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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | A LINEARLY-IMPLICIT ENERGY-PRESERVING ALGORITHM FOR THE TWO-DIMENSIONAL SPACE-FRACTIONAL NONLINEAR SCHRÖDINGER EQUATION BASED ON THE SAV APPROACH显示文摘The main objective of this paper is to present an efficient structure-preserving scheme,which is based on the idea of the scalar auxiliary variable approach,for solving the twodimensional space-fractional nonlinear Schrodinger equation.First,we reformulate the equation as an canonical Hamiltonian system,and obtain a new equivalent system via introducing a scalar variable.Then,we construct a semi-discrete energy-preserving scheme by using the Fourier pseudo-spectral method to discretize the equivalent system in space direction.After that,applying the Crank-Nicolson method on the temporal direction gives a linearly-implicit scheme in the fully-discrete version.As expected,the proposed scheme can preserve the energy exactly and more efficient in the sense that only decoupled equations with constant coefficients need to be solved at each time step.Finally,numerical experiments are provided to demonstrate the efficiency and conservation of the scheme. | Yayun Fu Wenjun Cai Yushun Wang | 2023 | Journal of Computational Mathematics2023，41，5： | 0 |
| 3 | A 3D Measurement Method Based on Coded Image显示文摘The binocular stereo vision system is often used to reconstruct 3D point clouds of an object.However,it is challenging to find effective matching points in two object images with similar color or less texture.This will lead to mismatching by using the stereo matching algorithm to calculate the disparity map.In this context,the object can’t be reconstructed precisely.As a countermeasure,this study proposes to combine the Gray code fringe projection with the binocular camera as well as to generate denser point clouds by projecting an active light source to increase the texture of the object,which greatly reduces the reconstruction error caused by the lack of texture.Due to the limitation of the camera viewing angle,a one-perspective binocular camera can only reconstruct the 2.5D model of an object.To obtain the 3D model of an object,point clouds obtained from multiple-view images are processed by coarse registration using the coarse SAC-IA algorithm and fine registration using the ICP algorithm,which is followed by voxel filtering fusion of the point cloud.To improve the reconstruction quality,a polarizer is mounted in front of the cameras to filter out the redundant reflected light.Eventually,the 3D model and the dimension of a vase are obtained after calibration. | Jinxing Niu Yayun Fu Qingsheng Hu Shaojie Yang Tao Zhang Sunil Kumar Jha | 2021 | Computers, Materials & Continua2021，，11： | 0 |
| 4 | Study on Spray Characteristics of Dimethyl Carbonate Blended Fuel in IC Engines显示文摘The spray characteristics of the blended fuel composed of biodiesel and dimethyl carbonate were compared with those of biodiesel and diesel.The macroscopic spray characteristic parameters including spray tip penetration,maximum spray width,average spray cone angle,and peak tip velocity were used to evaluate the spray characteristics of the blended fuel.The results showed that the spray tip penetration of blended fuel was lower than that of biodiesel,while the spray cone angle and maximum spray width of blended fuel were both larger than that of biodiesel.On the basis of the Hiroyasu and Arai mathematical model combined with the actual working conditions of this experiment,including physical parameters such as the viscosity and density of the fuel,a correct model of spray penetration was established,and the experimental results were compared. | Fu Wei Zhou Kun Liu Junya Xie Hongxi Li Yayun Lu Lei Bao Jihu Cheng Yunlang | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 0 |
| 5 | Image Deblurring of Video Surveillance System in Rainy Environment显示文摘Video surveillance system is used in various fields such as transportation and social life.The bad weather can lead to the degradation of the video surveillance image quality.In rainy environment,the raindrops and the background are mixed,which lead to make the image degradation,so the removal of the raindrops has great significance for image restoration.In this article,after analyzing the inter-frame difference method in detecting and removing raindrops,a background difference method is proposed based on Gaussian model.In this method,the raindrop is regarded as a moving object relative to the background.The principle and procedure of the method are given to detect and remove raindrops.The parameters of the single Gaussian background model are studied in this article.The important parameter of the learning rate of Gaussian model is explored in order to better detection and removal of raindrops.Experiment shows that the results of removal of raindrops by using the proposed algorithm are better than that by using the inter-frame difference method.The image processing effect is the best when the learning rate is 0.6.The research results can provide technical reference for similar research on eliminating the influence of rainy weather. | Jinxing Niu Yajie Jiang Yayun Fu Tao Zhang Nicola Masini | 2020 | Computers, Materials & Continua2020，，10： | 0 |
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