|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要)显示文摘 | Gao, Y Yao, A Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 25 |
| 3 | 中国道路交通死亡率:2006—2016年国家疾病监测数据分析显示文摘可持续发展目标(SDG)3.6旨在2020年将全球道路交通事故伤亡人数减半。本研究目的在于评价中国2006—2016年降低道路交通伤害死亡率的进展。采用国家死因监测系统数据,用标准误计算粗率和年龄标准化死亡率,采用断点回归分析评价和量化2006—2016年整体和亚组道路交通死亡率的趋势。 | Wang L Ning P Yin P 李若曈(编译) 胡国清(编译) | 2019 | 中华预防医学杂志2019，53，9： | 15 |
| 4 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 5 | Relationship Between Programmed Death-ligand 1 and Clinicopathological Characteristics in Non-small Cell Lung Cancer Patients显示文摘Objective To evaluate the correlation between programmed death-ligand 1(PD-L1)expression in primary lung cancer cells,tumor associated macrophages(TAM)and patients’clinicopathological characteristics.Methods From 2008 to 2010,208 non-small cell lung cancer patients who underwent surgery or CT-guided biopsy were recruited from Huadong Hospital,Fudan University.Immunohistochemistry staining was performed to evaluate the PD-L1 expression in both primary lung cancer cells and CD68 positive TAM.The relationship between PD-L1 expression and the clinical pathology was evaluated usingχ2test.Spearman’s rank correlations were used to determine the correlation between PD-L1 expression in tumor cells and macrophages.Results Positive PD-L1 expression in primary cancer cells was found in 136(65.3%)patients,which were negatively correlated with lymph node metastasis(P=0.009)and smoking history(P=0.036).Besides,TAM with PD-L1 expression(found in 116 patients)was positively associated with smoking history(P=0.034),well-differentiation(P=0.029)and negative lymph node metastasis(P=0.0096).A correlation between PD-L1 expression in primary tumor cells and non-small cell lung cancer associated macrophages was found(r=0.228,P=0.021).Conclusion PD-L1,secreted from TAM,might induce cancer cells apoptosis,and decrease lymph node metastasis. | Yan-yan Chen Liu-bo Wang Hui-li Zhu Xiang-yang Li Yan-ping Zhu Yu-lei Yin Fan-zhen Lü Zi-li Wang Jie-ming Qu | 2013 | Chinese Medical Sciences Journal2013，28，3： | 14 |
| 6 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 7 | Burden Distribution Calculation of Bell-Less Top of Blast Furnace Based on Multi-Radar Data显示文摘The burden distribution real-time estimation problem of multi-loop charging based on the real multi-radar data is resolved.Firstly , an iterative algorithm is introduced to calculate the radial coordinate of the pile-top.Then , based on the multi-radar data , the burden profile is estimated by a cubic-curve equation at the end of the multi-loop charging.Furthermore , the burden profile before the next multi-loop charging is calculated based on multi-radar data by considering the impact of burden descent.On the basis of these burden profiles , a more accurate thickness ratio of ore to coke ( RO/C ) at the radial direction of blast furnace can be obtained.Finally , an example is given to calculate the burden profiles and RO/C by using the real multi-radar data sampled from Baosteel , which shows the effectiveness of the method introduced. | ZHU Qiao L Cheng-long YIN Yi-xin CHEN Xian-zhong | 2013 | Journal of Iron and Steel Research(International)2013，20，6： | 9 |
| 8 | Relationship between fluorescence characteristics and molecular weight distribution of natural dissolved organic matter in Lake Hongfeng and Lake Baihua,China显示文摘Dissolved organic matter (DOM) is one of the most interesting and difficult problems in recent years due to its important functions in the ecological and environmental system and the complexity of its chemical composition and structure. It is well ac- cepted that fluorescence characteristics and mo- lecular weight distribution are two important pa- rameters in the DOM characterization. However, the relationship between them is still unknown. In this study, fluorescence and molecular weight distribution of DOM in Lake Hongfeng, Lake Baihua and their rivers, and their relationship were investigated using the combination of fluorescence spectroscopy and high-performance size exclusion chromatography (HPSEC) with on-line UV absorbance and fluores- cence detectors. The results show that there were two obvious humic-like fluorescence peaks (Peaks A and B) in DOM from lake water. But there was an- other obvious protein-like fluorescence peak (Peak C) in DOM from river water. The humic-like fluorescence material consisted of DOM fraction with smaller mo- lecular weight, ranging from 1.0 to 3.0 kDa, while the protein-like fluorescence material mainly consisted of DOM fraction with MW larger than 2.0 kDa. The cal- culation of MW using HPSEC was related to the UV absorbance wavelength chosen. | YUE Lanxiu WU Fengchang LiU Congqiang LI Wen FU Pingqing BAI Yingchen WANG Liying YIN Zuoying Lü Zhicheng | 2006 | Chinese Science Bulletin2006，51，1： | 9 |
| 9 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 10 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 11 | A preliminary study on correlations of triple-phase multi-slice CT scan with histological differentiation and intratumoral microvascular/lymphatic invasion in gastric cancer显示文摘许多研究显示出的背景那癌症房间区别和 microvascular 侵略在癌症起一个原则作用前进和转移,和象估计区别和外科的 resectibility 和癌症的预后的 CT, MRI 和美国那样的非侵略的成像技术现在是很重要的。这研究试图与组织学的区别和现在的学习包括了的进步胃的 cancer.Methods 的 intratumor microvascular/lymphatic 侵略探索三倍阶段的多片 CT 扫描的关联有胃的癌症的 64 个病人,所有谁在外科前经历了 routinal 和上面的腹部的双阶段的对比改进多片 CT 考试。手术后的标本被用于组织学的区别,容器由 CD34 识别了的 intratumoral microvascular/lyrnphatic 的癌症房间侵略和 D2-40 表示的决心。在在胃的癌症和组织学的区别以及 intraturnoral microvascular/lymphatic 侵略的三倍阶段的多片 CT 扫描的对比改进比率(CER ) 之间的关联被比较,在那里的 analyzed.Results 是在在胃的癌症和肿瘤的三倍阶段的 CT 扫描的 CER 之间的重要关联组织学的区别(P0.05 ) 。没有侵略,在有 intratumoral microvascular 侵略的胃的癌症的动脉的阶段的 CER 比那显著地高(0.61 楶祴椬灭汵楳楶祴愠摮椠慮瑴湥楴湯愠摮瀠瑵 ? 牧慥? 畢摲湥漠 ? 档汩牤湥琠敨獭汥敶 ? 桴楥? 慦業楬獥愠摮琠敨猠' 覕媮聸维樲鏍剾 D 慥敳漠慲? 祳瑳浥洠瑥票灬敨楮慤整 ? 剏协 ??? 獩愠漠据 ? 慤汩 ? 潣瑮潲汬摥爭汥慥敳映牯畭慬楴湯搠癥汥灯摥琠? 癯牥潣敭猠浯 ? 景琠敨氠浩瑩瑡潩獮愠獳' 覒 X 整 ? 楷桴椠浭摥慩整爭汥慥敳洠瑥票灬敨楮慤整 ? 剉??? 瑉栠獡戠敥 ? 慭歲瑥摥椠 ? 桃湩 ? 楳据 ??? 戠瑵猠楴汬氠捡獫搠瑡 ?... | YIN Xin-dao HUANG Wen-bin L(U) Cheng-yu ZHANG Lin WANG Li-wei XIE Guang-hui | 2011 | Chinese Medical Journal2011，，3： | 6 |
| 12 | Spatial and Seasonal Variations of Nutrients in Sediment Profiles and Their Sediment-Water Fluxes in the Pearl River Estuary,Southern China显示文摘Three cruises were launched in the Pearl River Estuary(PRE)in 2005 to investigate the biogeochemical cycling of nutrients associated with early diagenesis related to degradation of organic matter.Seasonal and spatial variations of pore water nutrient concentrations and profile patterns in sediments were studied.Nutrient fluxes at the sediment-water interface(SWI)were measured by incubation experiments,and we here discussed the accumulation and transformation processes of nutrients at the SWI.The nutrients generally decreased from the Pearl River outlets downstream,indicating anthropogenic influences on the nutrient inputs in the estuary.NO3-N concentration was the highest of the three forms of DIN(dissolved inorganic nitrogen,the sum of NH4-N,NO3-N and NO2-N)in the overlying water,and NH4-N was the main component of DIN in pore water.The gradual increase of NH4-N and the rapid decrease of NO3-N with sediment depth provided the evidence for anaerobic conditions below the SWI.Negative fluxes of NO3-N and positive fluxes of NH4-N were commonly observed,suggesting the denitrification of NO3-N at the SWI.The DIN flux direction suggested that the sediment was the sink of DIN in spring,however,the sediment was generally the source of DIN in summer and winter.PO4-P distribution patterns were distinct while SiO4-Si inconspicuously varied in sediment profiles in different seasons.The flux results indicated that PO4-P mainly diffused from the water column to the sediment while SiO4-Si mainly diffused from the sediment to the water column.Generally,the incubated fluxes were the coupling of diffusion,bioturbation and biochemical reactions,and were relatively accurate in this study. | Ling Zhang Lu Wang Kedong Yin Ying Lü Yongqiang Yang Xiaoping Huang | 2014 | Journal of Earth Science2014，25，1： | 5 |
| 13 | A novel XPF-357A 〉 C polymorphism predicts risk and recurrence of bladder cancer(摘要)显示文摘 | Wang, M Yuan, L Wu, D Zhang, Z Yin, C Fu, G Wei, Q | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 5 |
| 14 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 15 | Relations of 3D directional derivatives and expressions of typical differential operators显示文摘Relations of the 3D multi-directional derivatives are studied in this paper.These relations are applied to a general second-order linear elliptical operator and the corresponding expression are obtained.These relations and expressions play important roles in the meshless finite point method. | YIN Li Lü Gui-xia SHEN Long-jun Laboratory of Computational Physics,Institute of Applied Physics and Computational Mathematics,Beijing 100088,China | 2009 | Applied Mathematics(A Journal of Chinese Universities)2009，24，2： | 3 |
| 16 | BMI对肝硬化患者预后的影响显示文摘【据Frontiers in Nutrition 2021年8月报道】题:BMI对肝硬化患者预后的影响(作者Yin Y等)目前,BMI与肝硬化患者预后的相关性仍存在争议。来自北部战区总医院消化内科的Yin等旨在评估BMI对肝硬化患者预后的影响。该研究包括两个部分。第一部分研究基于前瞻性建立的单中心数据库,共纳入436例无恶性肿瘤的肝硬化患者,评估长期病死率。第二部分研究基于回顾性多中心数据,共纳入379例肝硬化伴急性消化道出血(AGIB)的患者,评估院内病死率。计算所有纳入患者的BMI,并将其分为低体质量组(BMI<18.5 kg/m^(2))、正常体质量组(18.5≤BMI<23.0 kg/m^(2))和超重/肥胖组(BMI≥23.0 kg/m^(2))。 | 殷悦 祁兴顺 YIN Y LI Y SHAO L | 2021 | 临床肝胆病杂志2021，37，11： | 3 |
| 17 | Numerical investigation of the interactions between a laser-generated bubble and a particle near a solid wall显示文摘The interactions between the bubbles and the particles near structures are important issues for the applications of the cavitation in the fluid machinery.To study the hidden microscopic mechanisms,a numerical method for simulating the laser-generated bubble between the solid wall and a particle is developed in this paper with considerations of the viscosities and the compressibility of the gas and the liquid phases,as well as the surface tension between them.The gas-liquid interface is tracked by the coupling level set and the volume of fluid(CLSVOF)method.The numerical results clearly reveal that the particle can influence the cavitation bubble behaviors.The potential damage of the nearby structures is numerically quantified in terms of the wall pressure,which helps better understand the synergetic effects of the particle on the cavitation.The effects of three dimensionless parameters on the wall pressure are also investigated,especially,on the peak pressure,namely,γ1(defined as L_(1)/R_(max),where L_(1)is the distance from the center of the initial bubble to the solid wall and R_(max)is the maximum bubble radius),γ_(2)(defined as L_(2)/R_(max),where L_(2)is the distance from the lower surface of the spherical particle to the initial bubble center)andθ(defined as Rp/R_(max),where Rp is the spherical particle radius).Further numerical results show that these parameters play a dominant role in determining the peak pressure.When y_(1)<1.00,the peak pressure on the solid wall during the bubble collapse is mainly resulted from the liquid jet.Whenγ1>1.00,the peak pressure is caused by the shock wave.With the increase ofθor decrease ofγ_(2),the peak pressure increases.Whenγ_(2)>2.00,the effect of the particle on the bubble behavior can be neglected. | Jian-yong Yin Yong-xue Zhang Jian-jun Zhu Liang Lü Shi-da Li | 2021 | Journal of Hydrodynamics2021，33，2： | 3 |
| 18 | Coastal erosion in Shandong of China:status and protection challenges显示文摘Shandong has more than 70% of natural coasts are under erosion.Coastal erosion started from the 1970's and became a very serious problem at 1990 's.The dramatic decrease of sediment supplies from rivers caused rapid erosion at the delta and estuary areas,especially in the abandoned Yellow River Delta.Most sandy coasts along the Peninsula were eroded due to lack of sand supply and interruption of alongshore sediment drift,sand dredging from the beach or the offshore area caused serious erosion during short time. Sea-level rise causes slow but constant shoreline retreats and became a more serious threat.Different types of hard solutions for coastal protection against erosion were used in Shandong.Seawalls are most widely used,especially at the Yellow River Delta and city center waterfront.Groynes,jetties and breakwater are used on the north and east sandy coast of the Peninsula.Hard approaches are effective to protect the coast erosion but not change the erosion causes and led secondary impact on the coast.Soft engineering solution or the combined solutions are taken into acts.Beach nourishment is mostly considered as the better soft solution,especially to those tourists attracting sandy beaches along the Shandong coast.Long term monitoring and continuous lessons learning from the coastal erosion management will be adaptive for better coast solution in the future. | Ping Yin Xiao-yong Duan Fei Gao Mei-na Li Sheng-hua Lü Jian-dong Qiu Liang-yong Zhou | 2018 | China Geology2018，1，4： | 3 |
| 19 | Vitamin C promotes the proliferation and effector functions of human γδ T cells显示文摘γδT cells are of interest as effector cells for cellular immunotherapy due to their HLA-non-restricted lysis of many different tumor cell types.Potential applications include the adoptive transfer of in vitro-expandedγδT cells.Therefore,it is important to optimize the culture conditions to enable maximal proliferative and functional activity.Vitamin C(L-ascorbic acid)is an essential vitamin with multiple effects on immune cells.It is a cofactor for several enzymes,has antioxidant activity,and is an epigenetic modifier.Here,we investigated the effects of vitamin C(VC)and its more stable derivative,L-ascorbic acid 2-phosphate(pVC),on the proliferation and effector function of humanγδT cells stimulated with zoledronate(ZOL)or synthetic phosphoantigens(pAgs).VC and pVC did not increaseγδT-cell expansion within ZOL-or pAg-stimulated PBMCs,but increased the proliferation of purifiedγδT cells and 14-day-expandedγδT-cell lines in response toγδT-cell-specific pAgs.VC reduced the apoptosis ofγδT cells during primary stimulation.While pVC did not prevent activation-induced death of pAg-restimulatedγδT cells,it enhanced the cell cycle progression and cellular expansion.Furthermore,VC and pVC enhanced cytokine production during primary activation,as well as upon pAg restimulation of 14-day-expandedγδT cells.VC and pVC also increased the oxidative respiration and glycolysis ofγδT cells,but stimulus-dependent differences were observed.The modulatory activity of VC and pVC might help to increase the efficacy ofγδT-cell expansion for adoptive immunotherapy. | Léonce Kouakanou Yan Xu Christian Peters Junyi He Yangzhe Wu Zhinan Yin Dieter Kabelitz | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 20 | TanSat Mission Achievements: from Scientific Driving to Preliminary Observations显示文摘The Chinese global carbon dioxide monitoring satellite(TanSat)was successfully launched in December 2016 and has completed its on-orbit tests and calibration.TanSat aims to measure the atmospheric Carbon Dioxide column-averaged dry air mole fractions(X_(CO_2))with a precision of 4 ppm at the regional scale,and further to derive the CO_2 global and regional fluxes.Progress toward these objectives is reviewed and the first scientific results from TanSat measurements are presented.During the design phase,Observation System Simulation Experiments(OSSE)on TanSat measurements performed prior to launch measurements using a nadir and a glint alternative mode when considering the balance of stable measurements and reduces the flux uncertainty(64%).The constellation measurements of two satellites indicate an extra 10%improvement in flux inversion if the satellite measurements have no bias and similar precision.The TanSat on-orbit test indicates that the instrument is stable and beginning to produce X_(CO_2)products.The preliminary TanSat measurements have been validated with Total Carbon Column Observing Network(TCCON)measurements and have inter-compared with OCO-2 measurements in an overlap measurement. | LIU Yi WANG Jing YAO Lu CHEN Xi CAI Zhaonan YANG Dongxu YIN Zengshan GU Songyan TIAN Longfei LU Naimeng L Daren | 2018 | 空间科学学报2018，38，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员