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| 1 | Interaction between the gut microbiome and mucosal immune system显示文摘The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development.The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses,influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies. | Na Shi Na Li Xinwang Duan Haitao Niu | 2017 | Military Medical Research2017，4，3： | 65 |
| 2 | FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers显示文摘forkhead 盒子抄写因素 A2 (FOXA2 ) 是在动物开发和身体动态平衡的一个重要管理者。然而, FOXA2 是否涉及转变生长因素尾 1 (TGF-尾 1 ) ,调停了 epithelial-to-mesenchymal 转变(EMT ) 和肿瘤转移仍然保持未知。现在的学习证明在人的肺癌症房间线,许多 FOXA2 断然与上皮的显型相关并且否定地与房间的间充质的显型相关,并且 TGF-尾 1 治疗减少了 FOXA2 蛋白质水平。一致地, FOXA2 击倒肺癌症房间的支持的 EMT 和侵略,而 FOXA2 的 overexpression 减少了侵略并且压制了 TGF- ,尾 1 导致了 EMT。另外, FOXA2 击倒禁止的 FOXA2 的导致的蛞蝓表示,和宫外的表示猛击抄写。而且,我们鉴别 FOXA2 能绑通过一个保存有约束力的地点猛击倡导者,并且 FOXA2 的 DNA 有约束力的区域和 transactivation 区域 II 为蛞蝓倡导者的压抑被要求。这些数据证明 FOXA2 由 EMT 的抑制作为肿瘤转移的 suppressor 工作。 | Yunneng Tang Guangwen Shu Xinwang Yuan Naihe Jing Jianguo Song | 2011 | Cell Research2011，21，2： | 27 |
| 3 | Hepatitis B virus X gene induces human telomerase reverse transcriptase mRNA expression in cultured normal human cholangiocytes显示文摘AIM: To study the transcriptional regulation of human telomerase reverse transcriptase (hTERT) mRNA in normal human cholangiocytes (HBECs) after hepatitis B virus X (HBx) gene transfection and to elucidate the possible mechanism of HBV infection underlying cholangiocarcinoma.METHODS: HBECs were cultured in vitroand co-transfected with a eukaryotic expression vector containing the HBx coding region and a doning vector containing coding sequences of enhanced green fluorescent protein (EGFP) using lipidmediated gene transfer. The transfection efficiency was determined by the expression of EGFP. The expressions of hTERT mRNA and HBx protein in HBECs were detected by RT-PCR and immunocytochemical stain, respectively.RESULTS: The transfection efficiencies were about 15% for both HBx gene expression plasmid and empty vector.No hTERT mRNA was expressed in HBECs when transfected with OPTI-NEN medium and empty vector, but a dramatic increase was observed for hTERT mRNA expression in HBECs when transfected with HBx expression vector. HBx proyein was only expressed in HBECs when transfected with HBx expression vector.CONCLUSION: HBx transfection can activate thet ranscriptional expression of hTERT mRNA. Cis-activation of hTERT mRNA by HBx gene is the primary mechanism underlying the proliferation, differentiation and tumorigenesis of biliary epithelia. | Sheng-QuanZou Zhen-LiangQu Zhan-FeiLi XinWang | 2004 | World Journal of Gastroenterology2004，10，15： | 15 |
| 4 | Surfactant induced reservoir wettability alteration:Recent theoretical and experimental advances in enhanced oil recovery显示文摘Reservoir wettability plays an important role in various oil recovery processes.The origin and evolution of reservoir wettability were critically reviewed to better understand the complexity of wettability due to interactions in crude oil-brine-rock system,with introduction of different wetting states and their influence on fluid distribution in pore spaces.The effect of wettability on oil recovery of waterflooding was then summarized from past and recent research to emphasize the importance of wettability in oil displacement by brine.The mechanism of wettability alteration by different surfactants in both carbonate and sandstone reservoirs was analyzed,concerning their distinct surface chemistry,and different interaction patterns of surfactants with components on rock surface.Other concerns such as the combined effect of wettability alteration and interfacial tension (IFT) reduction on the imbibition process was also taken into account.Generally,surfactant induced wettability alteration for enhanced oil recovery is still in the stage of laboratory investigation.The successful application of this technique relies on a comprehensive survey of target reservoir conditions,and could be expected especially in low permeability fractured reservoirs and forced imbibition process. | Wang Yefei XU Huaimin Yu Weizhao Bai Baojun Song Xinwang Zhang Jichao | 2011 | Petroleum Science2011，8，4： | 14 |
| 5 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6svkc0pquoqbfo6fwk.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 6 | Experiment and simulation study on construction of a three-dimensional network model显示文摘The construction of a network model is one of the key techniques in organic com-bination of microscopic flow experiment and simulation. The construction method of a three-dimensional network model is presented on the basis of CT scanning images in this paper. A series of CT slice images describing microscopic pore structure and fluid distribution of actual rock is obtained with the help of the in-dustrial microfocus CT system. Based on the extraction of pore space skeleton, pore and throat information, the corresponding network model is established, and the conversion from three-dimensional CT image information to pore-throat size distribution and topological information is also achieved. The feature of this me-thod lies in the fact that complicated pore space of rock may be characterized by pores and throats with a simple shape while keeping the geometry and flow char-acteristics. It is indicated that the calculated results of porosity, permeability, rela-tive permeability curve and microscopic remaining oil distribution match very well the experimental results of water flooding and polymer flooding. This network model may fairly well characterize the rock microscopic pore-throat size and topo-logical characteristics. | HOU Jian LI ZhenQuan ZHANG SunKang CAO XuLong SONG XinWang GAO DeBo | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 5 |
| 7 | Reconstructing past subsistence patterns on Zhongba Site using stable carbon and oxygen isotopes of fossil tooth enamel显示文摘The oxygen and carbon isotopic ratios in human and animal tooth enamel were measured to reconstruct the subsistence patterns on Zhongba Site between 2400 and 4200 aBP.The results indicate that human consumed chiefly C4 resources,such as millet,and the C3 plants,such as rice and wheat,constituted only a small fraction of the human diets,normally no more than 15%.There are significant differences in food sources between human and pig,and the percentages of C3 plants in pig diets were higher than those in human diets.But theδ13C values of pig partially overlap those of human,demonstrating some similarities in their food sources.The differences in water sources between human and pig are significant.There are significant differences in food and water sources between cattle and deer. This indicates that the two kinds of mammals subsisted in different niches.But theirδ13C values also partially overlap each other,suggesting some similarities in their food sources.There are both signifi- cant differences in meanδ13C andδ18O values between the omnivores,human and pig and the herbi- vores,cattle and deer,implying significant differences in food and water sources between the two categories.During the period the dietary habits of human had not changed,but the pig breeding strategies had changed,from breeding in house to breeding in confinement,and the proportion of C3 plants in pig food increased with time.The scope of human migration had been considerably large by the Warring States because of the development of productive forces. | XiaoSi Tian Cheng Zhu XinWang Xu ChunMei Ma ZhiBin Sun Qian Yin Qing Zhu Wei Shi | 2008 | Chinese Science Bulletin2008，53，S1： | 4 |
| 8 | Interval-valued intuitionistic fuzzy aggregation operators显示文摘The notion of the interval-valued intuitionistic fuzzy set (IVIFS) is a generalization of that of the Atanassov's intuitionistic fuzzy set. The fundamental characteristic of IVIFS is that the values of its membership function and non-membership function are intervals rather than exact numbers. There are various averaging operators defined for IVIFSs. These operators are not monotone with respect to the total order of IVIFS, which is undesirable. This paper shows how such averaging operators can be represented by using additive generators of the product triangular norm, which simplifies and extends the existing constructions. Moreover, two new aggregation operators based on the ukasiewicz triangular norm are proposed, which are monotone with respect to the total order of IVIFS. Finally, an application of the interval-valued intuitionistic fuzzy weighted averaging operator is given to multiple criteria decision making. | Weize Wang Xinwang Liu Yong Qin | 2012 | Journal of Systems Engineering and Electronics2012，23，4： | 4 |
| 9 | Linear goal programming approach to obtaining the weights of intuitionistic fuzzy ordered weighted averaging operator显示文摘The multiple attribute decision making problems are studied, in which the information about attribute weights is partly known and the attribute values take the form of intuitionistic fuzzy numbers. The operational laws of intuitionistic fuzzy numbers are introduced, and the score function and accuracy function are presented to compare the intuitionistic fuzzy numbers. The intuitionistic fuzzy ordered weighted averaging (IFOWA) operator which is an extension of the well-known ordered weighted averaging (OWA) operator is investigated to aggregate the intuitionistic fuzzy information. In order to determine the weights of intuitionistic fuzzy ordered weighted averaging operator, a linear goal programming procedure is proposed for learning the weights from data. Finally, an example is illustrated to verify the effectiveness and practicability of the developed method. | Yejun Xu Chao Huang Qingli Da Xinwang Liu | 2010 | Journal of Systems Engineering and Electronics2010，21，6： | 3 |
| 10 | Sulindac induces apoptosis and protects against colon carcinoma in mice显示文摘AIM: To study the effect of sulindac on colon cancer induction in mice.METHODS: The chemo-preventive action of 80 ppm sulindac fed during initiation and post-initiation and 100 ppm sulindac fed during progressive stages of induction of colon carcinogenesis in mice was investigated using 1,2-dimethylhydrazine (DMH). Using the terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL)technique and PCNA immunohistochemical staining, we observed the apoptotic and proliferative cell density changes at different carcinogenic stages and the effect of sulindac on these two phenomena.RESULTS: Dietary sulindac significantly inhibited the incidence of colonic neoplasmas in mice. Compared with the control group, feeding sulindac during initiation and post-initiation stages inhibited the incidence by 46.7-50.4%,and feeding sulindac during progressive stages inhibited the incidence by 41.1%. Animals that were fed sulindac showed less serious pathological changes than those that were fed the control diet (P<0.01, H= 33.35). There was no difference in the density of proliferating cells among those groups which were or were not fed sulindac. In the same period, feeding sulindac resulted in a higher density of apoptotic cells than feeding control diet. CONCLUSION: Sulindac has an anti-carcinogenic function in mice. Its effect on preventing colon carcinogenesis is better than its effect on treating established tumors. By inducing apoptosis, sulindac inhibited the development of colon cancer and delayed canceration. Sulindac has no effect on proliferation. The anti-carcinogenic properties of sulindac are most effective in the moderate and severe stages of dysplasia and canceration. | Bao-CunSun Xiu-LanZhao Shi-WuZhang Yi-XinLiu LanWang XinWang | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 11 | ACBD3 is required for FAPP2 transferring glucosylceramide through maintaining the Golgi integrity显示文摘Glycosphingolipid (GSL) metabolism is involved in various physiological processes, including all major cell signaling pathways, and its dysregulation is linked to some diseases. The four-phosphate adaptor protein FAPP2-mediated glucosylceramide (GlcCer) transport for complex GSL synthesis has been studied extensively. However, the molecular machinery of FAPP2 as a GlcCer-transferring protein remains poorly defined. Here, we identify a Golgi-resident protein, acyl-coenzyme A binding domain containing 3 (ACBD3), as an interacting partner of FAPP2. We find that ACBD3 knockdown leads to dramatic Golgi fragmentation, which subsequently causes FAPP2 dispersal throughout the cytoplasm and a decreased localization at trans-Golgi network. The further quantitative Upidomic analysis indicates that ACBD3 knockdown triggers abnormal sphingolipid metabolism. Interestingly, the expression of siRNA-resistant full-length ACBD3 can rescue these defects caused by ACBD3 knockdown. These data reveal critical roles for ACBD3 in maintaining the integrity of Golgi morphology and cellular sphingolipid homeostasis and establish the importance of the integrated Golgi complex for the transfer of GlcCer and complex GSL synthesis. | Jing Liao Yuxiang Guan Wei Chen Can Shi Dongdong Yao Fengsong Wang Sin Man Lam Guanghou Shui Xinwang Cao | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 12 | Polarized sorting and trafficking in epithelial cells显示文摘在在形成的上皮的房间结果的表面膜的蛋白质和类脂化合物的极化的分发一顶端并且一个 basolateral 领域,它被紧密的连接分开。上皮的极性的产生和维护要求保证正确排序和货物分子的 vectorial 交货的精致的机制。这个动态过程包含与排序机械和运输搬运人的形成排序信号的相互作用。这里,我们在在上皮的房间排序极化的地里考察最近的进展。我们特别在顶端的排序加亮类脂化合物椽子的角色。 | Xinwang Cao Michal A Surma Kai Simons | 2012 | Cell Research2012，22，5： | 2 |
| 13 | Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid显示文摘The application of paclitaxel(PTX) in clinic has been restricted due to its poor solubility.Several traditional nano-medicines have been developed to improve this defect,while they are still lack of tumor targeting ability and rapid drug release. In this work,an amphiphilic polymeric micelle of hyaluronic acid(HA) – all-trans-retinoid acid(ATRA) with a disulfide bond,was developed successfully for the co-delivery of PTX and ATRA. The combination chemotherapy of PTX and ATRA can strengthen the anti-tumor activity. Along with selfassembling to micelles in water,the delivery system displayed satisfying drug loading capacities for both PTX(32.62% ± 1.39%) and ATRA,due to directly using ATRA as the hydrophobic group. Rapid drug release properties of the PTX-loaded redox-sensitive micelles(HA-SS-ATRA) in vitro were confirmed under reducing condition containing GSH. Besides,HA-CD44 mediated endocytosis promoted the uptake of HA-SS-ATRA micelles by B16 F10 cells. Due to these properties,cytotoxicity assay verified that PTX-loaded HA-SS-ATRA micelles showed concentration-dependent cytotoxicity and displayed obvious combination therapy of PTX and ATRA. Importantly,HA-SS-ATRA micelles could remarkably prolong plasma circulation time after intravenously administration. Therefore,redox-sensitive HASS-ATRA micelles could be utilized and explored as a promising drug delivery system for cancer combination chemotherapy. | Lingfei Han Lejian Hu Fulei Liu XinWang Xiaoxian Huang Bowen Liu Feng Feng Wenyuan Liu Wei Qu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 2 |
| 14 | On the room-temperature tensile deformation behavior of a cast dual-phase high-entropy alloy CrFeCoNiAl_(0.7)显示文摘The microstructure and room-temperature tensile deformation behavior of the cast CrFeCoNiAl0.7 high-entropy alloy(HEA)were studied in details.The cast HEA consisted of a dual-phase structure of 77.3 vol.%face-centered-cubic(FCC)phase plus 22.7 vol.%B2 phase,and exhibited excellent room-temperature tensile properties with a high yield strength of 876 MPa,ultimate tensile strength of 1198 MPa and a relatively large elongation to fracture of~9%.Dislocations gliding in the FCC phase governed the plastic deformation at the early stage of room-temperature tensile,and disordered dislocations were to form dislocation walls as the deformation proceeded.With further increase in strain to a high level,the stacking faults were generated through the dissociation of the geometrically necessary dislocations,serving as the potential heterogeneous nucleation sites for the deformation twins. | Qiang Wang Liangcai Zeng Tengfei Gao Hui Du Xinwang Liu | 2021 | Journal of Materials Science & Technology2021，，28： | 2 |
| 15 | A Multi-Stage Green Barrier Strategy for the Control of Global SARS-CoV-2 Transmission via Cold Chain Goods显示文摘1.The object-to-human transmission route of SARS-CoV-2 At the time of writing,coronavirus disease 2019(COVID-19),which is caused by the severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2),has been a global pandemic for more than a year.As of 22 September 2021,the global cumulative incidence exceeds 229 million cases,and the number of deaths has exceeded 4.75 million[1].The current situation of epidemic prevention and control within the countries around the world can be roughly divided into two stages:the pandemic stage that the United States,the United Kingdom,and India are still experiencing(as of 23 September 2021,newly reported cases in the last 24 h in the United States,United Kingdom,and India are 202840,31095,and 26964,respectively[1]);and the normalized epidemic pre-vention and control stage that countries such as China and New Zealand are currently in. | Xu He Xinwang Liu Pan Li Panpan Wang Haijun Cheng Wenqian Li Boda Li Ting Liu Jun Ma | 2022 | Engineering2022，8，2： | 2 |
| 16 | Effects of Shear Fracture on In-depth Profile Modification of Weak Gels显示文摘Two sand packs were filled with fine glass beads and quartz sand respectively.The characteristics of crosslinked polymer flowing through the sand packs as well as the influence of shear fracture of porous media on the in-depth profile modification of the weak gel generated from the crosslinked polymer were investigated.The results indicated that under the dynamic condition crosslinking reaction happened in both sand packs,and the weak gels in these two cases became small gel particles after water flooding.The differences were:the dynamic gelation time in the quartz sand pack was longer than that in the glass bead pack.Residual resistance factor(FRR)caused by the weak gel in the quartz sand pack was smaller than that in the glass bead pack.The weak gel became gel particles after being scoured by subsequent flood water.A weak gel with uniform apparent viscosity and sealing characteristics was generated in every part of the glass bead pack,which could not only move deeply into the sand pack but also seal the high capacity channels again when it reached the deep part.The weak gel performed in-depth profile modification in the glass bead pack,while in the quartz sand pack,the weak gel was concentrated with 100 cm from the entrance of the sand pack.When propelled by the subsequent flood water,the weak gel could move towards the deep part of the sand pack but then became tiny gel particles and could not effectively seal the high capacity channels there.The in-depth profile modification of the weak gel was very weak in the quartz sand pack.It was the shear fracture of porous media that mainly affected the properties and weakened the in-depth profile modification of the weak gel. | Li Xianjie Song Xinwang Yue Xiang'an Hou Jirui Fang Lichun Zhang Huazhen | 2007 | Petroleum Science2007，4，1： | 2 |
| 17 | Supramolecular vesicles of cationic gemini surfactants modulated by p-sulfonatocalix[4]arene显示文摘Supramolecular binary vesicles were constructed by host-guest complex formation between p-sulfonatocalix[4]arene and three cationic gemini surfactants, which were identified by UV-vis, dynamic laser scattering, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, and surface tension experiments. The critical aggregation concentration of gemini surfactants decreased pronouncedly by a factor of ca. 1000 owing to the complexation of p-sulfonato-calix[4]arene. | LI ZhenQuan HU ChunXiu CHENG YuQiao XU Hui CAO XuLong SONG XinWang ZHANG HengYi LIU Yu | 2012 | Science China Chemistry2012，55，10： | 2 |
| 18 | The prvalenee of functional disability in activities of daily living and instrumental activities of daily living among elderly Beijing Chinese 显示文摘 | Zhe Tang Hui Xinwang | 1999 | Archives of Geronology and Geriatrics1999，29，2： | 1 |
| 19 | Effects of NPY Gene on Total Number of Eggs at 300 Days of Age in Donglan Black-bone Chicken显示文摘In this study,PCR-RFLP technique was employed to detect the genetic polymorphism of NPY gene and analyze the effects of various genotypes on the total number of eggs at 300 days of age in 135 Donglan black-bone chicken. According to the results,there were three genotypes( AA,AB and BB) of NPY gene in Donglan black-bone chicken group. Different genotypes exhibited significant effects( P < 0. 05) on the total number of eggs at 300 days of age. The total number of eggs at 300 days of age of AA genotype was significantly higher than that of BB genotype( P < 0. 05). Therefore,the polymorphic site of NPY gene could be used as a candidate molecular marker that affects egg laying in Donglan black-bone chicken. | Yuying LIAO Junli SUN Xinwang WEN Yingfei HUANG Bing ZHANG Fengying WEI | 2015 | Agricultural Biotechnology2015，4，4： | 1 |
| 20 | Measuring the satisfaction of constraints in fuzzy linear programming显示文摘 | Liu Xinwang | 2001 | Fuzzy Sets and Systems2001，，122： | 1 |
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