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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 3 | 鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大,以及低盐膳食模式与高血压的患病率和控制率相关显示文摘食物对高血压患病率和控制率的影响尚不清晰。本文旨在中国人群中调查鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大以及低盐膳食模式是否与高血压有关。方法:从2012年9月到2014年12月共招募15303名受试者进行病例对照研究,分为高血压组(n=1604)和正常血压组(n=13660),其中高血压组又分为血压控制亚组(n=397)和血压未控制亚组(n=1207)。收集过去1 年里每周平均鱼、蛋、牛奶、坚果、蔬菜、水果和盐摄入量数据。鱼、蛋、牛奶、坚果、蔬菜、水果和盐的平均摄入量分别为117、150、35、20、2100、300和58g/周。 | Yu G Fu H Huang W Zhang N Deng D Li G Lei H | 2019 | 中华高血压杂志2019，27，5： | 2 |
| 4 | Formation characteristics of nitric oxide in a three-staged air/LPG flame显示文摘 | Kim H S Baek S W Yu M J | 2003 | International Journal of Heat and Mass Transfer2003，46，： | 2 |
| 5 | Faminial risk of hepatocelluarear cinoma among chronic hepatitis B carriers and their relatives显示文摘 | Yu M W Chang H C LiawYF | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
| 6 | Antiprotozal activities of Centipeda minima显示文摘 | Yu H W WRIGHT C W CAI Y | 1994 | Phytoherapy Research1994，8，： | 1 |
| 7 | Layered Copper Metagermanate Nanobelts: Hydrothennal Synthesis, Structure, and Magnetic Properties显示文摘 | Song R Q Xu A W Yu S H | 2007 | J Am Chem Soc2007，129，14： | 1 |
| 8 | Reversal of atrial electrical remodeling following cardioversion of long-standing atrial fibrillation in man显示文摘 | YU W C LEE S H TAI C T | 1999 | Cardiovasc Res1999，42，： | 1 |
| 9 | Mechanical prope- rties of TiN thin film coatings on 304 stainless steel substrates显示文摘 | CHOU W J YU G P HUANG J H | 2002 | Serface and Coatings Technology2002，，149： | 1 |
| 10 | Thermo-sensitive swelling behavior in crosslinked N-isopropylacrylamide networks:cationic,anionic,and ampholytic hydrogels显示文摘 | Yu H Grainger D W | 1993 | Journal of Applied Polymer Science1993，49，： | 1 |
| 11 | Expression of cyclooxygenase-2 (Cox-2) in human esophageal cancer and in vitro inhibition by a specific Cox-2 inhibitor, NS-398 显示文摘 | Yu H P Shi L Y Lu W H | 2004 | J Gastroenterol Hepatol2004，19，6： | 1 |
| 12 | Isolation and characterization of 23 polymorphic microsatellite markers for diversity and stock analysis in tiger shrimp (Penaeus monodon) 显示文摘 | Yu W P Chou H H You E M | 2004 | Mol Eco Notes2004，4，： | 1 |
| 13 | An investigation of a new near-beta forging process for titanium alloys and its application in aviation components显示文摘 | Zhou Y G Zeng W D Yu H Q | 2005 | Mater Sci Eng A2005，393，1： | 1 |
| 14 | Functional and surface-active membranes from poly(vinylidene fluoride)-graft-poly(acrylic acid) prepared via RAFT-mediated graft copolymerization显示文摘 | Ying L Yu W H Kang E T | 2004 | Langmuir2004，20，： | 1 |
| 15 | Selective hydrogenation of o- chloronitrobenzene over polymer-stabilized ruthenium colloidal clusters显示文摘 | Liu M Yu W Liu H | 1999 | J Mol Catal A:Chem1999，138，23： | 1 |
| 16 | Foaming behavior of polypropylene/polystyrene blends enhanced by improved in- terracial compatibility显示文摘 | ZHAI W T WANG H Y YU J | 2008 | Journal of Polymer Science2008，46，16： | 1 |
| 17 | The synthesis of a chiral-amino acid derivative by the Grignard reaction of an aspartic acid equivalent 显示文摘 | LIU F YU W S OU W H | 2010 | J Chem Res2010，34，9： | 1 |
| 18 | Enhancement of 26S proteasomefunctionality connects oxidative stress and vascular endothelialinflammatory response in diabetes mellitus 显示文摘 | Liu H Yu S Xu W | 2012 | ArteriosclerThromb Vase Biol2012，32，9： | 1 |
| 19 | Overexpression of synthesized cephalosporin C acylase containing mutations in the substrate transport tunnel显示文摘 | Wang Y Yu H Song W | 2012 | J Biosci Bioeng2012，113，1： | 1 |
| 20 | Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide显示文摘 | Tang D W Yu S H Ho Y C | | 0，，01： | 1 |
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