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您的检索式：作者名="Xinxian DAI"
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| 1 | Host cellular signaling induced by influenza virus显示文摘A wide range of host cellular signal transduction pathways can be stimulated by influenza virus infection. Some of these signal transduction pathways induce the host cell's innate immune response against influenza virus, while others are essential for efficient influenza virus replication. This review examines the cellular signaling induced by influenza virus infection in host cells, including host pattern recognition receptor (PRR)-related signaling, protein kinase C (PKC), Raf/MEK/ERK and phosphatidylinositol-3-kinase (PI3K)/Akt signaling, and the corresponding effects on the host cell and/or virus, such as recognition of virus by the host cell, viral absorption and entry, viral ribonucleoprotein (vRNP) export, translation control of cellular and viral proteins, and virus-induced cell apoptosis. Research into influenza virus-induced cell signaling promotes a clearer understanding of influenza virus-host interactions and assists in the identification of novel antiviral targets and antiviral strategies. | DAI XinXian ZHANG LiShu HONG Tao | 2011 | Science China(Life Sciences)2011，54，1： | 12 |
| 2 | 流感病毒引起的宿主细胞信号通路研究进展显示文摘流感每年造成全球数千人死亡.造成巨大的经济损失,是一个非常重要的公共卫生问题。流感病毒易发生变异。快速变异的病毒株能够逃逸宿主免疫系统的攻击。每年都投入大量的疫苗用于预防季节性流感.但是疫苗并不能预防所有的流感病毒株感染。 | DAI XinXian 吴华伟(译) 樊晓旭(校) | 2011 | 河南畜牧兽医(市场版)2011，32，12： | 2 |
| 3 | Cross-talking between autophagy and viral infection in mammalian cells显示文摘Autophagy is a cellular process in degradation of long-lived proteins and organelles in the cytosol for maintaining cellular homeostasis,which has been linked to a wide range of human health and disease states,including viral infection.The viral infected cells exhibit a compli-cated cross-talking between autophagy and virus.It has been shown that autophagy interacts with both adaptive and innate immunity.For adaptive immunity,viral antigens can be processed in autophagosomes by acidic proteases before major histocompatibility complex(MHC)class II presentation.For innate immunity,autophagy may assist in the delivery of viral nucleic acids to endosomal TLRs and also functions as a part of the TLR-or-PKR-downstream responses.Autophagy was also reported to suppress the magnitude of host innate antiviral immunity in certain cases.On the other hand,viruses has evolved many strategies to combat or utilize the host autophagy for their own benefit.In this review we discussed recent advances toward clarifying the cross-talking between autophagy and viral infection in mammalian cells. | Hongya HAN Lishu ZHANG Xinxian DAI Yanpeng ZHENG | 2010 | Frontiers in Biology2010，5，6： | 1 |
| 4 | Immunogenicity and protective efficacy of an inactivated SFTS vaccine candidate in mice显示文摘Severe fever with thrombocytopenia syndrome(SFTS),caused by a novel identified bunyavirus SFTS virus(SFTSV),was an emerging viral infectious disease that was firstly reported in China.There are no licensed vaccines and therapeutics against SFTSV currently.B‐Propiolactone(BPL)inactivated whole virions of SFTSV strain AH12 were prepared as experimental vaccine in different antigen dose with or without Al(OH)3 adjuvant.The experimental SFTS vaccine was a satisfying immunogen,which could efficiently trigger the development of high levels of SFTSV NP‐specific IgG antibodies and neutralizing antibodies against SFTSV Strain HB29 in BALB/c and C57/BL6 mice,and could induce SFTS virus‐specific cellular immune responses to a certain extent.A single dose of vaccine was immunogenically insufficient in BALB/c mice;the second and third dose resulted in significant boost in antibody response.The use of Al(OH)3 adjuvant resulted in higher antibody titers.The mediate‐dose of vaccine could induce as high and equivalent level of antibody titer as that of high‐dose.The experimental SFTS vaccine in mediate‐and high antigen dose with adjuvant resulted in solid protection of C57/BL6 mice against wild‐type SFTSV challenge with markedly accelerated virus clearance from blood and spleen compared with controls.The experimental SFTS vaccine prepared in this study could efficiently elicit virus specific humoral and cellular immune responses in both BALB/c and C57/BL6 mice,and could protect C57/BL6 mice against SFTS virus challenge.These results supplied evidence that inactivated vaccine was a promising vaccine candidate for the prevention of SFTSV infection. | Aqian Li Xinxian Dai Lei Chen Lin Liu Chuan Li Yang Liu Wei Wu Xiaoxia Huang Jiandong Li Shiwen Wang Mifang Liang Xiuling Li Dexin Li | 2022 | Biosafety and Health2022，4，1： | 0 |
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