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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression显示文摘MicroRNAs(miRNAs) are small,noncoding RNAs which can often act as an oncogene or a tumor suppressor.Several miRNAs are associated with the development of hepatocellular carcinoma(HCC).We demonstrated that miR-125b significantly suppresses HCC cell proliferation and promotes apoptosis by inhibiting the gene expression of the anti-apoptotic protein,Bcl-2.Bioinformatic analysis indicated that the 3'UTR of Bcl-2 has binding sites for miR-125b.Luciferase reporter assay confirmed the ability of miR-125b to dramatically suppress Bcl-2 transcription,suggesting that Bcl-2 is a target gene for miR-125b.We concluded that miR-125b acts as a tumor suppressor in hepatic tumor development by targeting Bcl-2 and inducing cancer cell apoptosis. | Aihua Zhao Quan Zeng Xiaoyan Xie Junnian Zhou Wen Yue Yali Li Xuetao Pei | 2012 | Journal of Genetics and Genomics2012，39，1： | 30 |
| 3 | Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas显示文摘Epstein-Barr virus(EBV)is associated with nasopharyngeal carcinoma(NPC)tumorigenesis.However,the mechanism(s)connecting EBV infection and NPC remain unclear.Recently,a new class of EBV microRNAs(miRNAs)has been described.To determine how EBV miRNAs control the expression of host genes,and to understand their potential role in NPC tumorigenesis,we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues.We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC.Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC.A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated,suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis.An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis. | ZENG ZhaoYang HUANG HongBin HUANG LiLi SUN MengXi YAN QiJia SONG YaLi WEI Fang BO Hao GONG ZhaoJian ZENG Yong LI Qiao ZHANG WenLing LI XiaYu XIANG Bo LI XiaoLing LI Yong XIONG Wei LI GuiYuan | 2014 | Science China(Life Sciences)2014，57，3： | 10 |
| 4 | ON THE EXISTENCE OF FIXED POINTS FOR LIPSCHITZIAN SEMIGROUPS IN BANACH SPACES显示文摘Let C be a nonempty bounded subset of a p-uniformly convex Banach space X, and T = {T(t): t S} be a Lipschitzian semigroup on C with lim inf |||T(t)||| < Np, where Np is n→ t s the normal structure coefficient of X. Suppose also there exists a nonempty bounded closed convex subset E of C with the following properties: (P1)x: E implies ωω(χ) C E; (P2)T is asymptotically regular on E. The authors prove that there exists a z E such that T(s)z = z for all s S. Fruther, under the similar condition, the existence of fixed points of Lipschitzian semigroups in a uniformly convex Banach space is discussed. | ZENG LUCHUAN, YANG YALI Department of Matematics, Shanghai Normal University, Shanghai 200234, China. | 2001 | Chinese Annals of Mathematics,Series B2001，22，3： | 1 |
| 5 | Denaturing gradient gel electrophoresis (DGGE) analysis of bacterial community composition in deep-sea sediments of the South China Sea显示文摘 | Xintian Lai Xiaofan Zeng Shu Fang Yali Huang Lixiang Cao Shining Zhou | 2006 | World Journal of Microbiology and Biotechnology2006，，12： | 1 |
| 6 | Labyrinth maze-like long travel-reduction of sulfur and polysulfides in micropores of a spherical honeycomb carbon to greatly confine shuttle effects in lithium-sulfur batteries显示文摘Polysulfide absorption in a micropore-rich structure has been reported to be capable of efficiently confining the shuttle effect for high-performance lithium-sulfur(Li–S)batteries.Here,a labyrinth maze-like spherical honeycomb-like carbon with micropore-rich structure was synthesized,which is employed as a template host material of sulfur to study the shuttle effects.The results strongly confirm that a diffusion controlled process rather than an absorption resulted surface-controlled process occurs in an even micropore-rich cathode but still greatly inhibits the shuttle effect.Thus,the battery achieves a high initial discharge specific capacity of 1120 mAh g1 at 0.25 C and super cycling stability for 1635 cycles with only 0.035%capacity decay per cycle with 100%Coulombic efficiency.We would like to propose a new mechanism for shuttle effect inhibition in micropores.In terms of the diffusion control process in microporous paths of a labyrinth maze structure,polysulfides experience a long travel to realize continuous reductions of sulfur and polysulfides until formation of the final solid product.This efficiently prevents the polysulfides escaping to electrolyte.The labyrinth maze-like honeycomb structure also offers fast electron transfer and enhanced mass transport as well as robust mechanical strength retaining intact structure for long cycle life.This work sheds lights on new fundamental insights behind the shuttle effects with universal significance while demonstrating prominent merits of a robust labyrinth maze-like structure in high performance cathode for high-performance Li–S batteries. | Yanyan Chang Jie Chen Zhuo Zou Juan Li Chao Wu Yali Jiang Yue Chen Qingxin Zeng Xiaoshui Wu Wei Sun Chang Ming Li | 2022 | Materials Reports(Energy)2022，2，4： | 1 |
| 7 | Role of epimorphin in bile duct formation of rat liver epithelial stem‐like cells: Involvement of small G protein RhoA and C/EBPβ显示文摘 | Yali Jia Hailei Yao Junnian Zhou Lin Chen Quan Zeng Hongfeng Yuan Lei Shi Xue Nan Yunfang Wang Wen Yue Xuetao Pei | 2011 | J Cell Physiol2011，，11： | 1 |
| 8 | Alternative moving window factor analysis for comparison analysis between complex chromatographic data显示文摘 | ZENG Zhongda LIANG Yizeng WANG Yali | 2006 | J Chromatogr2006，1107，12： | 1 |
| 9 | Alternative moving window factor analysis for comparison analysis between complex chromatographic data 显示文摘 | Zeng Zhongda Liang Yizeng Wang Yali | 2006 | J Chromatogr A2006，1107，： | 1 |
| 10 | Immunometabolism and potential targets in severe COVID-19 peripheral immune responses显示文摘In a recent single cell transcriptomic investigation of the peripheral immune responses of the patients with severe COVID-19[1],no substantial expression of pro-inflammatory cytokines has been identified in the peripheral monocytes and lymphocytes,while these peripheral immune cells exhibit phenotypes of heterogeneously expressed interferon-stimulated genes in certain COVID-19 patients.These genes may contribute to the inhibitory response to the viral entry,translation,replication and egress.Questions remain regarding why the peripheral cytokine production is constrained,what additional roles these peripheral immune cells may play in COVID-19 pathophysiology,and which potential targets can be explored for facilitating COVID-19 therapeutics. | Shanshan Wang Xian Zeng Yali Wang Yuzong Chen Chaoxin Wang Dongzhi Zhuoma Fengying Zhang Yufen Zhao | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 11 | Risk factors for anastomotic leakage following anterior resection for colorectal cancer: the effect of epidural analgesia on occurrence显示文摘 | Renchun Lai Yali Lu Qiuli Li Jin Guo Gong Chen Weian Zeng | 2013 | International Journal of Colorectal Disease2013，，4： | 1 |
| 12 | Super-assembly of integrated gold magnetic assay with loopmediated isothermal amplification for point-of-care testing显示文摘With the increasing global threat of various diseases and infections,it is essential to develop a fast,low-cost,and easy-to-use point-of-care testing(POCT)system for inspections at all levels of medical institutions and self-examination at home.In this work,gold magnetic nanoparticles(GMNPs)are used as the key material,and a rapid visual detection method is designed through integrating loop-mediated isothermal amplification(LAMP)and lateral flow assay(LFA)biosensor for detecting a variety of analytes which includes whole blood,buccal swabs,and DNA.It is worth to note that the proposed method does not need DNA extraction.Furthermore,uracil DNA glycosylase(UDG)is employed to eliminate carrier contamination for preventing false positive results.The whole detection process can be finished within 25 min.The accuracy of detection is measured by assessing the polymorphisms of the methylenetetrahydrofolate reductase(MTHFR)C677T.The detection limit of the newly developed extraction-free detection system for MTHFR C677T is 0.16 ng/μL.A preliminary clinical study of the proposed method is carried out by analyzing 600 clinical samples(including 200 whole blood samples,100 buccal swabs,and 300 genomic DNA samples).The results indicate that the proposed method is 100%consistent with the sequencing results which provides a new choice for POCT and shows a broad application prospect in all levels of medical clinics and at home. | Jianping Liang Jie Zeng Xiaojuan Huang Tengteng Zhu Yonglong Gong Chen Dong Xiangrong Wang Lingzhi Zhao Lei Xie Kang Liang Qiongxiang Tan Yali Cui Biao Kong Wenli Hui | 2023 | Nano Research2023，16，1： | 0 |
| 13 | Study on the Quality Characteristics of Gas Field Water in Eastern Sichuan显示文摘Gas field water is the formation water produced together with natural gas in the process of natural gas exploitation.The gas field water treated is difficult to reach the standard due to its wide sources,numerous types and complex composition.In addition,it can pollute soil,surface water and groundwater.In this study,the quality and pollution characteristics of gas field water in eastern Sichuan were studied by conventional water quality determination and GC-MS.The results show that the main components of gas field water in eastern Sichuan were chloride,COD Cr,SS,anionic surfactant,sulfide and other substances.The gas field water could be divided into two types according to the characteristics of water quality,of which one had high mineralization and high organic compounds,and the other had high sulfur and high organic compounds.There were 17 kinds of organic pollutants in the gas field water,mainly including alkanes,alcohols,esters and a small amount of acids. | Zeng YUAN Yi ZHANG Kaiyang TAN Na LI Bangyun SHU Deshun GAN Jun LU Yali LI | 2020 | Meteorological and Environmental Research2020，11，5： | 0 |
| 14 | Anisotropic Fermat’s principle for controlling hyperbolic van der Waals polaritons显示文摘Transformation optics(TO)facilitates flexible designs of spatial modulation of optical materials via coordinate transformations,thus,enabling on-demand manipulations of electromagnetic waves.However,the application of TO theory in control of hyperbolic waves remains elusive due to the spatial metric signature transition from(+,+)to(−,+)of a two-dimensional hyperbolic geometry.Here,we proposed a distinct Pythagorean theorem,which leads to establishing an anisotropic Fermat’s principle.It helps to construct anisotropic geometries and is a powerful tool for manipulating hyperbolic waves at the nanoscale and polaritons.Making use of absolute instruments,the excellent collimating and focusing behaviors of naturally in-plane hyperbolic polaritons in van der Waals��α–MoO_(3)layers are demonstrated,which opens up a new way for polaritons manipulation. | SICEN TAO TAO HOU YALI ZENG GUANGWEI HU ZIXUN GE JUNKE LIAO SHAN ZHU TAN ZHANG CHENG-WEI QIU HUANYANG CHEN | 2022 | Photonics Research2022，10，10： | 0 |
| 15 | Effect and mechanism of ferulic acid inclusion complexes on tyramine production by Enterobacter hormaechei MW386398 in smoked horsemeat sausages显示文摘Ferulic acid inclusion complexes(FA-HP-β-CD)effects on tyramine accumulation and gene expression of Enterobacter hormaechei MW386398 in traditional smoked horsemeat sausages were studied.Reverse transcription-quantitative polymerase chain reaction(RT-qPCR)was used to identify the expression of tyrosine decarboxylase(TDC)clusters in the tyramine producing pathway.In addition,relevant parameters such as microbial growth,moisture content,pH,and tyramine accumulation in pure cultures and during fermentation of smoked horsemeat sausages were evaluated.Ferulic acid(FA)and FA-HP-β-CD inclusion complexes both significantly decreased tyramine accumulation,as well as significantly inhibited tyrosine decarboxylase(tdcA)and tyrosine/tyramine antiporter(tyrP)genes expression(p<0.05).Furthermore,FA and FA-HP-β-CD inclusion complexes both reduced the number of Enterobacteriaceae in smoked horsemeat sausages,but did not alter the main microbiota.However,FA-HP-β-CD inclusion complexes exhibited stronger ability in hindering TDC related gene expression,reducing tyramine accumulation and antibacterial properties.These results indicate that FA-HP-β-CD inclusion complexes are able to reduce tyramine accumulation in smoked horsemeat sausages by inhibiting Enterobacteriaceae growth and gene expression. | Yali Huang Honghong Yu Shiling Lu Liangjun Zou Zonggui Tang Tao Zeng Juan Tang | 2022 | Food Bioscience2022，46，2： | 0 |
| 16 | Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer显示文摘Background:Nuclear Yes1-associated transcriptional regulator(YAP1)promotes tumor progression.However,the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear.Our research aimed to explore the biological function of cytoplasmic YAP1 in breast cancer cells and the possibility of cytoplasmic YAP1 as a predictive marker of breast cancer survival.Methods:We constructed cell mutant models,including NLS-YAP15SA(nuclear localized),YAP1S94A(incapable of binding to the TEA domain transcription factor family)and YAP1S127D(cytoplasmic localized),and used Cell Counting Kit-8(CCK-8)assays,5-ethynyl-2’-deoxyuridine(EdU)incorporation assays,and Western blotting(WB)analysis to detect cell proliferation and apoptosis.The specific mechanism of cytoplasmic YAP1-mediated endosomal sorting complexes required for transport III(ESCRT-III)assembly was studied by co-immunoprecipitation,immunofluorescence staining,and WB analysis.Epigallocatechin gallate(EGCG)was used to simulate YAP1 retention in the cytoplasm in in vitro and in vivo experiments to study the function of cytoplasmic YAP1.YAP1 binding to NEDD4-like E3 ubiquitin protein ligase(NEDD4L)was identified using mass spectrometry and was verified in vitro.Breast tissue microarrays were used to analyze the relationship between cytoplasmic YAP1 expression and the survival of breast cancer patients.Results:YAP1 was mainly expressed in the cytoplasm in breast cancer cells.Cytoplasmic YAP1 promoted autophagic death of breast cancer cells.Cytoplasmic YAP1 bound to the ESCRT-III complex subunits charged multivesicular body protein 2B(CHMP2B)and vacuolar protein sorting 4 homolog B(VPS4B),promoting assembly of CHMP2B-VPS4B and activating autophagosome formation.EGCG retained YAP1 in the cytoplasm,promoting the assembly of CHMP2B-VPS4B to promote autophagic death of breast cancer cells.YAP1 bound to NEDD4L,and NEDD4L mediated ubiquitination and degradation of YAP1.Breast tissue microarrays revealed that high levels of cytoplasmic YAP1 were beneficial to the survival of breast cancer patients.Conclusions:Cytoplasmic YAP1 mediated autophagic death of breast cancer cells by promoting assembly of the ESCRT-III complex;furthermore,we established a new breast cancer survival prediction model based on cytoplasmic YAP1 expression. | Yan Guo Yuqing Cui Yangyang Li Xiaoying Jin Dandan Wang Mengxia Lei Fengzhi Chen Yali Liu Jinwen Xu Guanyu Yao Guangchun Zeng Xuesong Chen | 2023 | Cancer Communications2023，43，5： | 0 |
| 17 | Photonic crystal slabs with maximal chiroptical response empowered by bound states in the continuum显示文摘To enhance the strength of chiral light–matter interaction for practical applications,the chirality and quality factors(Q-factors)of current methods need to be strengthened simultaneously.Here,we propose a design of photonic crystal slabs(Ph Cs)supporting chiral bound states in the continuum(BICs)of transverse electric(TE)and transverse magnetic(TM)modes,exhibiting maximal chiroptical responses with high Q-factors and near-unity circular dichroism(CD=0.98).Different from the past,the Ph Cs we employed only have reduced in-plane symmetry and can support simultaneously chiral quasi-BICs(q-BICs)of TE and TM mode with two-dimensional ultra-strong external and internal chirality.Based on the temporal coupled-mode theory,two analytical expressions of CD of chiral q-BICs response are revealed,which are consistent with the simulation results.Furthermore,we elucidate these results within the charge-current multipole expansion framework and demonstrate that the co-excitation of higher-order multipole electric/magnetic modes is responsible for near-perfect CD.Our results may provide more flexible opportunities for various applications requiring high Q-factors and chirality control,such as chiral lasing,chiral sensing,and enantiomer separation. | QILIN DUAN YALI ZENG YUHANG YIN JINYING XU ZHINING CHEN ZHANLEI HAO HUANYANG CHEN YINENG LIU | 2023 | Photonics Research2023，11，11： | 0 |
| 18 | A self-power photodetector based on controlled growth of single crystal MAPbBr_(3)/WO_(3) heterojunction显示文摘Compared with polycrystalline films, perovskite single crystal is considered as a promising photoelectric material due to its unique advantages in quantum efficiency and carrier diffusion length. In this work, the micron-thickness MAPbBr_(3) single crystal was prepared through a highly repeatable process based on the crystal seed dissolution-growth method. A heterojunction of MAPbBr_(3)/WO_(3) single crystal was realized through a simple thermal evaporation process, and the integrated C/MAPbBr_(3)/WO_(3)/C device demonstrated self-powered characteristics and high photoelectric performance, which showed good responsivity of about 111 mA/W, detectivity of 9.64×10^(11) Jones and fast response speed(0.11/0.56 ms). Meanwhile, the device exhibited good rectification performance(ratio of 125 at ±2 V) and reduced dark current due to the built-in electric field formed in the heterojunction. This study provides a facile, flexible, and highly repeatable method for the preparation of high-performance photodetectors based on MAPbBr_(3) single crystals with micrometer thickness. | YAO JianFeng ZHANG Hu LU JunZheng YANG LiangPan LIU DuanWangDe HU YaLi ZENG Wei GUI PengBin CHEN ZhiLiang REN XinGang | 2023 | Science China(Technological Sciences)2023，66，9： | 0 |
| 19 | The synthesis and properties study of 6,13-diphenylpentacene显示文摘6,13-diphenylpentacene(DPP) was synthesized by 6,13-pentacenequinone and the Grignard reagent with the SnCl2/HCl as the reducing agent. It was detected by 1H NMR, infrared spectra, X-ray diffraction (XRD), UV-visible spectra and fluorescence spectra. Substitution with phenyl at the C-6 and C-13 posi- tions of pentacene leads to phenomenal enhancement in solubility and a little enhancement in photooxidative stability. XRD results showed that the pattern of 6,13-diphenylpentacene was different from the patterns of pentacene and 6,13-pentacenequinone. UV-Visible spectra showed that the λmax of DPP in HCCl3 was 600 nm. The fluorescence spectra showed that DPP emitted purple (430 nm) and red (612 nm) when excited by UV, while only emitted red when excited by visible light. But it is still sus- ceptible to photooxidation. The photooxidation product of DPP was also studied. | FU YaLi ZHANG JingChang ZENG Ting HUANG Zhong CAO WeiLiang | 2008 | Chinese Science Bulletin2008，53，17： | 0 |
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