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| 1 | Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 层次调整多重生物功能的一些短 RNA,例如 tumorigenic 过程,煽动性的损害和房间 apoptosis。(ZEB1 ) 锌手指电子盒子有约束力的 homeobox 因素 1 是上皮间充质的转变(EMT ) 的一个关键调停人。它包括人的食道的有鳞房间的癌(ESCC ) 导致各种各样的癌症的恶意的前进。在这研究,我们发现 miR-128-3p 由使用 PCR 是在 ESCC 纸巾和房间的 downregulated。而且, miR-128-3p 的下面调整的表示被证明与 ESCC 病人的差的预后被联系并且可能被认为是一个独立预示的因素。然后,我们在 ESCC 房间检验了 miR-128-3p 的角色,并且发现 miR-128-3p 能在 vitro 压制房间迁居和侵略。而且, ZEB1 被证实是由酶记者试金的 miR-128-3p 的一个直接目标。营救实验证明 EMT 被 miR-128-3p 经由 ZEB1 的抑制调整。一起拿所有,我们断定 miR-128-3p 压制 EMT,经由 ZEB1 的转移,和 miR-128-3p 可以是在 ESCC 的一个批评调停人。 | Lili Zhao Rui Li Shanling Xu Yi Li Pei Zhao Wei Dong Zhenjun Liu Qian Zhao Bo Tan | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 21 |
| 2 | Simulation research on the influence of eroded primary key strata on dynamic strata pressure of shallow coal seams in gully terrain显示文摘In Huojitu Coal Mine of Shendong mining area, the dynamic strata pressure (DSP) accidents occurred when the working faces passed the gully terrain. Focusing on this problem, we used physical simulation experimental method to thoroughly study the influence of eroded overlying primary key strata (PKS) in the gully terrain on DSP of shallow coal seams in this paper. The result show that when mining activities took place in the uphill section of shallow coal seams in gully terrain and the PKS were eroded, the blocks could not form stable bond-beam structures since the horizontal force of PKS blocks in adjacent sloping surfaces were relatively small. The sliding instability of blocks caused rapid increase of the load on the sub-key strata (SKS) blocks, which resulted into coal slide and roof fall as well as sharp drop of active columns. This led to DSP phenomenon. When the PKS blocks were intact, there was no DSP phenomenon to enable blocks provide certain horizontal force to maintain stable bond-beam structure. The simulation results were verified by the mining practices of working face 21306 crossing the gully terrain in the Huojitu Coal Mine. | Zhang Zhiqiang Xu Jialin Zhu Weibing Shan Zhenjun | 2012 | International Journal of Mining Science and Technology2012，22，1： | 12 |
| 3 | Exploitation of Bi2O2Se/graphene van der Waals heterojunction for creating efficient photodetectors and short-channel field-effect transistors显示文摘The formation of heterojunction within solid-state devices enables them with eventually high performances,but provides a challenge for material synthesis and device fabrication because strict conditions such as lattice match are needed.Herein,we show a facile method to fabricate a van der Waals(vdW)heterojunction between two-dimensional(2D)bismuth oxyselenide(Bi2O2Se)and graphene,during which the graphene is directly transferred to the Bi2O2Se and served as a lowcontract-resistant electrode with small work function mismatch(~50 meV).As an optoelectronic device,the Bi2O2Se/graphene vdW heterojunction allows for the efficient sensing toward 1200-nm incident laser.Regarding the application of fieldeffect transistors(FETs),the short-channel(50 nm)sample can be synthesized by utilizing these two 2D materials(ie,channel:Bi2O2Se;drain/source terminal:graphene)and the n-type characteristic can be observed with the accordant field modulation.It is confirmed that we show a simple way to prepare the vdW heterojunction which is aiming to the high-performance applications among optoelectronics and FETs. | Congwei Tan Shipu Xu Zhenjun Tan Luzhao Sun Jinxiong Wu Tianran Li Hailin Peng | 2019 | InfoMat2019，1，3： | 8 |
| 4 | Multiscale modeling of mechanical behavior and failure mechanism of 3D angle-interlock woven aluminum composites subjected to warp/weft directional tension loading显示文摘The mechanical behavior and progressive damage mechanism of novel aluminum matrix composites reinforced with 3D angle-interlock woven carbon fibers were investigated using a multiscale modeling approach.The mechanical properties and failure of yarns were evaluated using a microscale model under different loading scenarios.On this basis,a mesoscale model was developed to analyze the tensile behavior and failure mechanism of the composites.The interfacial decohesion,matrix damage,and failure of fibers and yarns were incorporated into the microscopic and mesoscopic models.The stress–strain curves and fracture modes from simulation show good agreement with the experimental curves and fracture morphology.Local interface and matrix damage initiate first under warp directional tension.Thereafter,interfacial failure,weft yarn cracking,and matrix failure occur successively.Axial fracture of warp yarn,which displays a quasi-ductile fracture characteristic,dominates the ultimate composites failure.Under weft directional tension,interfacial failure and warp yarn rupture occur at the early and middle stages.Matrix failure and weft yarn fracture emerge simultaneously at the final stage,leading to the cata-strophic failure of composites.The weft directional strength and fracture strain are lower than the warp directional ones because of the lower weft density and the more serious brittle fracture of weft yarns. | Zhenjun WANG Siyuan YANG Shiping SUN Yingfeng ZHANG Changchun CAI Bowen XIONG Wei YANG Zhifeng XU Huan YU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 4 |
| 5 | Computer Simulation of Mechanical Properties of Nano-scale Cu/FeS Composite显示文摘The mechanical properties of nano-scale Cu/FeS composite were simulated by molecular dynamics (MD) simulation in this paper. Through the analysis on the stress-strain curves, the results of MD simulation were in good agreement with mechanisms of macroscopic deformation. When the size of particles was smaller than a certain value, the relationship between yield strength and size, which was different from the large size crystals abided by the contrary Hall-Petch relationship. Based on the discussion of nano-scale Cu/FeS composite, some interesting conclusions were obtained. For example, the 'S' type curves were discovered in stress-strain curves and the anisotropy of FeS was very evident when the exposures of reinforcing phase (FeS) were different and so on. The basic theories and calculations of the composite that contains nano-scale particles were discussed. At the same time, a new modeling building method of composites, which was close to actual experiences, were considered in this paper. | Zhenjun Hong Jingchao Chen Jing Feng Yeping Du Jie Yu Lijuan Zhang Shuzhen Wu Futai Xu | 2010 | Journal of Materials Science & Technology2010，26，4： | 2 |
| 6 | Robust Image Hashing via Random Gabor Filtering and DWT显示文摘Image hashing is a useful multimedia technology for many applications,such as image authentication,image retrieval,image copy detection and image forensics.In this paper,we propose a robust image hashing based on random Gabor filtering and discrete wavelet transform(DWT).Specifically,robust and secure image features are first extracted from the normalized image by Gabor filtering and a chaotic map called Skew tent map,and then are compressed via a single-level 2-D DWT.Image hash is finally obtained by concatenating DWT coefficients in the LL sub-band.Many experiments with open image datasets are carried out and the results illustrate that our hashing is robust,discriminative and secure.Receiver operating characteristic(ROC)curve comparisons show that our hashing is better than some popular image hashing algorithms in classification performance between robustness and discrimination. | Zhenjun Tang Man Ling Heng Yao Zhenxing Qian Xianquan Zhang Jilian Zhang Shijie Xu | 2018 | Computers, Materials & Continua2018，，5： | 2 |
| 7 | Spatial variations in the trophic status of Favia palauensis corals in the South China Sea:Insights into their different adaptabilities under contrasting environmental conditions显示文摘Scleractinian corals exhibit a dual trophic pattern of autotrophic photosynthesis and heterotrophic predation.However,whether corals can adjust their trophic status under contrasting environmental conditions remains unclear.In our study,70 scleractinian corals(Favia palauensis)were collected from Sanya and the Xisha and Nansha Islands in the South China Sea.We measured the zooxanthellae density(ZD)andδ^(13)C of zooxanthellae(δ^(13)C_(z))and host tissue(δ^(13)C_(h))and analyzed the difference betweenδ^(13)C_(h) andδ^(13)C_(z)(i.e.,△^(h-z)^(13)C).The relatively high ZD andδ^(13)C_(z) values in the samples from Sanya indicate that these corals might have higher photosynthetic rates and autotrophic abilities than those from Xisha and Nansha.In contrast,the relatively lowδ^(13)C_(h) and△^(h-z)^(13)C values in the samples from Xisha and Nansha suggest that these corals might have a higher heterotrophic ability than those from Sanya.In addition,we tested the coral tissue biomass and skeletalδ^(13)C(δ^(13)C_(s))in the samples from Sanya and examined their correlations with△^(h-z)^(13)C.The results showed a negative correlation,indicating that the more the organic material produced by the coral,the stronger its heterotrophic ability.Our results show that corals can adjust their trophic status under different environmental and physiological conditions,which is essential for increasing their adaptability to different environmental conditions. | Shendong XU Zhinan ZHANG Kefu YU Xueyong HUANG Hanji CHEN Zhenjun QIN Risheng LIANG | 2021 | Science China Earth Sciences2021，64，6： | 2 |
| 8 | Saving energy in the heat pump air conditioning system driven by gas engine 显示文摘 | Xu Zhenjun Yang Zhao | 2009 | Energy andBuildings2009，41，2： | 1 |
| 9 | Saving energy in the heat pump air conditioning system driven by gas engine 显示文摘 | Xu Zhenjun Yang Zhao | 2009 | Energy and Buildings2009，41，2： | 1 |
| 10 | Fusion of Infrared and Visible Images Based on Infrared Object Extraction显示文摘The ideal fused results of infrared and visible images,should contain the important infrared objects,and preserve the visible textural detail information as much as possible.The fused images are more consistent with human visual perception effect.For this purpose,a novel infrared and visible image fusion framework is proposed.Under the guidance of the model,the source images are decomposed into large-scale edge,small-scale textural detail and coarse-scale base level information.Among which,the large-scale edge information contains the main infrared features,on this basis,the infrared image is further segmented into the object,transition and background regions by OTSU multi-threshold segmentation algorithm.In the end,the fused weights for the decomposed sub-information are determined by the segmented results,so that,the infrared object information can be effectively injected into the fused image,and the important visible textural detail information can be preserved as much as possible in the fused image.Experimental results show that,the proposed method can not only highlight the infrared objects,but also preserve the visual information in the visible image as much as possible.The fused results are superior to the commonly used representative fusion methods,both in subjective perception and objective evaluation. | RONG Chuanzhen LIU Gaohang PING Zhuolin JIA Yongxing YUE Zhenjun XU Guanghui | 2021 | Chinese Journal of Electronics2021，30，2： | 1 |
| 11 | HWM: a hybrid workload migration mechanism of metadata server cluster in data center显示文摘 | Jian LU Huanqing DONG Junwei ZHANG Zhenjun LIU Lu XU | 2017 | Frontiers of Computer Science2017，11，1： | 1 |
| 12 | Development of a Widely Applicable and Simple Prognostic Score for Patients with Acute-on-chronic Liver Failure显示文摘Background and Aims:Acute-on-chronic liver failure(ACLF)tends to progress rapidly with high short-term mortality.We aimed to create a widely applicable,simple prognostic(WASP)score for ACLF patients.Methods:A retrospective cohort of ACLF cases recruited from three centers in China were divided into training and validation sets to develop the new score.A prospective longitudinal cohort was recruited for further validation.Results:A total of 541 cases were included in the training set,and seven independent ACLF prognostic factors were screened to construct a new quantitative WASP-ACLF table.In the validation set of 671 cases,WASP-ACLF showed better predictive ability for 28-day and 90-day mortality than the currently used prognostic scores at baseline,day 3,week 1,and week 2.The predictive efficacy and clinical validity of the model improved over time.Patients were assigned to low-,intermediate-,and high-risk groups by their WASP-ACLF scores.Compared with the other two groups,intermediate-risk patients had a more uncertain prognosis,with a 90-day mortality of 44.4–50.6%.Sequential assessments at weeks 1 and 2 found the 90-day mortality of intermediate-risk groups was<20%forpatients with a≥2 point decrease in WASP-ACLF and was up to 56%for patients with a≥2 points increase.Similar results were observed in prospective data.Conclusions:The new ACLF prognostic score was simple,widely applicable,and had good predictive efficacy.Continuous assessments and trend of change in WASP-ACLF need to be considered,especially for intermediate-risk patients. | Zhenjun Yu Yu Zhang Yuhan Li Feng Zhou Manman Xu Shaoli You Yu Chen Bing Zhu Ming Kong Fangjiao Song Shaojie Xin Zhongping Duan Tao Han China Network for Severe Liver Diseases | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 13 | Public health implications of Yersinia enterocolitica investigation:an ecological modeling and molecular epidemiology study显示文摘Background Yersinia enterocolitica has been sporadically recovered from animals,foods,and human clinical samples in various regions of Ningxia,China.However,the ecological and molecular characteristics of Y.enterocolitica,as well as public health concerns about infection in the Ningxia Hui Autonomous Region,remain unclear.This study aims to analyze the ecological and molecular epidemiological characteristics of Y.enterocolitis in order to inform the public health intervention strategies for the contains of related diseases.Methods A total of 270 samples were collected for isolation[animals(n=208),food(n=49),and patients(n=13)],then suspect colonies were isolated and identified by the API20E biochemical identification system,serological tests,biotyping tests,and 16S rRNA-PCR.Then,we used an ecological epidemiological approach combined with machine learning algorithms(general linear model,random forest model,and eXtreme Gradient Boosting)to explore the associations between ecological factors and the pathogenicity of Y.enterocolitis.Furthermore,average nucleotide identity(ANI)estimation,single nucleotide polymorphism(SNP),and core gene multilocus sequence typing(cgMLST)were applied to characterize the molecular profile of isolates based on whole genome sequencing.The statistical test used single-factor analysis,Chi-square tests,t-tests/ANOVA-tests,Wilcoxon rank-sum tests,and Kruskal–Wallis tests.Results A total of 270 isolates of Yersinia were identified from poultry and livestock(n=191),food(n=49),diarrhoea patients(n=13),rats(n=15),and hamsters(n=2).The detection rates of samples from different hosts were statistically different(χ^(2)=22.636,P<0.001).According to the relatedness clustering results,270 isolates were divided into 12 species,and Y.enterocolitica(n=187)is a predominated species.Pathogenic isolates made up 52.4%(98/187),while non-pathogenic isolates made up 47.6%(89/187).Temperature and precipitation were strongly associated with the pathogenicity of the isolates(P<0.001).The random forest(RF)prediction model showed the best performance.The prediction result shows a high risk of pathogenicity Y.enterocolitica was located in the northern,northwestern,and southern of the Ningxia Hui Autonomous Region.The Y.enterocolitica isolates were classified into 54 sequence types(STs)and 125 cgMLST types(CTs),with 4/O:3 being the dominant bioserotype in Ningxia.The dominant STs and dominant CTs of pathogenic isolates in Ningxia were ST429 and HC100_2571,respectively.Conclusions The data indicated geographical variations in the distribution of STs and CTs of Y.enterocolitica isolates in Ningxia.Our work offered the first evidence that the pathogenicity of isolates was directly related to fluctuations in temperature and precipitation of the environment.CgMLST typing strategies showed that the isolates were transmitted to the population via pigs and food.Therefore,strengthening health surveillance on pig farms in high-risk areas and focusing on testing food of pig origin are optional strategies to prevent disease outbreaks. | Yuan Yue Jinxin Zheng Mei Sheng Xiang Liu Qiong Hao Shunxian Zhang Shuai Xu Zhiguo Liu Xuexin Hou Huaiqi Jing Yang Liu Xuezhang Zhou Zhenjun Li | 2023 | Infectious Diseases of Poverty2023，12，2： | 1 |
| 14 | Energy performance and consumption for biogas heat pump air conditioner显示文摘 | Xu Zhenjun Wu Huaizhi Wu Meiling | 2010 | Energy2010，35，12： | 1 |
| 15 | Up-regulation of Thioredoxin 1 by aerobic exercise training attenuates endoplasmic reticulum stress and cardiomyocyte apoptosis following myocardial infarction显示文摘Exercise training(ET)has been reported to reduce oxidative stress and endoplasmic reticulum(ER)stress in the heart following myocardial infarction(MI).Thioredoxin 1(Trx1)plays a protective role in the infarcted heart.However,whether Trx1 regulates ER stress of the infarcted heart and participates in ET-induced cardiac protective effects are still not well known.In this work,H9c2 cells were treated with hydrogen peroxide(H_(2)O_(2))and recombinant human Trx1 protein(TXN),meanwhile,adult male C57B6L mice were used to establish the MI model,and subjected to a six-week aerobic exercise training(AET)with or without the injection of Trx1 inhibitor,PX-12.Results showed that H_(2)O_(2)significantly increased reactive oxygen species(ROS)level and the expression of TXNIP,CHOP and cleaved caspase12,induced cell apoptosis;TXN intervention reduced ROS level and the expression of CHOP and cleaved caspase12,and inhibited cell apoptosis in H_(2)O_(2)-treated H9c2 cells.Furthermore,AET up-regulated endogenous Trx1 protein expression and down-regulated TXNIP expression,restored ROS level and the expression of ER stress-related proteins,inhibited cell apoptosis as well as improved cardiac fibrosis and heart function in mice after MI.PX-12 partly inhibited the AET-induced beneficial effects in the infarcted heart.This study demonstrates that Trx1 attenuates ER stress-induced cell apoptosis,and AET reduces MI-induced ROS overproduction,ER stress and cell apoptosis partly through up-regulating of Trx1 expression in mice with MI. | Mengxin Cai Zujie Xu Wenyan Bo Fangnan Wu Wenpu Qi Zhenjun Tian | 2020 | Sports Medicine and Health Science2020，2，3： | 1 |
| 16 | DGConv: A Novel Convolutional Neural Network Approach for Weld Seam Depth Image Detection显示文摘We propose a novel image segmentation algorithm to tackle the challenge of limited recognition and segmentation performance in identifying welding seam images during robotic intelligent operations.Initially,to enhance the capability of deep neural networks in extracting geometric attributes from depth images,we developed a novel deep geometric convolution operator(DGConv).DGConv is utilized to construct a deep local geometric feature extraction module,facilitating a more comprehensive exploration of the intrinsic geometric information within depth images.Secondly,we integrate the newly proposed deep geometric feature module with the Fully Convolutional Network(FCN8)to establish a high-performance deep neural network algorithm tailored for depth image segmentation.Concurrently,we enhance the FCN8 detection head by separating the segmentation and classification processes.This enhancement significantly boosts the network’s overall detection capability.Thirdly,for a comprehensive assessment of our proposed algorithm and its applicability in real-world industrial settings,we curated a line-scan image dataset featuring weld seams.This dataset,named the Standardized Linear Depth Profile(SLDP)dataset,was collected from actual industrial sites where autonomous robots are in operation.Ultimately,we conducted experiments utilizing the SLDP dataset,achieving an average accuracy of 92.7%.Our proposed approach exhibited a remarkable performance improvement over the prior method on the identical dataset.Moreover,we have successfully deployed the proposed algorithm in genuine industrial environments,fulfilling the prerequisites of unmanned robot operations. | Pengchao Li Fang Xu Jintao Wang Haibing Guo Mingmin Liu Zhenjun Du | 2024 | Computers, Materials & Continua2024，78，2： | 0 |
| 17 | Review and prospect of maintenance technology for traction system of high-speed train显示文摘In the past few decades,high-speed trains have witnessed tremendous and vigorous development with the appearance of the oil crisis and industrialization,which became a significant trend in the transportation industry the world over.With the increase of high-speed railway mileage,the amount of high-speed train has grown sharply,the service life of the trains has increased gradually and the components of the vehicle traction system have become worn and aged as a result.Therefore,advanced maintenance technology and its application are key factors to reduce maintenance cost,human resource input and ensure safe,stable and reliable operation of trains.This paper summarizes and discusses the development,application mode,maintenance management and maintenance technology of high-speed railways of the major countries in the world,especially discusses the condition-based maintenance and the key technology of the traction electrical system,and offers the prospect of research direction and the development of traction maintenance technology. | Shaolong Xu Chunyang Chen Zhenjun Lin Xiao Zhang Jisheng Dai Liangjie Liu | 2021 | Transportation Safety and Environment2021，3，3： | 0 |
| 18 | Introduction to special issue on high-efficiency and intelligent train traction system显示文摘The development of train technology is mainly reflected in the development of the traction system.The train traction system includes several key pieces of equipment,such as the pantograph,traction transformer,traction converter and traction motor.It determines the performance of train start,acceleration,constant speed operation and braking. | Shaolong Xu Chunyang Chen Zhenjun Lin Xiao Zhang | 2022 | Transportation Safety and Environment2022，4，1： | 0 |
| 19 | Eco-physiological mechanisms of Caragana korshinskii Kom. adaptation to extreme drought stress: Leaf abscission and maintaining stem chloroplast integrity显示文摘In order to study the eco-physiological mechanisms of C. korshinskii adaptation to extreme drought stress, we investigated the variations of water content in soil, leaves, and stems, the chlorophyll a and b and the carotenoid content in leaves and stems, as well as changes of chloroplast ultrastructure in 2-year-old C. korshinskii specimens during a progressive soil drought process (by ceasing watering until all leaves were shed) and a subsequent rehydration process. During the dehydration process, the chlorophyll a and b and carotenoid contents in the leaves decreased, as did the carotenoid content in the stems. During the 4-day rehydration process, the chlorophyll a and b and carotenoid contents in the leaves and stems increased and gradually returned to normal levels. During ongoing drought stress, chloroplasts in the leaves broke away from cell walls and appeared in the center of cells. Under severe drought stress, the mesophyll ultrastructure and chloroplast configuration in leaves were irreversibly disturbed, as mani- fested by the inner and outer membranes being destroyed; the thylakoid system disintegrated, the starch grain disappeared, and parts of cell tissue were dismantled into debris. However, the mesophyll ultrastructure and chloroplast configuration in the stems remained complete. This indicates that C. korshinskii utilizes leaf abscission to reduce the surface area to avoid damage from extreme drought stress, and maintains chloroplast integrity and a considerable amount of chlorophyll to enable a rapid recovery of photosynthesis under the rehydration process. | DangHui Xu XiangWen Fang ZhenJun Bin Gang Wang PeiXi Su | 2012 | Research in Cold and Arid Regions2012，4，6： | 0 |
| 20 | The loop effects on the chargino decays _1~±→_1~0ff' in the MSSM显示文摘The lighter chargino three body decays_1~±→_1~0ff' via the W boson and the charged Higgs boson H± were studied in the R-parity conserved Minimal Supersymmetric Standard Model(MSSM).We treat _1~± decays as production and decay of W± and H±:i.e.,_1~±→_1~0W±(H±)→_1~0ff'.Both higgsinolike and wino-like^v1decays were well investigated.These decays are calculated at 1-loop level and the loop corrections are found to be less than three percent.The signal of the charged Higgs H production from^v1decays is discussed.It will offer important information about the chargino and neutralino sector,as well as the charged Higgs sector in the MSSM. | Qingjun Xu Shusheng Xu Zhenjun Xiao Ligang Jin | 2014 | Chinese Science Bulletin2014，59，17： | 0 |
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