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| 1 | 异位甲状腺与甲状腺肿瘤显示文摘目的 :探讨异位甲状腺及其肿瘤的临床病理学特点及诊治原则。方法 :对32例舌根甲状腺及6例其它中线部位的异位甲状腺之临床病理学资料进行了分析。对59例因“侧方异位甲状腺”而行同侧或双侧甲状腺切除的术后病理亦作了分析。结果 :32例舌根甲状腺无症状者11例 ,有症状性者21例 ,完全性异位16例 ,部分性异位16例 ,16例给予甲状腺素治疗仅1例无效 ,8例行手术切除术后病理显示2例腺瘤性甲状腺肿、2例甲状腺腺瘤、1例甲状腺滤泡癌和3例正常甲状腺组织。所有的因“侧方异位甲状腺”而行正常位置甲状腺切除术后病理均找到甲状腺原发癌。结论 :甲状腺胚胎发育异常是异位甲状腺的主要原因。通常位于中线部位。异位甲状腺可以发生正常位置甲状腺可发生的所有病变。“侧方异位甲状腺”应定义为颈动脉鞘外侧 ,基本上都是隐性甲状腺癌的转移灶 。 | 杨红健 Rapoport Yoram | 2000 | 中国肿瘤临床2000，27，2： | 14 |
| 2 | Treatment of hepatocellular carcinoma: Steps forward but still a long way to go显示文摘Hepatocellular carcinoma(HCC) is the fifth most common malignancy and the third cause of tumor associated deaths worldwide. HCC incidence rates are increasing in many parts of the world including developing and developed countries. Potentially curative treatments for HCC are resection and liver transplantation, but these are only suitable for patients with small tumors, meeting strict pre-defined criteria, or well-compensated liver disease. Early diagnosis of HCCcan be achieved by surveillance of at-risk populations. For patients with non-resectable disease treatments modalities include loco-ablative and systemic therapies. In this review we focus on treatment options in HCC and their allocation. Although significant research is in progress, to this date, the results are unsatisfactory with limited long-term survival. In the fight against this deadly disease, there is still a long way to go. | Liat Mlynarsky Yoram Menachem Oren Shibolet | 2015 | World Journal of Hepatology2015，7，3： | 13 |
| 3 | Utility of routine blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones显示文摘AIM To evaluate the value of blood testing after elective laparoscopic cholecystectomy and its association with procedure related complications.METHODS Charts of all patients undergoing elective laparoscopic cholecystectomy from January 2013 through December2014 were reviewed retrospectively for demographics,indication for surgery,operative course and outcome.In our institution the decision to perform postoperative blood analysis is left for the discretion of the surgeon,therefore we had the possibility to compare the results of those who had blood analyses results to those who did not.Analysis was performed to identify variables associated with the decision to perform postoperative blood tests.Subsequently a univariate and multivariate analyses was performed comparing the two cohorts.Secondary subgroup analysis was performed to identify factors associated with procedure related complications.RESULTS Five hundred and thirty-two elective laparoscopic cholecystectomies for symptomatic gallstones were performed during the study period.Sixty-four percent of the patients(n=340)had blood tests taken post operatively.Patients that had laboratory tests taken were older(P=0.006,OR=1.01),had longer surgery(P<0.001,OR=3.22)had more drains placed(P<0.001,OR=3.2)and stayed longer in the hospital(P<0.001,OR=1.2).A subgroup analysis of the patients who experienced complications revealed longer stay in the hospital(P<0.001),higher body mass index(BMI)(P=0.04,OR=1.08),increased rates of drain placement(P=0.006,OR=3.1)and higher conversion rates(P=0.01,OR=14.6).Postoperative blood tests withdrawals were not associated with complications(P=0.44).On Multivariate analysis BMI and drain placement were independently associated with complications.CONCLUSION The current study indicate that routine postoperative blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones does not predict complications and may have an added benefit in diagnosis and management of cases were the surgeon encountered true technical difficulty during surgery. | Offir Ben-Ishay Marina Zeltser Yoram Kluger | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 7 |
| 4 | 诺西那生治疗脊髓性肌萎缩显示文摘目的观察诺西那生(Nusinersen)治疗脊髓性肌萎缩(SMA)患者的疗效和不良反应。方法回顾性分析2017年9月至2018年3月以色列施耐德儿童医学中心神经内科就诊的12例SMA患儿的临床资料。所有患儿均经基因检测证实为运动神经元存活基因(SMN)1纯合子7号外显子缺失,无SMN1杂合子突变。应用诺西那生12mg腰椎穿刺鞘内注射治疗,前4次鞘内给药为负荷剂量12mg,分别于1、15、30、60d给药,以后每4个月给予1次维持剂量12mg。于181d运用费城儿童医院神经肌肉障碍婴儿测试量表(CHOP-INTEND)和Hammersmith运动功能评分量表(HFMSE)量表评价患儿运动功能改善情况。结果治疗181d评价,早发型(SMA-Ⅰ)4例中2例CHOP-INTEND评分提高3分和5分,另2例肌张力有明显改善;晚发型(SMA-Ⅱ/SMA-Ⅲ/SMA-Ⅳ)8例HFMSE评分均有不同程度改善,最低提高3.1分,最高提高5.2分,平均提高4.1分。不良反应少且轻微。结论诺西那生治疗SMA的疗效肯定,安全性较好。 | 陈峥 Yoram Nevo Tanya Moss | 2019 | 中国临床研究2019，32，6： | 7 |
| 5 | 交易成本与合约选择 | Yoram Barzel 江静 刘健 刘镭 王芃 | 2004 | 南大商学评论2004，4，2： | 6 |
| 6 | Etiology and long-term outcome of extrahepatic portal vein obstruction in children显示文摘AIM:To study the management and outcome of children with extrahepatic portal vein obstruction(EHPVO) in a whole country population.METHODS:A nationwide multicenter retrospective case series of children with EHPVO was conducted.Data on demographics,radiographic studies,laboratory workup,endoscopic and surgical procedures,growth and development,were extracted from the patients' charts.Characteristics of clinical presentation,etiology of EHPVO,management and outcome were analyzed.RESULTS:Thirty patients,13 males and 17 females,19(63.3%) Israeli and 11(36.7%) Palestinians,were included in the analysis.Age at presentation was 4.8± 4.6 years,and mean follow-up was 4.9±4.3 years.Associated anomalies were found in 4 patients.The incidence of EHPVO in Israeli children aged 0-14 years was 0.72/million.Risk factors for EHPVO were detected in 13(43.3%)patients,including 9 patients(30%) with perinatal risk factors,and 4 patients(13.3%) with prothrombotic states:two had low levels of protein S and C,one had lupus anticoagulant,and one was homozygous for methyltetrahydrofolate reductase mutations.In 56.6% of patients,no predisposing factors were found.The most common presenting symptoms were an incidental finding of splenomegaly(43.3%),and upper gastrointestinal bleeding(40%).No differences were found between Israeli and Palestinian children with regard to age at presentation,etiology and clinical symptoms.Bleeding occurred in 18 patients(60%),at a median age of 3 years.Sclerotherapy or esophageal banding was performed in 20 patients.No sclerotherapy complications were reported.Portosystemic shunts were performed in 11 patients(36.6%),at a median age of 11(range 3-17)years:splenorenal in 9,mesocaval in 1,and a meso-Rex shunt in 1 patient.One patient underwent splenectomy due to severe pancytopenia.Patients were followed up for a median of 3(range 0.5-15)years.One patient died aged 3 years due to mucopolysaccharidase deficiency type Ⅲ.None of the patients died due to gastrointestinal bleeding.CONCLUSION:EHPVO is a rare disorder.The etiological factors are still mostly unknown,and the endoscopic and surgical treatment options ensure a good long-term prognosis. | Batia Weiss Eyal Shteyer Asaf Vivante Drora Berkowitz Shimon Reif Zvi Weizman Yoram Bujanover Rivka Shapiro | 2010 | World Journal of Gastroenterology2010，16，39： | 6 |
| 7 | Confounding factors affect the pathophysiology of eosinophilic esophagitis显示文摘Eosinophilic esophagitis is a newly diagnosed esophageal disease in adult and children. The clinical and pathological characteristics of this disease have been established and were recently summarized in the expert clinical guideline published in 2011. In spite of the wide knowledge accumulated on this disease, there are many areas where scientific data are missing, especially in regard to the disease's pathophysiology. Recent publications have suggested that other confounding factors modify the disease and may affect its clinicalphenotypic presentation. Those factors may include place of living, air pollution, race, genetic factors and other. In the present report we discussed and review those confounding factors, the new developments, and what direction we should go to further advance our knowledge of this disease. | Yoram Elitsur | 2012 | World Journal of Gastroenterology2012，18，33： | 6 |
| 8 | Reconfigurable manufacturing systems: Principles, design, and future trends显示文摘 | Yoram KOREN Xi GU Weihong GUO | 2018 | Frontiers of Mechanical Engineering2018，13，2： | 6 |
| 9 | Arahidopsis CHLOROPHYLLASE 1 protects young leaves from long-term photodamage by facilitating FtsH-mediated D1 degradation in photosystemⅡrepair显示文摘The proteolytic degradation of the photodamaged D1 core subunit during the photosystemⅡ(PSⅡ)repair cycle is well understood,but chlorophyll turnover during D1 degradation remains unclear.Here,we report that Arabidopsis thaliana CHLOROPHYLLASE 1(CLH1)plays important roles in the PSII repair process.The abundance of CLH1 and CLH2 peaks in young leaves and is induced by high-light exposure.Seedlings of clh1 single and clh1-1/2-2 double mutants display increased photoinhibition after long-term high-light exposure,whereas seedlings overexpressing CLH1 have enhanced light tolerance compared with the wild type.CLH1 is localized in the developing chloroplasts of young leaves and associates with the PSⅡ-dismantling complexes RCC1 and RC47,with a preference for the latter upon exposure to high light.Furthermore,degradation of damaged D1 protein is retarded in young clh1-1/2-2 leaves after 18-h highlight exposure but is rescued by the addition of recombinant CLH1 in vitro.Moreover,overexpression of CLH1 in a variegated mutant(var2~2)that lacks thylakoid protease FtsH2,with which CLH1 interacts,suppresses the variegation and restores D1 degradation.A var2-2 clh1-1/2-2triple mutant shows more severe variegation and seedling death.Taken together,these results establish CLH1 as a long-sought chlorophyll dephytylation enzyme that is involved in PSⅡrepair and functions in long-term adaptation of young leaves to high-light exposure by facilitating FtsH-mediated D1 degradation. | Ya-nan Tian Rui-hao Zhong Jun-bin Wei Hong-hui Luo Yoram Eyal Hong-lei Jin La-jie Wu Ke-ying Liang Ying-man Li Shu-zhen Chen Zhao-qi Zhang Xue-qun Pang | 2021 | Molecular Plant2021，14，7： | 6 |
| 10 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 11 | Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn’s Disease显示文摘 | Pierre Desreumaux Arnaud Foussat Matthieu Allez Laurent Beaugerie Xavier Hébuterne Yoram Bouhnik Maria Nachury Valérie Brun Hervé Bastian Nathalie Belmonte Michel Ticchioni Agnès Duchange Patricia Morel–Mandrino Virginie Neveu Nathalie Clerget–Chossat Mig | 2012 | Gastroenterology2012，，5： | 4 |
| 12 | Autoimmune pancreatitis misdiagnosed as a tumor of the head of the pancreas显示文摘Autoimmune pancreatitis can mimic pancreatic cancer in its clinical presentation, imaging features and laboratory parameters. Differentiating between those two entities requires implementation of clinical judgment and experience along with objective parameters that may suggest either condition. Few strategies have been proposed for the surgeon to implement when facing borderline cases. The following case is an example of a clinical scenario compatible with an accepted algorithm for diagnosis of pancreatic cancer, which eventually proved wrong. We present a 75-year-old patient who was admitted for obstructive jaundice. Imaging features were highly suggestive for pancreatic cancer as was the carbohydrate antigen 19-9 (CA 19-9) level, leading to a decision for surgery. Pathological examination revealedautoimmune pancreatitis. Though no frank carcinoma was found, premalignant ductal changes of pancreatic intraepithelial neoplasia (PanIN)Ⅰand PanIN Ⅱ were discovered throughout the pancreatic duct. Caution is advised when relying on the combination of highly suggestive radiology features and elevated levels of CA 19-9 in the diagnosis of pancreatic cancer. When the tissue diagnosis is not conclusive, obtaining IgG4 and antinuclear Ab levels is advised, to rule out the rare possibility of autoimmune pancreatitis. Patients with autoimmune pancreatitis should be followed carefully as precancerous lesions may accompany the benign disease and the correlation of these two entities has not been ruled out. | Eran Brauner Jesse Lachter Offir Ben-Ishay Euvgeni Vlodavsky Yoram Kluger | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 4 |
| 13 | Capacitive deionization (CDI) for desalination and water treatment — past, present and future (a review)显示文摘 | Yoram Oren | 2008 | Desalination2008，，1： | 4 |
| 14 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 15 | 一种进行基因表达研究的有效技术——小鼠全胚胎RNA原位杂交显示文摘目的 建立小鼠整体胚胎水平研究基因表达的方法。 方法 采用地高辛配基标记的造血相关基因 Runx1和神经发生相关基因 Runx3RNA探针 ,对 10 .5~ 14天小鼠全胚胎进行 RNA原位杂交 ,通过检测胚胎组织中 m RNA的存在状况来观察基因的表达。结果 在小鼠胚胎观察到 Runx1和 Runx3基因在不同组织中的清晰的杂交信号 ;不同探针和不同大小的胚胎需要不同的最适蛋白酶 K处理条件。 结论 小鼠全胚胎 RNA原位杂交技术是一种有效的研究基因表达的方法 ,可以从整体水平反映基因表达的全貌 ,在功能基因组学时代将具有很大的应用潜力 ,为基因表达研究提供了一种可与 L ac Z染色和免疫组织化学媲美的选择。蛋白酶 K处理条件是否适当是小鼠全胚胎 RNA原位杂交成功的关键因素。 | 肖翠英 Ditsa Levanon 张思仲 Yoram Groner | 2004 | 中华医学遗传学杂志2004，21，1： | 3 |
| 16 | Use of a green channel in remote sensing of global vegetation from EOS-MODIS显示文摘 | Anatoly A. Gitelson Yoram J. Kaufman Mark N. Merzlyak | 1996 | Remote Sensing of Environment1996，，3： | 3 |
| 17 | Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation显示文摘 | Konstantinos Hatzimouratidis Edouard Amar Ian Eardley Francois Giuliano Dimitrios Hatzichristou Francesco Montorsi Yoram Vardi Eric Wespes | 2010 | European Urology2010，，5： | 3 |
| 18 | STUDIES ON SLOW RELEASE FERTILIZERS: 1. EFFECTS OF TEMPERATURE, SOIL MOISTURE, AND WATER VAPOR PRESSURE显示文摘 | MALKA KOCHBA SHARON GAMBASH YORAM AVNIMELECH | 1990 | Soil Science1990，，6： | 2 |
| 19 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 20 | Novel algorithms for remote estimation of vegetation fraction显示文摘 | Anatoly A. Gitelson Yoram J. Kaufman Robert Stark Don Rundquist | 2002 | Remote Sensing of Environment2002，，1： | 2 |
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