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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 3 | Xp11易位性肾细胞癌和免疫组化TFE3强阳性的透明细胞性肾细胞癌:形态学、免疫组化和FISH分析显示文摘TFE3是诊断Xp11易位性肾细胞癌的良好标志物。然而,TFE3在其他类型肾细胞癌中的意义尚不清楚。作者利用自动化Ventana BenchMark XT系统采用免疫组化法检测了1 818例肾细胞癌组织中TFE3的表达情况,并用TFE3分裂探针采用荧光原位杂交和RNA测序技术检测了TFE3强阳性病例。27例免疫组化TFE3强阳性的肾细胞癌中,20例诊断为Xp11易位性肾细胞癌,7例诊断为透明细胞性肾细胞癌。作者进一步分析了形态学和临床病理特征,以及免疫组化标志物(CK7、CD117、CD10、P504s、vimentin、CA-IX、CK(AE1/AE3)、EMA、HMB-45、Melan-A和组织蛋白酶K)的表达情况。暗淡至嗜酸性絮状胞质及砂粒体样钙化仅见于Xp11易位性肾细胞癌( P <0.05)。4例pT3a期Xp11易位肾性细胞癌均发生肿瘤性坏死,3年内出现局部复发和远处转移(其中2例死亡)。vimentin、CA-IX、CK(AE1/AE3)和EMA在这两种肾细胞癌中的表达差异有显著性( P <0.05)。 | 魏建国(摘译) 方三高(审校) Yang B Duan H Cao W | 2019 | 临床与实验病理学杂志2019，35，8： | 11 |
| 4 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 5 | 深部地球条件下铁和氧元素的化学变化显示文摘氧与铁分别为地球上丰度最高的元素与占地球质量最大的元素,它们所形成的化合物遍布我们的星球,具有-2价的氧控制着地球的氧逸度,随着深度的增加氧逸度逐渐降低,与铁所形成的氧化物中铁的价态也逐渐降低,O/Fe逐渐增加,近些年来科学家们发现深部地球条件下铁的一系列氧化物,其中具有高压黄铁矿结构的铁超氧化物FeO2具有最高的O/Fe,并且它还能够携带一定量的H(表示为Py-FeO2H,, x=0-1)。 | 夏群科 Liu J Hu Q Y Bi W L Yang L X Xiao Y M Chow P Meng Y.Prakapenka V B Mao H K Mao W L | 2019 | 矿物岩石地球化学通报2019，38，3： | 2 |
| 6 | Phylogenetic relationships of the Tropiduchidae-group(Homoptera:Fulgoroidea)of planthoppers inferred through nucleotide sequences显示文摘 | YEH W B YANG C T HUI C F | 1998 | Zool Stu1998，37，1： | 2 |
| 7 | State of the art of membrane bioreactors: worldwide research and commercial applications in North Ameirca显示文摘 | Yang W B Cicek N Ilg J | 2006 | Journal of Mebmrane Science2006，270，12： | 1 |
| 8 | A serologic survey of antibody against chicken infectious anemia virus by indirect immunofluorescent assay in domestic poultry in China 显示文摘 | Zhou W Yang B Shen B | 1996 | Avi Dis1996，40，2： | 1 |
| 9 | Y-W Superplastie behavior in a two-phase TiAl alloy显示文摘 | Yang H S Kim | 1993 | Scripta Metallurgica et Materialia1993，，29： | 1 |
| 10 | PRDM16 controls a brown fat/skeletal muscle switch显示文摘 | SEALE P BJORK B YANG W L | 2008 | Nature2008，454，7207： | 1 |
| 11 | Electrocatalytic properties of platinum on hard carbon spherules derived from deoiled asphalt for methanol oxidation显示文摘 | Xu B S Guo J J Jia H S Yang X W Liu X G | 2007 | Catalysis Today2007，125，34： | 1 |
| 12 | Delay and its time-derivative dependent robust stability of neutral control system 显示文摘 | Zhao Z Wang W Yang B | 2007 | Applied Mathematics and Computation2007，187，： | 1 |
| 13 | Association between a G894T polymorphism of eNOSgene and essential hypertension in Hani and Yi minority groups of China显示文摘 | Tang W Yang Y Wang B | 2008 | Arch Med Res2008，39，1： | 1 |
| 14 | Effect of surface composi-tion of Pt-Au alloy cathode catalyst on the performance of directmethanol fuel cells显示文摘 | XU J B ZHAO T S YANG W W | 2010 | International Journal of Hydrogen Energy2010，16，35： | 1 |
| 15 | Storm wave reactivation of a submarine landslide显示文摘 | Prior D B Suhayda J N Lu N J Bomhold B D Keller G H Wiseman W J Wright L D Yang Z S | 1989 | Nature1989，341，： | 1 |
| 16 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 17 | Growth and Magnetic Properties of MnO2-β Nanowire Microspheres显示文摘 | YANG J B ZHOU X D JAMES W J | 2004 | Appl Phys Lett2004，85，15： | 1 |
| 18 | Gas-assisted In- jection Molded Polypropylene: The Skin-core Structure 显示文摘 | Zheng G Q Yang W Yang M B | 2008 | Polymer Engineering and Science2008，48，5： | 1 |
| 19 | Ultra - performance liquid chro- matography coupled with electrospray ionization/quadrupole - time - of - flight mass spectrometry for rapid analysis of constituents of Su- anzaoren decoction显示文摘 | Yang B Dong W Zhang A | 2011 | J Sep Sci2011，34，22： | 1 |
| 20 | Triple-negative breast cancer types exhibit a distinct poor clinical characteristic in lymph node-negative Chinese patients 显示文摘 | LIU Z B LIU G Y YANG W T | 1994 | Oncol Rep1994，20，4： | 1 |
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