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| 1 | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy显示文摘The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism.Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases. | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 18 |
| 2 | Multi-shelled TiO2/Fe2TiO5 heterostructured hollow microspheres for enhanced solar water oxidation显示文摘 | Muhammad Waqas Yanze Wei Dan Mao Jian Qi Yu Yang Bao Wang Dan Wang | 2017 | Nano Research2017，10，11： | 6 |
| 3 | Efficient sequential harvesting of solar light by heterogeneous hollow shells with hierarchical pores显示文摘In nature,sequential harvesting of light widely exists in the old life entity,i.e.cyanobacteria,to maximize the light absorption and enhance the photosynthesis efficiency.Inspired by nature,we propose a brand new concept of temporally-spatially sequential harvesting of light in one single particle,which has purpose-designed heterogeneous hollow multi-shelled structures(HoMSs)with porous shells composed of nanoparticle subunits.Structurally,HoMSs consist of different band-gap materials outside-in,thus realizing the efficient harvesting of light with different wavelengths.Moreover,introducing oxygen vacancies into each nanoparticle subunit can also enhance the light absorption.With the benefit of sequential harvesting of light in HoMSs,the quantum efficiency at wavelength of 400 nm is enhanced by six times compared with the corresponding nanoparticles.Impressively,using these aforementioned materials as photocatalysts;highly efficient photocatalytic water splitting is realized,which cannot be achieved by using the nanoparticle counterparts.This new concept of temporally-spatially sequential harvesting of solar light paves the way for solving the ever-growing energy demand. | Yanze Wei Jiawei Wan Nailiang Yang Yu Yang Yanwen Ma Songcan Wang Jiangyan Wang Ranbo Yu Lin Gu Lianhui Wang Lianzhou Wang Wei Huang Dan Wang | 2020 | National Science Review2020，7，11： | 2 |
| 4 | High-gain integrated in-line few-mode amplifier enabling 3840-km long-haul transmission显示文摘An integrated few-mode erbium-doped fiber amplifier(FM-EDFA)with high modal gain is suitable for the in-line amplification in mode-division multiplexing transmission(MDM)systems.We first experimentally demonstrate a dual-stage integrated FM-EDFA supporting three linear polarization modes.Consisting of integrated passive components with low insertion losses,the FM-EDFA has a similar structure and performance to widely used commercial single-mode EDFAs.The averaged modal gain of 25 dB,the differential modal gain(DMG)of<1.1 dB,and noise figures of 5–7 dB are simultaneously achieved.In addition,the DMG of the 3M-EDF itself is~0.3 dB.Moreover,an MDM transmission experiment with the in-line few-mode amplification by our proposed FM-EDFA over a 3840-km few-mode fiber link for a 28-Gbaud quadrature phase-shift keying(QPSK)signal is demonstrated. | TAo Xu TIANYU GAO YANZE WANG WENHAO LI WEI LI CHENG Du ZHIQUN YANG YAPING LIU LIN ZHANG | 2022 | Photonics Research2022，10，12： | 2 |
| 5 | Effect of a brief post-weld heat treatment on the microstructure evolutionand pitting corrosion of laser beam welded UNS $31803 duplex stainless steel显示文摘 | Yanze Yang Zhiyu Wang Hua Tan et O1 | 2012 | Corrosion Science2012，65，12： | 1 |
| 6 | Effect of a brief post-weld heat treatment on the microstructure evolution and pitting corrosion of laser beam welded UNS S31803 duplex stainless steel显示文摘 | Yang Yanze Wang Zhiyu Tan Hua | 2012 | Corrosion Science2012，65，： | 1 |
| 7 | Production of tumor necrosis factor alpha in human T lymphocytes by staphylococcal enterotoxin B correlates with toxin-induced proliferation and is regulated through protein kinase C 显示文摘 | YanZ Yang DC NeillR | 1999 | Infect Immun1999，67，12： | 1 |
| 8 | Cooperative planning ofmulti-agent systems based on task-oriented knowledge fusion with graph neural networks显示文摘Cooperative planning is one of the critical problems in the field of multi-agent system gaming.This work focuses on cooperative planning when each agent has only a local observation range and local communication.We propose a novel cooperative planning architecture that combines a graph neural network with a task-oriented knowledge fusion sampling method.Two main contributions of this paper are based on the comparisons with previous work:(1)we realize feasible and dynamic adjacent information fusion using GraphSAGE(i.e.,Graph SAmple and aggreGatE),which is the first time this method has been used to deal with the cooperative planning problem,and(2)a task-oriented sampling method is proposed to aggregate the available knowledge from a particular orientation,to obtain an effective and stable training process in our model.Experimental results demonstrate the good performance of our proposed method. | Hanqi DAI Weining LU Xianglong LI Jun YANG Deshan MENG Yanze LIU Bin LIANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，7： | 0 |
| 9 | Arabidopsis ROOT ELONGATION RECEPTOR KINASES negatively regulate root growth putatively via altering cell wall remodeling gene expression显示文摘Receptor-like kinases(RLKs)play key roles in regulating various physiological aspects in plant growth and development.In Arabidopsis thaliana,there are at least 223 leucine-rich repeat(LRR)RLKs.The functions of the majority of RLKs in the LRR XI subfamily were previously revealed.Only three RLKs were not characterized.Here we report that two independent triple mutants of these RLKs,named ROOT ELONGATION RECEPTOR KINASES(REKs),exhibit increased cell numbers in the root apical meristem and enhanced cell size in the elongation and maturation zones.The promoter activities of a number of Quiescent Center marker genes are significantly up-regulated in the triple mutant.However,the promoter activities of several marker genes known to control root stem cell niche activities are not altered.RNA-seq analysis revealed that a number of cell wall remodeling genes are significantly up-regulated in the triple mutant.Our results suggest that these REKs play key roles in regulating root development likely via negatively regulating the expression of a number of key cell wall remodeling genes. | Yanze Wang Weiyue Chen Yang Ou Yingying Zhu Jia Li | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
| 10 | Bispecific antibodies in cancer therapy:Target selection and regulatory requirements显示文摘In recent years,the development of bispecific antibodies(bsAbs)has been rapid,with many new structures and target combinations being created.The boom in bsAbs has led to the successive issuance of industry guidance for their development in the US and China.However,there is a high degree of similarity in target selection,which could affect the development of diversity in bsAbs.This review presents a classification of various bsAbs for cancer therapy based on structure and target selection and examines the advantages of bsAbs over monoclonal antibodies(mAbs).Through database research,we have identified the preferences of available bsAbs combinations,suggesting rational target selection options and warning of potential wastage of medical resources.We have also compared the US and Chinese guidelines for bsAbs in order to provide a reference for their development. | Yanze Sun Xinmiao Yu Xiao Wang Kai Yuan Gefei Wang Lingrong Hu Guoyu Zhang Wenli Pei Liping Wang Chengliang Sun Peng Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 11 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents显示文摘Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy.Despite the inherent advantages of small-molecule inhibitors over antibodies,the discovery of small-molecule inhibitors has fallen behind that of antibody drugs.Based on docking studies between small molecule inhibitor and PD-L1 protein,changing the chemical linker of inhibitor from a flexible chain to an aromatic ring may improve its binding capacity to PD-L1 protein,which was not reported before.A series of novel phthalimide derivatives from structure-based rational design was synthesized.P39 was identified as the best inhibitor with promising activity,which not only inhibited PD-1/PD-L1 interaction(IC_(50)=8.9 nmol/L),but also enhanced killing efficacy of immune cells on cancer cells.Co-crystal data demonstrated that P39 induced the dimerization of PD-L1 proteins,thereby blocking the binding of PD-1/PD-L1.Moreover,P39 exhibited a favorable safety profile with a LD_(50)>5000 mg/kg and showed significant in vivo antitumor activity through promoting CD8^(+)T cell activation.All these data suggest that P39 acts as a promising small chemical inhibitor against the PD-1/PD-L1 axis and has the potential to improve the immunotherapy efficacy of T-cells. | Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang Haojie Dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
| 12 | Distribution Characteristics and Optimization Strategies of Spatial Attractiveness of the Roof Garden in Meilecheng Commercial Complex of Handan City显示文摘With the rapid development of urban commercial complex in China,its roof garden becomes an important container for outdoor consumption and activities as the link between itself and the city,and more and more attention has been paid to its attractiveness.First,roof garden of Handan Meilecheng is taken as research object,and quantitative method of spatial attractiveness is established based on the number of spontaneous and chain activities and their intensity score.On this basis,data are collected via field investigation,and spatial attractiveness of roof garden of Meilecheng is quantified,and its distribution characteristics are summarized.Second,the cause of the characteristics formation is explained from the perspective of built environment elements.Finally,corresponding optimization strategies are proposed from four aspects:setting of landscape platform,increase of interest in sculpture sketches,design of space boundary,and improvement of spatial accessibility,which could provide reference for planning,design and transformation of roof garden of commercial complex in the future. | BAI Mei GUO Yanze XIANG Sirong LIU Yang | 2021 | Journal of Landscape Research2021，13，4： | 0 |
| 13 | An error analysis and optimization method for combined measurement with binocular vision显示文摘The accurate measurement of surfaces of large aviation components is vital for the assessment of manufacturing and assembly quality of such components.To satisfy the measurement requirement of large-size components,most current researches pay more attention to combined measurement methods utilizing different measuring instruments,but the related researches on error analysis and optimization methods are not taken enough attention.This paper proposes a combined laser-assisted measurement method with feature enhancement techniques,and it also develops an error propagation model of the main factors affecting the overall measurement error in detail.Firstly,the surface of a large-size component is measured by the measurement system at multiple stations.Secondly,a control point coordinate system is established as a bridge to unify all local measurement data into the global coordinate system.To improve the overall measurement accuracy,the pixel extraction error as a key factor causing the overall measurement error is analyzed in detail.Next,the error propagation model is established,and some optimization strategies of layout for minimizing measurement error and transformation error are researched.Finally,experiments are carried out to verify the effectiveness of the proposed method.The results show that the measurement error of the proposed method reaches 0.073%and 0.14%with a 1 D standard ruler and a flat plate,respectively. | Yongkang LU Wei LIU Yang ZHANG Junqing LI Weiqi LUO Yanze ZHANG Hongwen XINGb Lei ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，10： | 0 |
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