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| 1 | Empirical Changes in the Prevalence of Overweight and Obesity among Chinese Students from 1985 to 2010 and Corresponding Preventive Strategies显示文摘Objective To determine the extent of the obesity epidemic in school‐aged Chinese children in 2010 and track the increasing trend in different socioeconomic regions over the preceding 25 years. Strategies for preventing childhood obesity are suggested. Methods We used a dataset provided by the Chinese National Survey on Students' Constitution and Health from 1985‐2010. Subjects were 7‐18‐year‐old students randomly selected from urban and rural areas in 30 provinces. Eight subgroups were created according to region and socioeconomic status. Results Increased rates of the epidemic (overweight and obesity combined) were greatest in large coastal cities‐32.6% and 19.1% among males and females, respectively. These rates has neared that of developed countries. Similar increases were found in all other regions, including the once poverty‐stricken rural west. The epidemic in most of the rural areas began after 2000, but has spread swiftly over the last decade. In 2010, it was estimated that 9.9% of Chinese school‐aged children and adolescents were overweight and that an additional 5.1% were obese, representing an estimated 30.43 million individuals. Conclusion The prognosis for China's childhood‐obesity epidemic is dire. To prevent childhood obesity, we suggest several strategies, including reasonable dietary intake, increase physical activity, a change in sedentary lifestyles and corresponding behavioral modifications. | JI Cheng Ye CHEN Tian Jiao Working Group on Obesity in China (WGOC) | 2013 | Biomedical and Environmental Sciences2013，26，1： | 49 |
| 2 | Expert consensus on the use of human serum albumin in critically ill patients显示文摘Introduction Human serum albumin(HSA)is a non-glycosylated,negatively charged,single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD.It is synthesized by the liver at a rate of approximately 200 mg·kg^(-1)·day^(-1),with a half-life of 21 days,and subjected to catabolism in the muscles,liver,and kidneys at a rate of 4%per day.[1]Albumin,accounting for 60%of the total plasma protein,has various physiological functions,[2]such as maintaining 70%to 80%of effective plasma colloid osmotic pressure,coordinating vascular endothelial integrity,anti-oxidant and anti-inflammatory activities,maintaining the acidbase balance,and participating in the transport,distribution,and metabolism of a variety of endogenous and exogenous substances. | Yue-Tian Yu Jiao Liu Bo Hu Rui-Lan Wang Xiang-Hong Yang Xiu-Ling Shang Gang Wang Chang-Song Wang Bai-Ling Li Ye Gong Sheng Zhang Xin Li Lu Wang Min Shao Mei Meng Feng Zhu You Shang Qiang-Hong Xu Zhi-Xiong Wu De-Chang Chen | 2021 | Chinese Medical Journal2021，，14： | 22 |
| 3 | Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis显示文摘Background:Critical patients with the coronavirus disease 2019(COVID-19),even those whose nucleic acid test results had turned negative and those receiving maximal medical support,have been noted to progress to irreversible fatal respiratory failure.Lung transplantation(LT)as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients.Methods:From February 10 to March 10,2020,three male patients were urgently assessed and listed for transplantation.After conducting a full ethical review and after obtaining assent from the family of the patients,we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores.Results:Two of the three recipients survived post-LT and started participating in a rehabilitation program.Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved.The pathological results of the explanted lungs were concordant with the critical clinical manifestation,and provided insight towards better understanding of the disease.Government health affair systems,virology detection tools,and modern communication technology all play key roles towards the survival of the patients and their rehabilitation.Conclusions:LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis.If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT,LT provided the final option for these patients to avoid certain death,with proper protection of transplant surgeons and medical staffs.By ensuring instant seamless care for both patients and medical teams,the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained. | Jing-Yu Chen Kun Qiao Feng Liu Bo Wu Xin Xu Guo-Qing Jiao Rong-Guo Lu Hui-Xing Li Jin Zhao Jian Huang Yi Yang Xiao-Jie Lu Jia-Shu Li Shu-Yun Jiang Da-Peng Wang Chun-Xiao Hu Gui-Long Wang Dong-Xiao Huang Guo-Hui Jiao Dong Wei Shu-Gao Ye Jian-An Huang Li Zhou Xiao-Qin Zhang Jian-Xing He | 2020 | Chinese Medical Journal2020，，12： | 19 |
| 4 | Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis显示文摘OBJECTIVE: Traditional Chinese medicine(TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer.METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status(KPS) score were measured as the main outcome.RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3-and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups(χ2 = 42.244, P < 0.001). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively(P < 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overall survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer. | xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue | 2017 | Journal of Integrative Medicine2017，15，6： | 18 |
| 5 | Ulva prolifera green-tide outbreaks and their environmental impact in the Yellow Sea, China显示文摘The Ulva prolifera green tides in the Yellow Sea, China, which have been occurring since 2007, are a serious environmental problem attracting worldwide attention. Despite extensive research, the outbreak mechanisms have not been fully understood. Comprehensive analysis of anthropogenic and natural biotic and abiotic factors reveals that human activities, regional physicochemical conditions and algal physiological characteristics as well as ocean warming and biological interactions(with microorganism or other macroalgae) are closely related to the occurrence of green tides. Dynamics of these factors and their interactions could explain why green tides suddenly occurred in 2007 and decreased abruptly in 2017.Moreover, the consequence of green tides is serious. The decay of macroalgal biomass could result in hypoxia and acidification, possibly induce red tide and even have a long-lasting impact on coastal carbon cycles and the ecosystem. Accordingly, corresponding countermeasures have been proposed in our study for future reference in ecosystem management strategies and sustainable development policy. | Yongyu Zhang Peimin He Hongmei Li Gang Li Jihua Liu Fanglue Jiao Jianheng Zhang Yuanzi Huo Xiaoyong Shi Rongguo Su Naihao Ye Dongyan Liu Rencheng Yu Zongling Wang Mingjiang Zhou Nianzhi Jiao | 2019 | National Science Review2019，6，4： | 17 |
| 6 | Biosorption of Cu(Ⅱ) on extracellular polymers from Bacillus sp.F19显示文摘Biosorption can be an effective process for the removal of heavy metals from aqueous solutions.The adsorption of Cu(Ⅱ) from aqueous solution on the extracellular polymers (EPS) from Bacillus sp.(named MBFF19) with respect to pH,incubation time,concentration of initial Cu(Ⅱ),and biosorbent dose was studied.Biosorption of Cu(Ⅱ) is highly pH dependent.The maximum uptake of Cu(Ⅱ) (89.62 mg/g) was obtained at pH 4.8.Biosorption equilibrium was established in approximately 10 min.The correlation coeffcient of more than 0.90 turned out that the adsorption process of Cu(Ⅱ) on MBFF19 was in accordance with both Langmuir and Freundlich isotherms.The pseudo-first and second order models were applied to examine the kinetics of the adsorption,whereas the latter was found to be in harmony with the kinetic data better.Because of the outstanding uptake capacity of Cu(Ⅱ),MBFF19 produced by Bacillus sp.was proved to be an excellent biosorbent for removing Cu(Ⅱ) from aqueous solutions. | ZHENG Yan,FANG Xuliang,YE Zhilong,LI Yahong,CAI weimin School of Environmental Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China. | 2008 | Journal of Environmental Sciences2008，20，11： | 15 |
| 7 | Liver-Adipose Tissue Crosstalk:A Key Player in the Pathogenesis of Glucolipid Metabolic Disease显示文摘Glucolipid metabolic disease(GLMD),a complex of interrelated disorders in glucose and lipid metabolism,has become one of the leading chronic diseases causing public and clinical problem worldwide.As the metabolism of lipid and glucose is a highly coordinated process under both physiological and diseased conditions,the impairment in the signals corresponding to the metabolism of either lipid or glucose represents the common mechanism underlying the pathogenesis of GLMD.The liver and adipose tissue are the major metabolic organs responsible for energy utilization and storage,respectively.This review article aims to summarize the current advances in the investigation of the functional roles and the underling mechanisms of the interplay between the liver and adipose tissue in the modulation of GLMD development.Fibroblast growth factor 21(FGF21) and adiponectin represent the two major hormones secreted from the liver and adipose tissues,respectively.FGF21 exerts pleiotropic effects on regulating glucose and lipid homeostasis majorly through inducing the expression and secretion of adiponectin.Therefore,FGF21-adiponectin axis functions as the key mediator for the crosstalk between the liver and adipose tissue to exert the beneficial effects on the maintenance of the homeostasis of energy consumption.The liver-and adipose tissue-derived factors with pleiotropic effects on regulating of lipid and glucose metabolism function as the key mediator for the crosstalk between these two highly active metabolic organs,thereby coordinating the initiation and development of GLMD. | YE De-wei RONG Xiang-lu XU Ai-min GUO Jiao | 2017 | Chinese Journal of Integrative Medicine2017，23，6： | 14 |
| 8 | Syntheses and Fungicidal Activities of Thiazole-5-carboxanilides Bearing Thioether Group显示文摘 | XUE Hansong LIU Aiping LIU Weidong LI Jianming REN Yeguo HUANG Lu HE Lian OU Xiaoming YE Jiao HUANG Mingzhi | 2016 | Chemical Research in Chinese Universities2016，32，5： | 13 |
| 9 | Bearing capacity analysis of reinforced concrete L-shaped cross-section under biaxial eccentric compression显示文摘The ultimate capacity of short L-shaped reinforced concrete(RC) mernbers subjected to biaxial eccentric compression is investigated to provide a new tool for structure engineers.On the basis of nonlinear analysis of RC arbitrary cross-section,a new simplified cross-section numerical integration method is suggested.The cross-section is divided into several triangles,and each one is integrated with Gauss integration method.And L-shaped cross-sections subjected to biaxial eccentric compression are analyzed.The interaction curves of (N-M) and (My-Mz) for L-shaped sections are derived.The analytical results are well consistent with the experimental data and other analytical results. | JIAO Junting , YE Yinghua and DIAO Bo(Department of Civil Engineering, Beijing University of Aeronautics and Astronautics, Beijing 100083, China) | 2003 | Progress in Natural Science:Materials International2003，13，6： | 12 |
| 10 | Scorpion toxin BmKI directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats显示文摘在主要感觉神经原的电压门钠隧道(VGSC ) 在把疼痛信号传给中央神经系统起一个关键作用。BmK 我, site-3 钠从蝎子 Buthus martensi Karsch 的隧道特定的毒素,在老鼠导致疼痛行为。然而,我不是的 BmK 指向的 VGSC 的子类型完全变清。我们因此调查了 BmK 的效果我在当前的振幅, gating 和 Na 在 DRG 神经原与 neuronal hyperexcitability 被联系的 v 1.8, 。它被发现我 dose-dependently 增加了的那 BmK Na v 1.8 电流在小型(< 25 ? m ) 尖锐地分裂的 DRG 神经原,它在快、慢的 inactivation 上与它的抑制相关。而且,电压依赖者激活和不变的 inactivation Na v 1.8 在一个 hyperpolarized 方向被转移。因此, BmK 我减少了 neuronal 易兴奋性的阀值并且增加了在 DRG 神经原开火的行动潜力。在结论,我们的数据清楚地表明了我调制了的那 BmK Na v 1.8 显著地,建议我为学习 Na v 1.8。并且 Nav1.8 是与 BmK 我唤起疼痛有关的一个重要目标。 | Pin Ye Yunlu Jiao Zhenwei Li Liming Hua Jin Fu Feng Jiang Tong Liu Yonghua Ji | 2015 | Protein & Cell2015，6，6： | 10 |
| 11 | Secular Changes on the Distribution of Body Mass Index among Chinese Children and Adolescents, 1985-2010显示文摘Objective To analyze the change in Body Mass Index (BMI) distribution among Chinese children and adolescents for the development of more effective intervention for childhood obesity. Methods Data on the national students' constitution and health survey between 1985 and 2010 was used for this study. Subjects were students aged 7-18 randomly selected from 30 provinces in China. BMI for-age curves were developed by LMS method, and the trend of BMI distribution was determined by comparing the upper BMI percentiles and analyzing the skew shift of distribution between 1985 and 2010. Results An overall positive swift trend of BMI between 1985 and 2010 was observed among the Chinese school-age children and adolescents. The average median of the BMI increased from 16.8 and 17.0 kg/m2 to 18.2 and 17.9 kg/m2 in 25 years, with increments 0.56 and 0.36 kg/m2 per decade for males and females, respectively. The more obvious increments were found at the high BMI. The total increments of BMI in this period were 4.03 and 2.20 kg/m2 at the 85th, 6.14 and 3.57 kg/m2 at the 95th, and 6.99 and 4.27 kg/m2 at the 97th percentiles, for males and females, respectively. Conclusion Obvious increments were observed at high BMI of the Chinese children and adolescents. More effective interventions should be taken for control and prevention of obesity and its health consequence for these subgroups. It is necessary to establish a risk-complex system consisting of the identification of BMI scope, the screen of the disease risk factors and the assessment of excessive adiposity. | JI Cheng Ye CHEN Tian Jiao SUN Xiao | 2013 | Biomedical and Environmental Sciences2013，26，7： | 9 |
| 12 | Effect of Cold Rolling on Microstructure and Mechanical Properties of AISI 301LN Metastable Austenitic Stainless Steels显示文摘The microstructure and mechanical properties evolution of AISI 301LN metastable austenitic stainless steels during cold rolling were investigated. A wide range of cold thickness reduction (10%-80%) was carried out in a four-high rolling mill at ambient temperature. The X-ray and Feritscope MP30 were used to identify the strain-induced α′-martensite phase and its volume fraction, respectively. The microstructure was observed by optical micrograph and the mechanical properties were determined by tensile tests and microhardness. The results show that the strain-induced α′-martensite nucleated at the shear bands intersections and the growth of α′-martensite occurred by the repeated nucleation of new embryos. The volume fraction of strain-induced α′-martensite increased with increasing the cold rolling reduction. In addition, the percentage increased in the tensile strength is the same as that of hardness. The ratio between the average tensile strength and the average microhardness was found to range between 2.82 and 3.17. | HUANG Jun-xia1, YE Xiao-ning1, XU Zhou2 (1. Shanghai Baosteel Research Institute, Shanghai 200431, China 2. School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，10： | 7 |
| 13 | Effects of Bacterial-Feeding Nematode Grazing and Tea Saponin Addition on the Enhanced Bioremediation of Pyrene-Contaminated Soil Using Polycyclic Aromatic Hydrocarbon-Degrading Bacterial Strain显示文摘As one of the most widely distributed bacterial predators in the soil, the role of bacterivorous nematodes on the enhanced bioremediation of polycyclic aromatic hydrocarbon-contaminated soils is crucial, but remains to be investigated.A microcosm-level study was conducted to examine the effects of bacterial-feeding nematode grazing and tea saponin(TS) addition on bioremediation of a pyrene-contaminated soil enhanced by the polycyclic aromatic hydrocarbon(PAH)-degrading bacterial strain Sphingobium sp.PHE9.After 180 d of incubation, the highest pyrene dissipation(71.3%) was achieved through a combination of Sphingobium sp.PHE9 inoculation with nematode and TS addition.Meanwhile, high counts of culturable PAH-degrading bacteria, soil enzyme activity, and biodiversity indices were observed under the combined treatment, implying that the microbiological function of the contaminated soil was significantly restored.Additionally, the results of Tenax~ extraction with the first-order three-compartment model indicated that rate-limiting factors varied among treatments.The lack of degrading microorganisms was the main rate-limiting factor for the treatments involving TS/nematode addition, and inadequate bioaccessible pyrene was the vital rate-limiting factor in the treatments involving Sphingobium sp.PHE9 inoculation.The proposed combined clean-up strategy proved to be a promising bioremediation technology for aged pyrene-contaminated soils. | SUN Mingming LIU Kuan ZHAO Yuanchao TIAN Da YE Mao LIU Manqiang JIAO Jiaguo JIANG Xin | 2017 | Pedosphere2017，27，6： | 7 |
| 14 | Bile acid and receptors:biology and drug discovery for nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD),a series of liver metabolic disorders manifested by lipid accumulation within hepatocytes,has become the primary cause of chronic liver diseases worldwide.About 20%–30%of NAFLD patients advance to nonalcoholic steatohepatitis(NASH),along with cell death,inflammation response and fibrogenesis.The pathogenesis of NASH is complex and its development is strongly related to multiple metabolic disorders(e.g.obesity,type 2 diabetes and cardiovascular diseases).The clinical outcomes include liver failure and hepatocellular cancer.There is no FDA-approved NASH drug so far,and thus effective therapeutics are urgently needed.Bile acids are synthesized in hepatocytes,transported into the intestine,metabolized by gut bacteria and recirculated back to the liver by the enterohepatic system.They exert pleiotropic roles in the absorption of fats and regulation of metabolism.Studies on the relevance of bile acid disturbance with NASH render it as an etiological factor in NASH pathogenesis.Recent findings on the functional identification of bile acid receptors have led to a further understanding of the pathophysiology of NASH such as metabolic dysregulation and inflammation,and bile acid receptors are recognized as attractive targets for NASH treatment.In this review,we summarize the current knowledge on the role of bile acids and the receptors in the development of NAFLD and NASH,especially the functions of farnesoid X receptor(FXR)in different tissues including liver and intestine.The progress in the development of bile acid and its receptors-based drugs for the treatment of NASH including bile acid analogs and non-bile acid modulators on bile acid metabolism is also discussed. | Ting-ying Jiao Yuan-di Ma Xiao-zhen Guo Yun-fei Ye Cen Xie | 2022 | Acta Pharmacologica Sinica2022，43，5： | 7 |
| 15 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 16 | Suitability Evaluation of Rural Settlements Based on Accessibility of Production and Living: A Case Study of Tingzu Town in Hubei Prov- ince of China显示文摘Rural settlements are the main carriers of agriculture, rural areas and farmers; thus, optimizing the production and living space of rural settlements is highly significant to rural development. Taking the effective allocation of resources as the starting point, a suitability evaluation system of rural settlements, based on accessibility of production and living, was proposed in this study to provide scientific basis for the optimization of production and living space. The accessibility of production and living was measured by an improved two-step floating catchment area method, which considered proximity and availability based on the inclination of rural residents. The suitability evaluation system consisted of traditional suitability evaluation and newly proposed limiting factor identification based on the loss score proportion of suitability. Tingzu Town of Hubei Province, China, was chosen as the case study area. Based on the results of the suitability evaluation system, corresponding suggestions on rural land consolidation, industry division, as well as the layout of health care and education facilities were proposed to optimize the production and living space of rural settlements in Tingzu Town. It is found that the suitability evaluation based on accessibility of production and living is more scientific and accurate than the traditional ones which significantly overestimate production and living convenience. Moreover, the limiting factor identification can help us put forward suggestions according to local conditions and bring about the highly targeted optimization of production and living space of rural settlements. | LIU Yaolin YE Qingqing LI Jiwei KONG Xuesong JIAO Limin | 2016 | Chinese Geographical Science2016，26，4： | 7 |
| 17 | An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway显示文摘Objective:Angiogenesis plays a vital role in tumor growth and metastasis.Here,we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A(VEGFA)at the transcriptional level to treat triple-negative breast cancer(TNBC).Methods:We used a cell-based seryl tRNA synthetase(SerRS)promoter-driven dual-luciferase reporter system to screen an in-house library of 384 naturally occurring small molecules and their derivatives to find candidate molecules that could upregulate the expression of SerRS,a potent transcriptional repressor of VEGFA.The levels of SerRS and VEGFA were examined by quantitative RT-PCR(qRT-PCR),western blotting,and/or ELISAs in TNBC cells after candidate molecule administration.Zebrafish,the Matrigel plug angiogenesis assay in mice,the TNBC allograft,and xenograft mouse models were used to evaluate thein vivoanti-angiogenic and anti-cancer activities.Furthermore,the potential direct targets of the candidates were identified by proteomics and biochemical studies.Results:We found the most active compound was 3-(4-methoxyphenyl)quinolin-4(1H)-one(MEQ),an isoflavone derivative.In TNBC cells,MEQ treatment resulted in increased SerRS mRNA(P<0.001)and protein levels and downregulated VEGFA production.Both the vascular development of zebrafish and Matrigel plug angiogenesis in mice were inhibited by MEQ.MEQ also suppressed the angiogenesis in TNBC allografts and xenografts in mice,resulting in inhibited tumor growth and prolonged overall survival(P<0.05).Finally,we found that MEQ regulated SerRS transcription by interacting with MTA2(Metastasis Associated 1 Family Member 2).Conclusions:Our findings suggested that the MTA2/SerRS/VEGFA axis is a drug-treatable anti-angiogenic target,and MEQ is a promising anti-tumor molecule that merits further investigation for clinical applications. | Xiaotong Zhang Gengyi Zou Xiyang Li Lun Wang Tianyu Xie Jin Zhao Longlong Wang Shunchang Jiao Rong Xiang Haoyu Ye Yi Shi | 2020 | Cancer Biology & Medicine2020，17，3： | 6 |
| 18 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 19 | Multiple action sites of ultrasound on Escherichia coli and Staphylococcus aureus显示文摘Ultrasound,is thought to a potential non-thermal sterilization technology in food industry.However,the exact mechanisms underlying microbial inactivation by ultrasound still remain obscure.In this study,the action modes of ultrasound on both Gram-negative and Gram-positive microorganisms were estimated.From colony results,ultrasound acted as an irreversible effect on both Eshcerichia coli and Staphylococcus aureus without sublethal injury.The result in this study also showed that a proportion of bacteria subpopulation suffered from serious damage of intracellular components(e.g.DNA and enzymes)but with intact cell envelopes.We speculated that the inactivated effects of ultrasound on microbes might more than simply completed disruption of cell exteriors.Those microbial cells who had not enter the valid area of ultrasonic cavitation might be injected with free radicals produced by ultrasound and experienced interior injury with intact exterior structure,and others who were in close proximity to the ultrasonic wave field would be immediately and completely disrupted into debris by high power mechanic forces.These findings here try to provide extension for the inactivation mechanisms of ultrasound on microorganisms. | Xinyu Liao Jiao Li Yuanjie Suo Shiguo Chen Xingqian Ye Donghong Liu Tian Ding | 2018 | Food Science and Human Wellness2018，7，1： | 6 |
| 20 | Secular Changes of Stature in Rural Children and Adolescents in China, 1985-2010显示文摘Objective To analyze and assess secular change in stature in rural children and adolescents in China from 1985 to 2010.Methods Data were obtained from the 6 rounds of the Chinese National Survey on Student’s Constitution and Health.The subjects enrolled in the study were children and adolescents aged 7-18years in rural areas of provincial capitals.Results An overall positive secular trend in stature occurred in rural areas of provincial capitals in China from 1985 to 2010.The overall average increase rates were 3.1 and 2.4 cm/decade for boys and girls,respectively.The total body height increases for grown up boys and girls were 3.6 and 2.3 cm and the increase rates were 1.4 and 0.9 cm/decade,respectively.There were differences in body height increase among eastern,central and western regions.The average body height of the children or adolescents in eastern region was highest,followed by central region and western region.The overall increase rates in central region were highest among the three regions.The difference between eastern/central region and western region was obvious.Conclusion Positive secular trend in stature of children or adolescents has occurred in rural area of China,and rural boys and girls showed a great potential for continuous growth.More attention should be paid to the differences in children’s body height between western region and eastern/central region. | CHEN Tian Jiao JI Cheng Ye | 2014 | Biomedical and Environmental Sciences2014，27，8： | 6 |
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