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186篇 您的检索式:作者名="Xu Leng"
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1Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study显示文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a safe and effective treatment for acute cerebral infarction patients,especially for moderate stroke patients.This study was approved by the Ethical Committee of Peking University Third Hospital,China(approval No.2013-068-2)on May 20,2013,and registered in the Chinese Clinical Trial Registry(registration No.ChiCTR1800017937).Hui Zhang Chuan-Ling Li Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan 2020Neural Regeneration Research2020,15,7:54
2Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow.Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 2018Stroke & Vascular Neurology2018,3,3:37
3Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing.JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU 2017Photonics Research2017,5,4:20
4Clinical analysis of surgical treatment of portal hypertension显示文摘AIM: To review the experience in surgery for 508 patients with portal hypertension and to explore the selection of reasonable operation under different conditions.METHODS: The data of 508 patients with portal hypertension treated surgically in 1991-2001 in our centers were analyzed. Of the 508 patients, 256 were treated with portaazygous devascularization (PAD),167 with portasystemic shunt (PSS), 62 with selective shunt (SS), 11 with combined portasystemic shunt and portaazygous devascularization (PSS+PAD), 9 with liver transplantation (LT), 3 with union operation for hepatic carcinoma and portal hypertension (HCC+PH).RESULTS: In the 167 patients treated with PSS, free portal pressure (FPP) was significantly higher in the patients with a longer diameter of the anastomotic stoma than in those with a shorter diameter before the operation (P<0.01). After the operation, FPP in the former patients markedly decreased compared to the latter ones (P<0.01).The incidence rate of hemorrhage in patients treated with PAD, PSS, SS, PSS+PAD, and HCC+PH was 21.09% (54/256), 13.77 (23/167), 11.29 (7/62), 36.36% (4/11),and 100% (3/3), respectively. The incidence rate of hepatic encephalopathy was 3.91% (10/256), 9.58% (16/167),4.84% (3/62), 9.09% (1/11), and 100% (3/3), respectively while the operative mortality was 5.49% (15/256), 4.22% (7/167), 4.84% (3/62), 9.09% (1/11), and 66.67% (2/3) respectively. The operative mortality of liver transplantation was 22.22% (2/9).CONCLUSION: Five kinds of operation in surgical treatment of portal hypertension have their advantages and disadvantages. Therefore, the selection of operation should be based on the actual needs of the patients.Xin-Bao Xu Jing-Xiu Cai Xi-Sheng Leng Jia-Hong Dong Ji-Ye Zhu Zhen-Ping He Fu-Shun Wang Ji-Run Peng Ben-Li Han Ru-Yu Du 2005World Journal of Gastroenterology2005,11,29:15
5dentification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis显示文摘Xiao-Xuan Xu Shuang-Zheng Jia Yi Dai Jun-Ji Zhang Xiao-Yan Li Jing-Hua Shi Jin-Hua Leng Jing-He Lang 2018Chinese Medical Journal2018,,5:14
6Epidemiological Features of Nontraumatic Spontaneous Subarachnoid Hemorrhage in China: A Nationwide Hospital-based Multicenter Study显示文摘JJan-Ping Song Wei Ni Yu-Xiang Gu Wei Zhu Liang Chen Bin Xu Bin Leng Yan-Long Tian Ying Mao 2017Chinese Medical Journal2017,,7:12
7Water regime-nitrogen fertilizer incorporation interaction:Field study on methane and nitrous oxide emissions from a rice agroecosystem in Harbin, China显示文摘Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH_4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N_2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH_4 emissions at low level(75 kg N/ha). But both CH_4 and N_2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields.Wenjun Dong Jia Guo Lijun Xu Zhifeng Song Jun Zhang Ao Tang Xijuan Zhang Chunxu Leng Youhong Liu Lianmin Wang Lizhi Wang Yang Yu Zhongliang Yang Yilei Yu Ying Meng Yongcai Lai 2018Journal of Environmental Sciences2018,30,2:12
8Association of biochar properties with changes in soil bacterial,fungal and fauna communities and nutrient cycling processes显示文摘Soil microorganisms play crucial roles in soil nutrient cycling,carbon sequestration,fertility maintenance and crop health and production.To date,the responses of microorganisms,such as microbial activity,diversity,community structure and nutrient cycling processes,to biochar addition have been widely reported.However,the relationships between soil microbial groups(bacteria,fungi and microscopic fauna)and biochar physicochemical properties have not been summarized.In this review,we conclude that biochar affects soil microbial growth,diversity and community compositions by directly provid-ing growth promoters for soil biota or indirectly changing soil basic properties.The porous structure,labile C,high pH and electrochemical properties of biochar play an important role in determining soil microbial abundance and communities,and their mediated N and P cycling processes,while the effects and underlying mechanisms vary with biochar types that are affected by pyrolysis temperature and feedstock type.Finally,we highlight some issues related to research methodology and subjects that are still poorly understood or controversial,and the perspectives for further research in microbial responses to biochar addition.Zhongmin Dai Xinquan Xiong Hang Zhu Haojie Xu Peng Leng Jihui Li CTang Jianming Xu 2021Biochar2021,3,3:12
9Menorrhagia and Uterine Volume Associated with Lower Urinary Tract Symptoms in Patients with Adenomyosis显示文摘Ting Li Xiao-Xuan Xu Yi Dai Jun-Ji Zhang Jing-He Lang Jin-Hua Leng 2017Chinese Medical Journal2017,,13:10
10Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity显示文摘Yan-qiu OU Wen bo ZHU Yan LI Peng-xin QIU Yi-jun HUANG Jun XIE Song-min HE Xiao-ke ZHENG Tian-dong LENG Dong XU Guang-mei YAN 2010Acta Pharmacologica Sinica2010,31,1:9
11The status of exploitation techniques of natural gas hydrate显示文摘Natural gas hydrate(NGH)has been widely considered as an alternative form of energy with huge potential,due to its tremendous reserves,cleanness and high energy density.Several countries involving Japan,Canada,India and China have launched national projects on the exploration and exploitation of gas hydrate resources.At the beginning of this century,an early trial production of hydrate resources was carried out in Mallik permafrost region,Canada.Japan has conducted the first field test from marine hydrates in 2013,followed by another trial in 2017.China also made its first trial production from marine hydrate sediments in 2017.Yet the low production efficiency,ice/hydrate regeneration,and sand problems are still commonly encountered;the worldwide progress is far before commercialization.Up to now,many gas production techniques have been proposed,and a few of them have been adopted in the field production tests.Nevertheless,hardly any method appears really promising;each of them shows limitations at certain conditions.Therefore,further efforts should be made on the economic efficiency as well as sustainability and environmental impacts.In this paper,the investigations on NGH exploitation techniques are comprehensively reviewed,involving depressurization,thermal stimulation,chemical inhibitor injection,CO2–CH4 exchange,their combinations,and some novel techniques.The behavior of each method and its further potential in the field test are discussed.The advantages and limitations of laboratory studies are also analyzed.The work could give some guidance in the future formulation of exploitation scheme and evaluation of gas production behavior from hydrate reservoirs.Lei Yang Yulong Liu Hanquan Zhang Bo Xiao Xianwei Guo Rupeng Wei Lei Xu Lingjie Sun Bin Yu Shudong Leng Yanghui Li 2019Chinese Journal of Chemical Engineering2019,27,9:9
12Tandem pumping architecture enabled high power random fiberlaser with near-diffraction-limited beam quality显示文摘In this contribution, we present the tandem pumping avenue leveraged performance scaling of random fiber laser to record 3 kW level with inherent temporal stability and near-diffraction-limited beam quality. The high power system employs a four-stage master oscillator power amplifier chain. The master oscillator is a half-opened cavity structured random distributed feedback fiber laser centered at 1080 nm and pumped by incoherent amplified spontaneous emission source. Narrowband random laser seed is selected by employing a spectral filtering module with a maximum output power of 1.08 W, full width at half maximum linewidth of 0.47 nm and spectral optical-signal-to-noise ratio of about 42 dB. As to the main amplification stage, for given 104 W pre-amplified random laser seed and 3.61 kW pump laser, an ultimate output power of 3.03 kW can be obtained,corresponding to an optical-to-optical conversion efficiency of 81.05%. Nearly single-transverse-mode amplified random laser can be achieved even at full power level for inherent high thermal modal instability threshold enabled by tandem pumping and inducing bending loss for high-order transverse-mode. Further performance scaling of this high power random laser system, such as power boosting, operation wavelength tuning and linewidth alteration, is the next goal.XU JiangMing YE Jun ZHOU Pu LENG JinYong XIAO Hu ZHANG HangWei WU Jian CHEN JinBao 2019Science China(Technological Sciences)2019,62,1:8
13Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species.Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li 2021Molecular Plant2021,14,6:8
14A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation.Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang 2021Engineering2021,7,7:7
15Sustainable Practice in Pavement Engineering through Value-Added Collective Recycling of Waste Plastic and Waste Tyre Rubber显示文摘Waste plastics,such as waste polyethylene terephthalate(PET)beverage bottles and waste rubber tyres are major municipal solid wastes,which may lead to various environmental problems if they are not appropriately recycled.In this study,the feasibility of collectively recycling the two types of waste into performance-increasing modifiers for asphalt pavements was analyzed.This study aimed to investigate the recycling mechanisms of waste PET-derived additives under the treatment of two amines,triethylenetetramine(TETA)and ethanolamine(EA),and characterize the performances of these additives in modifying rubberized bitumen,a bitumen modified by waste tyre rubber.To this end,infrared spectroscopy and thermal analyses were carried out on the two PET-derived additives(PET–TETA and PET–EA).In addition,infrared spectroscopy,viscosity,dynamic shear rheology,and multiple stress creep recovery tests were performed on the rubberized bitumen samples modified by the two PET-derived additives.We concluded that waste PET can be chemically upcycled into functional additives,which can increase the overall performance of the rubberized bitumen.The recycling method developed in this study not only helps alleviate the landfilling problems of both waste PET plastic and scrap tyres,but also turns these wastes into value-added new materials for building durable pavements.Xiong Xu Zhen Leng Jingting Lan Wei Wang Jiangmiao Yu Yawei Bai Anand Sreeram Jing Hu 2021Engineering2021,7,6:7
16Mechanism and kinetics study on removal of Iron from phosphoric acid by cation exchange resin显示文摘Iron element is one of the main impurities in wet-process phosphoric acid and it has a significant impact on the subsequent phosphorus chemical products. This paper studied the feasibility of using Sinco-430 cation exchange resin for iron removal from phosphoric acid. The specific surface area and the total exchange capacity of resin were 8.91 m2·g-1 and 5.18 mmol·g-1, respectively. The sorption mechanism was determined by FTIR and XPS and the results indicated that iron was combined with-SO3 H in resin. The removal process was studied as a function of temperature, H3 PO4 content and mass ratio between resin and solution. The unit mass of resin to remove iron was 0.058 g·g-1 resin when the operating parameters were T = 50 ℃, H3 PO4 content = 27.61 wt%and S/L = 0.1, respectively. Kinetics study demonstrated that pseudo-second-order reaction model fits this study best and the calculated activation energy of overall reaction is 29.10 kJ·mol-1. The overall reaction process was mainly controlled by pore diffusion.Xinke Leng Yanjun Zhong Dehua Xu Xinlong Wang Lin Yang 2019Chinese Journal of Chemical Engineering2019,27,5:7
17Analysis of pore system model and physical property of coal reservoir in the Qinshui Basin显示文摘The Qinshui Basin in China is a major area for exploration and development of high rank coalbed methane. Due to the high rank coal and complicated pore system, no substantial breakthrough in the exploration and development of coalbed methane has been made until now. Many systematic tests show that a pore system of coal reservoir has some features as follows: the porosity is relatively low; the pore system is dominated by micropores and transition pores; mesopores take the second place, and macropores are nearly absent, which is exceedingly adverse for production of coal-bed methane. However, testing data also revealed the differential development for the pore of high rank coal reservoirs in the Qinshui Basin, which necessarily led to the different physical properties of desorption, diffusion and permeability. This paper classifies the testing data using cluster analysis method and selects the typical samples to establish four pore system models, analyzes the differences of reservoir physical property, and provides a guidance for the exploration and development of coalbed methane in the Qinshui Basin.XU Hao ZHANG Shanghu LENG Xue TANG Dazhen WANG Mingshou 2005Chinese Science Bulletin2005,50,S1:5
18In-band pumping avenue based high power superfluorescent fiber source with record power and near-diffraction-limited beam quality显示文摘High power superfluorescent fiber sources(SFSs), which could find wide applications in many fields such as middle infrared laser generation, Raman fiber laser pumping and spectral beam combination, have experienced a flourishing time in recent years for its unique properties, such as short coherence length and high temporal stability. The challenge for performance scalability of powerful SFS mainly lies on the physical issues including parasitic laser oscillation and modal instability(MI). In this contribution, by employing in-band pumping avenue and high-order transverse-mode management, we explore a high power SFS with record power, near-diffraction-limited beam quality and spectral manipulation flexibility. An ultimate output power of 3.14 kW can be obtained with high temporal stability and a beam quality of M^2= 1.59 for the amplified light. Furthermore, the dynamics of spectral evolutions, including redshifting of central wavelength and unsymmetrical broadening in spectral wings, of the main amplifier with different seed linewidths are investigated contrastively. Benefiting from the unique high pump brightness and high MI threshold of in-band pumping scheme, the demonstrated system also manifests promising performance scaling potential.Jiangming Xu Jun Ye Hu Xiao Jinyong Leng Wei Liu Pu Zhou 2018High Power Laser Science and Engineering2018,6,3:5
19Retrospective analysis of interventional treatment of hepatic metastasis from gastroenteropancreatic neuroendocrine tumors显示文摘Objective: To analyze the angiography appearance of liver metastases from gastroenteropancreatic neuroendocrine tumors(GEP-NETs),and evaluate the clinical efficacy and prognostic factors of interventional treatment for hepatic metastases.Methods: Fifty GEP-NETs patients with hepatic metastases were treated from January 2012 to December 2016,and received transarterial embolization(TAE) in the hepatic tumor or hepatic arterial infusion chemotherapy(HAIC).All patients received 179 times of the intervention therapy in total.Results: Blood supplies were identified in the 50 cases with angiography,which showed that 35 cases had abundant vessels,while 15 cases had poor blood supply.Twenty-two cases were found either collateral blood supply,or portal vein invasion or arterial-portal vein fistula.The best curative efficacy was complete remission(CR)in 4 cases,partial remission(PR) in 28 cases and stable disease(SD) in 18 cases during the process of treatment.The angiography(P=0.047) and the frequency of intervention(P=0.037) showed significantly statistical difference with Kaplan-Meier analysis.The Cox analysis showed that more than 3 times of interventional therapy was an independent prognostic factor.Conclusions: Interventional treatment is safe and effective for GEP-NETs,and is beneficial to patients with main hepatic metastases after endocrine therapy.Peng Liu Xu Zhu Jie Li Ming Lu Jiahua Leng Ying Li Jiangyuan Yu 2017Chinese Journal of Cancer Research2017,29,6:4
20The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice显示文摘Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1(AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules.AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein(GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes.Deyong Ren Yuchun Rao Liwen Wu Qiankun Xu Zizhuang Li Haiping Yu Yu Zhang Yujia Leng Jiang Hu Li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian 2016Journal of Integrative Plant Biology2016,58,6:4
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