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| 1 | Cloning and Characterization of Genes Coding for Fructan Biosynthesis Enzymes (FBEs) in Triticeae Plants显示文摘Fructan is not only a carbon source for storage but also plays an important role as anti-stress agents in many plant species. Complex fructans having both β-(2,1)- and β-(2,6)-linked fructosyl units accumulate in Triticeae plants commonly. Three enzymes (sucrose: sucrose 1-fructosyltransferase, 1-SST, EC: 2.4.1.99; sucrose: fructan 6-fructosyltransferase, 6- SFT, EC: 2.4.1.10; and fructan: fructan 1-fructosyltransferase, 1-FFT, EC: 2.4.1.100) were involved in fructan biosynthesis in Triticeae plant species. We successfully isolated these genes from tetraploid wheat (Triticum turgidum, genotype: AABB), common wheat (Triticum aestivum L., genotype: AABBDD) and three wild relatives of common wheat, Triticum urartu Thum. (the origin of the AA genome), Aegilops speltoides (Tausch) Gren. (the putative source of the SS genome) and Aegilops tauschii Coss. (the source of the DD genome). Sequence analysis revealed that all the FBEs (fructan biosynthetic enzymes) had three highly conserved functional motifs except 1-SST (EU981912) from tetraploid wheat species only with conserved DPNG. Low pI (isoelectric point) and potential N-glycosylation sites were predicted, which were crucial for protein compartmentation and post-translational process. Analysis on subcelluar localization signals showed that only 6-SFT had vacuolar-directed signal. Sequences alignment result showed that 1-SST and 1-FFT were more conservative and had closer relationship each other, while 6-SFT was more active during the evolution processing. According to the syntenic relationship between wheat and rice genome, FBEs were predicated to be located on the homeologous group 6 and group 2 chromosomes. Expression profile confirmed that expression of all the three FBEs were drought-stress induced. This study can assist to establish a useful theoretical platform for cold- or drought-tolerant improvement of wheat by modulating FBEs expression. | GAO Xiang SHE Mao-yun YIN Gui-xiang YU Yang QIAO Wei-hua DU Li-pu YE Xing-guo | 2010 | Agricultural Sciences in China2010，9，3： | 9 |
| 2 | Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain显示文摘以便与优异抗菌剂活动和克服的 multidrug 抵抗发现新奇抗菌剂代理人,有新奇 C (14 ) 方面链的一系列 pleuromutilin 衍生物被综合并且评估为他们的在里面 vitro 抗菌剂活动。抗菌剂 acticities 的结果显示大多数衍生物对克积极的有机体显示出有势力活动。特别地,复合 10d 展出了大多数有势力禁止的活动与 pleuromutilin 和 linezoid 相比,为进一步的调查的出现同样潜在的分子。 | Li Qiang Fu Chen Yu Ling Xing Sheng Guo Hui Li He Yu She Yang | 2012 | Chinese Chemical Letters2012，23，1： | 5 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives显示文摘In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity,a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity.The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity,and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. | Li Qiang Fu Xing Sheng Guo Xin Liu Hui Li He Yu Ling Wang Yu She Yang | 2010 | Chinese Chemical Letters2010，21，5： | 5 |
| 5 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | Design,synthesis and in vitro evaluation of mono(2,2,2-trifluoroethyl)esters,mono L-amino acid ester prodrugs of acyclic nucleoside phosphonates as anti-HBV agents显示文摘A series of novel mono(2,2,2-trifluoroethyl) esters,mono L-amino acid ester prodrugs of acyclic nucleoside phosphonates was synthesized and their in vitro anti-HBVactivity was evaluated in HepG 2 2.2.15 cells.Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil and alamifovir(MCC-478) with EC_(50) and CC_(50) values of 0.01μmol/L and >8000μmol/L respectively. | Xiao Zhong Fu Yu Ou Jan Xin Yu She Yang | 2011 | Chinese Chemical Letters2011，22，12： | 2 |
| 8 | The genetic diversity of mtDNA D - loop and the origin of Chinese goats 显示文摘 | Liu Ruo - yu Yang Gong - she Lei Chu - zhao | 2006 | Acta Genetiea Sinica2006，33，5： | 1 |
| 9 | Effect of Gal-13 on the content of immunoglobulin, proliferation of lymphocyte and antibody titers after vaccination with infectious bursal disease virus vaccine in chickens显示文摘 | YANG Yu rong SHE Rui-ping PENG Kai-song | 2007 | AsiarcAust J Anim Sci2007，20，3： | 1 |
| 10 | A Mild and Efficient Procedure for the Preparation of Chromone-2-carboxylates显示文摘A mild and efficient procedure to build up various chromone-2-carboxylates was developed. Condensation of diverse 2-hydroxyacetophones with tetr-butyl oxalate in the presence of sodium ethoxide could be accomplished rapidly under mild condition. Cyclo- dehydration was carried out to achieve chromone-2-carboxylates in one-pot with impressive yield. Advantages over conventional methods with diethyl oxalate were observed in yield and reaction time. | Juan Hong YU Yu She YANG Ru Yun JI | 2006 | Chinese Chemical Letters2006，17，8： | 1 |
| 11 | Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent显示文摘A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBVactivity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 mmol/L and 2530 mmol/L, respectively. | Xiao Zhong Fu Sai Hong Jiang Jian Xin Yu She Yang RU Yun Ji | 2007 | Chinese Chemical Letters2007，18，7： | 1 |
| 12 | Exploring the catalytic function and active sites of a novel C-glycosyltransferase from Anemarrhena asphodeloides显示文摘Anemarrhena asphodeloides is an immensely popular medicinal herb in China,which contains an abundant of mangiferin.As an important bioactive xanthone C-glycoside,mangiferin possesses a variety of pharmacological activities and is derived from the cyclization reaction of a benzophenone C-glycoside(maclurin).Biosyntheti-cally,C-glycosyltransferases are critical for the formation of benzophenone C-glycosides.However,the benzo-phenone C-glycosyltransferases from Anemarrhena asphodeloides have not been discovered.Herein,a promiscuous C-glycosyltransferase(AaCGT)was identified from Anemarrhena asphodeloides.It was able to catalyze efficiently mono-C-glycosylation of benzophenone,together with di-C-glycosylation of dihydrochalcone.It also exhibited the weak O-glycosylation or potent S-glycosylation capacities toward 12 other types of flavonoid scaffolds and a simple aromatic compound with–SH group.Homology modeling and mutagenesis experiments revealed that the glycosylation reaction of AaCGT was initiated by the conserved residue H23 as the catalytic base.Three critical residues H356,W359 and D380 were involved in the recognition of sugar donor through hydrogen-bonding interactions.In particular,the double mutant of F94W/L378M led to an unexpected enzy-matic conversion of mono-C-to di-C-glycosylation.This study highlights the important value of AaCGT as a potential biocatalyst for efficiently synthesizing high-value C-glycosides. | Jia Huang Yaru She Jingyang Yue Yidu Chen Yu Li Jing Li Yonger Hu Deying Yang Jiabo Chen Lu Yang Zhongqiu Liu Ruibo Wu Pengfei Jin Lixin Duan | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 1 |
| 13 | Design,synthesis and anti-HBV activity of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir显示文摘acyclovir 的一系列新奇二度(trifluoroethyl ) phosphonomethyl 醚衍生物被综合并且他们的在里面 vitro anti-HBV 活动在 HepG2 2.2.15 房间被评估。与 acyclovir 相对照,大多数描述的 phosphonates 作为 HBV 复制的有势力禁止者出现了。特别, 11 2.92 μ 与 IC 50 珍视的最活跃的混合物; mol/L 比有 100 μ 的 IC 50 价值的 acyclovir 是乘更多的有势力的 33; mol/L。 | Peng Lu Sai Hong Jiang Jiang Xia Liu Yu She Yang Ru Yun Ji | 2009 | Chinese Chemical Letters2009，20，5： | 1 |
| 14 | Knockdown of PU.1 AS lncRNA inhibits adipogenesis through enhancing PU.1 mRNA translation显示文摘 | Wei‐Jun Pang Li‐Gen Lin Yan Xiong Ning Wei Yu Wang Qing‐Wu Shen Gong‐She Yang | 2013 | J Cell Biochem2013，，11： | 1 |
| 15 | Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development显示文摘Dear Editor,Necroptosis,a form of caspase-independent cell death,is tightly regulated to maintain tissue homeostasis.The execution of necroptosis depends on receptor interacting protein kinase 3(RIP3)-activated mixed lineage kinase domain-like protein(MLKL).MLKL is phosphorylated by RIP3,which releases MLKL autoinhibi-tion and drives its self-oligomerization.1-3 Oligomerized MLKL translocates to cellular membranes,where it disrupts membrane integrity causing necroptotic cell death. | Xinxin Zhu Na Yang Yu Yang Feiyang Yuan Dandan Yu Yu Zhang Zhaoqian Shu Ning Nan Hong Hu Xiaoyan Liu She Chen Liming Sun Huayi Wang | 2022 | Cell Research2022，32，4： | 1 |
| 16 | A NEW METHOD FOR THE PREPARATION OF FULLEROL显示文摘ANEWMETHODFORTHEPREPARATIONOFFULLEROL￥DaYongSUN;ZiYangLIU;XingHuaGUO;YiMinSHE;YuZHOU;ShuYingLIU(TheKeyLaboratoryofAppliedSpec... | Da Yong SUN Zi Yang LIU Xing Hua GUO Yi Min SHE Yu ZHOU Shu Ying LIU (The Key Laboratory of Applied Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun. Jilin 130022) | 1996 | Chinese Chemical Letters1996，7，5： | 0 |
| 17 | Non-escaping frost tolerant QTL linked genetic loci at reproductive stage in six wheat DH populations显示文摘Reproductive stage frost poses a major constraint for wheat production in countries such as Australia.However,little progress has been made in identifying key genes to overcome the constraint.In the present study,a severe frost event hit two large-scale field trials consisting of six doubled haploid(DH)wheat populations at reproductive stage(young microspore stage)in Western Australia,leading to the identification of 30 robust frost QTL on 17 chromosomes.The major 18 QTL with the phenotype variation over 9.5%were located on 13 chromosomes including 2 A,2 B,2 D,3 A,4 A,4 B,4 D,5 A,5 D,6 D,7 A,7 B and7 D.Most frost QTL were closely linked to the QTL of anthesis,maturity,Zadok stages as well as linked to anthesis related genes.Out of those,six QTL were repetitively detected on the homologous regions on 2 B,4 B,4 D,5 A,5 D,7 A in more than two populations.Results showed that the frost damage is associated with alleles of Vrn-A1 a,Vrn-D1 a,Rht-B1 b,Rht-D1 b,and the high copy number of Ppd-B1.However,anthesis QTL and anthesis related genes of Vrn-B1 a and Ta FT3-1 B on chromosomes 5 B and 1 B did not lead to frost damage,indicating that these early-flowering phenotype related genes are compatible with frost tolerance and thus can be utilised in breeding.Our results also indicate that wild-type alleles Rht-B1 a and Rht-D1 a can be used when breeding for frost-tolerant varieties without delaying flowering time. | Jingjuan Zhang MD Shahidul Islam Yun Zhao Masood Anwar Zaid Alhabbar Maoyun She Rongchang Yang Angela Juhasz Guixiang Tang Jiansheng Chen Hang Liu Yanjie Jiang Shengnan Zhai Xin Hu Junkang Rong Yingquan Zhang Yebo Qin Qier Liu Zitong Yu Yujuan Zhang Sadegh Balotf Mirza Dowla Sonia Afrin Nandita Roy Md Resad Mallik Md Atik Us Saieed Shanjida Rahman Nigarin Sultana Sarah Al-Sheikh Ahmed Chris Florides Kefei Chen Darshan Sharma Nathan Height Ben Biddulph Meiqin Lu Jorge EMayer Wujun Ma | 2022 | The Crop Journal2022，10，1： | 0 |
| 18 | Geology and mineralization of the Bayan Obo supergiant carbonatite-type REE-Nb-Fe deposit in Inner Mongolia, China: A review显示文摘The Bayan Obo supergiant carbonatite-related rare-earth-element-niobium-iron(REE-Nb-Fe) endogenetic deposit(thereafter as the Bayan Obo deposit), located at 150 km north of Baotou City in the Inner Mongolia Autonomous Region, is the largest rare-earth element(REE) resource in the world. Tectonically,this deposit is situated on the northern margin of the North China Craton and adjacent to the Xing’anMongolian orogenic belt to the south. The main strata within the mining area include the Neoarchean Se’ertengshan Group and the Mesoproterozoic Bayan Obo Group. Generally, the rare earth, niobium, and iron mineralization within the deposit are intrinsically related to the dolomite carbonatites and the extensive alteration of the country rocks caused by the carbonatite magma intrusion. The alteration of country rocks can be categorized into three types: contact metasomatism(anti-skarn and skarn alteration), fenitization,and hornfelsic alternation. As indicated by previous studies and summarized in this review, the multielement mineralization at Bayan Obo is closely associated with the metasomatic replacement of siliceous country rocks by carbonatite magmatic-hydrothermal fluids. The metasomatic process is comparable to the conventional skarnification that formed due to the intrusion of intermediate-acid magmatic rocks into limestone strata. However, the migration pattern of Si O2, Ca O, and Mg O in this novel metasomatic process is opposite to the skarn alteration. Accordingly, this review delineates, for the first time, an antiskarn metallogenic model for the Bayan Obo deposit, revealing the enigmatic relationship between the carbonatite magmatic-hydrothermal processes and the related iron and rare earth mineralization.Moreover, this study also contributes to a better understanding of the REE-Nd-Fe metallogenetic processes and the related fluorite mineralization at the Bayan Obo deposit. | Yi-ke Li Chang-hui Ke Hong-quan She Deng-hong Wang Cheng Xu An-jian Wang Rui-ping Li Zi-dong Peng Ze-ying Zhu Kui-feng Yang Wei Chen Jian-wei Zi Wen-lei Song Yong-gang Zhao Li Zhang Hong Yu Bin Guo Sheng-quan Zhou Xing-yu Yuan Jing-yao Liu | 2023 | China Geology2023，6，4： | 0 |
| 19 | An Efficient Process for Preparing 4-Methyl-2-phenyl Piperazine Hydrochloride and its Derivatives显示文摘An improved method for preparation of 4-methyl-2-phenyl piperazine and its derivatives with higher yield and inexpensive reagents was developed, the products were characterized by 1H-NMR and MS. | Bai Shu GUO, Yu She YANG*, Ru Yun JI Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Shanghai 200031 | 2003 | Chinese Chemical Letters2003，14，4： | 0 |
| 20 | Author Correction:863 genomes reveal the origin and domestication of chicken显示文摘We apologize for a mistake in Fig.2 that was immediately identified by Edward McClure in our article published online on June 25,2020.In the labels of Fig.2a,b,the blue color should represent West Asian chickens while the brown color should depict South Asian chickens.The correct version of Fig.2 is shown below.This correction does not affect the description and conclusion of this article. | Ming-Shan Wang Mukesh Thakur Min-Sheng Pen Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan She Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamad Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，9： | 0 |
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