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| 1 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 2 | On false data-injectien attacks against power system state estimation: modeling and countermeasures显示文摘 | YangQ YangJ Yu W etal | 2014 | IEEE Transactions on Parallel and Distributed Systems2014，25，3： | 1 |
| 3 | Enzymatic cascade systems for D-amino acid synthesis:progress and perspectives显示文摘D-amino acids,different from the ubiquitous L-amino acids,are recognized as the“unnatural”amino acids.The applications of D-amino acids have drawn increasing interest from researchers in recent years,and D-amino acids are widely used in various industries,including for food products,pharmaceuticals,and agricultural chemicals.Inspired by the prevalent appli-cations,many synthetic methods for D-amino acids have been developed,which are mainly divided into chemical synthetic methods and biosynthetic methods.Chemical synthesis of D-amino acids has a variety of disadvantages such as multiple reaction steps,low yields,low reaction rates,and difficulties in product extraction.Thus,biosynthetic methods utilizing enzymes are attracting increasing attention because they are more energy-saving and environmentally friendly compared to traditional chemical synthesis.Among all enzymatic methods,multi-enzymatic cascade catalytic methods have significant advantages,such as lower costs,no need for intermediate separation,and higher catalytic efficiency,which is ascribed to the spatial proximity of biocatalysts.In this review,advances in multi-enzyme cascade catalytic systems as well as chemo-enzymatic approaches to synthesize D-amino acids are discussed. | Anwen Fan Jiarui Li Yangqing Yu Danping Zhang Yao Nie Yan Xu | 2021 | Systems Microbiology and Biomanufacturing2021，1，4： | 1 |
| 4 | Highly selective adsorption of phosphate by pyromellitic acid intercalated ZnAI-LDHs: Assembling hydrogen bond acceptor sites显示文摘 | Yu Qiangqiang Zheng Yangqing Wang Yuanpeng | 2015 | Chemical Engineering Journal2015，260，： | 1 |
| 5 | Effect of Lentinus edodes polysaccharide on oxidative stress, immunity activity and oral ulceration of rats stimulated by phenol显示文摘 | Yu ZH Yin LH YangQ | 2009 | Carbohydr Polyms2009，，75： | 1 |
| 6 | Alteration of the respiratory microbiome in COVID-19 patients with different severities显示文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients. | Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 7 | Zhu Xi:a pioneer of experimental biology显示文摘Zhu Xi(朱洗,1900-1962)(Fig.1),one of the founders of cell biology and experimental biology in China,was bom in Linhai,Zhejiang Province in 1900.In 1931,he obtained his doctorate in France.After returning China,he devoted himself to toad reproduction research.With the spirit of innovation and dedication to research,he had made marvelous contributions to China,especially in biology.At the same time,he put his patriotism into action,promoting the vigorous development of agriculture and other industries. | Yujing Qian Xiazhao Yu Yangqing Sun Qun Xie Ge Liang Gaiping Bai | 2023 | Protein & Cell2023，14，9： | 0 |
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