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| 1 | 点阵激光联合富血小板血浆治疗痤疮瘢痕显示文摘背景富血小板血浆(PRP)因其富含大量的生长因子,已经被应用于增强激光治疗痤疮瘢痕的临床疗效,但是其具体作用机制尚不得而知。目的 本研究旨在探讨PRP联合点阵激光治疗痤疮瘢痕背后的分子机制。方法 受试者的痤疮瘢痕程度从轻度到中度,采用自身对照的方法,受试者在使用点阵CO_2激光治疗后,一侧面部使用PRP辅助治疗,另一侧不使用PRP。设立患者皮肤活检状态的基线,在治疗后第1天、第3天、第7天和第28天分别获得皮肤活检标本并进行检测,研究激光联合PRP后皮肤相关变化的分子层面因素。结果 激光联合PRP治疗痤疮瘢痕的临床疗效更佳,降低了红斑、肿胀和渗出等不良反应的严重程度。 | Min S Yoon JY Park SY | 2018 | 中国医疗美容2018，8，1： | 12 |
| 2 | Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission显示文摘Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities.In this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone.This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 nm.Such long wavelength emission prompted a superior bioimaging resolution in vivo.In particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of mice.More significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence imaging.This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission. | Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang | 2022 | CCS Chemistry2022，4，6： | 2 |
| 3 | Effector function of type Ⅱ collagen-stimulated T cells from rheumatoid arthritis patients: Cross-talk between T cells and synovial fibroblasts显示文摘 | Cho ML Yoon CH Hwang SY | 2004 | Arthritis Rheum2004，50，3： | 1 |
| 4 | Cinnamaldehyde inhibits Iymphocyte proliferation and modulates T-cell differentiation 显示文摘 | Yoon SY Kwon BM Jeong TC | 1998 | Int J Immunopharmacol1998，20，11： | 1 |
| 5 | Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons显示文摘 | Yoon SY Choi JE Choi JM | 2008 | NeurosciLett2008，437，2： | 1 |
| 6 | Interleukin-17 increases the expression of Toll-like receptor 3 via the STAT3 pathway in rheumatoid arthritis fibroblast-like synoviocytes显示文摘 | Lee SY Yoon BY Kim JI | 2014 | Immunology2014，141，3： | 1 |
| 7 | Activation of the spinal sigma-! receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice显示文摘 | Kim HW Roh DH Yoon SY | 2008 | Br J Pharmacol2008，154，5： | 1 |
| 8 | Coxsackievirus B4 uses autoph- agy for replication after calpain activation in rat primary neurons 显示文摘 | Yoon SY Ha YE Choi JE | 2008 | J Virol2008，82，11： | 1 |
| 9 | 显示文摘 | Hanson CA Yoon SY | 2000 | Blood2000，96，： | 1 |
| 10 | Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron显示文摘 | Yoon SY Choi HI Choi JE | 2007 | Biochem Biophys Res Commun2007，363，3： | 1 |
| 11 | Production of poly-γ-glutamic acid by fed-batch culture of Bacillus licheniformis显示文摘 | Yoon SH Do JH Lee SY | 2000 | Biotechnology Letters2000，22，7： | 1 |
| 12 | Cellular distribution of plateletderived growth factor, trans-forming growth 显示文摘 | Yoon SY Tefferi A Li CY | 2000 | Acta Haematol2000，104，4： | 1 |
| 13 | TRAF-6 mediated regulation of the PI3kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival 显示文摘 | Yoon K Jung EJ Lee SY | 2008 | Biochem Biophys Res Commun2008，371，1： | 1 |
| 14 | Acetylcholine controls mouse ooc- yte maturation via downregulation of cAMP 显示文摘 | Yoon SY Choe C Kim E J | 2011 | Clin Exp Pharmacol Physiol2011，38，7： | 1 |
| 15 | The complete nucleotide sequence and gene organization of the mitochondrial genome of the bumblebee,Bombus ignitus (Hymenoptera:Apidae)显示文摘 | Cha SY Yoon HJ Lee EM Yoon MH Hwang JS Jin BR Han YS Kim I | | 0，，1： | 1 |
| 16 | Effect of dexmedetomidine on sevoflurane requirements and emergence agitation in chil- dren undergoing ambulatory surgery 显示文摘 | Kim NY Kim SY Yoon H J | 2014 | Yonsei Med J2014，55，1： | 1 |
| 17 | Interleukin-17 increasesthe expression of Toll -like receptor 3 via the STAT3pathway in rheumatoid arthritis fibroblast -like synovio-cytes 显示文摘 | Lee SY Yoon BY Kim JI | 2014 | Immunology2014，141，3： | 1 |
| 18 | The usefulness of the ivy sign on fluid-attenuated intensity recovery images in improved brain hemody- namic changes after superficial temporal artery-middle cerebral artery anastomosis in adult patients with moyamoya disease 显示文摘 | Lee JK Yoon Bid Chung SY | 2013 | J Korean Neurosurg Soc2013，54，： | 1 |
| 19 | Pregnancies and deliveries after transfer of human blastocysts derived from in vitro matured oocytes in in vitro maturation cycles显示文摘 | Son WY Lee SY Yoon SH | 2007 | Fertil Steril2007，87，6： | 1 |
| 20 | OK-432 and 5-fluorouracil,doxorubicin,and mitomycinC(FAM-P) versus FAM chemotherapy in patients with curatively resected gastric carcinoma:arandomized Phase Ⅲ trial显示文摘 | Kim SY Park HC Yoon C | 1998 | Cancer1998，83，10： | 1 |
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