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| 1 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 2 | MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions显示文摘Pancreatic ductal adenocarcinoma(PDAC) is the 4^(th) deadliest cancer in the United States, due to its aggressive nature, late detection, and resistance to chemotherapy. The majority of PDAC develops from 3 precursor lesions, pancreatic intraepithelial lesions(PanIN), intraductual papillary mucinous neoplasm(IPMN), and mucinous cystic neoplasm. Early detection and surgical resection can increase PDAC 5-year survival rate from 6% for Stage Ⅳ to 50% for Stage Ⅰ. To date, there are no reliable biomarkers that can detect PDAC. MicroRNAs(miRNA) are small noncoding RNAs(18-25 nucleotides) that regulate gene expression by affecting translation of messenger RNA(mRNA). A large body of evidence suggests that miRNAs are dysregulated in various types of cancers. MiRNA has been profiled as a potential biomarker in pancreatic tumor tissue, blood, cyst fluid, stool, and saliva. Four mi RNA biomarkers(miR-21, miR-155, miR-196, and miR-210) have been consistently dysregulated in PDAC. MiR-21, miR-155, and miR-196 have also been dysregulated in IPMN and PanIN lesions suggesting their use as early biomarkers of this disease. In this review, we explore current knowledge of miRNA sampling, miR NA dysregulation in PDAC and its precursor lesions, and advances that have been made in using miRNA as a biomarker for PDAC and its precursor lesions. | yasmin g hernandez aimee l lucas | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 6 |
| 3 | HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro显示文摘瞄准:与丙肝的长期的复制建立一个房间文化系统病毒(HCV ) 染色体和病毒的抗原的表示在试管内。方法:HepG2 房间线被孵化与长期的丙肝从一个病人与浆液为它的危险性测试到 HCV。房间和上层清液在文化期间在各种各样的时间点被收获。文化上层清液为它感染天真的房间的能力被测试。存在减(反感觉) 在房间的核心和 E1 抗原的 RNA 海滨,和察觉被 RT-PCR 和免疫学的技术(流动血细胞计数和西方的污点) 分别地检验。结果:细胞内部的 HCV RNA 首先在 d 上被检测 3 在感染以后然后能一致地在至少三个月的一个时期上在房间和上层清液被检测。新鲜房间能从有教养的感染的房间感染上层清液。流动 cytometric 分析证明表面和在房子里使用的细胞内部的 HCV 抗原表示使 polyclonal 成为了抗体(反核心,和 anti-E1 ) 。西方的污点分析证明在分子量的产生免疫性的肽的簇的表示在一个月内在 31 和 45 kDa 之间延长了感染的房间的旧文化而这簇在 uninfected HepG2 房间是无法发现的。结论:HepG2 房间线产生 HCV 感染而且支持它的复制在试管内不仅。HCV 结构的蛋白质的表示能在感染的 HepG2 房间被检测。这些房间也能够流病毒的粒子进接着对 uninfected 房间变得传染的培养基。 | Mostafa K El-Awady Ashraf A Tabll Yasmine S El-Abd Mahmoud M Bahgat Hussein A Shoeb Samar S Youssef Noha G Bader El Din El-Rashdy M Redwan Maha El-Demellawy Moataza H Omran Wael T El-Garf Said A Goueli | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 4 | Comparing 15N-labelling techniques for enriching above and below-ground components of the plant-soil system显示文摘 | Yasmin K Kadisch G Baggs E M | 2006 | Soil Biology and Biochemistry2006，38，： | 1 |
| 5 | Long-term outcome of skull base surgery with microvascular Reconstruction for malignant disease显示文摘 | Reza N Yasmin I Christopher G | 2006 | Plast Reconstr Surg2006，118，5： | 1 |
| 6 | Can procalcitonin be used for the diagnosis and follow-up of postoperative complications after fracture surgery? 显示文摘 | Yasmin D Bulut G Yildiz M | 2006 | Acta Orthop Traumatol Turc2006，40，1： | 1 |
| 7 | Comparing ^15N-labelling techniques for enriching above and below-ground components of the plant-soil system显示文摘 | Yasmin K Cadisch G Baggs E M | 2006 | Soil Biology and Biochemistry2006，38，： | 1 |
| 8 | Development of a fast analytical method for the determination of sudan dyes in chili-and currycontaining foodstuffs by high-performance liquid chromatography-photodiode array detection显示文摘 | VANESSA C YASMINE G GOEDELE M | 2006 | J Agric Food Chem2006，54，3： | 1 |
| 9 | Long-term outcome of skull base surgery with microvascular reconstruction for malignant disease显示文摘 | REZA N YASMIN I CHRISTOPHER G | 2006 | Plast Reconstr Surg2006，118，： | 1 |
| 10 | Development of a Fast Analytical Method for the Determination of Sudan Dyes in Chilli an Curry-Containing Foodstuffs by High-Performance Liquid Chromatography-Photodiode Array Detection显示文摘 | Vanessa C Yasmine G Goedele M | | 0，，01： | 1 |
| 11 | development of a fast analytical method for the detenninalion of sudan dyes in chili- and curry-containing foodstuffs by high-performance liquid chromatography photodiode array detection显示文摘 | CORMET V YASMINE G GOEDELE M | 2006 | J Agric Food Chem2006，54，： | 1 |
| 12 | Development of a fast analytical method for the determination of sudan dyes in chili and curry-containing foodstuffs by high performance liquid chromatography-photodiode array detection 显示文摘 | Vanessa C Yasmine G Goedele M | 2006 | Agri cult Food Chem2006，54，： | 1 |
| 13 | Provable security of a pairing - free one -pass authenticated key establishment protocol for wire- less sensor networks显示文摘 | R Yasmin E Ritter G Wang | 2013 | International Journal of Information Se- curity2013，13，5： | 1 |
| 14 | Can procalcitonin be used for the di~ agnosis and follow-up of postoperative complications after fracture surgery显示文摘 | Yasmin D Bulut G Yildiz M | 2006 | Acta Orthop Traumato Turc2006，40，1： | 1 |
| 15 | Effect of elemental sulfur,gypsum,and elemental sulfur coated fertilizers,on the availability of sulfur to rice显示文摘 | Yasmin N Blair G Till R | 2007 | Journal of Plant Nutrition2007，30，1： | 1 |
| 16 | Can procalcitonin be used for the diag- nosis and follow-up of postoperative complications after fracture surgery显示文摘 | Yasmin D Bulut G Yildiz M | 2006 | Acta Orthop Trumatol Ture2006，40，1： | 1 |
| 17 | Effect of elemental sulfur,gypsum,and elemental sulfur coated fertilizers,on the availability of sulfur to rice显示文摘 | Yasmin N Blair G Till R | 2007 | Journal of Plant Nutrition2007，30，1： | 1 |
| 18 | Development of a fast analytical method for the deter- mination of Sudan dyes in chilli-and curry-containing foodstuffs by high-performance liquid chromatography- photodiode array detection显示文摘 | CORNET V YASMINE G G()EDELE M | 2006 | Journal of Agricultural and Food Chemistry2006，54，： | 1 |
| 19 | Can procalcitonin be usedfor the diagnosis and follow-up of postoperative complica- tions after fracture surgery? 显示文摘 | Yasmin D Bulut G Yildiz M | 2006 | Acta Orthop Traumatol Turc2006，40，1： | 1 |
| 20 | Rheonix CARD Technology:an innovative and fully automated molecular diagnostic device显示文摘 | Spizz G Young L Yasmin R | 2012 | Point Care2012，11，： | 1 |
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