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| 1 | Recent progress of surface coating on cathode materials for high-performance lithium-ion batteries显示文摘Lithium-ion batteries (LIB) have received substantial attention in the last 10 years,as they offer great promise as power sources that can lead to the electric vehicle (EV) revolution in the next 5 years.Since the cathode serves as a key component in LIB,its properties significantly affect the performance of the whole system.Recently,the cathode surface modification based on coating technique has been widely employed to enhance the electrochemical performances by improving the material conductivity,stabilising the physical structure of materials,as well as preventing the reactions between the electrode and electrolyte.In this work,we reviewed the present of a number of promising cathode materials for Li-ion batteries.After that,we summarized the very recent research progress focusing on the surface coating strategies,mainly including the coating materials,the coating technologies,as well as the corresponding working mechanisms for cathodes.At last,the challenges faced and future guidelines for optimizing cathode materials are discussed.In this study,we propose that the structure of cathode is a crucial factor during the selection of coating materials and technologies. | Peiyuan Guan Lu Zhou Zhenlu Yu Yuandong Sun Yunjian Liu Feixiang Wu Yifeng Jiang Dewei Chu | 2020 | Journal of Energy Chemistry2020，29，4： | 28 |
| 2 | Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer显示文摘Metformin is a widely prescribed hypoglycemic drug.Many studies have shown its anti-cancer properties.In the present study,we aimed to explore the effect of metformin on breast cancer and clarify the underlying mechanism.Our results showed that metformin induced ferroptosis in MDA-MB-231 cells through upregulating miR-324-3p expression.Overexpression of miR-324-3p inhibited cancer cell viability.miR-324-3p inhibitor promoted cell viability.Further studies showed that the effect of miR-324-3p was mediated by directly targeting glutathione peroxidase 4(GPX4).miR-324-3p bound to the 3ʹ-UTR of GPX4 and led to the downregulation of GPX4.In vivo studies showed that metformin induced ferroptosis by upregulating miR-324-3p in the xenograft model of breast cancer in mice.Our study suggested that metformin promotes ferroptosis of breast cancer by targeting the miR-324-3p/GPX4 axis.Metformin could act as a potential anti-cancer agent through the induction of ferroptosis. | Yifeng Hou Shuang Cai Shouyang Yu Hui Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 11 |
| 3 | Interface-induced formation of onion-like alloy nanocrystals by defects engineering显示文摘缺点的控制介绍的能力,在基于磅的 nanocrystals (NC ) 的特别地成双的缺点提供可能性调整基于磅的 nanocatalyst 的表演。然而,因为高内部的紧张,精力在孪生的结构存在,在基于磅的 NC 的缺点的制造是足够地挑战性的。这里,我们证明在 PtCu nanoparticles 上提供精确控制的一条低温度的导致接口的汇编途径集合在 hexadecylamine/water 接口,产出暴露的像洋葱的 PtCu NC 成双的缺点的高密度。而且,弯曲机制被建议阐明膨胀的成双的缺点和格子(收缩) 的外观基于错误改正了扫描传播电子显微镜学分析。这个工作打开新线路在 metalbased 合金 NC 设计缺点,启用在催化作用的更多的机会。 | Wei Jia Yuen Wu Yifeng Chen Dongsheng He Jinpeng Li Yu Wang Zhuo Wang Wei Zhu Chen Chen Qing Peng Dingsheng Wang Yadong Li | 2016 | Nano Research2016，9，2： | 5 |
| 4 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 5 | Conversion characteristics and mechanism analysis of gaseous dichloromethane degraded by a VUV light in different reaction media显示文摘The photodegradation of gaseous dichloromethane(DCM) by a vacuum ultraviolet(VUV) light in a spiral reactor was investigated with different reaction media and initial concentrations.Through the combination of direct photolysis,O 3 oxidation and HO· oxidation,DCM was ultimately mineralized into inorganic compounds(such as HCl,CO 2,H 2 O,etc.) in the air with relative humidity(RH) of 75%-85%.During the photodegradation process,some small organic acids(including formic acid,acetic acid) were also detected and the intermediates were more soluble than DCM,providing a possibility for its combination with subsequent biodegradation.Based on the detected intermediates and the confirmed radicals,a photodegradation pathway of DCM by VUV was proposed.With RH 75%-80% air as the reaction medium,the DCM removal followed the second-order kinetic model at inlet concentration of 100-1000 mg/m 3.Kinetic analysis showed that the reaction media affected the kinetic constants of DCM conversion by a large extent,and RH 80% air could cause a much lower half-life for its conversion.Such results supported the possibility that VUV photodegradation could be used not only for the mineralization of DCM but also as a pretreatment before biodegradation. | Jianming Yu Wenji Cai Jianmeng Chen Li Feng Yifeng Jiang Zhuowei Cheng | 2012 | Journal of Environmental Sciences2012，24，10： | 4 |
| 6 | Study on risk factors of extrapyramidal symptoms induced by antipsychotics and its correlation with symptoms of schizophrenia显示文摘Background Extrapyramidal symptoms (EPS) are one of the most common and neglected side effects during the treatment of schizophrenia. The risk factors of EPS in Chinese patients with schizophrenia and its relationship with psychiatric symptoms and mood symptoms of schizophrenia remain unknown. Aims The main objective of this study is to explore the risk factors of EPS caused by antipsychotics and the relationship between EPS and psychotic symptoms and mood symptoms of schizophrenia. Method This study included 679 patients with schizophrenia who have met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders- Fourth Edition. Patients were divided into the EPS group and the non-EPS group according to the scale rating criteria and whether the anticholinergics have been used. The differences between demographic data and characters of drug intake were compared between the two groups, and the risk factors of EPS were selected between those factors. Correlation analysis was performed on the severity of schizophrenia (Positive and Negative Symptoms Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS) score) and EPS scale (Simpson-Angus Scale (SAS), Barnes Akathisia Rating Scale (BARS), Abnormal Involuntary Movement Scale (AIMS) score) in 679 patients. The differences between the PANSS subscale score and the CDSS score between the EPS grong and the non-EPS group were compared. Result Compared with the non-EPS group, the EPS group patients are older, and they have a longer duration since first prescribed antipsychotics. The EPS group patients have higher frequency of atypical antipsychotics polytherapy and typical and atypical antipsychotics polytherapy or combined treatments with mood stabilisers. Logistic regression analysis shows that antipsychotics with high D2 receptor antagonistic effect and illness duration are the risk factors of EPS. The SAS score was significantly correlated with PANSS negative score, PANSS general psychopathological score and PANSS total score. The BARS scale score was significantly correlated with PANSS positive score, PANSS general psychopathological score, PANSS total score and CDSS total score. The AIMS scale score was significantly correlated with PANSS negative score. Compared with the non-EPS group, the EPS group patients have significantly higher PANSS negative score, PANSS general psychopathological score, PANSS total score and CDSS total score. | Jiajun Weng Yan Zhang Huafang Li Yifeng Shen Wenjuan Yu | 2019 | General Psychiatry2019，32，1： | 4 |
| 7 | N-doped ordered mesoporous carbon spheres derived by confined pyrolysis for high supercapacitor performance显示文摘Herein, we report a confined pyrolysis strategy to prepare mesoporous carbon nanospheres by which surface area of carbon spheres is increased, pore size is enlarged and effective N-doping is achieved. In this method, the mesoporous polymer sphere as carbon precursor and 2-methylimidazole as nitrogen precursor are encapsulated in a compact silica shell which provides a confined nano-space for the pyrolysis treatment. The in situ generated gases from mesoporous polymer sphere and 2-methylimidazole under pyrolysis diffuse into the pores of mesoporous polymer sphere in the confined compact silica shell,resulting in increased surface area, larger pore size and N-doping due to self-activation effect. As electrodes in supercapacitor, the N-doped mesoporous carbon nanospheres exhibit a significantly enhanced specific capacitance of 326 Fg^-1 at 0.5 Ag^-1, which is 2 times higher than that of mesoporous carbon spheres under unconfined pyrolysis condition, exhibiting its potential for electrode materials with high performance. | Juan Du Lei Liu Yifeng Yu Yue Zhang Haijun Lv Aibing Chen | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 8 | Safety and related factors of treatment with long-term atypical antipsychotic in Chinese patients with schizophrenia:observational study显示文摘Background Atypical antipsychotics as first-line drugs have been used in patients with schizophrenia in China and abroad.However,its safety still needs to be evaluated in a large population,especially in Chinese patients.Objective The main objective of this study is to evaluate the safety and related factors of long-term atypical antipsychotic use in patients with schizophrenia in China.The secondary objective includes the long-term efficacy of atypical antipsychotics in these patients,as well as pharmacoeconomic evaluation,population pharmacokinetic studies and pharmacogenomics studies.Methods This study has an observational design.The atypical antipsychotics include quetiapine,olanzapine,risperidone,aripiprazole,ziprasidone,paliperidone,amisulpride,perospirone and clozapine.Visits occur at 0,4,8,13,26,52,78,104,130 and 156 weeks.The efficacy evaluations include symptoms,social function,recurrence rate and hospitalisation.The safety measures include physical examination,vital signs,abdominal circumference,laboratory tests(such as blood cell analysis,blood biochemical tests and serum prolactin/thyroxine levels),12-lead ECG,extrapyramidal syndrome assessment,sexual function evaluation,medication and other adverse events.The secondary measures include the Positive and Negative Syndrome Scale,Clinical Global Impression-Severity of Illness Scale,Calgary Depression Scale for Schizophrenia,Personal and Social Performance Scale,relapse rate,drug consolidation,medical-related expenses,income,drug plasma concentration and genetic information.Results This is a large sample,non-interventional and long-term prospective clinical study designed to truly reflect the specific details of clinical practice,fully respect patients’needs,and understand patients’treatment intentions and actual treatment details.Conclusions This research method details the aims,methods,study design,strengths and limitations of the study. | Wenjuan Yu Jingjing Huang Sidi He Lei Zhang Yifeng Shen Huafang Li | 2021 | General Psychiatry2021，34，1： | 4 |
| 9 | Dynamic memory paravirtualization transparent to guest OS显示文摘This paper introduces dynamic paravirtualization, which imitates paravirtualization and aims at reducing VM exits of full virtualization with hardware support. In dynamic paravirtualization, VMM (virtual machine monitor) dynamically monitors and replaces the hot instructions, which cause most VM exits. It is transparent to the guest OS such that the legacy OSes can benefit from this optimization. Our study focuses on reducing the overhead of memory virtualization-dynamic memory paravirtualization (DMP). We implant a new memory management mechanism in VMM such that all user-mode page faults can be handled by the guest OS directly without VM exits. We implement a prototype of dynamic memory paravirtulization based on a version of KVM using Intel VT. Our experimental results show that our technique essentially eliminates the overhead of VM exits caused by page faults. Dynamic memory paravirtualization can achieve the effectiveness of paravirtualization without changing the source code of guest OS. | WANG XiaoLin SUN YiFeng LUO YingWei WANG ZhenLin LI Yu ZHANG BinBin CHEN HaoGang LI XiaoMing | 2010 | Science China(Information Sciences)2010，53，1： | 4 |
| 10 | Study on phase retardation characteristic of LCVR using dispersion analysis and SVM显示文摘To calibrate the phase retardance of a Liquid crystal variable retarder(LCVR),its birefringence dispersion characteristic was analyzed,and the Support vector machines(SVM) algorithm was adopted to establish the prediction model.The obtained SVM decision function was used as a part of LCVR phase retardance,which was generated by the driving voltage.The experimental verification was carried out with a 568 nm laser.The results show that the deviation of the experimental value and the theoretical value is about 0.0061λ.SVM method could be used as an effective method for LCVR phase retardance characteristic calibration. | HU Dongmei LIU Quan NIU Guocheng ZHU Yifeng YU Lintao | 2015 | Instrumentation2015，2，2： | 4 |
| 11 | Adoptively transferred donor IL-17-producing CD4^(+) T cells augment, but IL-17 alleviates, acute graft-versus-host disease显示文摘The role of IL-17 and IL-17-producing CD4^(+) T cells in acute graft-versus-host disease(GVHD)has been controversial in recent mouse and human studies.We carried out studies in a murine acute GVHD model of fully major histocompatibility complex-mismatched myeloablative bone marrow transplantation.We showed that donor wild-type CD4^(+) T cells exacerbated acute GVHD compared with IL-17−/−CD4^(+) T cells,while IL-17 reduced the severity of acute GVHD.The augmentation of acute GVHD by transferred donor IL-17-producing CD4^(+) T cells was associated with increased Th1 responses,while IL-17 decreased the percentages of Th1 cells in the GVHD target organs.Furthermore,IL-17 reduced the infiltration of macrophages into the GVHD tissues.In vitro study showed that IL-17 could downregulate Th1 responses,possibly through inhibiting IL-12 production by donor macrophages.Depletion of macrophages in vivo diminished the protective effect of IL-17.Our results demonstrated the differential roles of adoptively transferred donor IL-17-producing CD4^(+) T cells and IL-17 in the same acute GVHD model. | Yifeng Cai Shoubao Ma Yuejun Liu Huanle Gong Qiao Cheng Bo Hu Yan Wu Xiao Yu Chen Dong Kai Sun Depei Wu Haiyan Liu | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 12 | Refinement mechanism of cerium addition on solidification structure and sigma phase of super austenitic stainless steel S32654显示文摘The influence of Ce addition on the solidification structure and σphase of super austenitic stainless steel S32654 was systematically investigated via microstructural characterization and thermodynamic calcula- tion. The results indicate that a small addition of Ce could modify MgO and MnS into Ce-bearing inclu- sions Ce_(2)O_(3)and Ce_(2)O_(2)S. Ce addition led to noticeable refinement of both the dendrite structure and σphase. The refinement mechanism could be attributed to the combined actions of effective Ce-bearing inclusions and solute Ce. Effective Ce-bearing inclusions could serve as heterogeneous nucleation cores of austenite as well as σphase, which provided a favorable prerequisite for their refinement. Solute Ce significantly enhanced the undercooling degree of the system, further promoting dendrite structure re- finement. Meanwhile, solute Ce improved the eutectic precipitation conditions of σphase and further promoted its nucleation, while the dendrite refinement limited its growth space. Finally, more fine and dispersed σphase particles formed in S32654 with Ce addition. The refinement of dendrite structure and σ phase will reduce the temperature and time required for high-temperature homogenization, which is beneficial to the hot working of this steel. | Shucai Zhang Jiangtao Yu Huabing Li Zhouhua Jiang Yifeng Geng Hao Feng Binbin Zhang Hongchun Zhu | 2022 | Journal of Materials Science & Technology2022，，7： | 3 |
| 13 | Evaluation of the relative risk of stroke in patients with hypertension using cerebrovascular hemodynamic accumulative score显示文摘The relative risk(RR)of stroke in patients with hypertension was evaluated by using synthetic index of cerebrovascular hemodynamics.A total of 7,371 patients with hypertension with ages i40 years were selected from a population-based cohort study of the risk factors for stroke.The data on the baseline investigation of risk factors,the determination of cerebrovascular hemodynamic parameters(CVHP),and stroke follow-up were analyzed.The RR of stroke in patients with hypertension was evaluated by CVHP scores.Univariate analysis indicated that hypertension,complicated by other risk factors,had significant statistical association with the onset of stroke.RRs for stroke when hypertension complicated with decrease of hemodynamic scores,heart disease,cigarette smoking and alcohol consumption were 4.93(95%CI,3.26–7.45),1.90(95%CI,1.36–2.66),1.99(95%CI,1.42–2.79)and 1.73(95%CI,1.19–2.53)respectively.In multivariate analysis,hemodynamic score,age,sex,cigarette smoking,family history of stroke and systolic blood pressure were selected by the Cox regression for inclusion in the final analysis.Among them,the RR of hemodynamic score was highest.The analysis of doseresponse relationships indicated that when the hemodynamic scores in patients with hypertension were lower than 75 points,the RR of stroke at 75,60,45,30 and 15 points were 2.85,4.43,4.54,5.40 and 9.88,respectively.The risk of stroke in patients with hypertension is closely asso ciated with hemodynamic impairment and the hemodynamic score may be used for quantitative evaluation of relative risks of stroke. | HUANG Jiuyi WANG Guiqing GUO Jiping CAO Yifeng WANG Yan YANG Yongju YU Xuehai | 2007 | Frontiers of Medicine2007，1，3： | 2 |
| 14 | Bimetallic PdCo catalyst for selective direct formylation of amines by carbon monoxide显示文摘高度有效、选择的二金属的 Pd 0.88 公司 0.12 nanoparticle 催化剂被碳一氧化物为胺的直接 N-formylation 开发。这催化剂与大量底层兼容,负担得起在实际、温和的反应条件下面的各种各样的综合地有用的 formamides。 | Yifeng Chen Junjie Mao Rongan Shen Dingsheng Wang Qing Peng Zhixin Yu Huifang Guo Wei He | 2017 | Nano Research2017，10，3： | 2 |
| 15 | Quantitative distinction of the relative actions of climate change and human activities on vegetation evolution in the Yellow River Basin of China during 1981-2019显示文摘Under the combined influence of climate change and human activities,vegetation ecosystem has undergone profound changes.It can be seen that there are obvious differences in the evolution patterns and driving mechanisms of vegetation ecosystem in different historical periods.Therefore,it is urgent to identify and reveal the dominant factors and their contribution rates in the vegetation change cycle.Based on the data of climate elements(sunshine hours,precipitation and temperature),human activities(population intensity and GDP intensity)and other natural factors(altitude,slope and aspect),this study explored the spatial and temporal evolution patterns of vegetation NDVI in the Yellow River Basin of China from 1989 to 2019 through a residual method,a trend analysis,and a gravity center model,and quantitatively distinguished the relative actions of climate change and human activities on vegetation evolution based on Geodetector model.The results showed that the spatial distribution of vegetation NDVI in the Yellow River Basin showed a decreasing trend from southeast to northwest.During 1981-2019,the temporal variation of vegetation NDVI showed an overall increasing trend.The gravity centers of average vegetation NDVI during the study period was distributed in Zhenyuan County,Gansu Province,and the center moved northeastwards from 1981 to 2019.During 1981-2000 and 2001-2019,the proportion of vegetation restoration areas promoted by the combined action of climate change and human activities was the largest.During the study period(1981-2019),the dominant factors influencing vegetation NDVI shifted from natural factors to human activities.These results could provide decision support for the protection and restoration of vegetation ecosystem in the Yellow River Basin. | LIU Yifeng GUO Bing LU Miao ZANG Wenqian YU Tao CHEN Donghua | 2023 | Journal of Arid Land2023，15，1： | 2 |
| 16 | Crustal structure of the southeastern margin of the Ordos Block显示文摘我们由 teleseismic 接收装置功能组成使用侧面学习厄多斯·布洛克的东南的边缘的外壳的厚度和结构。Mohorovii 断绝(莫霍) 在所有车站下面被识别了。它的深度逐渐地向东南减少,从在到 Qinling Orogen 的北边缘附近的 30 km 的厄多斯·布洛克的大约 43 km。我们的结果在外壳的结构和莫霍的特征显示出清楚的侧面的变化。因此,学习区域能被划分成四部分:(1 ) 在厄多斯·布洛克,下面,莫霍在 40 km 的深度可见、扁平。外壳的结构被稳定的 cratonic 外壳最好描绘。(2 ) 在 Weihe 山西 Graben,莫霍被大约 3 km 高举,它可以是上面的披风材料的 upwelling 的结果。(3 ) 在 Xionger-Funiu 山下面,莫霍在在 36 和 33 km 之间的深度是扁平的,但是向东南变得更浅。(4 ) 在 Hehuai 盆,邻近 Qinling Orogen 的北边缘,莫霍与 31 km 的吝啬的深度显示出强壮的侧面的变化。这里的外壳的结构是复杂的,它可以显示复杂构造环境。另外,莫霍清楚地在二个地点被打断(在车站 st11 和 st18 下面) 近主要的构造边界。这些结果建议沿着厄多斯·布洛克的东南的边缘的深外壳的结构有大侧面的可变性,它强烈在表面上影响复杂地质的特征。而且,这些结果能帮助我们理解厄多斯·布洛克的东南的边缘的不同部分的相互关系。 | LU YiFeng XU MingJie WANG LiangShu MI Ning LI Hua YU DaYong | 2011 | Chinese Science Bulletin2011，56，35： | 2 |
| 17 | EXPRESSION OF p16 AND p53 IN GASTRIC CARCINOMA显示文摘Objective:To investigate the clinical significance of p53 and p16 expression in gastric carcinoma with special reference to the prognosis.Methods:One hundred and fifty-two patients with gastric carcinoma undergoing operation in our hospital between 1991 and 1998 were evaluated for expression of p53 and p16 in formalin-fixed and paraffin-embedded tumor tissue utilizing Avidin-Biotin immunohistochemistry techniques. Statistical correlations with stage, histological type, differentiation degree, location, size, and overall survival were done. The Cox proportional hazard model was also performed to evaluate which factors had an independent prognostic value.Results:In 152 cases of resected gastric cancer, 110 (72.4%) were p16 positive and 49 (32.2%) showed p53 overexpression. Differences were observed in the frequency of p16 positivity with respect to age, gender and tumor size. The frequency of p53 positivity cells in well-differentiated tumors was significantly higher than that in poorly differentiated tumors (41.9% vs. 25.6%; P = 0.034). In a multivariate analysis, tumor TNM stage, perioperation chemotherapy and the expression of p16 were independent prognostic factors in gastric cancer.Conclusions:The results of the current study suggest that expression of p16 may be a useful prognostic factor for patients with gastric carcinoma, but the expression of p53 as detected by immunohistochemistry were of no value in predicting the prognosis of patients with gastric carcinoma independently. | Ma Yu, Gao Liping 1, Song Yifeng, Jing Jiong, Wang ChunjiangFirst Department of Surgery,Shengzhou People’s Hospital, Shengzhou 312400 | 2003 | 中国现代医学杂志2003，13，1： | 1 |
| 18 | Pomelo Peel-Inspired 3D-Printed Porous Structure for Efficient Absorption of Compressive Strain Energy显示文摘The porous structure in pomelo peel is believed to be responsible for the protection of its fruit from damage during the free falling from a tree.The quantitative understanding of the relationship between the deformation behavior and the porous structure could pave the way for the design of porous structures for efficient energy absorption.Here,a universal feature of pore distribution in pomelo peels along the radial direction is extracted from three varieties of pomelos,which shows strong correlation to the deformation behavior of the peels under compression.Guided by the porous design found in pomelo peels,porous polyether-ether-ketone(PEEK)cube is additively manufactured and possesses the highest ability to absorb energy during compression as compared to the non-pomelo-inspired geometries,which is further confirmed by the finite element simulation.The nature-optimized porous structure revealed here could guide the design of lightweight and high-energy-dissipating materials/devices. | Baisong Yang Wenhui Chen Renlong Xin Xiaohong Zhou Di Tan Chuan Ding You Wu Liang Yin Chuyang Chen Shan Wang Zhenglei Yu Jonathan TPham Sheng Liu Yifeng Lei Longjian Xue | 2022 | Journal of Bionic Engineering2022，19，2： | 1 |
| 19 | Prediction of adolescent subjective well being: A machine learning approach显示文摘Background Subjective well-being(SWB),also known as happiness,plays an important role in evaluating both mental and physical health.Adolescents deserve specific attention because they are under a great variety of stresses and are at risk for mental disorders during adulthood.Aim The present paper aims to predict undergraduate students1 SWB by machine learning method.Methods Gradient Boosting Classifier which was an innovative yet validated machine learning approach was used to analyse data from 10518 Chinese adolescents.The online survey included 298 factors such as depression and personality.Quality control procedure was used to minimise biases due to online survey reports.We applied feature selection to achieve the balance between optimal prediction and result interpretation.Results The top 20 happiness risks and protective factors were finally brought into the predicting model.Approximately 90%individuals'SWB can be predicted correctly,and the sensitivity and specificity were about 92%and 90%,respectively.Conclusions This result identifies at-risk individuals according to new characteristics and established the foundation for adolescent prevention strategies. | Naixin Zhang Chuanxin Liu Zhixuan Chen Lin An Decheng Ren Fan Yuan Ruixue Yuan Lei Ji Yan Bi Zhenming Guo Gaini Ma Fei Xu Fengping Yang Liping Zhu Gabirel Robert Yifeng Xu Lin He Bo Bai Tao Yu Guang He | 2019 | General Psychiatry2019，32，5： | 1 |
| 20 | Feasibility of sentinel lymph node biopsy omission after integration of ^(18)F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial显示文摘Objective:Sentinel lymph node biopsy(SLNB)is currently the standard of care in clinically node negative(cN0)breast cancer.The present study aimed to evaluate the negative predictive value(NPV)of 18F-FDG dedicated lymph node positron emission tomography(LymphPET)in cN0 patients.Methods:This was a prospective phase II trial divided into 2 stages(NCT04072653).In the first stage,cN0 patients underwent axillary LymphPET followed by SLNB.In the second stage,SLNB was omitted in patients with a negative preoperative axillary assessment after integration of LymphPET.Here,we report the results of the first stage.The primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes(LN-macro).Results:A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological reports.Forty patients had LN-macro,and 16 patients had only lymph node micrometastasis.Of the 131 patients with a negative LymphPET result,16 patients had LN-macro,and the NPV was 87.8%.After combined axillary imaging evaluation with ultrasound and LymphPET,100 patients were found to be both LymphPET and ultrasound negative,9 patients had LN-macro,and the NPV was 91%.Conclusions:LymphPET can be used to screen patients to potentially avoid SLNB,with an NPV>90%.The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET. | Junjie Li Jingyi Cheng Guangyu Liu Yifeng Hou Genghong Di Benglong Yang Yizhou Jiang Liang Huang Feilin Qu Sheng Chen Yan Wang Keda Yu Zhimin Shao | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
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