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| 1 | Updated developments on molecular imaging and therapeutic strategies directed against necrosis显示文摘Cell death plays important roles in living organisms and is a hallmark of numerous disorders such as cardiovascular diseases, sepsis and acute pancreatitis. Moreover, cell death also plays a pivotal role in the treatment of certain diseases, for example, cancer. Noninvasive visualization of cell death contributes to gained insight into diseases, development of individualized treatment plans, evaluation of treatment responses, and prediction of patient prognosis. On the other hand, cell death can also be targeted for the treatment of diseases. Although there are many ways for a cell to die, only apoptosis and necrosis have been extensively studied in terms of cell death related theranostics. This review mainly focuses on molecular imaging and therapeutic strategies directed against necrosis. Necrosis shares common morphological characteristics including the rupture of cell membrane integrity and release of cellular contents, which provide potential biomarkers for visualization of necrosis and necrosis targeted therapy. In the present review, we summarize the updated joint efforts to develop molecular imaging probes and therapeutic strategies targeting the biomarkers exposed by necrotic cells. Moreover, we also discuss the challenges in developing necrosis imaging probes and propose several biomarkers of necrosis that deserve to be explored in future imaging and therapy research. | Dongjian Zhang Meng Gao Qiaomei Jin Yicheng Ni Jian Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 2 | Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT显示文摘TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-Hodgkin lymphoma(r/r B-NHL).From September 2016 to September 2020,257 r/r B-NHL patients were assessed for eligibility for two trials in our center,assessing anti-CD19 and anti-CD22 chimeric antigen receptor(CAR19/22)T-cell cocktail treatment alone or in combination with autologous stem cell transplantation(ASCT).TP53 alterations were screened in 123 enrolled patients and confirmed in 60.CAR19/22 T-cell administration resulted in best objective(ORR)and complete(CRR)response rate of 87.1%and 45.2%in patients with TP53 alterations. | Jia Wei Min Xiao Zekai Mao Na Wang Yang Cao Yi Xiao Fankai Meng Weimin Sun Ying Wang Xingcheng Yang Liting Chen Yicheng Zhang Haichuan Zhu Shangkun Zhang Tongcun Zhang Jianfeng Zhou Liang Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 3 | Genome-wide analysis of expression quantitative trait loci(eQTLs)reveals the regulatory architecture of gene expression variation in the storage roots of sweet potato显示文摘Dissecting the genetic regulation of gene expression is critical for understanding phenotypic variation and species evolution.However,our understanding of the transcriptional variability in sweet potato remains limited.Here,we analyzed two publicly available datasets to explore the landscape of transcriptomic variations and its genetic basis in the storage roots of sweet potato.The comprehensive analysis identified a total of 724,438 high-confidence single nucleotide polymorphisms(SNPs)and 26,026 expressed genes.Expression quantitative trait locus(eQTL)analysis revealed 4408 eQTLs regulating the expression of 3646 genes,including 2261 local eQTLs and 2147 distant eQTLs.Two distant eQTL hotspots were found with target genes significantly enriched in specific functional classifications.By combining the information from regulatory network analyses,eQTLs and association mapping,we found that IbMYB1-2 acts as a master regulator and is the major gene responsible for the activation of anthocyanin biosynthesis in the storage roots of sweet potato.Our study provides the first insight into the genetic architecture of genome-wide expression variation in sweet potato and can be used to investigate the potential effects of genetic variants on key agronomic traits in sweet potato. | Lei Zhang Yicheng Yu Tianye Shi Meng Kou Jian Sun Tao Xu Qiang Li Shaoyuan Wu Qinghe Cao Wenqian Hou Zongyun Li | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | Overexpression of phosphatidylserine synthase IbPSS1 affords cellular Na+homeostasis and salt tolerance by activating plasma membrane Na^(+)/H^(+)antiport activity in sweet potato roots显示文摘Phosphatidylserine synthase(PSS)-mediated phosphatidylserine(PS)synthesis is crucial for plant development.However,little is known about the contribution of PSS to Na^(+)homeostasis regulation and salt tolerance in plants.Here,we cloned the IbPSS1 gene,which encodes an ortholog of Arabidopsis AtPSS1,from sweet potato(Ipomoea batatas(L.)Lam.).The transient expression of IbPSS1 in Nicotiana benthamiana leaves increased PS abundance.We then established an efficient Agrobacterium rhizogenes-mediated in vivo root transgenic system for sweet potato.Overexpression of IbPSS1 through this system markedly decreased cellular Na^(+)accumulation in salinized transgenic roots(TRs)compared with adventitious roots.The overexpression of IbPSS1 enhanced salt-induced Na^(+)/H^(+)antiport activity and increased plasma membrane(PM)Ca^(2+)-permeable channel sensitivity to NaCl and H2O2 in the TRs.We confirmed the important role of IbPSS1 in improving salt tolerance in transgenic sweet potato lines obtained from an Agrobacterium tumefaciens-mediated transformation system.Similarly,compared with the wild-type(WT)plants,the transgenic lines presented decreased Na^(+)accumulation,enhanced Na^(+)exclusion,and increased PM Ca^(2+)-permeable channel sensitivity to NaCl and H2O2 in the roots.Exogenous application of lysophosphatidylserine triggered similar shifts in Na^(+)accumulation and Na^(+)and Ca^(2+)fluxes in the salinized roots of WT.Overall,this study provides an efficient and reliable transgenic method for functional genomic studies of sweet potato.Our results revealed that IbPSS1 contributes to the salt tolerance of sweet potato by enabling Na^(+)homeostasis and Na^(+)exclusion in the roots,and the latter process is possibly controlled by PS reinforcing Ca^(2+)signaling in the roots. | Yicheng Yu Ying Xuan Xiaofeng Bian Lei Zhang Zhiyuan Pan Meng Kou Qinghe Cao Zhonghou Tang Qiang Li Daifu Ma Zongyun Li Jian Sun | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Integrated photonic RF self-interference cancellation on a silicon platform for full-duplex communication显示文摘In-band full-duplex(IBFD) technology can double the spectrum utilization efficiency for wireless communications,and increase the data transmission rate of B5G and 6G networks and satellite communications. RF self-interference is the major challenge for the application of IBFD technology, which must be resolved. Compared with the conventional electronic method, the photonic self-interference cancellation(PSIC) technique has the advantages of wide bandwidth, high amplitude and time delay tuning precision, and immunity to electromagnetic interference.Integrating the PSIC system on chip can effectively reduce the size, weight, and power consumption and meet the application requirement, especially for mobile terminals and small satellite payloads. In this paper, the silicon integrated PSIC chip is presented first and demonstrated for IBFD communication. The integrated PSIC chip comprises function units including phase modulation, time delay and amplitude tuning, sideband filtering, and photodetection, which complete the matching conditions for RF self-interference cancellation. Over the wide frequency range of C, X, Ku, and K bands, from 5 GHz to 25 GHz, a cancellation depth of more than 20 dB is achieved with the narrowest bandwidth of 140 MHz. A maximum bandwidth of 630 MHz is obtained at a center frequency of10 GHz. The full-duplex communication experiment at Ku-band by using the PSIC chip is carried out. Cancellation depths of 24.9 dB and 26.6 dB are measured for a bandwidth of 100 MHz at central frequencies of 12.4 GHz and14.2 GHz, respectively, and the signal of interest(SOI) with 16-quadrature amplitude modulation is recovered successfully. The factors affecting the cancellation depth and maximum interference to the SOI ratio are investigated in detail. The performances of the integrated PSIC system including link gain, noise figure, receiving sensitivity, and spurious free dynamic range are characterized. | XIUYOU HAN XINXIN SU MENG CHAO XINDI YANG WEIHENG WANG SHUANGLING FU YICHENG DU ZHENLIN WU MINGSHAN ZHAO | 2023 | Photonics Research2023，11，10： | 1 |
| 6 | MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment显示文摘尽管 temozolomide (TMZ ) 是为 glioblastoma 的首要的化学疗法的代理人,它经常由于药抵抗是非药品。克服 glioblastoma 房间的抵抗到 TMZ,为结果预言识别预示的标记并且开发敏化 chemo 代理人是必要的。这里, TMZ 抵抗、 TMZ 敏感的样品的基因表示侧面被 microarray 分析,和激活 mitogen 的蛋白质 kinase kinase 比较(MEK2 ) 2 在抵抗 glioma 房间然而并非在敏感肿瘤房间或非肿瘤纸巾明确地是 upregulated。而且,耐心的数据的全面分析表明 MEK2 表示的增加的水平响应 TMZ 治疗与 glioma 等级和更坏的预后的前进相关很好。而且,在 U251 glioma 房间线或 xenografted glioma 减少 MEK2 的水平通过调停 shRNA 的基因为击倒的禁止的房间增长建模并且向 TMZ 治疗提高了房间的敏感。从由即时 PCR 的 glioma 病人的肿瘤样品的进一步的分析显示增加的 MEK2 表示水平仔细与许多药抵抗基因的激活被联系。最后,在 MEK2 是在 vitro 的 silenced 以后,这些抵抗基因是 downregulated,建议导致 MEK2 的 chemo 抵抗的机制能被这些抵抗基因的 transcriptional 激活调停。一起,我们的数据显示 MEK2 的表示水平能为 glioma 化疗用作一个预示的标记并且 MEK2 对手能被用作 chemo-sensitizers 提高 TMZ 的治疗功效。 | Hua He Maojin Yao Wenhao Zhang Bangbao Tao Feili Liu Shu Li Yan Dong Chenran Zhang Yicheng Meng Yuxin Li Guohan Hu Chun Luo Hui Zong Yicheng Lu | 2016 | Cellular & Molecular Immunology2016，13，5： | 1 |
| 7 | Resolution analysis of GEO spaceborne-airborne bistatic SAR based on sliding spotlight mode显示文摘For a synthetic aperture radar(SAR) system mounted on a geostationary Earth orbit(GEO) satellite, the track can be curvilinear. Thus, a bistatic SAR system based up on geostationary transmitter and 'receive-only' SAR system onboard airplanes, namely GEO spaceborne-airborne bistatic(GEO SA-Bi SAR), is significantly different from the traditional bistatic SAR. This paper mainly studies the resolution characteristic of the sliding spotlight GEO SA-Bi SAR system. Firstly, the common azimuth coverage and coherent accumulated time are theoretically analyzed in detail. Then,based on the gradient method, the accurate two dimensional resolution of a GEO SA-Bi SAR system is analytically calculated. Finally, the simulation data show the correctness and effectiveness of the proposed resolution analysis method. | Meng Lian Yicheng Jiang Bin Hu | 2016 | Journal of Systems Engineering and Electronics2016，27，2： | 1 |
| 8 | A Direct Route to Tetrahydropyridazine Derivatives via DMAP-Catalyzed [4+2] Annulation of Allenoates with Arylazosulfones显示文摘Herein,a DMAP-catalyzed[4+2]annulation ofα-substituted allenoates with arylazosulfones is reported,which affords facile access to tetrahydropyridazine derivative in synthetically useful yields.This reaction features mild conditions and good functional group tolerance.Moreover,the resultant products can be readily transformed into pyridazin-3-one derivatives in the presence of DDQ. | Xin Ji Ziyang Li Jinfeng Zhang Yicheng Zhang Ling-Guo Meng | 2023 | Chinese Journal of Chemistry2023，41，22： | 0 |
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