound for || A-l || oo of a strictly a-diagonally domi-nant M-matrix 显示文摘 | YANG Zhanshan ZHENG Bing LIU Xilan | 2013 | Adv Numer Anal2013，2013，： | 1 |
| 4 | The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype显示文摘Macrophages (Mφs) play a crucial role in the pathological progression of osteoarthritis (OA) by regulating inflammation and tissue repair. Decreasing pro-inflammatory M1-Mφs and increasing anti-inflammatory M2-Mφs can alleviate OA-related inflammation and promote cartilage repair. Apoptosis is a natural process associated with tissue repair. A large number of apoptotic bodies (ABs), a type of extracellular vesicle, are produced during apoptosis, and this is associated with a reduction in inflammation. However, the functions of apoptotic bodies remain largely unknown. In this study, we investigated the role of M2-Mφs-derived apoptotic bodies (M2-ABs) in regulating the M1/M2 balance of macrophages in a mouse model of OA. Our data show that M2-ABs can be targeted for uptake by M1-Mφs, and this reprograms M1-to-M2 phenotypes within 24 h. The M2-ABs significantly ameliorated the severity of OA, alleviated the M1-mediated pro-inflammatory environment, and inhibited chondrocyte apoptosis in mice. RNA-seq revealed that M2-ABs were enriched with miR-21–5p, a microRNA that is negatively correlated with articular cartilage degeneration. Inhibiting the function of miR-21–5p in M1-Mφs significantly reduced M2-ABs-guided M1-to-M2 reprogramming following in vitro cell transfection. Together, these results suggest that M2-derived apoptotic bodies can prevent articular cartilage damage and improve gait abnormalities in OA mice by reversing the inflammatory response caused by M1 macrophages. The mechanism underlying these findings may be related to miR-21-5p-regulated inhibition of inflammatory factors. The application of M2-ABs may represent a novel cell therapy, and could provide a valuable strategy for the treatment of OA and/or chronic inflammation. | Leilei Qin Jianye Yang Xudong Su Xilan li Yiting Lei Lili Dong Hong Chen Cheng Chen Chen Zhao Huan Zhang Jun Deng Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，3： | 0 |
| 5 | Mycobacteriaceae Phenome Atlas(MPA):A Standardized Atlas for the Mycobacteriaceae Phenome Based on Heterogeneous Sources显示文摘The bacterial family Mycobacteriaceae includes pathogenic and nonpathogenic bacteria,and systematic research on their genome and phenome can give comprehensive perspectives for exploring their disease mechanism.In this study,the pheno-types of Mycobacteriaceae were inferred from available phenomic data,and 82 microbial phenotypic traits were recruited as data elements of the microbial phenome.This Mycobacteriaceae phenome contains five categories and 20 subcategories of polyphasic phenotypes,and three categories and eight subcategories of functional phenotypes,all of which are complemen-tary to the existing data standards of microbial phenotypes.The phenomic data of Mycobacteriaceae strains were compiled by literature mining,third-party database integration,and bioinformatics annotation.The phenotypes were searchable and comparable from the website of the Mycobacteriaceae Phenome Atlas(MPA,http://gffzz9fa96046bf0d4f3es5qvo69f9pw0k6990.ffgz.tsg.suse.edu.cn no.org/mpa/).A topological data analysis of MPA revealed the co-evolution between Mycobacterium tuberculosis and virulence factors,and uncovered potential pathogenicity-associated phenotypes.Two hundred and sixty potential pathogen-enriched pathways were found by Fisher's exact test.The application of MPA may provide novel insights into the pathogenicity mechanism and antimicrobial targets of Mycobacteriaceae. | Wan Liu Hui Cen Zhile Wu Haokui Zhou Shuo Chen Xilan Yang Guoping Zhao Guoqing Zhang | 2023 | Phenomics2023，3，5： | 0 |
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