|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 2 | Speciation, distribution, and potential ecological risk assessment of heavy metals in Xiamen Bay surface sediment显示文摘Based on the survey of surface sediment in Xiamen Bay in October 2011, the speciation, distribution, and potential ecological risk assessment of heavy metals(Cu, Pb, Zn, Cd, and Cr) in this area were studied using the sequential extraction method and ecological risk assessment method. The results indicated:(1) the total concentrations of these heavy metals were influenced by runoff, industrial wastewater, and sewage, and were all higher in the coastal area than the offshore area while the highest area of Pb was a little farther away from the coastal water due to atmosphere deposition;(2) sequential extractions suggested that Cu was mainly composed with residual and Fe/Mn-oxide bound fractions, Pb was bound to Fe/Mn-oxide, Zn and Cr were dominated by residual, and Cd bound to exchangeable and carbonate fractions;(3) the order of migration and transformation sequence was Cd>Pb>Cu>Zn>Cr and the degree of pollution was Cd>Pb>Cu>Zn>Cr; and(4) the ratios of the secondary and primary phases showed that Zn and Cr were both clean, Cu may be polluted, Pb was moderately polluted, while Cd was heavily polluted. | LIN Cai LIU Yang LI Wenquan SUN Xiuwu JI Weidong | 2014 | Acta Oceanologica Sinica2014，33，4： | 11 |
| 3 | A four-gene signature-derived risk score for glioblastoma:prospects for prognostic and response predictive analyses显示文摘Objective: Glioblastoma(GBM) is the most common primary malignant brain tumor regulated by numerous genes, with poor survival outcomes and unsatisfactory response to therapy.Therefore, a robust, multi-gene signature-derived model is required to predict the prognosis and treatment response in GBM.Methods: Gene expression data of GBM from TCGA and GEO datasets were used to identify differentially expressed genes(DEGs)through DESeq2 or LIMMA methods.The DEGs were then overlapped and used for survival analysis by univariate and multivariate COX regression.Based on the gene signature of multiple survival-associated DEGs, a risk score model was established,and its prognostic and predictive role was estimated through Kaplan–Meier analysis and log-rank test.Gene set enrichment analysis(GSEA) was conducted to explore high-risk score-associated pathways.Western blot was used for protein detection.Results: Four survival-associated DEGs of GBM were identified: OSMR, HOXC10, SCARA3, and SLC39A10.The four-gene signature-derived risk score was higher in GBM than in normal brain tissues.GBM patients with a high-risk score had poor survival outcomes.The high-risk group treated with temozolomide chemotherapy or radiotherapy survived for a shorter duration than the low-risk group.GSEA showed that the high-risk score was enriched with pathways such as vasculature development and cell adhesion.Western blot confirmed that the proteins of these four genes were differentially expressed in GBM cells.Conclusions: The four-gene signature-derived risk score functions well in predicting the prognosis and treatment response in GBM and will be useful for guiding therapeutic strategies for GBM patients. | Mianfu Cao Juan Cai Ye Yuan Yu Shi Hong Wu Qing Liu Yueliang Yao Lu Chen Weiqi Dang XiangZhang Jingfang Xiao Kaidi Yang Zhicheng He Xiaohong Yao Yonghong Cui Xia Zhang Xiuwu Bian | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 4 | Distribution of dissolved oxygen and causes of maximum concentration in the Bering Sea in July 2010显示文摘According to data obtained in the Bering Sea during the 4th Chinese National Arctic Research Expedition, the distribution of dissolved oxygen(DO) was studied, causes of its maximum concentration were discussed, and the relationships between DO and other parameters, such as salinity, temperature, and chlorophyll a were analyzed. The results showed DO concentration ranged from 0.53 to 12.05 mg/L in the Bering Sea basin. The upper waters contained high concentrations and the maximum occurred at the depth range from 20 to 50 m. The DO concentration decreased rapidly when the depth was deeper than 200 m and reached the minimum at the depth range from 500 to 1 000 m, and then increased slowly with the depth increasing but still kept at a low level. On the shelf, the DO concentration ranged from 6.53 to 16.63 mg/L with a mean value of 10.75 mg/L, and showed a characteristic of decreasing from north to south. The DO concentration was higher in the area between the Bering Sea and Lawrence Island and was lower in the southeast and southwest of Lawrence Island at the latitude of 62°N. The formation of maximum DO concentration was concerned with phytoplankton photosynthesis and formation of the themocline. To the south of Sta. B07 in the Bering Sea basin, the oxygen produced by photosynthesis permeated to the deeper water and the themocline made it difficult to exchange vertically, and to the north of Sta. B07, the maximum DO concentration occurred above the themocline due to phytoplankton activities. On the shelf, the oxygen produced by phytoplankton photosynthesis gathered at the bottom of the thermocline and formed the DO maximum concentration. In the Bering Sea basin, the DO and salinity showed a weak negative correlation(r=0.40) when the salinity was lower than 33.1, a significant negative correlation(r=0.92) when the salinity ranged from 33.1 to 33.7, and an irregular reversed parabola(r=0.95) when the salinity was greater than 33.7. | SUN Xiuwu LIN Cai CHEN Yong ZHANG Yuanbiao WANG Jigang JI Weidong | 2014 | Acta Oceanologica Sinica2014，33，6： | 2 |
| 5 | Diagnosis and treatment of cytomegalovirus infection after renal transplantation显示文摘 | Guandelin M Xiuwu H Juzhong G | 2000 | Transplant Proc2000，32，： | 1 |
| 6 | Synthesis of ordered mesoporous carbon molecular sieve and its adsorption capacity for H2,N2,O2,CH4 and CO2显示文摘 | Li Zhou Xiuwu Liu Jingwen Li | 2005 | Chemical Physics Letters2005，413，： | 1 |
| 7 | An interactive sorting approach based on the assignment examples of multiple decision makers with different priorities显示文摘 | Cai Fuling Liao Xiuwu Wang Kanliang | 2012 | Annals of Operations Research2012，197，1： | 1 |
| 8 | Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm显示文摘Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 patients.These data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is limited.In the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients. | Jinghe Zhang Haibo Wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui Sun Zhigang Tian Xiuwu Bian Haiming Wei | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 9 | GW112, a novel antiapoptotic protein that promotes tumor growth 显示文摘 | Zhang Xiuwu Huang Qian Yang Zhonghui | 2004 | Cancer Res2004，64，7： | 1 |
| 10 | A model for selecting an ERP system based on linguistic information processing显示文摘 | Xiuwu Liao Yuan Li Bing Lu | 2006 | Information Systems2006，，7： | 1 |
| 11 | 显示文摘 | Liu Xiuwu Li J ingwen Zhou Li | 2005 | Chemical Physics Letters2005，415，： | 1 |
| 12 | 显示文摘 | Zhou Li Liu Xiuwu Li Jingwen | 2005 | Chemical Physics Letters2005，413，： | 1 |
| 13 | Magnetic P zeolites: Synthesis, characterization and the behavior in potassium extraction from seawater 显示文摘 | Cao Jilin Liu Xiuwu Fu Rui | 2008 | Separation and Purification Technology2008，63，： | 1 |
| 14 | Decision support for risk anal- ysis on dynamic alliance 显示文摘 | PYuan Li Xiuwu Liao | 2007 | Decision Support Systems2007，，4： | 1 |
| 15 | Impacts of lead/zinc mining and smelting on the environment and human health in China显示文摘 | Xiuwu Zhang Linsheng Yang Yonghua Li Hairong Li Wuyi Wang Bixiong Ye | 2012 | Environmental Monitoring and Assessment2012，，4： | 1 |
| 16 | A model for selecting anERP system based on linguistic information processing显示文摘 | Liao Xiuwu Li Yuan Lu Bing | 2007 | Information Systems2007，32，7： | 1 |
| 17 | MicroRNA-137, a HMGA1 Target, Suppresses Colorectal Cancer Cell Invasion and Metastasis in Mice by Directly Targeting FMNL2显示文摘 | Li Liang Xianzheng Li Xiaojing Zhang Zhenbing Lv Guoyang He Wei Zhao Xiaoli Ren Yuling Li Xiuwu Bian Wenting Liao Wei Liu Guangying Yang Yanqing Ding | 2012 | Gastroenterology2012，，： | 1 |
| 18 | Approaches to attribute reductions based on rough set and matrix computation in inconsistent ordered information systems显示文摘 | Xu Weihua Li Yuan Liao Xiuwu | 2012 | Knowledge?Based Systems2012，27，： | 1 |
| 19 | Adsorptinn and regeneration study of the mesoporous adsorbent SBA-15 adapted to the capture/separation of CO2 and CH4显示文摘 | Liu Xiuwu Zhou Li Fn Xin | 2007 | Chemical Engineering Science2007，62，4： | 1 |
| 20 | Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma显示文摘 | Liang Yi Hualiang Xiao Minhui Xu Xianzong Ye Jun Hu Fei Li Mei Li Chunxia Luo Shicang Yu Xiuwu Bian Hua Feng | 2010 | Journal of Neuroimmunology2010，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员